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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ST8SIA1
Full Name:
Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase
Alias:
Alpha-2,8-sialyltransferase 8A; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; EC 2.4.99.8; Ganglioside GD3 synthase; GD3S; SIA8A; SIAT8; SIAT8A; ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1; ST8Sia I
Type:
Glycan Metabolism - glycosphingolipid biosynthesis - globo series; Glycan Metabolism - glycosphingolipid biosynthesis - lacto and neolacto series; Transferase; Glycan Metabolism - glycosphingolipid biosynthesis - ganglio series; EC 2.4.99.8
Mass (Da):
40519
Number AA:
356
UniProt ID:
Q92185
International Prot ID:
IPI00020197
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030173
Uniprot
OncoNet
Molecular Function:
GO:0003828
PhosphoSite+
KinaseNET
Biological Process:
GO:0006688
GO:0006486
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T11
C
G
R
A
R
R
Q
T
S
R
G
A
M
A
V
Site 2
S12
G
R
A
R
R
Q
T
S
R
G
A
M
A
V
L
Site 3
T26
L
A
W
K
F
P
R
T
R
L
P
M
G
A
S
Site 4
Y49
W
L
Y
I
F
P
V
Y
R
L
P
N
E
K
E
Site 5
T73
T
A
W
R
R
N
Q
T
A
A
R
A
F
R
K
Site 6
T95
P
A
H
L
F
A
M
T
K
M
N
S
P
M
G
Site 7
Y107
P
M
G
K
S
M
W
Y
D
G
E
F
L
Y
S
Site 8
Y113
W
Y
D
G
E
F
L
Y
S
F
T
I
D
N
S
Site 9
S114
Y
D
G
E
F
L
Y
S
F
T
I
D
N
S
T
Site 10
T116
G
E
F
L
Y
S
F
T
I
D
N
S
T
Y
S
Site 11
S120
Y
S
F
T
I
D
N
S
T
Y
S
L
F
P
Q
Site 12
T121
S
F
T
I
D
N
S
T
Y
S
L
F
P
Q
A
Site 13
S123
T
I
D
N
S
T
Y
S
L
F
P
Q
A
T
P
Site 14
T129
Y
S
L
F
P
Q
A
T
P
F
Q
L
P
L
K
Site 15
S150
N
G
G
I
L
K
K
S
G
C
G
R
Q
I
D
Site 16
S171
R
C
N
L
P
P
L
S
S
E
Y
T
K
D
V
Site 17
S172
C
N
L
P
P
L
S
S
E
Y
T
K
D
V
G
Site 18
Y174
L
P
P
L
S
S
E
Y
T
K
D
V
G
S
K
Site 19
T175
P
P
L
S
S
E
Y
T
K
D
V
G
S
K
S
Site 20
S182
T
K
D
V
G
S
K
S
Q
L
V
T
A
N
P
Site 21
T186
G
S
K
S
Q
L
V
T
A
N
P
S
I
I
R
Site 22
T205
N
L
L
W
S
R
K
T
F
V
D
N
M
K
I
Site 23
Y217
M
K
I
Y
N
H
S
Y
I
Y
M
P
A
F
S
Site 24
Y219
I
Y
N
H
S
Y
I
Y
M
P
A
F
S
M
K
Site 25
S232
M
K
T
G
T
E
P
S
L
R
V
Y
Y
T
L
Site 26
Y236
T
E
P
S
L
R
V
Y
Y
T
L
S
D
V
G
Site 27
Y237
E
P
S
L
R
V
Y
Y
T
L
S
D
V
G
A
Site 28
T238
P
S
L
R
V
Y
Y
T
L
S
D
V
G
A
N
Site 29
S240
L
R
V
Y
Y
T
L
S
D
V
G
A
N
Q
T
Site 30
S258
A
N
P
N
F
L
R
S
I
G
K
F
W
K
S
Site 31
S265
S
I
G
K
F
W
K
S
R
G
I
H
A
K
R
Site 32
S274
G
I
H
A
K
R
L
S
T
G
L
F
L
V
S
Site 33
T275
I
H
A
K
R
L
S
T
G
L
F
L
V
S
A
Site 34
Y311
E
Q
P
I
S
H
H
Y
Y
D
N
V
L
P
F
Site 35
Y312
Q
P
I
S
H
H
Y
Y
D
N
V
L
P
F
S
Site 36
S351
L
D
P
C
E
D
T
S
L
Q
P
T
S
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation