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Updated November 2019
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Protein Info
Short Name:
TOPBP1
Full Name:
DNA topoisomerase 2-binding protein 1
Alias:
DNA topoisomerase II beta-bindin; DNA topoisomerase II binding protein 1; DNA topoisomerase IIbeta-binding protein 1; DNA topoisomerase II-binding protein 1; KIAA0259; TOP2BP1; TOPB1; Topoisomerase (DNA) II binding protein 1
Type:
DNA replication
Mass (Da):
170679
Number AA:
1522
UniProt ID:
Q92547
International Prot ID:
IPI00293921
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016605
GO:0005813
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0008022
PhosphoSite+
KinaseNET
Biological Process:
GO:0006281
GO:0010212
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S16
F
F
V
K
F
L
K
S
S
D
N
S
K
C
F
Site 2
S20
F
L
K
S
S
D
N
S
K
C
F
F
K
A
L
Site 3
S56
K
I
K
E
N
D
R
S
L
Y
I
C
D
P
F
Site 4
Y58
K
E
N
D
R
S
L
Y
I
C
D
P
F
S
G
Site 5
Y102
P
R
A
E
H
P
V
Y
N
M
V
M
S
D
V
Site 6
S112
V
M
S
D
V
T
I
S
C
T
S
L
E
K
E
Site 7
Y127
K
R
E
E
V
H
K
Y
V
Q
M
M
G
G
R
Site 8
Y136
Q
M
M
G
G
R
V
Y
R
D
L
N
V
S
V
Site 9
S142
V
Y
R
D
L
N
V
S
V
T
H
L
I
A
G
Site 10
T144
R
D
L
N
V
S
V
T
H
L
I
A
G
E
V
Site 11
S153
L
I
A
G
E
V
G
S
K
K
Y
L
V
A
A
Site 12
Y156
G
E
V
G
S
K
K
Y
L
V
A
A
N
L
K
Site 13
S170
K
K
P
I
L
L
P
S
W
I
K
T
L
W
E
Site 14
T174
L
L
P
S
W
I
K
T
L
W
E
K
S
Q
E
Site 15
S179
I
K
T
L
W
E
K
S
Q
E
K
K
I
T
R
Site 16
T185
K
S
Q
E
K
K
I
T
R
Y
T
D
I
N
M
Site 17
T188
E
K
K
I
T
R
Y
T
D
I
N
M
E
D
F
Site 18
T222
R
K
E
V
Q
Q
L
T
V
K
H
G
G
Q
Y
Site 19
Y251
Q
E
P
K
G
Q
K
Y
E
C
A
K
R
W
N
Site 20
S280
K
G
F
C
Q
D
E
S
I
Y
K
T
E
P
R
Site 21
T284
Q
D
E
S
I
Y
K
T
E
P
R
P
E
A
K
Site 22
T292
E
P
R
P
E
A
K
T
M
P
N
S
S
T
P
Site 23
S296
E
A
K
T
M
P
N
S
S
T
P
T
S
Q
I
Site 24
S297
A
K
T
M
P
N
S
S
T
P
T
S
Q
I
N
Site 25
T298
K
T
M
P
N
S
S
T
P
T
S
Q
I
N
T
Site 26
S301
P
N
S
S
T
P
T
S
Q
I
N
T
I
D
S
Site 27
T305
T
P
T
S
Q
I
N
T
I
D
S
R
T
L
S
Site 28
S308
S
Q
I
N
T
I
D
S
R
T
L
S
D
V
S
Site 29
T310
I
N
T
I
D
S
R
T
L
S
D
V
S
N
I
Site 30
S312
T
I
D
S
R
T
L
S
D
V
S
N
I
S
N
Site 31
S315
S
R
T
L
S
D
V
S
N
I
S
N
I
N
A
Site 32
S328
N
A
S
C
V
S
E
S
I
C
N
S
L
N
S
Site 33
S332
V
S
E
S
I
C
N
S
L
N
S
K
L
E
P
Site 34
S350
N
L
E
N
L
D
V
S
A
F
Q
A
P
E
D
Site 35
S370
R
I
Y
L
C
G
F
S
G
R
K
L
D
K
L
Site 36
S383
K
L
R
R
L
I
N
S
G
G
G
V
R
F
N
Site 37
T397
N
Q
L
N
E
D
V
T
H
V
I
V
G
D
Y
Site 38
Y404
T
H
V
I
V
G
D
Y
D
D
E
L
K
Q
F
Site 39
S438
F
S
K
G
Y
M
L
S
E
E
P
Y
I
H
A
Site 40
Y442
Y
M
L
S
E
E
P
Y
I
H
A
N
Y
Q
P
Site 41
Y447
E
P
Y
I
H
A
N
Y
Q
P
V
E
I
P
V
Site 42
S455
Q
P
V
E
I
P
V
S
H
Q
P
E
S
K
A
Site 43
S460
P
V
S
H
Q
P
E
S
K
A
A
L
L
K
K
Site 44
S470
A
L
L
K
K
K
N
S
S
F
S
K
K
D
F
Site 45
S471
L
L
K
K
K
N
S
S
F
S
K
K
D
F
A
Site 46
S473
K
K
K
N
S
S
F
S
K
K
D
F
A
P
S
Site 47
S480
S
K
K
D
F
A
P
S
E
K
H
E
Q
A
D
Site 48
S492
Q
A
D
E
D
L
L
S
Q
Y
E
N
G
S
S
Site 49
Y494
D
E
D
L
L
S
Q
Y
E
N
G
S
S
T
V
Site 50
S498
L
S
Q
Y
E
N
G
S
S
T
V
V
E
A
K
Site 51
S499
S
Q
Y
E
N
G
S
S
T
V
V
E
A
K
T
Site 52
T500
Q
Y
E
N
G
S
S
T
V
V
E
A
K
T
S
Site 53
T506
S
T
V
V
E
A
K
T
S
E
A
R
P
F
N
Site 54
S507
T
V
V
E
A
K
T
S
E
A
R
P
F
N
D
Site 55
S515
E
A
R
P
F
N
D
S
T
H
A
E
P
L
N
Site 56
T516
A
R
P
F
N
D
S
T
H
A
E
P
L
N
D
Site 57
S524
H
A
E
P
L
N
D
S
T
H
I
S
L
Q
E
Site 58
S528
L
N
D
S
T
H
I
S
L
Q
E
E
N
Q
S
Site 59
S535
S
L
Q
E
E
N
Q
S
S
V
S
H
C
V
P
Site 60
S536
L
Q
E
E
N
Q
S
S
V
S
H
C
V
P
D
Site 61
S545
S
H
C
V
P
D
V
S
T
I
T
E
E
G
L
Site 62
S554
I
T
E
E
G
L
F
S
Q
K
S
F
L
V
L
Site 63
S564
S
F
L
V
L
G
F
S
N
E
N
E
S
N
I
Site 64
T624
V
T
C
I
D
Y
Q
T
L
F
D
P
K
S
N
Site 65
S630
Q
T
L
F
D
P
K
S
N
P
L
F
T
P
V
Site 66
T635
P
K
S
N
P
L
F
T
P
V
P
V
M
T
G
Site 67
S654
E
D
C
V
I
S
F
S
Q
C
A
G
A
E
K
Site 68
Y678
L
G
A
S
V
Q
E
Y
F
V
R
K
S
N
A
Site 69
S692
A
K
K
G
M
F
A
S
T
H
L
I
L
K
E
Site 70
T693
K
K
G
M
F
A
S
T
H
L
I
L
K
E
R
Site 71
S703
I
L
K
E
R
G
G
S
K
Y
E
A
A
K
K
Site 72
Y705
K
E
R
G
G
S
K
Y
E
A
A
K
K
W
N
Site 73
T727
W
L
L
E
T
A
R
T
G
K
R
A
D
E
S
Site 74
S734
T
G
K
R
A
D
E
S
H
F
L
I
E
N
S
Site 75
S741
S
H
F
L
I
E
N
S
T
K
E
E
R
S
L
Site 76
T742
H
F
L
I
E
N
S
T
K
E
E
R
S
L
E
Site 77
S747
N
S
T
K
E
E
R
S
L
E
T
E
I
T
N
Site 78
T753
R
S
L
E
T
E
I
T
N
G
I
N
L
N
S
Site 79
S760
T
N
G
I
N
L
N
S
D
T
A
E
H
P
G
Site 80
T762
G
I
N
L
N
S
D
T
A
E
H
P
G
T
R
Site 81
T768
D
T
A
E
H
P
G
T
R
L
Q
T
H
R
K
Site 82
T772
H
P
G
T
R
L
Q
T
H
R
K
T
V
V
T
Site 83
T776
R
L
Q
T
H
R
K
T
V
V
T
P
L
D
M
Site 84
T779
T
H
R
K
T
V
V
T
P
L
D
M
N
R
F
Site 85
S788
L
D
M
N
R
F
Q
S
K
A
F
R
A
V
V
Site 86
S796
K
A
F
R
A
V
V
S
Q
H
A
R
Q
V
A
Site 87
S805
H
A
R
Q
V
A
A
S
P
A
V
G
Q
P
L
Site 88
S817
Q
P
L
Q
K
E
P
S
L
H
L
D
T
P
S
Site 89
T822
E
P
S
L
H
L
D
T
P
S
K
F
L
S
K
Site 90
S824
S
L
H
L
D
T
P
S
K
F
L
S
K
D
K
Site 91
S828
D
T
P
S
K
F
L
S
K
D
K
L
F
K
P
Site 92
S836
K
D
K
L
F
K
P
S
F
D
V
K
D
A
L
Site 93
T848
D
A
L
A
A
L
E
T
P
G
R
P
S
Q
Q
Site 94
S853
L
E
T
P
G
R
P
S
Q
Q
K
R
K
P
S
Site 95
S860
S
Q
Q
K
R
K
P
S
T
P
L
S
E
V
I
Site 96
T861
Q
Q
K
R
K
P
S
T
P
L
S
E
V
I
V
Site 97
S864
R
K
P
S
T
P
L
S
E
V
I
V
K
N
L
Site 98
S886
S
R
N
A
V
A
L
S
A
S
P
Q
L
K
E
Site 99
S888
N
A
V
A
L
S
A
S
P
Q
L
K
E
A
Q
Site 100
S896
P
Q
L
K
E
A
Q
S
E
K
E
E
A
P
K
Site 101
S917
V
C
V
S
K
K
L
S
K
K
Q
S
E
L
N
Site 102
S921
K
K
L
S
K
K
Q
S
E
L
N
G
I
A
A
Site 103
S929
E
L
N
G
I
A
A
S
L
G
A
D
Y
R
W
Site 104
Y934
A
A
S
L
G
A
D
Y
R
W
S
F
D
E
T
Site 105
S937
L
G
A
D
Y
R
W
S
F
D
E
T
V
T
H
Site 106
Y947
E
T
V
T
H
F
I
Y
Q
G
R
P
N
D
T
Site 107
Y958
P
N
D
T
N
R
E
Y
K
S
V
K
E
R
G
Site 108
S960
D
T
N
R
E
Y
K
S
V
K
E
R
G
V
H
Site 109
Y989
K
H
L
P
E
S
L
Y
P
H
T
Y
N
P
K
Site 110
T992
P
E
S
L
Y
P
H
T
Y
N
P
K
M
S
L
Site 111
Y993
E
S
L
Y
P
H
T
Y
N
P
K
M
S
L
D
Site 112
S998
H
T
Y
N
P
K
M
S
L
D
I
S
A
V
Q
Site 113
S1002
P
K
M
S
L
D
I
S
A
V
Q
D
G
R
L
Site 114
S1012
Q
D
G
R
L
C
N
S
R
L
L
S
A
V
S
Site 115
S1016
L
C
N
S
R
L
L
S
A
V
S
S
T
K
D
Site 116
S1019
S
R
L
L
S
A
V
S
S
T
K
D
D
E
P
Site 117
S1020
R
L
L
S
A
V
S
S
T
K
D
D
E
P
D
Site 118
S1046
M
A
T
N
N
K
E
S
A
P
S
N
G
S
G
Site 119
S1049
N
N
K
E
S
A
P
S
N
G
S
G
K
N
D
Site 120
S1057
N
G
S
G
K
N
D
S
K
G
V
L
T
Q
T
Site 121
T1062
N
D
S
K
G
V
L
T
Q
T
L
E
M
R
E
Site 122
T1064
S
K
G
V
L
T
Q
T
L
E
M
R
E
N
F
Site 123
S1093
K
P
Q
G
Q
R
T
S
L
S
R
S
G
C
N
Site 124
S1095
Q
G
Q
R
T
S
L
S
R
S
G
C
N
S
A
Site 125
S1097
Q
R
T
S
L
S
R
S
G
C
N
S
A
S
S
Site 126
S1101
L
S
R
S
G
C
N
S
A
S
S
T
P
D
S
Site 127
S1103
R
S
G
C
N
S
A
S
S
T
P
D
S
T
R
Site 128
S1104
S
G
C
N
S
A
S
S
T
P
D
S
T
R
S
Site 129
T1105
G
C
N
S
A
S
S
T
P
D
S
T
R
S
A
Site 130
S1108
S
A
S
S
T
P
D
S
T
R
S
A
R
S
G
Site 131
T1109
A
S
S
T
P
D
S
T
R
S
A
R
S
G
R
Site 132
S1111
S
T
P
D
S
T
R
S
A
R
S
G
R
S
R
Site 133
S1114
D
S
T
R
S
A
R
S
G
R
S
R
V
L
E
Site 134
S1126
V
L
E
A
L
R
Q
S
R
Q
T
V
P
D
V
Site 135
T1129
A
L
R
Q
S
R
Q
T
V
P
D
V
N
T
E
Site 136
S1138
P
D
V
N
T
E
P
S
Q
N
E
Q
I
I
W
Site 137
T1149
Q
I
I
W
D
D
P
T
A
R
E
E
R
A
R
Site 138
S1159
E
E
R
A
R
L
A
S
N
L
Q
W
P
S
C
Site 139
S1165
A
S
N
L
Q
W
P
S
C
P
T
Q
Y
S
E
Site 140
Y1170
W
P
S
C
P
T
Q
Y
S
E
L
Q
V
D
I
Site 141
S1183
D
I
Q
N
L
E
D
S
P
F
Q
K
P
L
H
Site 142
S1192
F
Q
K
P
L
H
D
S
E
I
A
K
Q
A
V
Site 143
T1208
D
P
G
N
I
R
V
T
E
A
P
K
H
P
I
Site 144
S1216
E
A
P
K
H
P
I
S
E
E
L
E
T
P
I
Site 145
T1221
P
I
S
E
E
L
E
T
P
I
K
D
S
H
L
Site 146
T1231
K
D
S
H
L
I
P
T
P
Q
A
P
S
I
A
Site 147
T1256
H
P
R
E
K
I
I
T
I
E
E
T
H
E
E
Site 148
S1274
Q
Y
I
F
Q
L
S
S
L
N
P
Q
E
R
I
Site 149
Y1283
N
P
Q
E
R
I
D
Y
C
H
L
I
E
K
L
Site 150
Y1318
H
P
L
R
N
E
K
Y
L
A
S
V
A
A
G
Site 151
Y1333
K
W
V
L
H
R
S
Y
L
E
A
C
R
T
A
Site 152
T1339
S
Y
L
E
A
C
R
T
A
G
H
F
V
Q
E
Site 153
Y1349
H
F
V
Q
E
E
D
Y
E
W
G
S
S
S
I
Site 154
S1355
D
Y
E
W
G
S
S
S
I
L
D
V
L
T
G
Site 155
S1387
K
I
Q
Q
R
Q
E
S
G
I
V
E
G
A
F
Site 156
S1406
V
I
L
H
V
D
Q
S
R
E
A
G
F
K
R
Site 157
S1449
N
K
L
K
P
D
D
S
G
V
N
I
A
E
A
Site 158
Y1472
R
T
E
Y
I
A
D
Y
L
M
Q
E
S
P
P
Site 159
S1477
A
D
Y
L
M
Q
E
S
P
P
H
V
E
N
Y
Site 160
Y1484
S
P
P
H
V
E
N
Y
C
L
P
E
A
I
S
Site 161
S1504
K
E
L
G
T
G
L
S
Q
K
R
K
A
P
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation