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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HSPH1
Full Name:
Heat shock protein 105 kDa
Alias:
42 degrees C-HSP; Antigen NY-CO-25; H105; Heat shock 105kDa/110kDa protein 1; Heat shock 110 kDa protein; Heat shock-related 100 kDa protein E7I; Heat-shock protein 105 kDa; HS105; Hsp105 alpha; HSP105A; HSP105B; HSP110; HSP-E7I; KIAA0201; NY-CO-25
Type:
Chaperone protein
Mass (Da):
96865
Number AA:
858
UniProt ID:
Q92598
International Prot ID:
IPI00514983
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005524
PhosphoSite+
KinaseNET
Biological Process:
GO:0006986
Phosida
TranscriptoNet
STRING
Kinexus Products
Heat shock protein 105 kDa pan-specific antibody AB-NN269-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN269-1
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
V
V
G
L
D
V
G
S
Q
S
C
Y
I
A
V
Site 2
S12
G
L
D
V
G
S
Q
S
C
Y
I
A
V
A
R
Site 3
Y14
D
V
G
S
Q
S
C
Y
I
A
V
A
R
A
G
Site 4
T25
A
R
A
G
G
I
E
T
I
A
N
E
F
S
D
Site 5
S31
E
T
I
A
N
E
F
S
D
R
C
T
P
S
V
Site 6
T35
N
E
F
S
D
R
C
T
P
S
V
I
S
F
G
Site 7
S37
F
S
D
R
C
T
P
S
V
I
S
F
G
S
K
Site 8
S40
R
C
T
P
S
V
I
S
F
G
S
K
N
R
T
Site 9
S43
P
S
V
I
S
F
G
S
K
N
R
T
I
G
V
Site 10
T47
S
F
G
S
K
N
R
T
I
G
V
A
A
K
N
Site 11
T63
Q
I
T
H
A
N
N
T
V
S
N
F
K
R
F
Site 12
S88
Q
K
E
K
E
N
L
S
Y
D
L
V
P
L
K
Site 13
Y89
K
E
K
E
N
L
S
Y
D
L
V
P
L
K
N
Site 14
T118
L
F
S
V
E
Q
I
T
A
M
L
L
T
K
L
Site 15
T123
Q
I
T
A
M
L
L
T
K
L
K
E
T
A
E
Site 16
T128
L
L
T
K
L
K
E
T
A
E
N
S
L
K
K
Site 17
S155
F
T
D
A
E
R
R
S
V
L
D
A
A
Q
I
Site 18
T175
L
R
L
M
N
D
M
T
A
V
A
L
N
Y
G
Site 19
S190
I
Y
K
Q
D
L
P
S
L
D
E
K
P
R
I
Site 20
T225
G
K
L
K
V
L
G
T
A
F
D
P
F
L
G
Site 21
Y252
C
A
E
F
K
T
K
Y
K
L
D
A
K
S
K
Site 22
S258
K
Y
K
L
D
A
K
S
K
I
R
A
L
L
R
Site 23
Y267
I
R
A
L
L
R
L
Y
Q
E
C
E
K
L
K
Site 24
S278
E
K
L
K
K
L
M
S
S
N
S
T
D
L
P
Site 25
S281
K
K
L
M
S
S
N
S
T
D
L
P
L
N
I
Site 26
T282
K
L
M
S
S
N
S
T
D
L
P
L
N
I
E
Site 27
S304
V
S
G
K
M
N
R
S
Q
F
E
E
L
C
A
Site 28
Y322
Q
K
I
E
V
P
L
Y
S
L
L
E
Q
T
H
Site 29
S336
H
L
K
V
E
D
V
S
A
V
E
I
V
G
G
Site 30
S363
K
F
F
G
K
D
I
S
T
T
L
N
A
D
E
Site 31
T365
F
G
K
D
I
S
T
T
L
N
A
D
E
A
V
Site 32
S384
A
L
Q
C
A
I
L
S
P
A
F
K
V
R
E
Site 33
S410
S
L
I
W
N
H
D
S
E
D
T
E
G
V
H
Site 34
S429
R
N
H
A
A
P
F
S
K
V
L
T
F
L
R
Site 35
Y446
P
F
E
L
E
A
F
Y
S
D
P
Q
G
V
P
Site 36
S447
F
E
L
E
A
F
Y
S
D
P
Q
G
V
P
Y
Site 37
Y454
S
D
P
Q
G
V
P
Y
P
E
A
K
I
G
R
Site 38
S476
A
Q
K
D
G
E
K
S
R
V
K
V
K
V
R
Site 39
T486
K
V
K
V
R
V
N
T
H
G
I
F
T
I
S
Site 40
S493
T
H
G
I
F
T
I
S
T
A
S
M
V
E
K
Site 41
T494
H
G
I
F
T
I
S
T
A
S
M
V
E
K
V
Site 42
T503
S
M
V
E
K
V
P
T
E
E
N
E
M
S
S
Site 43
S509
P
T
E
E
N
E
M
S
S
E
A
D
M
E
C
Site 44
T527
R
P
P
E
N
P
D
T
D
K
N
V
Q
Q
D
Site 45
T540
Q
D
N
S
E
A
G
T
Q
P
Q
V
Q
T
D
Site 46
S552
Q
T
D
A
Q
Q
T
S
Q
S
P
P
S
P
E
Site 47
S554
D
A
Q
Q
T
S
Q
S
P
P
S
P
E
L
T
Site 48
S557
Q
T
S
Q
S
P
P
S
P
E
L
T
S
E
E
Site 49
T561
S
P
P
S
P
E
L
T
S
E
E
N
K
I
P
Site 50
S562
P
P
S
P
E
L
T
S
E
E
N
K
I
P
D
Site 51
Y614
G
K
D
L
L
N
M
Y
I
E
T
E
G
K
M
Site 52
Y641
A
K
N
A
V
E
E
Y
V
Y
E
F
R
D
K
Site 53
Y643
N
A
V
E
E
Y
V
Y
E
F
R
D
K
L
C
Site 54
T670
Q
N
F
L
R
L
L
T
E
T
E
D
W
L
Y
Site 55
T672
F
L
R
L
L
T
E
T
E
D
W
L
Y
E
E
Site 56
Y677
T
E
T
E
D
W
L
Y
E
E
G
E
D
Q
A
Site 57
Y688
E
D
Q
A
K
Q
A
Y
V
D
K
L
E
E
L
Site 58
T700
E
E
L
M
K
I
G
T
P
V
K
V
R
F
Q
Site 59
Y726
L
G
Q
R
L
Q
H
Y
A
K
I
A
A
D
F
Site 60
Y740
F
R
N
K
D
E
K
Y
N
H
I
D
E
S
E
Site 61
S746
K
Y
N
H
I
D
E
S
E
M
K
K
V
E
K
Site 62
S773
M
N
A
Q
A
K
K
S
L
D
Q
D
P
V
V
Site 63
T795
K
I
K
E
L
N
N
T
C
E
P
V
V
T
Q
Site 64
T801
N
T
C
E
P
V
V
T
Q
P
K
P
K
I
E
Site 65
S809
Q
P
K
P
K
I
E
S
P
K
L
E
R
T
P
Site 66
T815
E
S
P
K
L
E
R
T
P
N
G
P
N
I
D
Site 67
Y846
P
H
Q
N
G
E
C
Y
P
N
E
K
N
S
V
Site 68
S852
C
Y
P
N
E
K
N
S
V
N
M
D
L
D
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation