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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LPIN2
Full Name:
Phosphatidate phosphatase LPIN2
Alias:
Lipin-2
Type:
Mass (Da):
99399
Number AA:
896
UniProt ID:
Q92539
International Prot ID:
IPI00021956
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0043226
GO:0043227
Uniprot
OncoNet
Molecular Function:
GO:0003824
GO:0008195
GO:0016787
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y43
V
Q
Q
Q
D
G
S
Y
Q
C
S
P
F
H
V
Site 2
S46
Q
D
G
S
Y
Q
C
S
P
F
H
V
R
F
G
Site 3
S60
G
K
L
G
V
L
R
S
K
E
K
V
I
D
I
Site 4
Y102
E
Y
E
K
L
P
A
Y
L
A
T
S
P
I
P
Site 5
S106
L
P
A
Y
L
A
T
S
P
I
P
T
E
D
Q
Site 6
T110
L
A
T
S
P
I
P
T
E
D
Q
F
F
K
D
Site 7
T120
Q
F
F
K
D
I
D
T
P
L
V
K
S
G
G
Site 8
S125
I
D
T
P
L
V
K
S
G
G
D
E
T
P
S
Site 9
T130
V
K
S
G
G
D
E
T
P
S
Q
S
S
D
I
Site 10
S132
S
G
G
D
E
T
P
S
Q
S
S
D
I
S
H
Site 11
S134
G
D
E
T
P
S
Q
S
S
D
I
S
H
V
L
Site 12
S138
P
S
Q
S
S
D
I
S
H
V
L
E
T
E
T
Site 13
T148
L
E
T
E
T
I
F
T
P
S
S
V
K
K
K
Site 14
S150
T
E
T
I
F
T
P
S
S
V
K
K
K
K
R
Site 15
S151
E
T
I
F
T
P
S
S
V
K
K
K
K
R
R
Site 16
Y162
K
K
R
R
R
K
K
Y
K
Q
D
S
K
K
E
Site 17
S166
R
K
K
Y
K
Q
D
S
K
K
E
E
Q
A
A
Site 18
S174
K
K
E
E
Q
A
A
S
A
A
A
E
D
T
C
Site 19
T180
A
S
A
A
A
E
D
T
C
D
V
G
V
S
S
Site 20
S186
D
T
C
D
V
G
V
S
S
D
D
D
K
G
A
Site 21
S187
T
C
D
V
G
V
S
S
D
D
D
K
G
A
Q
Site 22
S199
G
A
Q
A
A
R
G
S
S
N
A
S
L
K
E
Site 23
S200
A
Q
A
A
R
G
S
S
N
A
S
L
K
E
E
Site 24
S203
A
R
G
S
S
N
A
S
L
K
E
E
E
C
K
Site 25
Y221
L
F
H
S
G
D
H
Y
P
L
S
D
G
D
W
Site 26
S224
S
G
D
H
Y
P
L
S
D
G
D
W
S
P
L
Site 27
S229
P
L
S
D
G
D
W
S
P
L
E
T
T
Y
P
Site 28
T233
G
D
W
S
P
L
E
T
T
Y
P
Q
T
A
C
Site 29
Y235
W
S
P
L
E
T
T
Y
P
Q
T
A
C
P
K
Site 30
T238
L
E
T
T
Y
P
Q
T
A
C
P
K
S
D
S
Site 31
S243
P
Q
T
A
C
P
K
S
D
S
E
L
E
V
K
Site 32
S245
T
A
C
P
K
S
D
S
E
L
E
V
K
P
A
Site 33
S254
L
E
V
K
P
A
E
S
L
L
R
S
E
S
H
Site 34
S258
P
A
E
S
L
L
R
S
E
S
H
M
E
W
T
Site 35
S260
E
S
L
L
R
S
E
S
H
M
E
W
T
W
G
Site 36
S272
T
W
G
G
F
P
E
S
T
K
V
S
K
R
E
Site 37
S276
F
P
E
S
T
K
V
S
K
R
E
R
S
D
H
Site 38
S281
K
V
S
K
R
E
R
S
D
H
H
P
R
T
A
Site 39
T287
R
S
D
H
H
P
R
T
A
T
I
T
P
S
E
Site 40
T289
D
H
H
P
R
T
A
T
I
T
P
S
E
N
T
Site 41
T291
H
P
R
T
A
T
I
T
P
S
E
N
T
H
F
Site 42
S303
T
H
F
R
V
I
P
S
E
D
N
L
I
S
E
Site 43
S309
P
S
E
D
N
L
I
S
E
V
E
K
D
A
S
Site 44
S316
S
E
V
E
K
D
A
S
M
E
D
T
V
C
T
Site 45
T320
K
D
A
S
M
E
D
T
V
C
T
I
V
K
P
Site 46
T334
P
K
P
R
A
L
G
T
Q
M
S
D
P
T
S
Site 47
S337
R
A
L
G
T
Q
M
S
D
P
T
S
V
A
E
Site 48
S341
T
Q
M
S
D
P
T
S
V
A
E
L
L
E
P
Site 49
T353
L
E
P
P
L
E
S
T
Q
I
S
S
M
L
D
Site 50
S356
P
L
E
S
T
Q
I
S
S
M
L
D
A
D
H
Site 51
S374
A
A
L
A
E
A
P
S
E
S
K
P
A
A
K
Site 52
S384
K
P
A
A
K
V
D
S
P
S
K
K
K
G
V
Site 53
S386
A
A
K
V
D
S
P
S
K
K
K
G
V
H
K
Site 54
S395
K
K
G
V
H
K
R
S
Q
H
Q
G
P
D
D
Site 55
Y404
H
Q
G
P
D
D
I
Y
L
D
D
L
K
G
L
Site 56
Y419
E
P
E
V
A
A
L
Y
F
P
K
S
E
S
E
Site 57
S423
A
A
L
Y
F
P
K
S
E
S
E
P
G
S
R
Site 58
S425
L
Y
F
P
K
S
E
S
E
P
G
S
R
Q
W
Site 59
S429
K
S
E
S
E
P
G
S
R
Q
W
P
E
S
D
Site 60
S435
G
S
R
Q
W
P
E
S
D
T
L
S
G
S
Q
Site 61
T437
R
Q
W
P
E
S
D
T
L
S
G
S
Q
S
P
Site 62
S439
W
P
E
S
D
T
L
S
G
S
Q
S
P
Q
S
Site 63
S441
E
S
D
T
L
S
G
S
Q
S
P
Q
S
V
G
Site 64
S443
D
T
L
S
G
S
Q
S
P
Q
S
V
G
S
A
Site 65
S446
S
G
S
Q
S
P
Q
S
V
G
S
A
A
A
D
Site 66
S449
Q
S
P
Q
S
V
G
S
A
A
A
D
S
G
T
Site 67
S454
V
G
S
A
A
A
D
S
G
T
E
C
L
S
D
Site 68
T456
S
A
A
A
D
S
G
T
E
C
L
S
D
S
A
Site 69
S460
D
S
G
T
E
C
L
S
D
S
A
M
D
L
P
Site 70
S462
G
T
E
C
L
S
D
S
A
M
D
L
P
D
V
Site 71
S478
L
S
L
C
G
G
L
S
E
N
G
E
I
S
K
Site 72
S484
L
S
E
N
G
E
I
S
K
E
K
F
M
E
H
Site 73
Y515
P
N
L
V
I
R
I
Y
N
R
Y
Y
N
W
A
Site 74
Y518
V
I
R
I
Y
N
R
Y
Y
N
W
A
L
A
A
Site 75
Y519
I
R
I
Y
N
R
Y
Y
N
W
A
L
A
A
P
Site 76
S537
S
L
Q
V
F
Q
K
S
L
P
K
A
T
V
E
Site 77
S574
M
T
K
Q
L
P
E
S
K
E
G
K
S
E
A
Site 78
S579
P
E
S
K
E
G
K
S
E
A
P
P
A
S
D
Site 79
S585
K
S
E
A
P
P
A
S
D
L
P
S
S
S
K
Site 80
S589
P
P
A
S
D
L
P
S
S
S
K
E
P
A
G
Site 81
S590
P
A
S
D
L
P
S
S
S
K
E
P
A
G
A
Site 82
S591
A
S
D
L
P
S
S
S
K
E
P
A
G
A
R
Site 83
S604
A
R
P
A
E
N
D
S
S
S
D
E
G
S
Q
Site 84
S605
R
P
A
E
N
D
S
S
S
D
E
G
S
Q
E
Site 85
S606
P
A
E
N
D
S
S
S
D
E
G
S
Q
E
L
Site 86
S610
D
S
S
S
D
E
G
S
Q
E
L
E
E
S
I
Site 87
S616
G
S
Q
E
L
E
E
S
I
T
V
D
P
I
P
Site 88
T618
Q
E
L
E
E
S
I
T
V
D
P
I
P
T
E
Site 89
S628
P
I
P
T
E
P
L
S
H
G
S
T
T
S
Y
Site 90
T632
E
P
L
S
H
G
S
T
T
S
Y
K
K
S
L
Site 91
S634
L
S
H
G
S
T
T
S
Y
K
K
S
L
R
L
Site 92
Y635
S
H
G
S
T
T
S
Y
K
K
S
L
R
L
S
Site 93
S638
S
T
T
S
Y
K
K
S
L
R
L
S
S
D
Q
Site 94
S642
Y
K
K
S
L
R
L
S
S
D
Q
I
A
K
L
Site 95
S643
K
K
S
L
R
L
S
S
D
Q
I
A
K
L
K
Site 96
S661
G
P
N
D
V
V
F
S
I
T
T
Q
Y
Q
G
Site 97
T695
S
D
I
D
G
T
I
T
K
S
D
A
L
G
Q
Site 98
S697
I
D
G
T
I
T
K
S
D
A
L
G
Q
I
L
Site 99
T712
P
Q
L
G
K
D
W
T
H
Q
G
I
A
K
L
Site 100
Y720
H
Q
G
I
A
K
L
Y
H
S
I
N
E
N
G
Site 101
S722
G
I
A
K
L
Y
H
S
I
N
E
N
G
Y
K
Site 102
Y732
E
N
G
Y
K
F
L
Y
C
S
A
R
A
I
G
Site 103
Y747
M
A
D
M
T
R
G
Y
L
H
W
V
N
D
K
Site 104
T756
H
W
V
N
D
K
G
T
I
L
P
R
G
P
L
Site 105
S801
I
K
N
L
F
A
P
S
K
Q
P
F
Y
A
A
Site 106
Y806
A
P
S
K
Q
P
F
Y
A
A
F
G
N
R
P
Site 107
Y817
G
N
R
P
N
D
V
Y
A
Y
T
Q
V
G
V
Site 108
Y819
R
P
N
D
V
Y
A
Y
T
Q
V
G
V
P
D
Site 109
T820
P
N
D
V
Y
A
Y
T
Q
V
G
V
P
D
C
Site 110
T831
V
P
D
C
R
I
F
T
V
N
P
K
G
E
L
Site 111
T843
G
E
L
I
Q
E
R
T
K
G
N
K
S
S
Y
Site 112
S848
E
R
T
K
G
N
K
S
S
Y
H
R
L
S
E
Site 113
S849
R
T
K
G
N
K
S
S
Y
H
R
L
S
E
L
Site 114
Y850
T
K
G
N
K
S
S
Y
H
R
L
S
E
L
V
Site 115
S854
K
S
S
Y
H
R
L
S
E
L
V
E
H
V
F
Site 116
S865
E
H
V
F
P
L
L
S
K
E
Q
N
S
A
F
Site 117
Y882
P
E
F
S
S
F
C
Y
W
R
D
P
I
P
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation