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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Trb2
Full Name:
Tribbles homolog 2
Alias:
TRIB2
Type:
Protein-serine kinase, CAMK group, Trbl family
Mass (Da):
38801
Number AA:
343
UniProt ID:
Q92519
International Prot ID:
IPI00012516
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005856
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004672
GO:0004860
PhosphoSite+
KinaseNET
Biological Process:
GO:0006468
GO:0043405
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T7
_
M
N
I
H
R
S
T
P
I
T
I
A
R
Y
Site 2
T10
I
H
R
S
T
P
I
T
I
A
R
Y
G
R
S
Site 3
Y14
T
P
I
T
I
A
R
Y
G
R
S
R
N
K
T
Site 4
T21
Y
G
R
S
R
N
K
T
Q
D
F
E
E
L
S
Site 5
S28
T
Q
D
F
E
E
L
S
S
I
R
S
A
E
P
Site 6
S29
Q
D
F
E
E
L
S
S
I
R
S
A
E
P
S
Site 7
S32
E
E
L
S
S
I
R
S
A
E
P
S
Q
S
F
Site 8
S36
S
I
R
S
A
E
P
S
Q
S
F
S
P
N
L
Site 9
S38
R
S
A
E
P
S
Q
S
F
S
P
N
L
G
S
Site 10
S40
A
E
P
S
Q
S
F
S
P
N
L
G
S
P
S
Site 11
S45
S
F
S
P
N
L
G
S
P
S
P
P
E
T
P
Site 12
S47
S
P
N
L
G
S
P
S
P
P
E
T
P
N
L
Site 13
T51
G
S
P
S
P
P
E
T
P
N
L
S
H
C
V
Site 14
S55
P
P
E
T
P
N
L
S
H
C
V
S
C
I
G
Site 15
Y127
I
L
G
E
T
K
A
Y
V
F
F
E
R
S
Y
Site 16
Y134
Y
V
F
F
E
R
S
Y
G
D
M
H
S
F
V
Site 17
S139
R
S
Y
G
D
M
H
S
F
V
R
T
C
K
K
Site 18
T143
D
M
H
S
F
V
R
T
C
K
K
L
R
E
E
Site 19
S195
R
T
R
V
K
L
E
S
L
E
D
A
Y
I
L
Site 20
Y200
L
E
S
L
E
D
A
Y
I
L
R
G
D
D
D
Site 21
S208
I
L
R
G
D
D
D
S
L
S
D
K
H
G
C
Site 22
S210
R
G
D
D
D
S
L
S
D
K
H
G
C
P
A
Site 23
Y218
D
K
H
G
C
P
A
Y
V
S
P
E
I
L
N
Site 24
S220
H
G
C
P
A
Y
V
S
P
E
I
L
N
T
S
Site 25
T226
V
S
P
E
I
L
N
T
S
G
S
Y
S
G
K
Site 26
S227
S
P
E
I
L
N
T
S
G
S
Y
S
G
K
A
Site 27
S229
E
I
L
N
T
S
G
S
Y
S
G
K
A
A
D
Site 28
S231
L
N
T
S
G
S
Y
S
G
K
A
A
D
V
W
Site 29
S260
P
F
H
D
I
E
P
S
S
L
F
S
K
I
R
Site 30
S261
F
H
D
I
E
P
S
S
L
F
S
K
I
R
R
Site 31
S264
I
E
P
S
S
L
F
S
K
I
R
R
G
Q
F
Site 32
T276
G
Q
F
N
I
P
E
T
L
S
P
K
A
K
C
Site 33
S287
K
A
K
C
L
I
R
S
I
L
R
R
E
P
S
Site 34
S294
S
I
L
R
R
E
P
S
E
R
L
T
S
Q
E
Site 35
T298
R
E
P
S
E
R
L
T
S
Q
E
I
L
D
H
Site 36
S299
E
P
S
E
R
L
T
S
Q
E
I
L
D
H
P
Site 37
T310
L
D
H
P
W
F
S
T
D
F
S
V
S
N
S
Site 38
S313
P
W
F
S
T
D
F
S
V
S
N
S
A
Y
G
Site 39
S315
F
S
T
D
F
S
V
S
N
S
A
Y
G
A
K
Site 40
S317
T
D
F
S
V
S
N
S
A
Y
G
A
K
E
V
Site 41
Y319
F
S
V
S
N
S
A
Y
G
A
K
E
V
S
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation