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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DNASE2B
Full Name:
Deoxyribonuclease-2-beta
Alias:
DLAD; DNase II beta; DNase II-like acid DNase; DNS2B; EC 3.1.22.1
Type:
Enzyme - Dnase. DNase II family.
Mass (Da):
41713
Number AA:
361
UniProt ID:
Q8WZ79
International Prot ID:
Isoform1 - IPI00103879
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005764
Uniprot
OncoNet
Molecular Function:
GO:0004531
PhosphoSite+
KinaseNET
Biological Process:
GO:0006259
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S31
V
L
G
A
A
T
I
S
C
R
N
E
E
G
K
Site 2
T44
G
K
A
V
D
W
F
T
F
Y
K
L
P
K
R
Site 3
Y46
A
V
D
W
F
T
F
Y
K
L
P
K
R
Q
N
Site 4
S56
P
K
R
Q
N
K
E
S
G
E
T
G
L
E
Y
Site 5
Y63
S
G
E
T
G
L
E
Y
L
Y
L
D
S
T
T
Site 6
Y65
E
T
G
L
E
Y
L
Y
L
D
S
T
T
R
S
Site 7
S68
L
E
Y
L
Y
L
D
S
T
T
R
S
W
R
K
Site 8
T69
E
Y
L
Y
L
D
S
T
T
R
S
W
R
K
S
Site 9
S72
Y
L
D
S
T
T
R
S
W
R
K
S
E
Q
L
Site 10
S76
T
T
R
S
W
R
K
S
E
Q
L
M
N
D
T
Site 11
T83
S
E
Q
L
M
N
D
T
K
S
V
L
G
R
T
Site 12
S85
Q
L
M
N
D
T
K
S
V
L
G
R
T
L
Q
Site 13
Y95
G
R
T
L
Q
Q
L
Y
E
A
Y
A
S
K
S
Site 14
Y98
L
Q
Q
L
Y
E
A
Y
A
S
K
S
N
N
T
Site 15
S100
Q
L
Y
E
A
Y
A
S
K
S
N
N
T
A
Y
Site 16
S102
Y
E
A
Y
A
S
K
S
N
N
T
A
Y
L
I
Site 17
Y107
S
K
S
N
N
T
A
Y
L
I
Y
N
D
G
V
Site 18
Y120
G
V
P
K
P
V
N
Y
S
R
K
Y
G
H
T
Site 19
Y124
P
V
N
Y
S
R
K
Y
G
H
T
K
G
L
L
Site 20
T127
Y
S
R
K
Y
G
H
T
K
G
L
L
L
W
N
Site 21
Y156
P
P
I
P
E
E
G
Y
D
Y
P
P
T
G
R
Site 22
Y158
I
P
E
E
G
Y
D
Y
P
P
T
G
R
R
N
Site 23
T161
E
G
Y
D
Y
P
P
T
G
R
R
N
G
Q
S
Site 24
S168
T
G
R
R
N
G
Q
S
G
I
C
I
T
F
K
Site 25
T173
G
Q
S
G
I
C
I
T
F
K
Y
N
Q
Y
E
Site 26
Y176
G
I
C
I
T
F
K
Y
N
Q
Y
E
A
I
D
Site 27
Y179
I
T
F
K
Y
N
Q
Y
E
A
I
D
S
Q
L
Site 28
S184
N
Q
Y
E
A
I
D
S
Q
L
L
V
C
N
P
Site 29
T214
I
H
M
P
Q
L
C
T
R
A
S
S
S
E
I
Site 30
S217
P
Q
L
C
T
R
A
S
S
S
E
I
P
G
R
Site 31
S218
Q
L
C
T
R
A
S
S
S
E
I
P
G
R
L
Site 32
S219
L
C
T
R
A
S
S
S
E
I
P
G
R
L
L
Site 33
T227
E
I
P
G
R
L
L
T
T
L
Q
S
A
Q
G
Site 34
S231
R
L
L
T
T
L
Q
S
A
Q
G
Q
K
F
L
Site 35
S243
K
F
L
H
F
A
K
S
D
S
F
L
D
D
I
Site 36
T261
W
M
A
Q
R
L
K
T
H
L
L
T
E
T
W
Site 37
S277
R
K
R
Q
E
L
P
S
N
C
S
L
P
Y
H
Site 38
S280
Q
E
L
P
S
N
C
S
L
P
Y
H
V
Y
N
Site 39
Y283
P
S
N
C
S
L
P
Y
H
V
Y
N
I
K
A
Site 40
Y286
C
S
L
P
Y
H
V
Y
N
I
K
A
I
K
L
Site 41
S294
N
I
K
A
I
K
L
S
R
H
S
Y
F
S
S
Site 42
S297
A
I
K
L
S
R
H
S
Y
F
S
S
Y
Q
D
Site 43
Y298
I
K
L
S
R
H
S
Y
F
S
S
Y
Q
D
H
Site 44
S300
L
S
R
H
S
Y
F
S
S
Y
Q
D
H
A
K
Site 45
S328
C
I
G
D
L
N
R
S
P
H
Q
A
F
R
S
Site 46
Y347
C
T
Q
N
W
Q
I
Y
Q
A
F
Q
G
L
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation