KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
SMPDL3A
Full Name:
Acid sphingomyelinase-like phosphodiesterase 3a
Alias:
Type:
Mass (Da):
51260
Number AA:
453
UniProt ID:
Q92484
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y52
D
L
H
L
D
P
T
Y
H
I
T
D
D
H
T
Site 2
T59
Y
H
I
T
D
D
H
T
K
V
C
A
S
S
K
Site 3
S71
S
S
K
G
A
N
A
S
N
P
G
P
F
G
D
Site 4
S98
A
F
D
F
I
K
N
S
G
Q
E
A
S
F
M
Site 5
T108
E
A
S
F
M
I
W
T
G
D
S
P
P
H
V
Site 6
Y154
P
A
L
G
N
H
D
Y
W
P
Q
D
Q
L
P
Site 7
S185
W
L
D
E
E
A
I
S
T
L
R
K
G
G
F
Site 8
T186
L
D
E
E
A
I
S
T
L
R
K
G
G
F
Y
Site 9
S194
L
R
K
G
G
F
Y
S
Q
K
V
T
T
N
P
Site 10
T198
G
F
Y
S
Q
K
V
T
T
N
P
N
L
R
I
Site 11
S207
N
P
N
L
R
I
I
S
L
N
T
N
L
Y
Y
Site 12
Y213
I
S
L
N
T
N
L
Y
Y
G
P
N
I
M
T
Site 13
Y214
S
L
N
T
N
L
Y
Y
G
P
N
I
M
T
L
Site 14
T236
Q
F
E
W
L
E
S
T
L
N
N
S
Q
Q
N
Site 15
S240
L
E
S
T
L
N
N
S
Q
Q
N
K
E
K
V
Site 16
S261
P
V
G
Y
L
P
S
S
Q
N
I
T
A
M
R
Site 17
T265
L
P
S
S
Q
N
I
T
A
M
R
E
Y
Y
N
Site 18
Y270
N
I
T
A
M
R
E
Y
Y
N
E
K
L
I
D
Site 19
Y271
I
T
A
M
R
E
Y
Y
N
E
K
L
I
D
I
Site 20
Y291
D
V
I
A
G
Q
F
Y
G
H
T
H
R
D
S
Site 21
T294
A
G
Q
F
Y
G
H
T
H
R
D
S
I
M
V
Site 22
S298
Y
G
H
T
H
R
D
S
I
M
V
L
S
D
K
Site 23
S303
R
D
S
I
M
V
L
S
D
K
K
G
S
P
V
Site 24
S324
P
A
V
T
P
V
K
S
V
L
E
K
Q
T
N
Site 25
T330
K
S
V
L
E
K
Q
T
N
N
P
G
I
R
L
Site 26
Y340
P
G
I
R
L
F
Q
Y
D
P
R
D
Y
K
L
Site 27
Y345
F
Q
Y
D
P
R
D
Y
K
L
L
D
M
L
Q
Site 28
Y372
E
S
I
W
K
L
E
Y
I
L
T
Q
T
Y
D
Site 29
T375
W
K
L
E
Y
I
L
T
Q
T
Y
D
I
E
D
Site 30
T377
L
E
Y
I
L
T
Q
T
Y
D
I
E
D
L
Q
Site 31
Y378
E
Y
I
L
T
Q
T
Y
D
I
E
D
L
Q
P
Site 32
S387
I
E
D
L
Q
P
E
S
L
Y
G
L
A
K
Q
Site 33
T396
Y
G
L
A
K
Q
F
T
I
L
D
S
K
Q
F
Site 34
Y406
D
S
K
Q
F
I
K
Y
Y
N
Y
F
F
V
S
Site 35
Y407
S
K
Q
F
I
K
Y
Y
N
Y
F
F
V
S
Y
Site 36
Y409
Q
F
I
K
Y
Y
N
Y
F
F
V
S
Y
D
S
Site 37
Y414
Y
N
Y
F
F
V
S
Y
D
S
S
V
T
C
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation