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Updated November 2019
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Protein Info
Short Name:
DOCK2
Full Name:
Dedicator of cytokinesis protein 2
Alias:
dedicator of cytokinesis 2; HCH; KIAA0209
Type:
Adapter/scaffold protein
Mass (Da):
211948
Number AA:
1830
UniProt ID:
Q92608
International Prot ID:
IPI00022449
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005856
GO:0005829
GO:0019898
Uniprot
OncoNet
Molecular Function:
GO:0030676
GO:0042608
GO:0009055
PhosphoSite+
KinaseNET
Biological Process:
GO:0030036
GO:0048247
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y17
E
R
H
G
V
A
I
Y
N
F
Q
G
S
G
A
Site 2
Y45
Q
E
T
C
G
D
W
Y
R
G
Y
L
I
K
H
Site 3
Y48
C
G
D
W
Y
R
G
Y
L
I
K
H
K
M
L
Site 4
T70
F
I
H
I
K
E
V
T
V
E
K
R
R
N
T
Site 5
T77
T
V
E
K
R
R
N
T
E
N
I
I
P
A
E
Site 6
Y106
G
S
I
W
K
Q
L
Y
V
A
S
K
K
E
R
Site 7
S129
Y
D
L
M
E
W
R
S
Q
L
L
S
G
T
L
Site 8
S133
E
W
R
S
Q
L
L
S
G
T
L
P
K
D
E
Site 9
T135
R
S
Q
L
L
S
G
T
L
P
K
D
E
L
K
Site 10
Y154
K
V
T
S
K
I
D
Y
G
N
K
I
L
E
L
Site 11
T195
E
E
A
T
D
K
I
T
E
R
I
K
E
E
M
Site 12
S203
E
R
I
K
E
E
M
S
K
D
Q
P
D
Y
A
Site 13
Y209
M
S
K
D
Q
P
D
Y
A
M
Y
S
R
I
S
Site 14
Y212
D
Q
P
D
Y
A
M
Y
S
R
I
S
S
S
P
Site 15
S213
Q
P
D
Y
A
M
Y
S
R
I
S
S
S
P
T
Site 16
S216
Y
A
M
Y
S
R
I
S
S
S
P
T
H
S
L
Site 17
S217
A
M
Y
S
R
I
S
S
S
P
T
H
S
L
Y
Site 18
S218
M
Y
S
R
I
S
S
S
P
T
H
S
L
Y
V
Site 19
T220
S
R
I
S
S
S
P
T
H
S
L
Y
V
F
V
Site 20
S222
I
S
S
S
P
T
H
S
L
Y
V
F
V
R
N
Site 21
S243
E
D
A
E
L
F
M
S
L
Y
D
P
N
K
Q
Site 22
Y245
A
E
L
F
M
S
L
Y
D
P
N
K
Q
T
V
Site 23
Y257
Q
T
V
I
S
E
N
Y
L
V
R
W
G
S
R
Site 24
S263
N
Y
L
V
R
W
G
S
R
G
F
P
K
E
I
Site 25
Y294
D
L
N
R
D
K
I
Y
L
I
C
Q
I
V
R
Site 26
T310
G
K
M
D
L
K
D
T
G
A
K
K
C
T
Q
Site 27
S340
I
I
K
G
K
A
E
S
D
E
E
K
Q
H
F
Site 28
S370
L
L
G
K
V
I
A
S
K
G
D
S
G
G
Q
Site 29
Y397
I
I
Q
I
R
K
D
Y
P
H
L
V
D
R
T
Site 30
T405
P
H
L
V
D
R
T
T
V
V
A
R
K
L
G
Site 31
Y427
G
D
V
R
N
D
I
Y
I
T
L
L
Q
G
D
Site 32
Y438
L
Q
G
D
F
D
K
Y
N
K
T
T
Q
R
N
Site 33
T441
D
F
D
K
Y
N
K
T
T
Q
R
N
V
E
V
Site 34
Y476
G
D
K
P
M
N
E
Y
R
S
V
V
Y
Y
Q
Site 35
Y481
N
E
Y
R
S
V
V
Y
Y
Q
V
K
Q
P
R
Site 36
Y482
E
Y
R
S
V
V
Y
Y
Q
V
K
Q
P
R
W
Site 37
T492
K
Q
P
R
W
M
E
T
V
K
V
A
V
P
I
Site 38
S515
R
F
M
F
R
H
R
S
S
L
E
S
K
D
K
Site 39
S516
F
M
F
R
H
R
S
S
L
E
S
K
D
K
G
Site 40
S519
R
H
R
S
S
L
E
S
K
D
K
G
E
K
N
Site 41
Y531
E
K
N
F
A
M
S
Y
V
K
L
M
K
E
D
Site 42
T540
K
L
M
K
E
D
G
T
T
L
H
D
G
F
H
Site 43
T541
L
M
K
E
D
G
T
T
L
H
D
G
F
H
D
Site 44
S563
S
K
K
M
E
D
A
S
A
Y
L
T
L
P
S
Site 45
Y565
K
M
E
D
A
S
A
Y
L
T
L
P
S
Y
R
Site 46
T567
E
D
A
S
A
Y
L
T
L
P
S
Y
R
H
H
Site 47
S570
S
A
Y
L
T
L
P
S
Y
R
H
H
V
E
N
Site 48
Y571
A
Y
L
T
L
P
S
Y
R
H
H
V
E
N
K
Site 49
T581
H
V
E
N
K
G
A
T
L
S
R
S
S
S
S
Site 50
S583
E
N
K
G
A
T
L
S
R
S
S
S
S
V
G
Site 51
S585
K
G
A
T
L
S
R
S
S
S
S
V
G
G
L
Site 52
S586
G
A
T
L
S
R
S
S
S
S
V
G
G
L
S
Site 53
S587
A
T
L
S
R
S
S
S
S
V
G
G
L
S
V
Site 54
S588
T
L
S
R
S
S
S
S
V
G
G
L
S
V
S
Site 55
S593
S
S
S
V
G
G
L
S
V
S
S
R
D
V
F
Site 56
T612
L
V
C
S
T
K
L
T
Q
N
V
G
L
L
G
Site 57
Y669
E
H
S
Q
S
D
E
Y
D
I
L
V
F
D
A
Site 58
T694
R
K
F
Q
H
F
N
T
V
L
E
A
Y
I
Q
Site 59
Y699
F
N
T
V
L
E
A
Y
I
Q
Q
H
F
S
A
Site 60
T719
K
L
M
T
V
L
K
T
Y
L
D
T
S
S
R
Site 61
Y720
L
M
T
V
L
K
T
Y
L
D
T
S
S
R
G
Site 62
T723
V
L
K
T
Y
L
D
T
S
S
R
G
E
Q
C
Site 63
S724
L
K
T
Y
L
D
T
S
S
R
G
E
Q
C
E
Site 64
T752
K
F
I
V
R
S
R
T
L
F
S
Q
L
Y
E
Site 65
S755
V
R
S
R
T
L
F
S
Q
L
Y
E
G
K
E
Site 66
Y758
R
T
L
F
S
Q
L
Y
E
G
K
E
Q
M
E
Site 67
S769
E
Q
M
E
F
E
E
S
M
R
R
L
F
E
S
Site 68
S776
S
M
R
R
L
F
E
S
I
N
N
L
M
K
S
Site 69
S783
S
I
N
N
L
M
K
S
Q
Y
K
T
T
I
L
Site 70
Y798
L
Q
V
A
A
L
K
Y
I
P
S
V
L
H
D
Site 71
S801
A
A
L
K
Y
I
P
S
V
L
H
D
V
E
M
Site 72
S845
S
M
N
E
I
V
Q
S
N
L
F
K
K
Q
E
Site 73
Y884
H
Q
V
L
E
R
K
Y
C
V
E
L
L
N
S
Site 74
T922
L
L
R
T
V
N
R
T
V
I
T
M
G
R
D
Site 75
Y952
N
Q
M
G
D
Q
H
Y
S
F
Y
I
E
T
F
Site 76
Y955
G
D
Q
H
Y
S
F
Y
I
E
T
F
Q
T
S
Site 77
T958
H
Y
S
F
Y
I
E
T
F
Q
T
S
S
E
L
Site 78
Y985
D
L
I
G
K
N
V
Y
P
G
D
W
M
A
M
Site 79
Y1052
E
Q
F
S
H
A
K
Y
N
K
I
L
N
K
Y
Site 80
Y1059
Y
N
K
I
L
N
K
Y
G
D
M
R
R
L
I
Site 81
Y1075
F
S
I
R
D
M
W
Y
K
L
G
Q
N
K
I
Site 82
Y1119
F
D
M
M
L
C
E
Y
Q
R
S
G
D
F
K
Site 83
Y1149
G
G
R
G
D
E
Q
Y
M
Q
L
L
E
S
I
Site 84
T1166
E
C
A
A
E
H
P
T
I
A
K
S
V
E
N
Site 85
S1170
E
H
P
T
I
A
K
S
V
E
N
F
V
N
L
Site 86
Y1188
L
L
E
K
L
L
D
Y
R
G
V
M
T
D
E
Site 87
S1196
R
G
V
M
T
D
E
S
K
D
N
R
M
S
C
Site 88
S1202
E
S
K
D
N
R
M
S
C
T
V
N
L
L
N
Site 89
Y1220
D
N
N
R
E
E
M
Y
I
R
Y
L
Y
K
L
Site 90
Y1223
R
E
E
M
Y
I
R
Y
L
Y
K
L
R
D
L
Site 91
Y1225
E
M
Y
I
R
Y
L
Y
K
L
R
D
L
H
L
Site 92
Y1237
L
H
L
D
C
D
N
Y
T
E
A
A
Y
T
L
Site 93
T1238
H
L
D
C
D
N
Y
T
E
A
A
Y
T
L
L
Site 94
T1272
T
G
Q
Q
H
P
Q
T
H
R
Q
L
K
E
T
Site 95
T1279
T
H
R
Q
L
K
E
T
L
Y
E
T
I
I
G
Site 96
Y1281
R
Q
L
K
E
T
L
Y
E
T
I
I
G
Y
F
Site 97
Y1287
L
Y
E
T
I
I
G
Y
F
D
K
G
K
M
W
Site 98
S1299
K
M
W
E
E
A
I
S
L
C
K
E
L
A
E
Site 99
Y1315
Y
E
M
E
I
F
D
Y
E
L
L
S
Q
N
L
Site 100
Y1342
I
L
R
P
K
P
D
Y
F
A
V
G
Y
Y
G
Site 101
Y1347
P
D
Y
F
A
V
G
Y
Y
G
Q
G
F
P
S
Site 102
Y1348
D
Y
F
A
V
G
Y
Y
G
Q
G
F
P
S
F
Site 103
Y1368
F
I
Y
R
G
K
E
Y
E
R
R
E
D
F
Q
Site 104
T1390
P
N
A
E
K
M
N
T
T
S
A
P
G
D
D
Site 105
Y1434
P
D
Q
I
I
N
F
Y
K
S
N
Y
V
Q
R
Site 106
Y1438
I
N
F
Y
K
S
N
Y
V
Q
R
F
H
Y
S
Site 107
Y1444
N
Y
V
Q
R
F
H
Y
S
R
P
V
R
R
G
Site 108
T1452
S
R
P
V
R
R
G
T
V
D
P
E
N
E
F
Site 109
S1488
W
F
E
V
V
H
M
S
Q
T
T
I
S
P
L
Site 110
S1493
H
M
S
Q
T
T
I
S
P
L
E
N
A
I
E
Site 111
T1504
N
A
I
E
T
M
S
T
A
N
E
K
I
L
M
Site 112
Y1516
I
L
M
M
I
N
Q
Y
Q
S
D
E
T
L
P
Site 113
T1521
N
Q
Y
Q
S
D
E
T
L
P
I
N
P
L
S
Site 114
Y1546
V
M
G
G
F
A
K
Y
E
K
A
F
F
T
E
Site 115
Y1555
K
A
F
F
T
E
E
Y
V
R
D
H
P
E
D
Site 116
T1567
P
E
D
Q
D
K
L
T
H
L
K
D
L
I
A
Site 117
S1592
K
I
H
E
K
R
V
S
D
N
L
R
P
F
H
Site 118
Y1617
K
M
K
V
E
K
E
Y
G
V
R
E
M
P
D
Site 119
S1635
R
R
V
G
R
P
R
S
M
L
R
S
Y
R
Q
Site 120
S1639
R
P
R
S
M
L
R
S
Y
R
Q
M
S
I
I
Site 121
Y1640
P
R
S
M
L
R
S
Y
R
Q
M
S
I
I
S
Site 122
S1644
L
R
S
Y
R
Q
M
S
I
I
S
L
A
S
M
Site 123
S1647
Y
R
Q
M
S
I
I
S
L
A
S
M
N
S
D
Site 124
S1653
I
S
L
A
S
M
N
S
D
C
S
T
P
S
K
Site 125
S1656
A
S
M
N
S
D
C
S
T
P
S
K
P
T
S
Site 126
T1657
S
M
N
S
D
C
S
T
P
S
K
P
T
S
E
Site 127
S1659
N
S
D
C
S
T
P
S
K
P
T
S
E
S
F
Site 128
S1663
S
T
P
S
K
P
T
S
E
S
F
D
L
E
L
Site 129
S1665
P
S
K
P
T
S
E
S
F
D
L
E
L
A
S
Site 130
S1672
S
F
D
L
E
L
A
S
P
K
T
P
R
V
E
Site 131
T1675
L
E
L
A
S
P
K
T
P
R
V
E
Q
E
E
Site 132
S1685
V
E
Q
E
E
P
I
S
P
G
S
T
L
P
E
Site 133
S1688
E
E
P
I
S
P
G
S
T
L
P
E
V
K
L
Site 134
T1689
E
P
I
S
P
G
S
T
L
P
E
V
K
L
R
Site 135
S1698
P
E
V
K
L
R
R
S
K
K
R
T
K
R
S
Site 136
T1702
L
R
R
S
K
K
R
T
K
R
S
S
V
V
F
Site 137
S1705
S
K
K
R
T
K
R
S
S
V
V
F
A
D
E
Site 138
S1706
K
K
R
T
K
R
S
S
V
V
F
A
D
E
K
Site 139
S1724
E
S
D
L
K
R
L
S
R
K
H
E
F
M
S
Site 140
S1731
S
R
K
H
E
F
M
S
D
T
N
L
S
E
H
Site 141
T1733
K
H
E
F
M
S
D
T
N
L
S
E
H
A
A
Site 142
S1736
F
M
S
D
T
N
L
S
E
H
A
A
I
P
L
Site 143
S1755
L
S
Q
M
S
F
A
S
Q
S
M
P
T
I
P
Site 144
T1779
P
G
L
D
E
A
N
T
S
P
R
L
S
Q
T
Site 145
S1780
G
L
D
E
A
N
T
S
P
R
L
S
Q
T
F
Site 146
S1784
A
N
T
S
P
R
L
S
Q
T
F
L
Q
L
S
Site 147
T1786
T
S
P
R
L
S
Q
T
F
L
Q
L
S
D
G
Site 148
S1791
S
Q
T
F
L
Q
L
S
D
G
D
K
K
T
L
Site 149
T1797
L
S
D
G
D
K
K
T
L
T
R
K
K
V
N
Site 150
T1799
D
G
D
K
K
T
L
T
R
K
K
V
N
Q
F
Site 151
T1809
K
V
N
Q
F
F
K
T
M
L
A
S
K
S
A
Site 152
S1813
F
F
K
T
M
L
A
S
K
S
A
E
E
G
K
Site 153
S1815
K
T
M
L
A
S
K
S
A
E
E
G
K
Q
I
Site 154
S1825
E
G
K
Q
I
P
D
S
L
S
T
D
L
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation