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Updated November 2019
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Protein Info
Short Name:
TMEM131
Full Name:
Transmembrane protein 131
Alias:
CC28; KIAA0257; PRO1048; Protein RW1; RW1; TM131; YR-23
Type:
Membrane protein, integral
Mass (Da):
200810
Number AA:
1834
UniProt ID:
Q92545
International Prot ID:
IPI00853149
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016020
GO:0016021
GO:0031224
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T37
G
G
L
L
Q
T
E
T
T
L
G
L
S
S
Y
Site 2
T38
G
L
L
Q
T
E
T
T
L
G
L
S
S
Y
Q
Site 3
Y44
T
T
L
G
L
S
S
Y
Q
Q
K
S
I
S
L
Site 4
S48
L
S
S
Y
Q
Q
K
S
I
S
L
Y
R
G
N
Site 5
S50
S
Y
Q
Q
K
S
I
S
L
Y
R
G
N
C
R
Site 6
Y52
Q
Q
K
S
I
S
L
Y
R
G
N
C
R
P
I
Site 7
Y82
M
P
K
M
E
K
V
Y
L
H
N
P
S
S
E
Site 8
S88
V
Y
L
H
N
P
S
S
E
E
T
I
T
L
V
Site 9
T91
H
N
P
S
S
E
E
T
I
T
L
V
S
I
S
Site 10
S188
I
N
I
H
N
P
H
S
E
P
L
Q
V
V
E
Site 11
Y197
P
L
Q
V
V
E
M
Y
S
S
G
G
D
L
H
Site 12
Y224
K
L
W
E
I
P
P
Y
E
T
K
G
V
M
R
Site 13
S233
T
K
G
V
M
R
A
S
F
S
S
R
E
A
D
Site 14
S235
G
V
M
R
A
S
F
S
S
R
E
A
D
N
H
Site 15
S236
V
M
R
A
S
F
S
S
R
E
A
D
N
H
T
Site 16
T250
T
A
F
I
R
I
K
T
N
A
S
D
S
T
E
Site 17
S253
I
R
I
K
T
N
A
S
D
S
T
E
F
I
I
Site 18
S275
T
T
A
P
G
I
Y
S
S
T
E
M
L
D
F
Site 19
S276
T
A
P
G
I
Y
S
S
T
E
M
L
D
F
G
Site 20
T284
T
E
M
L
D
F
G
T
L
R
T
Q
D
L
P
Site 21
T309
G
T
K
D
V
P
I
T
S
V
R
P
T
P
Q
Site 22
S310
T
K
D
V
P
I
T
S
V
R
P
T
P
Q
N
Site 23
T314
P
I
T
S
V
R
P
T
P
Q
N
D
A
I
T
Site 24
T321
T
P
Q
N
D
A
I
T
V
H
F
K
P
I
T
Site 25
T328
T
V
H
F
K
P
I
T
L
K
A
S
E
S
K
Site 26
S334
I
T
L
K
A
S
E
S
K
Y
T
K
V
A
S
Site 27
Y336
L
K
A
S
E
S
K
Y
T
K
V
A
S
I
S
Site 28
T337
K
A
S
E
S
K
Y
T
K
V
A
S
I
S
F
Site 29
S341
S
K
Y
T
K
V
A
S
I
S
F
D
A
S
K
Site 30
S343
Y
T
K
V
A
S
I
S
F
D
A
S
K
A
K
Site 31
S347
A
S
I
S
F
D
A
S
K
A
K
K
P
S
Q
Site 32
S353
A
S
K
A
K
K
P
S
Q
F
S
G
K
I
T
Site 33
T360
S
Q
F
S
G
K
I
T
V
K
A
K
E
K
S
Site 34
S369
K
A
K
E
K
S
Y
S
K
L
E
I
P
Y
Q
Site 35
S398
T
L
F
H
I
R
D
S
P
A
D
P
V
E
R
Site 36
Y408
D
P
V
E
R
P
I
Y
L
T
N
T
F
S
F
Site 37
T430
L
L
P
E
E
A
K
T
M
F
K
V
H
N
F
Site 38
T554
V
E
R
G
N
R
T
T
I
I
S
S
L
P
E
Site 39
S557
G
N
R
T
T
I
I
S
S
L
P
E
F
E
K
Site 40
S558
N
R
T
T
I
I
S
S
L
P
E
F
E
K
S
Site 41
S565
S
L
P
E
F
E
K
S
S
L
S
D
Q
S
S
Site 42
S566
L
P
E
F
E
K
S
S
L
S
D
Q
S
S
V
Site 43
S568
E
F
E
K
S
S
L
S
D
Q
S
S
V
T
L
Site 44
S571
K
S
S
L
S
D
Q
S
S
V
T
L
A
S
G
Site 45
S572
S
S
L
S
D
Q
S
S
V
T
L
A
S
G
Y
Site 46
S649
Q
S
L
N
I
M
N
S
F
S
Q
K
V
K
I
Site 47
S651
L
N
I
M
N
S
F
S
Q
K
V
K
I
Q
Q
Site 48
S661
V
K
I
Q
Q
I
R
S
L
S
E
D
V
R
F
Site 49
S663
I
Q
Q
I
R
S
L
S
E
D
V
R
F
Y
Y
Site 50
Y669
L
S
E
D
V
R
F
Y
Y
K
R
L
R
G
N
Site 51
Y670
S
E
D
V
R
F
Y
Y
K
R
L
R
G
N
K
Site 52
Y692
K
S
K
I
A
N
I
Y
F
D
P
G
L
Q
C
Site 53
S711
Y
V
G
L
P
F
L
S
K
S
E
P
K
V
Q
Site 54
S713
G
L
P
F
L
S
K
S
E
P
K
V
Q
P
G
Site 55
S749
W
T
G
I
K
E
N
S
G
H
R
L
S
A
I
Site 56
S754
E
N
S
G
H
R
L
S
A
I
F
E
V
N
T
Site 57
S776
S
K
I
T
A
E
L
S
W
P
S
I
L
S
S
Site 58
S779
T
A
E
L
S
W
P
S
I
L
S
S
P
R
H
Site 59
S782
L
S
W
P
S
I
L
S
S
P
R
H
L
K
F
Site 60
S783
S
W
P
S
I
L
S
S
P
R
H
L
K
F
P
Site 61
T792
R
H
L
K
F
P
L
T
N
T
N
C
S
S
E
Site 62
T794
L
K
F
P
L
T
N
T
N
C
S
S
E
E
E
Site 63
S798
L
T
N
T
N
C
S
S
E
E
E
I
T
L
E
Site 64
T803
C
S
S
E
E
E
I
T
L
E
N
P
A
D
V
Site 65
S857
E
F
Q
V
F
R
N
S
A
H
P
L
Q
S
S
Site 66
S863
N
S
A
H
P
L
Q
S
S
T
G
F
M
E
G
Site 67
S888
L
K
P
G
E
K
K
S
V
K
V
K
F
T
P
Site 68
T894
K
S
V
K
V
K
F
T
P
V
H
N
R
T
V
Site 69
S939
G
K
L
P
G
P
G
S
S
L
R
F
K
I
T
Site 70
S940
K
L
P
G
P
G
S
S
L
R
F
K
I
T
E
Site 71
T946
S
S
L
R
F
K
I
T
E
A
L
L
K
D
C
Site 72
T954
E
A
L
L
K
D
C
T
D
S
L
K
L
R
E
Site 73
S956
L
L
K
D
C
T
D
S
L
K
L
R
E
P
N
Site 74
T965
K
L
R
E
P
N
F
T
L
K
R
T
F
K
V
Site 75
T969
P
N
F
T
L
K
R
T
F
K
V
E
N
T
G
Site 76
T984
Q
L
Q
I
H
I
E
T
I
E
I
S
G
Y
S
Site 77
Y990
E
T
I
E
I
S
G
Y
S
C
E
G
Y
G
F
Site 78
S991
T
I
E
I
S
G
Y
S
C
E
G
Y
G
F
K
Site 79
Y995
S
G
Y
S
C
E
G
Y
G
F
K
V
V
N
C
Site 80
S1008
N
C
Q
E
F
T
L
S
A
N
A
S
R
D
I
Site 81
S1106
E
P
F
R
R
R
L
S
F
E
A
S
N
P
P
Site 82
S1110
R
R
L
S
F
E
A
S
N
P
P
F
D
V
G
Site 83
S1129
L
R
R
I
V
G
I
S
S
E
G
N
L
N
T
Site 84
T1136
S
S
E
G
N
L
N
T
L
S
C
D
P
G
H
Site 85
S1138
E
G
N
L
N
T
L
S
C
D
P
G
H
S
R
Site 86
S1144
L
S
C
D
P
G
H
S
R
G
F
C
G
A
G
Site 87
S1153
G
F
C
G
A
G
G
S
S
S
R
P
S
A
G
Site 88
S1154
F
C
G
A
G
G
S
S
S
R
P
S
A
G
S
Site 89
S1155
C
G
A
G
G
S
S
S
R
P
S
A
G
S
H
Site 90
S1158
G
G
S
S
S
R
P
S
A
G
S
H
K
Q
C
Site 91
S1161
S
S
R
P
S
A
G
S
H
K
Q
C
G
P
S
Site 92
S1168
S
H
K
Q
C
G
P
S
V
H
P
H
S
S
H
Site 93
S1173
G
P
S
V
H
P
H
S
S
H
S
N
R
N
S
Site 94
S1174
P
S
V
H
P
H
S
S
H
S
N
R
N
S
A
Site 95
S1176
V
H
P
H
S
S
H
S
N
R
N
S
A
D
V
Site 96
S1180
S
S
H
S
N
R
N
S
A
D
V
E
N
V
R
Site 97
S1191
E
N
V
R
A
K
N
S
S
S
T
S
S
R
T
Site 98
S1192
N
V
R
A
K
N
S
S
S
T
S
S
R
T
S
Site 99
S1193
V
R
A
K
N
S
S
S
T
S
S
R
T
S
A
Site 100
S1195
A
K
N
S
S
S
T
S
S
R
T
S
A
Q
A
Site 101
S1196
K
N
S
S
S
T
S
S
R
T
S
A
Q
A
A
Site 102
S1199
S
S
T
S
S
R
T
S
A
Q
A
A
S
S
Q
Site 103
S1205
T
S
A
Q
A
A
S
S
Q
S
A
N
K
T
S
Site 104
T1211
S
S
Q
S
A
N
K
T
S
P
L
V
L
D
S
Site 105
S1212
S
Q
S
A
N
K
T
S
P
L
V
L
D
S
N
Site 106
S1218
T
S
P
L
V
L
D
S
N
T
V
T
Q
G
H
Site 107
T1220
P
L
V
L
D
S
N
T
V
T
Q
G
H
T
A
Site 108
T1222
V
L
D
S
N
T
V
T
Q
G
H
T
A
G
R
Site 109
S1231
G
H
T
A
G
R
K
S
K
G
A
K
Q
S
Q
Site 110
S1237
K
S
K
G
A
K
Q
S
Q
H
G
S
Q
H
H
Site 111
S1241
A
K
Q
S
Q
H
G
S
Q
H
H
A
H
S
P
Site 112
S1247
G
S
Q
H
H
A
H
S
P
L
E
Q
H
P
Q
Site 113
S1273
E
P
Q
P
E
R
L
S
P
A
P
L
A
H
P
Site 114
S1281
P
A
P
L
A
H
P
S
H
P
E
R
A
S
S
Site 115
S1287
P
S
H
P
E
R
A
S
S
A
R
H
S
S
E
Site 116
S1288
S
H
P
E
R
A
S
S
A
R
H
S
S
E
D
Site 117
S1292
R
A
S
S
A
R
H
S
S
E
D
S
D
I
T
Site 118
S1293
A
S
S
A
R
H
S
S
E
D
S
D
I
T
S
Site 119
S1296
A
R
H
S
S
E
D
S
D
I
T
S
L
I
E
Site 120
T1299
S
S
E
D
S
D
I
T
S
L
I
E
A
M
D
Site 121
S1300
S
E
D
S
D
I
T
S
L
I
E
A
M
D
K
Site 122
S1314
K
D
F
D
H
H
D
S
P
A
L
E
V
F
T
Site 123
T1321
S
P
A
L
E
V
F
T
E
Q
P
P
S
P
L
Site 124
S1326
V
F
T
E
Q
P
P
S
P
L
P
K
S
K
G
Site 125
S1331
P
P
S
P
L
P
K
S
K
G
K
G
K
P
L
Site 126
S1367
Q
E
D
E
L
K
D
S
L
A
D
D
D
S
S
Site 127
S1373
D
S
L
A
D
D
D
S
S
S
T
T
T
E
T
Site 128
S1374
S
L
A
D
D
D
S
S
S
T
T
T
E
T
S
Site 129
S1375
L
A
D
D
D
S
S
S
T
T
T
E
T
S
N
Site 130
T1376
A
D
D
D
S
S
S
T
T
T
E
T
S
N
P
Site 131
T1377
D
D
D
S
S
S
T
T
T
E
T
S
N
P
D
Site 132
T1378
D
D
S
S
S
T
T
T
E
T
S
N
P
D
T
Site 133
T1380
S
S
S
T
T
T
E
T
S
N
P
D
T
E
P
Site 134
T1385
T
E
T
S
N
P
D
T
E
P
L
L
K
E
D
Site 135
T1393
E
P
L
L
K
E
D
T
E
K
Q
K
G
K
Q
Site 136
S1408
A
M
P
E
K
H
E
S
E
M
S
Q
V
K
Q
Site 137
S1411
E
K
H
E
S
E
M
S
Q
V
K
Q
K
S
K
Site 138
S1435
P
T
D
V
K
P
S
S
L
E
L
P
Y
T
P
Site 139
Y1440
P
S
S
L
E
L
P
Y
T
P
P
L
E
S
K
Site 140
T1441
S
S
L
E
L
P
Y
T
P
P
L
E
S
K
Q
Site 141
S1446
P
Y
T
P
P
L
E
S
K
Q
R
R
N
L
P
Site 142
S1454
K
Q
R
R
N
L
P
S
K
I
P
L
P
T
A
Site 143
T1460
P
S
K
I
P
L
P
T
A
M
T
S
G
S
K
Site 144
S1464
P
L
P
T
A
M
T
S
G
S
K
S
R
N
A
Site 145
S1468
A
M
T
S
G
S
K
S
R
N
A
Q
K
T
K
Site 146
T1474
K
S
R
N
A
Q
K
T
K
G
T
S
K
L
V
Site 147
S1495
L
A
K
F
L
P
N
S
Q
E
L
G
N
T
S
Site 148
T1501
N
S
Q
E
L
G
N
T
S
S
S
E
G
E
K
Site 149
S1503
Q
E
L
G
N
T
S
S
S
E
G
E
K
D
S
Site 150
S1504
E
L
G
N
T
S
S
S
E
G
E
K
D
S
P
Site 151
S1510
S
S
E
G
E
K
D
S
P
P
P
E
W
D
S
Site 152
S1517
S
P
P
P
E
W
D
S
V
P
V
H
K
P
G
Site 153
S1525
V
P
V
H
K
P
G
S
S
T
D
S
L
Y
K
Site 154
S1529
K
P
G
S
S
T
D
S
L
Y
K
L
S
L
Q
Site 155
Y1531
G
S
S
T
D
S
L
Y
K
L
S
L
Q
T
L
Site 156
S1534
T
D
S
L
Y
K
L
S
L
Q
T
L
N
A
D
Site 157
T1549
I
F
L
K
Q
R
Q
T
S
P
T
P
A
S
P
Site 158
S1550
F
L
K
Q
R
Q
T
S
P
T
P
A
S
P
S
Site 159
T1552
K
Q
R
Q
T
S
P
T
P
A
S
P
S
P
P
Site 160
S1555
Q
T
S
P
T
P
A
S
P
S
P
P
A
A
P
Site 161
S1557
S
P
T
P
A
S
P
S
P
P
A
A
P
C
P
Site 162
Y1571
P
F
V
A
R
G
S
Y
S
S
I
V
N
S
S
Site 163
S1572
F
V
A
R
G
S
Y
S
S
I
V
N
S
S
S
Site 164
S1573
V
A
R
G
S
Y
S
S
I
V
N
S
S
S
S
Site 165
S1577
S
Y
S
S
I
V
N
S
S
S
S
S
D
P
K
Site 166
S1578
Y
S
S
I
V
N
S
S
S
S
S
D
P
K
I
Site 167
S1579
S
S
I
V
N
S
S
S
S
S
D
P
K
I
K
Site 168
S1580
S
I
V
N
S
S
S
S
S
D
P
K
I
K
Q
Site 169
S1581
I
V
N
S
S
S
S
S
D
P
K
I
K
Q
P
Site 170
T1596
N
G
S
K
H
K
L
T
K
A
A
S
L
P
G
Site 171
S1600
H
K
L
T
K
A
A
S
L
P
G
K
N
G
N
Site 172
T1609
P
G
K
N
G
N
P
T
F
A
A
V
T
A
G
Site 173
S1620
V
T
A
G
Y
D
K
S
P
G
G
N
G
F
A
Site 174
S1630
G
N
G
F
A
K
V
S
S
N
K
T
G
F
S
Site 175
S1631
N
G
F
A
K
V
S
S
N
K
T
G
F
S
S
Site 176
T1634
A
K
V
S
S
N
K
T
G
F
S
S
S
L
G
Site 177
S1637
S
S
N
K
T
G
F
S
S
S
L
G
I
S
H
Site 178
S1638
S
N
K
T
G
F
S
S
S
L
G
I
S
H
A
Site 179
S1639
N
K
T
G
F
S
S
S
L
G
I
S
H
A
P
Site 180
S1643
F
S
S
S
L
G
I
S
H
A
P
V
D
S
D
Site 181
S1649
I
S
H
A
P
V
D
S
D
G
S
D
S
S
G
Site 182
S1652
A
P
V
D
S
D
G
S
D
S
S
G
L
W
S
Site 183
S1654
V
D
S
D
G
S
D
S
S
G
L
W
S
P
V
Site 184
S1655
D
S
D
G
S
D
S
S
G
L
W
S
P
V
S
Site 185
S1659
S
D
S
S
G
L
W
S
P
V
S
N
P
S
S
Site 186
S1662
S
G
L
W
S
P
V
S
N
P
S
S
P
D
F
Site 187
S1665
W
S
P
V
S
N
P
S
S
P
D
F
T
P
L
Site 188
S1666
S
P
V
S
N
P
S
S
P
D
F
T
P
L
N
Site 189
T1670
N
P
S
S
P
D
F
T
P
L
N
S
F
S
A
Site 190
S1674
P
D
F
T
P
L
N
S
F
S
A
F
G
N
S
Site 191
S1676
F
T
P
L
N
S
F
S
A
F
G
N
S
F
N
Site 192
S1695
V
F
S
K
L
G
L
S
R
S
C
N
Q
A
S
Site 193
S1697
S
K
L
G
L
S
R
S
C
N
Q
A
S
Q
R
Site 194
S1702
S
R
S
C
N
Q
A
S
Q
R
S
W
N
E
F
Site 195
Y1715
E
F
N
S
G
P
S
Y
L
W
E
S
P
A
T
Site 196
S1719
G
P
S
Y
L
W
E
S
P
A
T
D
P
S
P
Site 197
T1722
Y
L
W
E
S
P
A
T
D
P
S
P
S
W
P
Site 198
S1725
E
S
P
A
T
D
P
S
P
S
W
P
A
S
S
Site 199
S1727
P
A
T
D
P
S
P
S
W
P
A
S
S
G
S
Site 200
S1731
P
S
P
S
W
P
A
S
S
G
S
P
T
H
T
Site 201
S1732
S
P
S
W
P
A
S
S
G
S
P
T
H
T
A
Site 202
S1734
S
W
P
A
S
S
G
S
P
T
H
T
A
T
S
Site 203
T1736
P
A
S
S
G
S
P
T
H
T
A
T
S
V
L
Site 204
T1738
S
S
G
S
P
T
H
T
A
T
S
V
L
G
N
Site 205
S1741
S
P
T
H
T
A
T
S
V
L
G
N
T
S
G
Site 206
S1747
T
S
V
L
G
N
T
S
G
L
W
S
T
T
P
Site 207
S1751
G
N
T
S
G
L
W
S
T
T
P
F
S
S
S
Site 208
T1752
N
T
S
G
L
W
S
T
T
P
F
S
S
S
I
Site 209
T1753
T
S
G
L
W
S
T
T
P
F
S
S
S
I
W
Site 210
S1756
L
W
S
T
T
P
F
S
S
S
I
W
S
S
N
Site 211
S1757
W
S
T
T
P
F
S
S
S
I
W
S
S
N
L
Site 212
S1758
S
T
T
P
F
S
S
S
I
W
S
S
N
L
S
Site 213
S1761
P
F
S
S
S
I
W
S
S
N
L
S
S
A
L
Site 214
S1762
F
S
S
S
I
W
S
S
N
L
S
S
A
L
P
Site 215
S1788
G
L
M
G
T
E
N
S
P
A
P
H
A
P
S
Site 216
S1795
S
P
A
P
H
A
P
S
T
S
S
P
A
D
D
Site 217
T1796
P
A
P
H
A
P
S
T
S
S
P
A
D
D
L
Site 218
S1798
P
H
A
P
S
T
S
S
P
A
D
D
L
G
Q
Site 219
Y1807
A
D
D
L
G
Q
T
Y
N
P
W
R
I
W
S
Site 220
S1814
Y
N
P
W
R
I
W
S
P
T
I
G
R
R
S
Site 221
T1816
P
W
R
I
W
S
P
T
I
G
R
R
S
S
D
Site 222
S1821
S
P
T
I
G
R
R
S
S
D
P
W
S
N
S
Site 223
S1822
P
T
I
G
R
R
S
S
D
P
W
S
N
S
H
Site 224
S1826
R
R
S
S
D
P
W
S
N
S
H
F
P
H
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation