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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
BAP1
Full Name:
Ubiquitin carboxyl-terminal hydrolase BAP1
Alias:
BRCA1 associated protein 1; BRCA1 associated protein-1; Cerebral protein-6; HUCEP-6; KIAA0272; Ubiquitin carboxyl-terminal hydrolase BAP1: BRCA1-associated protein 1: Cerebral protein 6; Ubiquitin carboxy-terminal hydrolase; Ubiquitin C-terminal hydrolase X4; UCHL2; UCH-X4
Type:
Protease; EC 3.4.19.12; Ubiquitin conjugating system; Tumor suppressor
Mass (Da):
80362
Number AA:
729
UniProt ID:
Q92560
International Prot ID:
IPI00465087
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0008234
GO:0005515
GO:0004221
PhosphoSite+
KinaseNET
Biological Process:
GO:0008285
GO:0006464
GO:0006511
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
K
G
W
L
E
L
E
S
D
P
G
L
F
T
L
Site 2
Y33
G
V
Q
V
E
E
I
Y
D
L
Q
S
K
C
Q
Site 3
S58
K
W
I
E
E
R
R
S
R
R
K
V
S
T
L
Site 4
S63
R
R
S
R
R
K
V
S
T
L
V
D
D
T
S
Site 5
T64
R
S
R
R
K
V
S
T
L
V
D
D
T
S
V
Site 6
T111
S
S
V
D
L
G
P
T
L
S
R
M
K
D
F
Site 7
S113
V
D
L
G
P
T
L
S
R
M
K
D
F
T
K
Site 8
T119
L
S
R
M
K
D
F
T
K
G
F
S
P
E
S
Site 9
S123
K
D
F
T
K
G
F
S
P
E
S
K
G
Y
A
Site 10
S126
T
K
G
F
S
P
E
S
K
G
Y
A
I
G
N
Site 11
Y129
F
S
P
E
S
K
G
Y
A
I
G
N
A
P
E
Site 12
Y189
E
L
D
G
L
K
V
Y
P
I
D
H
G
P
W
Site 13
T218
M
E
R
I
G
L
A
T
A
G
E
P
Y
H
D
Site 14
Y223
L
A
T
A
G
E
P
Y
H
D
I
R
F
N
L
Site 15
Y241
V
P
D
R
R
I
K
Y
E
A
R
L
H
V
L
Site 16
T254
V
L
K
V
N
R
Q
T
V
L
E
A
L
Q
Q
Site 17
T266
L
Q
Q
L
I
R
V
T
Q
P
E
L
I
Q
T
Site 18
T273
T
Q
P
E
L
I
Q
T
H
K
S
Q
E
S
Q
Site 19
S276
E
L
I
Q
T
H
K
S
Q
E
S
Q
L
P
E
Site 20
S279
Q
T
H
K
S
Q
E
S
Q
L
P
E
E
S
K
Site 21
S285
E
S
Q
L
P
E
E
S
K
S
A
S
N
K
S
Site 22
S287
Q
L
P
E
E
S
K
S
A
S
N
K
S
P
L
Site 23
S289
P
E
E
S
K
S
A
S
N
K
S
P
L
V
L
Site 24
S292
S
K
S
A
S
N
K
S
P
L
V
L
E
A
N
Site 25
S305
A
N
R
A
P
A
A
S
E
G
N
H
T
D
G
Site 26
T310
A
A
S
E
G
N
H
T
D
G
A
E
E
A
A
Site 27
S319
G
A
E
E
A
A
G
S
C
A
Q
A
P
S
H
Site 28
S325
G
S
C
A
Q
A
P
S
H
S
P
P
N
K
P
Site 29
S327
C
A
Q
A
P
S
H
S
P
P
N
K
P
K
L
Site 30
T351
N
G
V
H
P
N
P
T
P
I
V
Q
R
L
P
Site 31
Y366
A
F
L
D
N
H
N
Y
A
K
S
P
M
Q
E
Site 32
S369
D
N
H
N
Y
A
K
S
P
M
Q
E
E
E
D
Site 33
S384
L
A
A
G
V
G
R
S
R
V
P
V
R
P
P
Site 34
Y394
P
V
R
P
P
Q
Q
Y
S
D
D
E
D
D
Y
Site 35
S395
V
R
P
P
Q
Q
Y
S
D
D
E
D
D
Y
E
Site 36
Y401
Y
S
D
D
E
D
D
Y
E
D
D
E
E
D
D
Site 37
Y418
N
T
N
S
A
L
R
Y
K
G
K
G
T
G
K
Site 38
S430
T
G
K
P
G
A
L
S
G
S
A
D
G
Q
L
Site 39
S432
K
P
G
A
L
S
G
S
A
D
G
Q
L
S
V
Site 40
S438
G
S
A
D
G
Q
L
S
V
L
Q
P
N
T
I
Site 41
S455
L
A
E
K
L
K
E
S
Q
K
D
L
S
I
P
Site 42
S460
K
E
S
Q
K
D
L
S
I
P
L
S
I
K
T
Site 43
S464
K
D
L
S
I
P
L
S
I
K
T
S
S
G
A
Site 44
T467
S
I
P
L
S
I
K
T
S
S
G
A
G
S
P
Site 45
S473
K
T
S
S
G
A
G
S
P
A
V
A
V
P
T
Site 46
S482
A
V
A
V
P
T
H
S
Q
P
S
P
T
P
S
Site 47
S485
V
P
T
H
S
Q
P
S
P
T
P
S
N
E
S
Site 48
T487
T
H
S
Q
P
S
P
T
P
S
N
E
S
T
D
Site 49
S489
S
Q
P
S
P
T
P
S
N
E
S
T
D
T
A
Site 50
S492
S
P
T
P
S
N
E
S
T
D
T
A
S
E
I
Site 51
T493
P
T
P
S
N
E
S
T
D
T
A
S
E
I
G
Site 52
T495
P
S
N
E
S
T
D
T
A
S
E
I
G
S
A
Site 53
S497
N
E
S
T
D
T
A
S
E
I
G
S
A
F
N
Site 54
S501
D
T
A
S
E
I
G
S
A
F
N
S
P
L
R
Site 55
S505
E
I
G
S
A
F
N
S
P
L
R
S
P
I
R
Site 56
S509
A
F
N
S
P
L
R
S
P
I
R
S
A
N
P
Site 57
S513
P
L
R
S
P
I
R
S
A
N
P
T
R
P
S
Site 58
T517
P
I
R
S
A
N
P
T
R
P
S
S
P
V
T
Site 59
S520
S
A
N
P
T
R
P
S
S
P
V
T
S
H
I
Site 60
S521
A
N
P
T
R
P
S
S
P
V
T
S
H
I
S
Site 61
T524
T
R
P
S
S
P
V
T
S
H
I
S
K
V
L
Site 62
S525
R
P
S
S
P
V
T
S
H
I
S
K
V
L
F
Site 63
S528
S
P
V
T
S
H
I
S
K
V
L
F
G
E
D
Site 64
Y546
L
R
V
D
C
I
R
Y
N
R
A
V
R
D
L
Site 65
S582
L
T
E
G
G
K
G
S
S
P
S
I
R
P
I
Site 66
S583
T
E
G
G
K
G
S
S
P
S
I
R
P
I
Q
Site 67
S585
G
G
K
G
S
S
P
S
I
R
P
I
Q
G
S
Site 68
S592
S
I
R
P
I
Q
G
S
Q
G
S
S
S
P
V
Site 69
S595
P
I
Q
G
S
Q
G
S
S
S
P
V
E
K
E
Site 70
S596
I
Q
G
S
Q
G
S
S
S
P
V
E
K
E
V
Site 71
S597
Q
G
S
Q
G
S
S
S
P
V
E
K
E
V
V
Site 72
S609
E
V
V
E
A
T
D
S
R
E
K
T
G
M
V
Site 73
T613
A
T
D
S
R
E
K
T
G
M
V
R
P
G
E
Site 74
S623
V
R
P
G
E
P
L
S
G
E
K
Y
S
P
K
Site 75
Y627
E
P
L
S
G
E
K
Y
S
P
K
E
L
L
A
Site 76
S628
P
L
S
G
E
K
Y
S
P
K
E
L
L
A
L
Site 77
Y646
V
E
A
E
I
A
N
Y
E
A
C
L
K
E
E
Site 78
Y671
D
Q
R
R
T
H
N
Y
D
E
F
I
C
T
F
Site 79
S697
N
L
V
E
Q
N
I
S
V
R
R
R
Q
G
V
Site 80
S705
V
R
R
R
Q
G
V
S
I
G
R
L
H
K
Q
Site 81
S721
K
P
D
R
R
K
R
S
R
P
Y
K
A
K
R
Site 82
Y724
R
R
K
R
S
R
P
Y
K
A
K
R
Q
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation