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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PIK3R3
Full Name:
Phosphatidylinositol 3-kinase regulatory subunit gamma
Alias:
P55; P55G; P55PIK; Phosphoinositide-3-kinase, regulatory subunit 3 (gamma); PI3K p85-gamma; PI3-kinase p85-gamma subunit; PtdIns-3-kinase p85-gamma
Type:
Regulator, inositol phosphate metabolism
Mass (Da):
54462
Number AA:
461
UniProt ID:
Q92569
International Prot ID:
IPI00513745
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005942
Uniprot
OncoNet
Molecular Function:
GO:0016303
GO:0035014
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0008286
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T46
P
K
P
P
K
P
M
T
S
A
V
P
N
G
M
Site 2
S47
K
P
P
K
P
M
T
S
A
V
P
N
G
M
K
Site 3
S57
P
N
G
M
K
D
S
S
V
S
L
Q
D
A
E
Site 4
S59
G
M
K
D
S
S
V
S
L
Q
D
A
E
W
Y
Site 5
Y66
S
L
Q
D
A
E
W
Y
W
G
D
I
S
R
E
Site 6
T86
L
R
D
M
P
D
G
T
F
L
V
R
D
A
S
Site 7
S93
T
F
L
V
R
D
A
S
T
K
M
Q
G
D
Y
Site 8
Y100
S
T
K
M
Q
G
D
Y
T
L
T
L
R
K
G
Site 9
T101
T
K
M
Q
G
D
Y
T
L
T
L
R
K
G
G
Site 10
T103
M
Q
G
D
Y
T
L
T
L
R
K
G
G
N
N
Site 11
Y116
N
N
K
L
I
K
I
Y
H
R
D
G
K
Y
G
Site 12
Y122
I
Y
H
R
D
G
K
Y
G
F
S
D
P
L
T
Site 13
S125
R
D
G
K
Y
G
F
S
D
P
L
T
F
N
S
Site 14
Y140
V
V
E
L
I
N
H
Y
H
H
E
S
L
A
Q
Site 15
Y148
H
H
E
S
L
A
Q
Y
N
P
K
L
D
V
K
Site 16
Y158
K
L
D
V
K
L
M
Y
P
V
S
R
Y
Q
Q
Site 17
S161
V
K
L
M
Y
P
V
S
R
Y
Q
Q
D
Q
L
Site 18
Y163
L
M
Y
P
V
S
R
Y
Q
Q
D
Q
L
V
K
Site 19
Y184
V
G
K
K
L
Q
E
Y
H
S
Q
Y
Q
E
K
Site 20
S186
K
K
L
Q
E
Y
H
S
Q
Y
Q
E
K
S
K
Site 21
Y188
L
Q
E
Y
H
S
Q
Y
Q
E
K
S
K
E
Y
Site 22
S192
H
S
Q
Y
Q
E
K
S
K
E
Y
D
R
L
Y
Site 23
Y195
Y
Q
E
K
S
K
E
Y
D
R
L
Y
E
E
Y
Site 24
Y199
S
K
E
Y
D
R
L
Y
E
E
Y
T
R
T
S
Site 25
Y202
Y
D
R
L
Y
E
E
Y
T
R
T
S
Q
E
I
Site 26
T203
D
R
L
Y
E
E
Y
T
R
T
S
Q
E
I
Q
Site 27
T205
L
Y
E
E
Y
T
R
T
S
Q
E
I
Q
M
K
Site 28
S206
Y
E
E
Y
T
R
T
S
Q
E
I
Q
M
K
R
Site 29
T222
A
I
E
A
F
N
E
T
I
K
I
F
E
E
Q
Site 30
T232
I
F
E
E
Q
C
H
T
Q
E
Q
H
S
K
E
Site 31
Y240
Q
E
Q
H
S
K
E
Y
I
E
R
F
R
R
E
Site 32
Y260
I
E
R
I
M
M
N
Y
D
K
L
K
S
R
L
Site 33
S265
M
N
Y
D
K
L
K
S
R
L
G
E
I
H
D
Site 34
S273
R
L
G
E
I
H
D
S
K
M
R
L
E
Q
D
Site 35
Y341
N
E
D
A
D
E
N
Y
F
I
N
E
E
D
E
Site 36
Y353
E
D
E
N
L
P
H
Y
D
E
K
T
W
F
V
Site 37
Y373
V
Q
A
E
D
L
L
Y
G
K
P
D
G
A
F
Site 38
S385
G
A
F
L
I
R
E
S
S
K
K
G
C
Y
A
Site 39
S386
A
F
L
I
R
E
S
S
K
K
G
C
Y
A
C
Site 40
Y391
E
S
S
K
K
G
C
Y
A
C
S
V
V
A
D
Site 41
Y407
E
V
K
H
C
V
I
Y
S
T
A
R
G
Y
G
Site 42
Y413
I
Y
S
T
A
R
G
Y
G
F
A
E
P
Y
N
Site 43
Y419
G
Y
G
F
A
E
P
Y
N
L
Y
S
S
L
K
Site 44
Y422
F
A
E
P
Y
N
L
Y
S
S
L
K
E
L
V
Site 45
Y432
L
K
E
L
V
L
H
Y
Q
Q
T
S
L
V
Q
Site 46
S443
S
L
V
Q
H
N
D
S
L
N
V
R
L
A
Y
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation