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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RTF1
Full Name:
RNA polymerase-associated protein RTF1 homolog
Alias:
KIAA0252; RNA polymerase-associated protein RTF1; RTF1 (cDNA FLJ75793); Rtf1, Paf1/RNA polymerase II complex component,
Type:
Transcription protein
Mass (Da):
76580
Number AA:
670
UniProt ID:
Q92541
International Prot ID:
IPI00303832
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0005730
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0003676
GO:0003677
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0006139
GO:0006325
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
K
G
R
V
V
I
D
S
D
T
E
D
S
G
S
Site 2
T15
R
V
V
I
D
S
D
T
E
D
S
G
S
D
E
Site 3
S18
I
D
S
D
T
E
D
S
G
S
D
E
N
L
D
Site 4
S20
S
D
T
E
D
S
G
S
D
E
N
L
D
Q
E
Site 5
S30
N
L
D
Q
E
L
L
S
L
A
K
R
K
R
S
Site 6
S37
S
L
A
K
R
K
R
S
D
S
E
E
K
E
P
Site 7
S39
A
K
R
K
R
S
D
S
E
E
K
E
P
P
V
Site 8
S47
E
E
K
E
P
P
V
S
Q
P
A
A
S
S
D
Site 9
S52
S
D
T
E
D
S
G
S
D
E
N
L
D
Q
E
Site 10
S53
V
S
Q
P
A
A
S
S
D
S
E
T
S
D
S
Site 11
S55
Q
P
A
A
S
S
D
S
E
T
S
D
S
D
D
Site 12
T57
A
A
S
S
D
S
E
T
S
D
S
D
D
E
W
Site 13
S58
A
S
S
D
S
E
T
S
D
S
D
D
E
W
T
Site 14
S60
S
D
S
E
T
S
D
S
D
D
E
W
T
F
G
Site 15
T65
S
D
S
D
D
E
W
T
F
G
S
N
K
N
K
Site 16
T85
R
K
I
E
K
K
G
T
M
K
K
Q
A
N
K
Site 17
T93
M
K
K
Q
A
N
K
T
A
S
S
G
S
S
D
Site 18
S95
K
Q
A
N
K
T
A
S
S
G
S
S
D
K
D
Site 19
S96
Q
A
N
K
T
A
S
S
G
S
S
D
K
D
S
Site 20
S99
K
T
A
S
S
G
S
S
D
K
D
S
S
A
E
Site 21
S103
S
G
S
S
D
K
D
S
S
A
E
S
S
A
P
Site 22
S104
G
S
S
D
K
D
S
S
A
E
S
S
A
P
E
Site 23
S107
D
K
D
S
S
A
E
S
S
A
P
E
E
G
E
Site 24
S108
K
D
S
S
A
E
S
S
A
P
E
E
G
E
V
Site 25
S116
A
P
E
E
G
E
V
S
D
S
D
S
N
S
S
Site 26
S118
E
E
G
E
V
S
D
S
D
S
N
S
S
S
S
Site 27
S120
G
E
V
S
D
S
D
S
N
S
S
S
S
S
S
Site 28
S122
V
S
D
S
D
S
N
S
S
S
S
S
S
D
S
Site 29
S123
S
D
S
D
S
N
S
S
S
S
S
S
D
S
D
Site 30
S124
D
S
D
S
N
S
S
S
S
S
S
D
S
D
S
Site 31
S125
S
D
S
N
S
S
S
S
S
S
D
S
D
S
S
Site 32
S126
D
S
N
S
S
S
S
S
S
D
S
D
S
S
S
Site 33
S127
S
N
S
S
S
S
S
S
D
S
D
S
S
S
E
Site 34
S129
S
S
S
S
S
S
D
S
D
S
S
S
E
D
E
Site 35
S131
S
S
S
S
D
S
D
S
S
S
E
D
E
E
F
Site 36
S132
S
S
S
D
S
D
S
S
S
E
D
E
E
F
H
Site 37
S133
S
S
D
S
D
S
S
S
E
D
E
E
F
H
D
Site 38
Y142
D
E
E
F
H
D
G
Y
G
E
D
L
M
G
D
Site 39
T160
R
A
R
L
E
Q
M
T
E
K
E
R
E
Q
E
Site 40
T213
E
Q
E
K
K
K
L
T
Q
I
Q
E
S
Q
V
Site 41
S218
K
L
T
Q
I
Q
E
S
Q
V
T
S
H
N
K
Site 42
S222
I
Q
E
S
Q
V
T
S
H
N
K
E
R
R
S
Site 43
S229
S
H
N
K
E
R
R
S
K
R
D
E
K
L
D
Site 44
S239
D
E
K
L
D
K
K
S
Q
A
M
E
E
L
K
Site 45
T268
A
K
K
Q
P
L
K
T
S
E
V
Y
S
D
D
Site 46
S273
L
K
T
S
E
V
Y
S
D
D
E
E
E
E
E
Site 47
S284
E
E
E
E
D
D
K
S
S
E
K
S
D
R
S
Site 48
S285
E
E
E
D
D
K
S
S
E
K
S
D
R
S
S
Site 49
S288
D
D
K
S
S
E
K
S
D
R
S
S
R
T
S
Site 50
S291
S
S
E
K
S
D
R
S
S
R
T
S
S
S
D
Site 51
S292
S
E
K
S
D
R
S
S
R
T
S
S
S
D
E
Site 52
S295
S
D
R
S
S
R
T
S
S
S
D
E
E
E
E
Site 53
S296
D
R
S
S
R
T
S
S
S
D
E
E
E
E
K
Site 54
S297
R
S
S
R
T
S
S
S
D
E
E
E
E
K
E
Site 55
S310
K
E
E
I
P
P
K
S
Q
P
V
S
L
P
E
Site 56
S314
P
P
K
S
Q
P
V
S
L
P
E
E
L
N
R
Site 57
S325
E
L
N
R
V
R
L
S
R
H
K
L
E
R
W
Site 58
S356
I
G
I
G
N
H
N
S
K
P
V
Y
R
V
A
Site 59
Y360
N
H
N
S
K
P
V
Y
R
V
A
E
I
T
G
Site 60
S403
V
F
R
L
E
F
V
S
N
Q
E
F
T
E
S
Site 61
S438
E
I
N
K
K
E
L
S
I
K
E
A
L
N
Y
Site 62
Y445
S
I
K
E
A
L
N
Y
K
F
N
D
Q
D
I
Site 63
Y469
F
R
K
A
P
P
N
Y
A
M
K
K
T
Q
L
Site 64
T514
E
A
L
D
R
Q
R
T
K
N
I
S
A
I
S
Site 65
S518
R
Q
R
T
K
N
I
S
A
I
S
Y
I
N
Q
Site 66
Y522
K
N
I
S
A
I
S
Y
I
N
Q
R
N
R
E
Site 67
T555
N
Q
Q
M
D
P
F
T
R
R
Q
C
K
P
T
Site 68
T562
T
R
R
Q
C
K
P
T
I
V
S
N
S
R
D
Site 69
S567
K
P
T
I
V
S
N
S
R
D
P
A
V
Q
A
Site 70
Y584
L
A
Q
L
N
A
K
Y
G
S
G
V
L
P
D
Site 71
S608
G
K
D
K
D
L
N
S
K
S
A
S
D
L
S
Site 72
S610
D
K
D
L
N
S
K
S
A
S
D
L
S
E
D
Site 73
S612
D
L
N
S
K
S
A
S
D
L
S
E
D
L
F
Site 74
S615
S
K
S
A
S
D
L
S
E
D
L
F
K
V
H
Site 75
S634
K
I
D
L
Q
V
P
S
S
E
S
K
A
L
A
Site 76
S635
I
D
L
Q
V
P
S
S
E
S
K
A
L
A
I
Site 77
S637
L
Q
V
P
S
S
E
S
K
A
L
A
I
T
S
Site 78
S657
K
D
G
A
P
R
R
S
L
N
L
E
D
Y
K
Site 79
Y663
R
S
L
N
L
E
D
Y
K
K
R
R
G
L
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation