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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RAPGEF5
Full Name:
Rap guanine nucleotide exchange factor 5
Alias:
GFR; Guanine nucleotide exchange factor for Rap1; KIAA0277; M-Ras-regulated GEF; M-Ras-regulated Rap GEF; MRGEF; MR-GEF; Rap guanine nucleotide exchange factor (GEF) 5; RPGF5
Type:
Mass (Da):
67730
Number AA:
UniProt ID:
Q92565
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0030742
GO:0017034
PhosphoSite+
KinaseNET
Biological Process:
GO:0007399
GO:0051056
GO:0007264
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S18
P
H
L
E
R
K
D
S
A
A
A
L
S
D
R
Site 2
S23
K
D
S
A
A
A
L
S
D
R
E
L
P
L
P
Site 3
T31
D
R
E
L
P
L
P
T
F
D
V
P
Y
F
K
Site 4
Y36
L
P
T
F
D
V
P
Y
F
K
Y
I
D
E
E
Site 5
Y39
F
D
V
P
Y
F
K
Y
I
D
E
E
D
E
D
Site 6
S50
E
D
E
D
D
E
W
S
S
R
S
Q
S
S
T
Site 7
S51
D
E
D
D
E
W
S
S
R
S
Q
S
S
T
E
Site 8
S53
D
D
E
W
S
S
R
S
Q
S
S
T
E
D
D
Site 9
S55
E
W
S
S
R
S
Q
S
S
T
E
D
D
S
V
Site 10
S56
W
S
S
R
S
Q
S
S
T
E
D
D
S
V
D
Site 11
T57
S
S
R
S
Q
S
S
T
E
D
D
S
V
D
S
Site 12
S61
Q
S
S
T
E
D
D
S
V
D
S
L
L
S
D
Site 13
S64
T
E
D
D
S
V
D
S
L
L
S
D
R
Y
V
Site 14
Y70
D
S
L
L
S
D
R
Y
V
V
V
S
G
T
P
Site 15
S74
S
D
R
Y
V
V
V
S
G
T
P
E
K
I
L
Site 16
T76
R
Y
V
V
V
S
G
T
P
E
K
I
L
E
H
Site 17
Y126
C
Q
A
L
L
R
H
Y
S
A
K
K
Y
Q
G
Site 18
S127
Q
A
L
L
R
H
Y
S
A
K
K
Y
Q
G
K
Site 19
Y131
R
H
Y
S
A
K
K
Y
Q
G
K
E
E
N
S
Site 20
S138
Y
Q
G
K
E
E
N
S
D
V
P
R
R
K
R
Site 21
Y158
V
S
Q
W
I
A
L
Y
K
D
W
L
P
E
D
Site 22
T174
H
S
K
M
F
L
K
T
I
Y
R
N
V
L
D
Site 23
Y184
R
N
V
L
D
D
V
Y
E
Y
P
I
L
E
K
Site 24
Y186
V
L
D
D
V
Y
E
Y
P
I
L
E
K
E
L
Site 25
T207
L
G
M
H
R
R
H
T
V
D
E
Y
S
P
Q
Site 26
Y211
R
R
H
T
V
D
E
Y
S
P
Q
K
K
N
K
Site 27
S212
R
H
T
V
D
E
Y
S
P
Q
K
K
N
K
A
Site 28
S225
K
A
L
F
H
Q
F
S
L
K
E
N
W
L
Q
Site 29
T236
N
W
L
Q
H
R
G
T
V
T
E
T
E
E
I
Site 30
T240
H
R
G
T
V
T
E
T
E
E
I
F
C
H
V
Site 31
S256
I
T
E
H
S
Y
V
S
V
K
A
K
V
S
S
Site 32
S262
V
S
V
K
A
K
V
S
S
I
A
Q
E
I
L
Site 33
S305
Q
P
N
D
L
V
I
S
K
S
L
E
A
S
G
Site 34
S307
N
D
L
V
I
S
K
S
L
E
A
S
G
R
I
Site 35
S311
I
S
K
S
L
E
A
S
G
R
I
Y
V
Y
R
Site 36
Y315
L
E
A
S
G
R
I
Y
V
Y
R
K
D
L
A
Site 37
T324
Y
R
K
D
L
A
D
T
L
N
P
F
A
E
N
Site 38
S334
P
F
A
E
N
E
E
S
Q
Q
R
S
M
R
I
Site 39
S338
N
E
E
S
Q
Q
R
S
M
R
I
L
G
M
N
Site 40
Y371
I
H
E
Q
E
L
I
Y
F
T
F
S
R
Q
G
Site 41
T373
E
Q
E
L
I
Y
F
T
F
S
R
Q
G
S
G
Site 42
S375
E
L
I
Y
F
T
F
S
R
Q
G
S
G
E
H
Site 43
S379
F
T
F
S
R
Q
G
S
G
E
H
T
A
N
L
Site 44
T383
R
Q
G
S
G
E
H
T
A
N
L
S
L
L
L
Site 45
S449
G
L
N
T
A
S
V
S
R
L
S
Q
T
W
E
Site 46
S452
T
A
S
V
S
R
L
S
Q
T
W
E
K
I
P
Site 47
T454
S
V
S
R
L
S
Q
T
W
E
K
I
P
G
K
Site 48
S467
G
K
F
K
K
L
F
S
E
L
E
S
L
T
D
Site 49
S471
K
L
F
S
E
L
E
S
L
T
D
P
S
L
N
Site 50
T473
F
S
E
L
E
S
L
T
D
P
S
L
N
H
K
Site 51
S476
L
E
S
L
T
D
P
S
L
N
H
K
A
Y
R
Site 52
Y482
P
S
L
N
H
K
A
Y
R
D
A
F
K
K
M
Site 53
T505
P
L
L
L
K
D
V
T
F
I
H
E
G
N
K
Site 54
T513
F
I
H
E
G
N
K
T
F
L
D
N
L
V
N
Site 55
T530
K
L
H
M
I
A
D
T
V
R
T
L
R
H
C
Site 56
T539
R
T
L
R
H
C
R
T
N
Q
F
G
D
L
S
Site 57
S546
T
N
Q
F
G
D
L
S
P
K
E
H
Q
E
L
Site 58
Y556
E
H
Q
E
L
K
S
Y
V
N
H
L
Y
V
I
Site 59
Y561
K
S
Y
V
N
H
L
Y
V
I
D
S
Q
Q
A
Site 60
S573
Q
Q
A
L
F
E
L
S
H
R
I
E
P
R
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation