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Updated November 2019
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Protein Info
Short Name:
CTTNBP2
Full Name:
Cortactin-binding protein 2
Alias:
C7orf8; cortactin binding protein 2; cortactin-binding 2; CORTBP2; CTTB2; KIAA1758; Orf4
Type:
Mass (Da):
181051
Number AA:
1663
UniProt ID:
Q8WZ74
International Prot ID:
IPI00103869
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
A
T
D
G
A
S
C
E
P
D
L
S
R
Site 2
S13
A
S
C
E
P
D
L
S
R
A
P
E
D
A
A
Site 3
T35
K
K
E
F
D
V
D
T
L
S
K
S
E
L
R
Site 4
S37
E
F
D
V
D
T
L
S
K
S
E
L
R
M
L
Site 5
S39
D
V
D
T
L
S
K
S
E
L
R
M
L
L
S
Site 6
Y75
E
V
F
I
Q
E
R
Y
G
R
F
N
L
N
D
Site 7
Y91
F
L
A
L
Q
R
D
Y
E
A
G
A
G
D
K
Site 8
S126
K
K
M
Q
E
R
M
S
A
Q
L
A
A
A
E
Site 9
S134
A
Q
L
A
A
A
E
S
R
Q
K
K
L
E
M
Site 10
T206
L
E
E
E
K
K
K
T
N
E
L
E
E
E
L
Site 11
S214
N
E
L
E
E
E
L
S
A
E
K
R
R
S
T
Site 12
S220
L
S
A
E
K
R
R
S
T
E
M
E
A
Q
M
Site 13
T221
S
A
E
K
R
R
S
T
E
M
E
A
Q
M
E
Site 14
S232
A
Q
M
E
K
Q
L
S
E
F
D
T
E
R
E
Site 15
T236
K
Q
L
S
E
F
D
T
E
R
E
Q
L
R
A
Site 16
T252
L
N
R
E
E
A
H
T
T
D
L
K
E
E
I
Site 17
T253
N
R
E
E
A
H
T
T
D
L
K
E
E
I
D
Site 18
S273
I
E
Q
L
K
R
G
S
D
S
K
P
S
L
S
Site 19
S275
Q
L
K
R
G
S
D
S
K
P
S
L
S
L
P
Site 20
S278
R
G
S
D
S
K
P
S
L
S
L
P
R
K
T
Site 21
S280
S
D
S
K
P
S
L
S
L
P
R
K
T
K
D
Site 22
T285
S
L
S
L
P
R
K
T
K
D
R
R
L
V
S
Site 23
S292
T
K
D
R
R
L
V
S
I
S
V
G
T
E
G
Site 24
S294
D
R
R
L
V
S
I
S
V
G
T
E
G
T
V
Site 25
T302
V
G
T
E
G
T
V
T
R
S
V
A
C
Q
T
Site 26
S304
T
E
G
T
V
T
R
S
V
A
C
Q
T
D
L
Site 27
T325
H
M
K
K
L
P
L
T
M
P
V
K
P
S
T
Site 28
S334
P
V
K
P
S
T
G
S
P
L
V
S
A
N
A
Site 29
S338
S
T
G
S
P
L
V
S
A
N
A
K
G
S
V
Site 30
S348
A
K
G
S
V
C
T
S
A
T
M
A
R
P
G
Site 31
S361
P
G
I
D
R
Q
A
S
Y
G
D
L
I
G
A
Site 32
Y362
G
I
D
R
Q
A
S
Y
G
D
L
I
G
A
S
Site 33
S377
V
P
A
F
P
P
P
S
A
N
K
I
E
E
N
Site 34
S387
K
I
E
E
N
G
P
S
T
G
S
T
P
D
P
Site 35
S390
E
N
G
P
S
T
G
S
T
P
D
P
T
S
S
Site 36
T391
N
G
P
S
T
G
S
T
P
D
P
T
S
S
T
Site 37
T395
T
G
S
T
P
D
P
T
S
S
T
P
P
L
P
Site 38
S396
G
S
T
P
D
P
T
S
S
T
P
P
L
P
S
Site 39
S397
S
T
P
D
P
T
S
S
T
P
P
L
P
S
N
Site 40
T398
T
P
D
P
T
S
S
T
P
P
L
P
S
N
A
Site 41
S403
S
S
T
P
P
L
P
S
N
A
A
P
P
T
A
Site 42
T412
A
A
P
P
T
A
Q
T
P
G
I
A
P
Q
N
Site 43
S420
P
G
I
A
P
Q
N
S
Q
A
P
P
M
H
S
Site 44
S427
S
Q
A
P
P
M
H
S
L
H
S
P
C
A
N
Site 45
S430
P
P
M
H
S
L
H
S
P
C
A
N
T
S
L
Site 46
S436
H
S
P
C
A
N
T
S
L
H
P
G
L
N
P
Site 47
T466
P
D
Q
N
G
N
T
T
Q
S
P
P
S
R
D
Site 48
S468
Q
N
G
N
T
T
Q
S
P
P
S
R
D
V
S
Site 49
S471
N
T
T
Q
S
P
P
S
R
D
V
S
P
T
S
Site 50
S475
S
P
P
S
R
D
V
S
P
T
S
R
D
N
L
Site 51
T477
P
S
R
D
V
S
P
T
S
R
D
N
L
V
A
Site 52
S478
S
R
D
V
S
P
T
S
R
D
N
L
V
A
K
Site 53
T491
A
K
Q
L
A
R
N
T
V
T
Q
A
L
S
R
Site 54
S497
N
T
V
T
Q
A
L
S
R
F
T
S
P
Q
A
Site 55
T500
T
Q
A
L
S
R
F
T
S
P
Q
A
G
A
P
Site 56
S501
Q
A
L
S
R
F
T
S
P
Q
A
G
A
P
S
Site 57
S508
S
P
Q
A
G
A
P
S
R
P
G
V
P
P
T
Site 58
T515
S
R
P
G
V
P
P
T
G
D
V
G
T
H
P
Site 59
T520
P
P
T
G
D
V
G
T
H
P
P
V
G
R
T
Site 60
S528
H
P
P
V
G
R
T
S
L
K
T
H
G
V
A
Site 61
T531
V
G
R
T
S
L
K
T
H
G
V
A
R
V
D
Site 62
S553
P
P
K
K
P
G
L
S
Q
T
P
S
P
P
H
Site 63
T555
K
K
P
G
L
S
Q
T
P
S
P
P
H
P
Q
Site 64
S557
P
G
L
S
Q
T
P
S
P
P
H
P
Q
L
K
Site 65
S569
Q
L
K
V
I
I
D
S
S
R
A
S
N
T
G
Site 66
S570
L
K
V
I
I
D
S
S
R
A
S
N
T
G
A
Site 67
S573
I
I
D
S
S
R
A
S
N
T
G
A
K
V
D
Site 68
T583
G
A
K
V
D
N
K
T
V
A
S
T
P
S
S
Site 69
S586
V
D
N
K
T
V
A
S
T
P
S
S
L
P
Q
Site 70
T587
D
N
K
T
V
A
S
T
P
S
S
L
P
Q
G
Site 71
S590
T
V
A
S
T
P
S
S
L
P
Q
G
N
R
V
Site 72
S606
N
E
E
N
L
P
K
S
S
S
P
Q
L
P
P
Site 73
S607
E
E
N
L
P
K
S
S
S
P
Q
L
P
P
K
Site 74
S608
E
N
L
P
K
S
S
S
P
Q
L
P
P
K
P
Site 75
S616
P
Q
L
P
P
K
P
S
I
D
L
T
V
A
P
Site 76
S672
C
S
S
I
N
P
V
S
A
S
S
C
R
P
G
Site 77
S674
S
I
N
P
V
S
A
S
S
C
R
P
G
A
S
Site 78
S675
I
N
P
V
S
A
S
S
C
R
P
G
A
S
D
Site 79
T687
A
S
D
S
L
L
V
T
A
S
G
W
S
P
S
Site 80
Y739
E
E
G
L
D
I
N
Y
S
C
E
D
G
H
S
Site 81
S740
E
G
L
D
I
N
Y
S
C
E
D
G
H
S
A
Site 82
S746
Y
S
C
E
D
G
H
S
A
L
Y
S
A
A
K
Site 83
Y749
E
D
G
H
S
A
L
Y
S
A
A
K
N
G
H
Site 84
S750
D
G
H
S
A
L
Y
S
A
A
K
N
G
H
T
Site 85
T757
S
A
A
K
N
G
H
T
D
C
V
R
L
L
L
Site 86
T812
H
A
A
D
G
G
Q
T
P
L
Y
L
A
C
K
Site 87
Y815
D
G
G
Q
T
P
L
Y
L
A
C
K
N
G
N
Site 88
S837
L
E
A
G
T
N
R
S
V
K
T
T
D
G
W
Site 89
T841
T
N
R
S
V
K
T
T
D
G
W
T
P
V
H
Site 90
T845
V
K
T
T
D
G
W
T
P
V
H
A
A
V
D
Site 91
T853
P
V
H
A
A
V
D
T
G
N
V
D
S
L
K
Site 92
S858
V
D
T
G
N
V
D
S
L
K
L
L
M
Y
H
Site 93
Y864
D
S
L
K
L
L
M
Y
H
R
I
P
A
H
G
Site 94
S873
R
I
P
A
H
G
N
S
F
N
E
E
E
S
E
Site 95
S879
N
S
F
N
E
E
E
S
E
S
S
V
F
D
L
Site 96
S881
F
N
E
E
E
S
E
S
S
V
F
D
L
D
G
Site 97
S882
N
E
E
E
S
E
S
S
V
F
D
L
D
G
G
Site 98
S892
D
L
D
G
G
E
E
S
P
E
G
I
S
K
P
Site 99
S897
E
E
S
P
E
G
I
S
K
P
V
V
P
A
D
Site 100
T949
R
R
D
K
C
N
R
T
V
H
D
V
A
T
D
Site 101
T955
R
T
V
H
D
V
A
T
D
D
C
K
H
L
L
Site 102
S982
S
V
G
E
I
E
P
S
N
Y
G
S
D
D
L
Site 103
Y984
G
E
I
E
P
S
N
Y
G
S
D
D
L
E
C
Site 104
S986
I
E
P
S
N
Y
G
S
D
D
L
E
C
E
N
Site 105
T1004
A
L
N
I
R
K
Q
T
S
W
D
D
F
S
K
Site 106
S1005
L
N
I
R
K
Q
T
S
W
D
D
F
S
K
A
Site 107
S1010
Q
T
S
W
D
D
F
S
K
A
V
S
Q
A
L
Site 108
S1014
D
D
F
S
K
A
V
S
Q
A
L
T
N
H
F
Site 109
T1018
K
A
V
S
Q
A
L
T
N
H
F
Q
A
I
S
Site 110
S1043
T
C
N
N
T
T
D
S
N
I
G
L
S
A
R
Site 111
S1048
T
D
S
N
I
G
L
S
A
R
S
I
R
S
I
Site 112
T1056
A
R
S
I
R
S
I
T
L
G
N
V
P
W
S
Site 113
S1063
T
L
G
N
V
P
W
S
V
G
Q
S
F
A
Q
Site 114
S1067
V
P
W
S
V
G
Q
S
F
A
Q
S
P
W
D
Site 115
S1071
V
G
Q
S
F
A
Q
S
P
W
D
F
M
R
K
Site 116
T1085
K
N
K
A
E
H
I
T
V
L
L
S
G
P
Q
Site 117
S1097
G
P
Q
E
G
C
L
S
S
V
T
Y
A
S
M
Site 118
Y1113
P
L
Q
M
M
Q
N
Y
L
R
L
V
E
Q
Y
Site 119
Y1120
Y
L
R
L
V
E
Q
Y
H
N
V
I
F
H
G
Site 120
Y1135
P
E
G
S
L
Q
D
Y
I
V
H
Q
L
A
L
Site 121
S1187
C
L
I
P
V
K
Q
S
P
S
K
K
K
I
I
Site 122
S1189
I
P
V
K
Q
S
P
S
K
K
K
I
I
I
I
Site 123
S1203
I
L
E
N
L
E
K
S
S
L
S
E
L
L
R
Site 124
S1204
L
E
N
L
E
K
S
S
L
S
E
L
L
R
D
Site 125
S1206
N
L
E
K
S
S
L
S
E
L
L
R
D
F
L
Site 126
S1220
L
A
P
L
E
N
R
S
T
E
S
P
C
T
F
Site 127
T1221
A
P
L
E
N
R
S
T
E
S
P
C
T
F
Q
Site 128
S1223
L
E
N
R
S
T
E
S
P
C
T
F
Q
K
G
Site 129
T1226
R
S
T
E
S
P
C
T
F
Q
K
G
N
G
L
Site 130
Y1238
N
G
L
S
E
C
Y
Y
F
H
E
N
C
F
L
Site 131
S1299
K
F
K
G
Q
A
P
S
P
C
D
P
V
C
K
Site 132
T1350
V
P
G
H
A
Q
V
T
V
K
W
M
S
K
L
Site 133
S1372
R
V
Q
E
A
I
L
S
R
A
S
V
K
R
Q
Site 134
S1375
E
A
I
L
S
R
A
S
V
K
R
Q
P
G
F
Site 135
T1386
Q
P
G
F
G
Q
T
T
A
K
R
H
P
S
Q
Site 136
S1392
T
T
A
K
R
H
P
S
Q
G
Q
Q
A
V
V
Site 137
T1426
R
A
E
L
D
Q
H
T
A
D
F
K
G
G
S
Site 138
S1437
K
G
G
S
F
P
L
S
I
V
S
S
Y
N
T
Site 139
S1440
S
F
P
L
S
I
V
S
S
Y
N
T
C
N
K
Site 140
S1441
F
P
L
S
I
V
S
S
Y
N
T
C
N
K
K
Site 141
T1444
S
I
V
S
S
Y
N
T
C
N
K
K
K
G
E
Site 142
S1461
A
W
R
K
V
N
T
S
P
R
R
K
S
G
R
Site 143
S1466
N
T
S
P
R
R
K
S
G
R
F
S
L
P
T
Site 144
S1470
R
R
K
S
G
R
F
S
L
P
T
W
N
K
P
Site 145
T1473
S
G
R
F
S
L
P
T
W
N
K
P
D
L
S
Site 146
S1480
T
W
N
K
P
D
L
S
T
E
G
M
K
N
K
Site 147
T1488
T
E
G
M
K
N
K
T
I
S
Q
L
N
C
N
Site 148
S1499
L
N
C
N
R
N
A
S
L
S
K
Q
K
S
L
Site 149
S1501
C
N
R
N
A
S
L
S
K
Q
K
S
L
E
N
Site 150
S1505
A
S
L
S
K
Q
K
S
L
E
N
D
L
S
L
Site 151
S1511
K
S
L
E
N
D
L
S
L
T
L
N
L
D
Q
Site 152
S1521
L
N
L
D
Q
R
L
S
L
G
S
D
D
E
A
Site 153
S1524
D
Q
R
L
S
L
G
S
D
D
E
A
D
L
V
Site 154
S1536
D
L
V
K
E
L
Q
S
M
C
S
S
K
S
E
Site 155
S1539
K
E
L
Q
S
M
C
S
S
K
S
E
S
D
I
Site 156
S1540
E
L
Q
S
M
C
S
S
K
S
E
S
D
I
S
Site 157
S1542
Q
S
M
C
S
S
K
S
E
S
D
I
S
K
I
Site 158
S1544
M
C
S
S
K
S
E
S
D
I
S
K
I
A
D
Site 159
S1547
S
K
S
E
S
D
I
S
K
I
A
D
S
R
D
Site 160
S1552
D
I
S
K
I
A
D
S
R
D
D
L
R
M
F
Site 161
S1561
D
D
L
R
M
F
D
S
S
G
N
N
P
V
L
Site 162
S1562
D
L
R
M
F
D
S
S
G
N
N
P
V
L
S
Site 163
S1569
S
G
N
N
P
V
L
S
A
T
I
N
N
L
R
Site 164
S1580
N
N
L
R
M
P
V
S
Q
K
E
V
S
P
L
Site 165
S1585
P
V
S
Q
K
E
V
S
P
L
S
S
H
Q
T
Site 166
S1588
Q
K
E
V
S
P
L
S
S
H
Q
T
T
E
C
Site 167
S1589
K
E
V
S
P
L
S
S
H
Q
T
T
E
C
S
Site 168
T1592
S
P
L
S
S
H
Q
T
T
E
C
S
N
S
K
Site 169
T1593
P
L
S
S
H
Q
T
T
E
C
S
N
S
K
S
Site 170
S1596
S
H
Q
T
T
E
C
S
N
S
K
S
K
T
E
Site 171
S1598
Q
T
T
E
C
S
N
S
K
S
K
T
E
L
G
Site 172
S1600
T
E
C
S
N
S
K
S
K
T
E
L
G
V
S
Site 173
T1602
C
S
N
S
K
S
K
T
E
L
G
V
S
R
V
Site 174
S1607
S
K
T
E
L
G
V
S
R
V
K
S
F
L
P
Site 175
S1618
S
F
L
P
V
P
R
S
K
V
T
Q
C
S
Q
Site 176
S1624
R
S
K
V
T
Q
C
S
Q
N
T
K
R
S
S
Site 177
T1627
V
T
Q
C
S
Q
N
T
K
R
S
S
S
S
S
Site 178
S1630
C
S
Q
N
T
K
R
S
S
S
S
S
N
T
R
Site 179
S1631
S
Q
N
T
K
R
S
S
S
S
S
N
T
R
Q
Site 180
S1632
Q
N
T
K
R
S
S
S
S
S
N
T
R
Q
I
Site 181
S1634
T
K
R
S
S
S
S
S
N
T
R
Q
I
E
I
Site 182
T1636
R
S
S
S
S
S
N
T
R
Q
I
E
I
N
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation