PhosphoNET

           
Protein Info 
   
Short Name:  HSD17B8
Full Name:  Estradiol 17-beta-dehydrogenase 8
Alias:  17-beta-HSD 8; 17-beta-hydroxysteroid dehydrogenase 8; D6S2245E; DHB8; FABGL; H2-KE6; HKE6; Hsd17b8; Hydroxysteroid (17-beta) dehydrogenase 8; KE6; Ke-6; Protein Ke6; RING2; SDR30C1; Short chain dehydrogenase/reductase family 30C, member 1; Testosterone 17-beta-dehydrogenase 8, 17-beta-hydroxysteroid dehydrogenase 8, 3-oxoacyl-[acyl-carrier-protein] reductase, Protein Ke6, Really interesting new gene 2 protein
Type:  EC 1.1.1.62; EC 1.1.1.63; Mitochondrial; Lipid Metabolism - androgen and estrogen; Oxidoreductase
Mass (Da):  26955
Number AA:  261
UniProt ID:  Q92506
International Prot ID:  IPI00021890
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005759     Uniprot OncoNet
Molecular Function:  GO:0005488  GO:0004303  GO:0050327 PhosphoSite+ KinaseNET
Biological Process:  GO:0006703  GO:0055114   Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1T51DRAAAQETVRLLGGP
Site 2S60RLLGGPGSKEGPPRG
Site 3Y169GNVGQTNYAASKAGV
Site 4T207GFIATPMTQKVPQKV
Site 5T219QKVVDKITEMIPMGH
Site 6S245AFLASEDSGYITGTS
Site 7Y247LASEDSGYITGTSVE
Site 8T249SEDSGYITGTSVEVT
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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