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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SMPDL3B
Full Name:
Acid sphingomyelinase-like phosphodiesterase 3b
Alias:
ASM3B; ASML3B; ASM-like phosphodiesterase 3b; EC 3.1.4.-
Type:
Enzyme - Hydrolase
Mass (Da):
50814
Number AA:
455
UniProt ID:
Q92485
International Prot ID:
IPI00386427
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005615
Uniprot
OncoNet
Molecular Function:
GO:0016798
GO:0004767
PhosphoSite+
KinaseNET
Biological Process:
GO:0006685
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y35
D
L
H
L
D
P
D
Y
K
V
S
K
D
P
F
Site 2
S47
D
P
F
Q
V
C
P
S
A
G
S
Q
P
V
P
Site 3
Y62
D
A
G
P
W
G
D
Y
L
C
D
S
P
W
A
Site 4
T91
E
P
D
F
I
L
W
T
G
D
D
T
P
H
V
Site 5
T95
I
L
W
T
G
D
D
T
P
H
V
P
D
E
K
Site 6
T116
L
E
I
V
E
R
L
T
K
L
I
R
E
V
F
Site 7
Y129
V
F
P
D
T
K
V
Y
A
A
L
G
N
H
D
Site 8
Y151
P
A
G
S
N
N
I
Y
N
Q
I
A
E
L
W
Site 9
S163
E
L
W
K
P
W
L
S
N
E
S
I
A
L
F
Site 10
Y176
L
F
K
K
G
A
F
Y
C
E
K
L
P
G
P
Site 11
T204
Y
Y
T
S
N
A
L
T
A
D
M
A
D
P
G
Site 12
T222
Q
W
L
E
D
V
L
T
D
A
S
K
A
G
D
Site 13
S225
E
D
V
L
T
D
A
S
K
A
G
D
M
V
Y
Site 14
Y259
R
E
G
F
N
E
K
Y
L
K
V
V
R
K
H
Site 15
Y287
T
D
S
F
R
M
L
Y
D
D
A
G
V
P
I
Site 16
T308
P
G
V
T
P
W
K
T
T
L
P
G
V
V
N
Site 17
T331
V
F
E
Y
D
R
A
T
L
S
L
K
D
M
V
Site 18
S333
E
Y
D
R
A
T
L
S
L
K
D
M
V
T
Y
Site 19
S345
V
T
Y
F
M
N
L
S
Q
A
N
A
Q
G
T
Site 20
T352
S
Q
A
N
A
Q
G
T
P
R
W
E
L
E
Y
Site 21
Y359
T
P
R
W
E
L
E
Y
Q
L
T
E
A
Y
G
Site 22
T362
W
E
L
E
Y
Q
L
T
E
A
Y
G
V
P
D
Site 23
Y365
E
Y
Q
L
T
E
A
Y
G
V
P
D
A
S
A
Site 24
S374
V
P
D
A
S
A
H
S
M
H
T
V
L
D
R
Site 25
S387
D
R
I
A
G
D
Q
S
T
L
Q
R
Y
Y
V
Site 26
T388
R
I
A
G
D
Q
S
T
L
Q
R
Y
Y
V
Y
Site 27
Y392
D
Q
S
T
L
Q
R
Y
Y
V
Y
N
S
V
S
Site 28
Y393
Q
S
T
L
Q
R
Y
Y
V
Y
N
S
V
S
Y
Site 29
Y395
T
L
Q
R
Y
Y
V
Y
N
S
V
S
Y
S
A
Site 30
S397
Q
R
Y
Y
V
Y
N
S
V
S
Y
S
A
G
V
Site 31
S401
V
Y
N
S
V
S
Y
S
A
G
V
C
D
E
A
Site 32
Y425
R
Q
V
D
I
D
A
Y
T
T
C
L
Y
A
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation