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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DDX1
Full Name:
ATP-dependent RNA helicase DDX1
Alias:
DBP-RB; DEAD (Asp-Glu-Ala-Asp) box polypeptide 1; DEAD box protein 1; DEAD box protein retinoblastoma; EC 3.6.1.-
Type:
EC 3.6.1.-; RNA binding protein; Helicase
Mass (Da):
82432
Number AA:
740
UniProt ID:
Q92499
International Prot ID:
IPI00293655
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030529
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0008026
GO:0003723
PhosphoSite+
KinaseNET
Biological Process:
GO:0007275
GO:0006446
GO:0000245
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y65
I
P
V
I
Q
I
V
Y
E
T
L
K
D
Q
Q
Site 2
T80
E
G
K
K
G
K
T
T
I
K
T
G
A
S
V
Site 3
T83
K
G
K
T
T
I
K
T
G
A
S
V
L
N
K
Site 4
Y96
N
K
W
Q
M
N
P
Y
D
R
G
S
A
F
A
Site 5
S100
M
N
P
Y
D
R
G
S
A
F
A
I
G
S
D
Site 6
T125
E
W
H
G
C
R
A
T
K
G
L
M
K
G
K
Site 7
Y134
G
L
M
K
G
K
H
Y
Y
E
V
S
C
H
D
Site 8
Y135
L
M
K
G
K
H
Y
Y
E
V
S
C
H
D
Q
Site 9
T160
Q
A
S
L
D
L
G
T
D
K
F
G
F
G
F
Site 10
T170
F
G
F
G
F
G
G
T
G
K
K
S
H
N
K
Site 11
Y182
H
N
K
Q
F
D
N
Y
G
E
E
F
T
M
H
Site 12
Y195
M
H
D
T
I
G
C
Y
L
D
I
D
K
G
H
Site 13
S259
K
D
G
F
V
A
L
S
K
A
P
D
G
Y
I
Site 14
Y265
L
S
K
A
P
D
G
Y
I
V
K
S
Q
H
S
Site 15
S269
P
D
G
Y
I
V
K
S
Q
H
S
G
N
A
Q
Site 16
T278
H
S
G
N
A
Q
V
T
Q
T
K
F
L
P
N
Site 17
Y312
N
I
K
Q
F
K
K
Y
I
D
N
P
K
L
R
Site 18
S334
V
A
A
R
D
Q
L
S
V
L
E
N
G
V
D
Site 19
S355
G
R
L
D
D
L
V
S
T
G
K
L
N
L
S
Site 20
S377
D
E
A
D
G
L
L
S
Q
G
Y
S
D
F
I
Site 21
Y380
D
G
L
L
S
Q
G
Y
S
D
F
I
N
R
M
Site 22
S381
G
L
L
S
Q
G
Y
S
D
F
I
N
R
M
H
Site 23
S419
S
F
D
V
K
K
L
S
E
K
I
M
H
F
P
Site 24
S436
V
D
L
K
G
E
D
S
V
P
D
T
V
H
H
Site 25
T440
G
E
D
S
V
P
D
T
V
H
H
V
V
V
P
Site 26
T452
V
V
P
V
N
P
K
T
D
R
L
W
E
R
L
Site 27
S462
L
W
E
R
L
G
K
S
H
I
R
T
D
D
V
Site 28
T466
L
G
K
S
H
I
R
T
D
D
V
H
A
K
D
Site 29
S481
N
T
R
P
G
A
N
S
P
E
M
W
S
E
A
Site 30
Y496
I
K
I
L
K
G
E
Y
A
V
R
A
I
K
E
Site 31
Y525
D
C
D
N
L
E
Q
Y
F
I
Q
Q
G
G
G
Site 32
Y599
L
P
D
E
K
Q
N
Y
V
H
R
I
G
R
V
Site 33
S617
E
R
M
G
L
A
I
S
L
V
A
T
E
K
E
Site 34
Y628
T
E
K
E
K
V
W
Y
H
V
C
S
S
R
G
Site 35
Y639
S
S
R
G
K
G
C
Y
N
T
R
L
K
E
D
Site 36
T641
R
G
K
G
C
Y
N
T
R
L
K
E
D
G
G
Site 37
Y653
D
G
G
C
T
I
W
Y
N
E
M
Q
L
L
S
Site 38
S660
Y
N
E
M
Q
L
L
S
E
I
E
E
H
L
N
Site 39
S671
E
H
L
N
C
T
I
S
Q
V
E
P
D
I
K
Site 40
S700
K
R
A
A
G
G
G
S
Y
K
G
H
V
D
I
Site 41
S725
L
E
K
E
A
Q
T
S
F
L
H
L
G
Y
L
Site 42
Y731
T
S
F
L
H
L
G
Y
L
P
N
Q
L
F
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation