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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
IHPK1
Full Name:
Inositol hexakisphosphate kinase 1
Alias:
ATP:1D-myo-inositol-hexakisphosphate phosphotransferase; EC 2.7.4.21; Inositol hexakisphosphate kinase 1; InsP6 kinase 1; IP6K1; KIAA0263; Pi uptake stimulator; PiUS
Type:
EC 2.7.4.21; Kinase (non-protein)
Mass (Da):
50236
Number AA:
441
UniProt ID:
Q92551
International Prot ID:
IPI00452669
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0008440
PhosphoSite+
KinaseNET
Biological Process:
GO:0046854
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y12
Q
T
M
E
V
G
Q
Y
G
K
N
A
S
R
A
Site 2
Y42
G
H
S
S
M
M
R
Y
D
D
H
T
V
C
K
Site 3
T46
M
M
R
Y
D
D
H
T
V
C
K
P
L
I
S
Site 4
Y59
I
S
R
E
Q
R
F
Y
E
S
L
P
P
E
M
Site 5
S61
R
E
Q
R
F
Y
E
S
L
P
P
E
M
K
E
Site 6
T70
P
P
E
M
K
E
F
T
P
E
Y
K
G
V
V
Site 7
Y73
M
K
E
F
T
P
E
Y
K
G
V
V
S
V
C
Site 8
S78
P
E
Y
K
G
V
V
S
V
C
F
E
G
D
S
Site 9
Y88
F
E
G
D
S
D
G
Y
I
N
L
V
A
Y
P
Site 10
Y94
G
Y
I
N
L
V
A
Y
P
Y
V
E
S
E
T
Site 11
T107
E
T
V
E
Q
D
D
T
T
E
R
E
Q
P
R
Site 12
T108
T
V
E
Q
D
D
T
T
E
R
E
Q
P
R
R
Site 13
S118
E
Q
P
R
R
K
H
S
R
R
S
L
H
R
S
Site 14
S121
R
R
K
H
S
R
R
S
L
H
R
S
G
S
G
Site 15
S125
S
R
R
S
L
H
R
S
G
S
G
S
D
H
K
Site 16
S127
R
S
L
H
R
S
G
S
G
S
D
H
K
E
E
Site 17
S129
L
H
R
S
G
S
G
S
D
H
K
E
E
K
A
Site 18
S137
D
H
K
E
E
K
A
S
L
S
L
E
T
S
E
Site 19
S139
K
E
E
K
A
S
L
S
L
E
T
S
E
S
S
Site 20
T142
K
A
S
L
S
L
E
T
S
E
S
S
Q
E
A
Site 21
S143
A
S
L
S
L
E
T
S
E
S
S
Q
E
A
K
Site 22
S145
L
S
L
E
T
S
E
S
S
Q
E
A
K
S
P
Site 23
S146
S
L
E
T
S
E
S
S
Q
E
A
K
S
P
K
Site 24
S151
E
S
S
Q
E
A
K
S
P
K
V
E
L
H
S
Site 25
S158
S
P
K
V
E
L
H
S
H
S
E
V
P
F
Q
Site 26
S160
K
V
E
L
H
S
H
S
E
V
P
F
Q
M
L
Site 27
S171
F
Q
M
L
D
G
N
S
G
L
S
S
E
K
I
Site 28
S174
L
D
G
N
S
G
L
S
S
E
K
I
S
H
N
Site 29
S175
D
G
N
S
G
L
S
S
E
K
I
S
H
N
P
Site 30
S179
G
L
S
S
E
K
I
S
H
N
P
W
S
L
R
Site 31
S184
K
I
S
H
N
P
W
S
L
R
C
H
K
Q
Q
Site 32
S193
R
C
H
K
Q
Q
L
S
R
M
R
S
E
S
K
Site 33
S197
Q
Q
L
S
R
M
R
S
E
S
K
D
R
K
L
Site 34
S199
L
S
R
M
R
S
E
S
K
D
R
K
L
Y
K
Site 35
Y205
E
S
K
D
R
K
L
Y
K
F
L
L
L
E
N
Site 36
S237
R
Q
H
G
D
D
A
S
A
E
K
A
A
R
Q
Site 37
S251
Q
M
R
K
C
E
Q
S
T
S
A
T
L
G
V
Site 38
S253
R
K
C
E
Q
S
T
S
A
T
L
G
V
R
V
Site 39
Y266
R
V
C
G
M
Q
V
Y
Q
L
D
T
G
H
Y
Site 40
Y273
Y
Q
L
D
T
G
H
Y
L
C
R
N
K
Y
Y
Site 41
Y279
H
Y
L
C
R
N
K
Y
Y
G
R
G
L
S
I
Site 42
Y280
Y
L
C
R
N
K
Y
Y
G
R
G
L
S
I
E
Site 43
S285
K
Y
Y
G
R
G
L
S
I
E
G
F
R
N
A
Site 44
Y294
E
G
F
R
N
A
L
Y
Q
Y
L
H
N
G
L
Site 45
Y296
F
R
N
A
L
Y
Q
Y
L
H
N
G
L
D
L
Site 46
S327
A
V
L
E
R
Q
A
S
Y
R
F
Y
S
S
S
Site 47
Y328
V
L
E
R
Q
A
S
Y
R
F
Y
S
S
S
L
Site 48
Y331
R
Q
A
S
Y
R
F
Y
S
S
S
L
L
V
I
Site 49
S334
S
Y
R
F
Y
S
S
S
L
L
V
I
Y
D
G
Site 50
Y339
S
S
S
L
L
V
I
Y
D
G
K
E
C
R
A
Site 51
S348
G
K
E
C
R
A
E
S
C
L
D
R
R
S
E
Site 52
S354
E
S
C
L
D
R
R
S
E
M
R
L
K
H
L
Site 53
S375
V
A
S
S
C
G
P
S
T
S
P
S
N
T
S
Site 54
T376
A
S
S
C
G
P
S
T
S
P
S
N
T
S
P
Site 55
S377
S
S
C
G
P
S
T
S
P
S
N
T
S
P
E
Site 56
S379
C
G
P
S
T
S
P
S
N
T
S
P
E
A
G
Site 57
T381
P
S
T
S
P
S
N
T
S
P
E
A
G
P
S
Site 58
S382
S
T
S
P
S
N
T
S
P
E
A
G
P
S
S
Site 59
S388
T
S
P
E
A
G
P
S
S
Q
P
K
V
D
V
Site 60
S389
S
P
E
A
G
P
S
S
Q
P
K
V
D
V
R
Site 61
T413
K
G
F
R
D
D
P
T
V
H
D
G
P
D
R
Site 62
Y422
H
D
G
P
D
R
G
Y
V
F
G
L
E
N
L
Site 63
S431
F
G
L
E
N
L
I
S
I
M
E
Q
M
R
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation