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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MAML1
Full Name:
Mastermind-like protein 1
Alias:
KIAA0200; Mam1; Mam-1; Mastermind; Mastermind-like 1
Type:
Transcription, coactivator/corepressor
Mass (Da):
108036
Number AA:
1016
UniProt ID:
Q92585
International Prot ID:
IPI00006108
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016607
Uniprot
OncoNet
Molecular Function:
GO:0042605
GO:0019901
GO:0003713
PhosphoSite+
KinaseNET
Biological Process:
GO:0007219
GO:0045944
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S17
E
F
A
L
P
R
H
S
A
V
M
E
R
L
R
Site 2
S35
E
L
C
R
R
H
H
S
T
C
E
A
R
Y
E
Site 3
T36
L
C
R
R
H
H
S
T
C
E
A
R
Y
E
A
Site 4
Y41
H
S
T
C
E
A
R
Y
E
A
V
S
P
E
R
Site 5
S45
E
A
R
Y
E
A
V
S
P
E
R
L
E
L
E
Site 6
T56
L
E
L
E
R
Q
H
T
F
A
L
H
Q
R
C
Site 7
T105
P
E
H
G
R
P
A
T
H
L
H
D
T
V
K
Site 8
T110
P
A
T
H
L
H
D
T
V
K
R
N
L
D
S
Site 9
S117
T
V
K
R
N
L
D
S
A
T
S
P
Q
N
G
Site 10
S120
R
N
L
D
S
A
T
S
P
Q
N
G
D
Q
Q
Site 11
Y130
N
G
D
Q
Q
N
G
Y
G
D
L
F
P
G
H
Site 12
T140
L
F
P
G
H
K
K
T
R
R
E
A
P
L
G
Site 13
S159
S
N
G
L
P
P
A
S
P
L
G
Q
S
D
K
Site 14
S164
P
A
S
P
L
G
Q
S
D
K
P
S
G
A
D
Site 15
S168
L
G
Q
S
D
K
P
S
G
A
D
A
L
Q
S
Site 16
S175
S
G
A
D
A
L
Q
S
S
G
K
H
S
L
G
Site 17
S176
G
A
D
A
L
Q
S
S
G
K
H
S
L
G
L
Site 18
S180
L
Q
S
S
G
K
H
S
L
G
L
D
S
L
N
Site 19
S185
K
H
S
L
G
L
D
S
L
N
K
K
R
L
A
Site 20
S194
N
K
K
R
L
A
D
S
S
L
H
L
N
G
G
Site 21
S195
K
K
R
L
A
D
S
S
L
H
L
N
G
G
S
Site 22
S202
S
L
H
L
N
G
G
S
N
P
S
E
S
F
P
Site 23
S205
L
N
G
G
S
N
P
S
E
S
F
P
L
S
L
Site 24
S207
G
G
S
N
P
S
E
S
F
P
L
S
L
N
K
Site 25
S211
P
S
E
S
F
P
L
S
L
N
K
E
L
K
Q
Site 26
S236
T
G
T
V
G
S
I
S
Q
S
N
L
M
P
D
Site 27
S238
T
V
G
S
I
S
Q
S
N
L
M
P
D
L
N
Site 28
S261
L
I
E
E
L
N
R
S
V
P
D
E
D
M
K
Site 29
S283
E
E
K
K
D
P
E
S
S
G
S
A
T
Q
T
Site 30
S286
K
D
P
E
S
S
G
S
A
T
Q
T
P
L
A
Site 31
T288
P
E
S
S
G
S
A
T
Q
T
P
L
A
Q
D
Site 32
T290
S
S
G
S
A
T
Q
T
P
L
A
Q
D
I
N
Site 33
S303
I
N
I
K
T
E
F
S
P
A
A
F
E
Q
E
Site 34
S314
F
E
Q
E
Q
L
G
S
P
Q
V
R
A
G
S
Site 35
S321
S
P
Q
V
R
A
G
S
A
G
Q
T
F
L
G
Site 36
T325
R
A
G
S
A
G
Q
T
F
L
G
P
S
S
A
Site 37
S330
G
Q
T
F
L
G
P
S
S
A
P
V
S
T
D
Site 38
S331
Q
T
F
L
G
P
S
S
A
P
V
S
T
D
S
Site 39
S335
G
P
S
S
A
P
V
S
T
D
S
P
S
L
G
Site 40
T336
P
S
S
A
P
V
S
T
D
S
P
S
L
G
G
Site 41
S338
S
A
P
V
S
T
D
S
P
S
L
G
G
S
Q
Site 42
S340
P
V
S
T
D
S
P
S
L
G
G
S
Q
T
L
Site 43
S344
D
S
P
S
L
G
G
S
Q
T
L
F
H
T
S
Site 44
T346
P
S
L
G
G
S
Q
T
L
F
H
T
S
G
Q
Site 45
S360
Q
P
R
A
D
N
P
S
P
N
L
M
P
A
S
Site 46
S367
S
P
N
L
M
P
A
S
A
Q
A
Q
N
A
Q
Site 47
S391
S
Q
G
P
G
G
A
S
E
L
S
S
A
H
Q
Site 48
S394
P
G
G
A
S
E
L
S
S
A
H
Q
L
Q
Q
Site 49
S395
G
G
A
S
E
L
S
S
A
H
Q
L
Q
Q
I
Site 50
T419
L
Q
N
P
Q
Q
A
T
P
A
P
A
P
G
Q
Site 51
S436
T
W
Q
Q
T
G
P
S
H
S
S
L
D
V
P
Site 52
S438
Q
Q
T
G
P
S
H
S
S
L
D
V
P
Y
P
Site 53
S439
Q
T
G
P
S
H
S
S
L
D
V
P
Y
P
M
Site 54
Y444
H
S
S
L
D
V
P
Y
P
M
E
K
P
A
S
Site 55
S451
Y
P
M
E
K
P
A
S
P
S
S
Y
K
Q
D
Site 56
S454
E
K
P
A
S
P
S
S
Y
K
Q
D
F
T
N
Site 57
Y455
K
P
A
S
P
S
S
Y
K
Q
D
F
T
N
S
Site 58
T460
S
S
Y
K
Q
D
F
T
N
S
K
L
L
M
M
Site 59
S462
Y
K
Q
D
F
T
N
S
K
L
L
M
M
P
S
Site 60
S469
S
K
L
L
M
M
P
S
V
N
K
S
S
P
R
Site 61
S473
M
M
P
S
V
N
K
S
S
P
R
P
G
G
P
Site 62
S474
M
P
S
V
N
K
S
S
P
R
P
G
G
P
Y
Site 63
Y481
S
P
R
P
G
G
P
Y
L
Q
P
S
H
V
N
Site 64
S485
G
G
P
Y
L
Q
P
S
H
V
N
L
L
S
H
Site 65
S491
P
S
H
V
N
L
L
S
H
Q
P
P
S
N
L
Site 66
S496
L
L
S
H
Q
P
P
S
N
L
N
Q
N
S
A
Site 67
S508
N
S
A
N
N
Q
G
S
V
L
D
Y
G
N
T
Site 68
Y512
N
Q
G
S
V
L
D
Y
G
N
T
K
P
L
S
Site 69
T515
S
V
L
D
Y
G
N
T
K
P
L
S
H
Y
K
Site 70
Y521
N
T
K
P
L
S
H
Y
K
A
D
C
G
Q
G
Site 71
S529
K
A
D
C
G
Q
G
S
P
G
S
G
Q
S
K
Site 72
S532
C
G
Q
G
S
P
G
S
G
Q
S
K
P
A
L
Site 73
S535
G
S
P
G
S
G
Q
S
K
P
A
L
M
A
Y
Site 74
Y542
S
K
P
A
L
M
A
Y
L
P
Q
Q
L
S
H
Site 75
S548
A
Y
L
P
Q
Q
L
S
H
I
S
H
E
Q
N
Site 76
S551
P
Q
Q
L
S
H
I
S
H
E
Q
N
S
L
F
Site 77
S571
P
G
N
M
P
F
R
S
L
V
P
P
G
Q
E
Site 78
S582
P
G
Q
E
Q
N
P
S
S
V
P
V
Q
A
Q
Site 79
S583
G
Q
E
Q
N
P
S
S
V
P
V
Q
A
Q
A
Site 80
S601
G
T
Q
P
P
A
V
S
V
A
S
S
H
N
S
Site 81
S604
P
P
A
V
S
V
A
S
S
H
N
S
S
P
Y
Site 82
S605
P
A
V
S
V
A
S
S
H
N
S
S
P
Y
L
Site 83
S608
S
V
A
S
S
H
N
S
S
P
Y
L
S
S
Q
Site 84
S609
V
A
S
S
H
N
S
S
P
Y
L
S
S
Q
Q
Site 85
Y611
S
S
H
N
S
S
P
Y
L
S
S
Q
Q
Q
A
Site 86
S613
H
N
S
S
P
Y
L
S
S
Q
Q
Q
A
A
V
Site 87
S614
N
S
S
P
Y
L
S
S
Q
Q
Q
A
A
V
M
Site 88
T667
Q
Q
F
Q
R
H
L
T
R
P
P
P
Q
Y
Q
Site 89
Y673
L
T
R
P
P
P
Q
Y
Q
D
P
T
Q
G
S
Site 90
T677
P
P
Q
Y
Q
D
P
T
Q
G
S
F
P
Q
Q
Site 91
S680
Y
Q
D
P
T
Q
G
S
F
P
Q
Q
V
G
Q
Site 92
T700
A
A
V
P
G
M
N
T
L
G
P
S
N
S
S
Site 93
S704
G
M
N
T
L
G
P
S
N
S
S
C
P
R
V
Site 94
S706
N
T
L
G
P
S
N
S
S
C
P
R
V
F
P
Site 95
S707
T
L
G
P
S
N
S
S
C
P
R
V
F
P
Q
Site 96
S727
P
M
G
P
G
H
A
S
V
S
S
L
P
T
N
Site 97
S729
G
P
G
H
A
S
V
S
S
L
P
T
N
S
G
Site 98
S730
P
G
H
A
S
V
S
S
L
P
T
N
S
G
Q
Site 99
T733
A
S
V
S
S
L
P
T
N
S
G
Q
Q
D
R
Site 100
S748
G
V
A
Q
F
P
G
S
Q
N
M
P
Q
S
S
Site 101
S754
G
S
Q
N
M
P
Q
S
S
L
Y
G
M
A
S
Site 102
S755
S
Q
N
M
P
Q
S
S
L
Y
G
M
A
S
G
Site 103
Y757
N
M
P
Q
S
S
L
Y
G
M
A
S
G
I
T
Site 104
T785
H
A
H
I
P
R
Q
T
N
V
G
Q
N
T
S
Site 105
S792
T
N
V
G
Q
N
T
S
V
S
A
A
Y
G
Q
Site 106
S794
V
G
Q
N
T
S
V
S
A
A
Y
G
Q
N
S
Site 107
S801
S
A
A
Y
G
Q
N
S
L
G
S
S
G
L
S
Site 108
S804
Y
G
Q
N
S
L
G
S
S
G
L
S
Q
Q
H
Site 109
S805
G
Q
N
S
L
G
S
S
G
L
S
Q
Q
H
N
Site 110
S808
S
L
G
S
S
G
L
S
Q
Q
H
N
K
G
T
Site 111
T815
S
Q
Q
H
N
K
G
T
L
N
P
G
L
T
K
Site 112
T821
G
T
L
N
P
G
L
T
K
P
P
V
P
R
V
Site 113
S829
K
P
P
V
P
R
V
S
P
A
M
G
G
Q
N
Site 114
S848
H
Q
G
M
P
N
L
S
G
Q
T
P
G
N
S
Site 115
T851
M
P
N
L
S
G
Q
T
P
G
N
S
N
V
S
Site 116
S855
S
G
Q
T
P
G
N
S
N
V
S
P
F
T
A
Site 117
S858
T
P
G
N
S
N
V
S
P
F
T
A
A
S
S
Site 118
T861
N
S
N
V
S
P
F
T
A
A
S
S
F
H
M
Site 119
S865
S
P
F
T
A
A
S
S
F
H
M
Q
Q
Q
A
Site 120
S878
Q
A
H
L
K
M
S
S
P
Q
F
S
Q
A
V
Site 121
S882
K
M
S
S
P
Q
F
S
Q
A
V
P
N
R
P
Site 122
S894
N
R
P
M
A
P
M
S
S
A
A
A
V
G
S
Site 123
S907
G
S
L
L
P
P
V
S
A
Q
Q
R
T
S
A
Site 124
S913
V
S
A
Q
Q
R
T
S
A
P
A
P
A
P
P
Site 125
T922
P
A
P
A
P
P
P
T
A
P
Q
Q
G
L
P
Site 126
S932
Q
Q
G
L
P
G
L
S
P
A
G
P
E
L
G
Site 127
S942
G
P
E
L
G
A
F
S
Q
S
P
A
S
Q
M
Site 128
S944
E
L
G
A
F
S
Q
S
P
A
S
Q
M
G
G
Site 129
S947
A
F
S
Q
S
P
A
S
Q
M
G
G
R
A
G
Site 130
Y961
G
L
H
C
T
Q
A
Y
P
V
R
T
A
G
Q
Site 131
S975
Q
E
L
P
F
A
Y
S
G
Q
P
G
G
S
G
Site 132
S981
Y
S
G
Q
P
G
G
S
G
L
S
S
V
A
G
Site 133
S984
Q
P
G
G
S
G
L
S
S
V
A
G
H
T
D
Site 134
S985
P
G
G
S
G
L
S
S
V
A
G
H
T
D
L
Site 135
S995
G
H
T
D
L
I
D
S
L
L
K
N
R
T
S
Site 136
S1002
S
L
L
K
N
R
T
S
E
E
W
M
S
D
L
Site 137
S1007
R
T
S
E
E
W
M
S
D
L
D
D
L
L
G
Site 138
S1015
D
L
D
D
L
L
G
S
Q
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation