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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TBC1D5
Full Name:
TBC1 domain family member 5
Alias:
KIAA0210; TBC1 domain family, member 5; TBC5; TBCD5
Type:
GTPase-activating protein for G protein
Mass (Da):
89004
Number AA:
795
UniProt ID:
Q92609
International Prot ID:
IPI00022450
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
Uniprot
OncoNet
Molecular Function:
GO:0005097
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0032313
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y2
_
_
_
_
_
_
M
Y
H
S
L
S
E
T
R
Site 2
T8
M
Y
H
S
L
S
E
T
R
H
P
L
Q
P
E
Site 3
S25
E
V
G
I
D
P
L
S
S
Y
S
N
K
S
G
Site 4
S26
V
G
I
D
P
L
S
S
Y
S
N
K
S
G
G
Site 5
Y27
G
I
D
P
L
S
S
Y
S
N
K
S
G
G
D
Site 6
S28
I
D
P
L
S
S
Y
S
N
K
S
G
G
D
S
Site 7
S31
L
S
S
Y
S
N
K
S
G
G
D
S
N
K
N
Site 8
S35
S
N
K
S
G
G
D
S
N
K
N
G
R
R
T
Site 9
T42
S
N
K
N
G
R
R
T
S
S
T
L
D
S
E
Site 10
S43
N
K
N
G
R
R
T
S
S
T
L
D
S
E
G
Site 11
S44
K
N
G
R
R
T
S
S
T
L
D
S
E
G
T
Site 12
T45
N
G
R
R
T
S
S
T
L
D
S
E
G
T
F
Site 13
S48
R
T
S
S
T
L
D
S
E
G
T
F
N
S
Y
Site 14
T51
S
T
L
D
S
E
G
T
F
N
S
Y
R
K
E
Site 15
S54
D
S
E
G
T
F
N
S
Y
R
K
E
W
E
E
Site 16
Y68
E
L
F
V
N
N
N
Y
L
A
T
I
R
Q
K
Site 17
T71
V
N
N
N
Y
L
A
T
I
R
Q
K
G
I
N
Site 18
S83
G
I
N
G
Q
L
R
S
S
R
F
R
S
I
C
Site 19
S84
I
N
G
Q
L
R
S
S
R
F
R
S
I
C
W
Site 20
S103
C
V
L
P
Q
D
K
S
Q
W
I
S
R
I
E
Site 21
S107
Q
D
K
S
Q
W
I
S
R
I
E
E
L
R
A
Site 22
Y116
I
E
E
L
R
A
W
Y
S
N
I
K
E
I
H
Site 23
T125
N
I
K
E
I
H
I
T
N
P
R
K
V
V
G
Site 24
S143
L
M
I
N
N
P
L
S
Q
D
E
G
S
L
W
Site 25
S148
P
L
S
Q
D
E
G
S
L
W
N
K
F
F
Q
Site 26
T170
I
E
Q
D
V
K
R
T
F
P
E
M
Q
F
F
Site 27
Y193
L
T
D
V
L
F
C
Y
A
R
E
N
E
Q
L
Site 28
Y202
R
E
N
E
Q
L
L
Y
K
Q
G
M
H
E
L
Site 29
S228
H
Q
A
F
L
H
A
S
E
S
A
Q
P
S
E
Site 30
S230
A
F
L
H
A
S
E
S
A
Q
P
S
E
E
M
Site 31
S234
A
S
E
S
A
Q
P
S
E
E
M
K
T
V
L
Site 32
T239
Q
P
S
E
E
M
K
T
V
L
N
P
E
Y
L
Site 33
Y245
K
T
V
L
N
P
E
Y
L
E
H
D
A
Y
A
Site 34
Y251
E
Y
L
E
H
D
A
Y
A
V
F
S
Q
L
M
Site 35
T260
V
F
S
Q
L
M
E
T
A
E
P
W
F
S
T
Site 36
S266
E
T
A
E
P
W
F
S
T
F
E
H
D
G
Q
Site 37
T267
T
A
E
P
W
F
S
T
F
E
H
D
G
Q
K
Site 38
T281
K
G
K
E
T
L
M
T
P
I
P
F
A
R
P
Site 39
Y317
K
K
H
D
I
E
L
Y
M
H
L
N
R
L
E
Site 40
T422
K
R
N
P
R
P
V
T
Y
Q
F
H
P
N
L
Site 41
Y423
R
N
P
R
P
V
T
Y
Q
F
H
P
N
L
D
Site 42
Y431
Q
F
H
P
N
L
D
Y
Y
K
A
R
G
A
D
Site 43
Y432
F
H
P
N
L
D
Y
Y
K
A
R
G
A
D
L
Site 44
S443
G
A
D
L
M
N
K
S
R
T
N
A
K
G
A
Site 45
S460
N
I
N
K
V
S
N
S
L
I
N
F
G
R
K
Site 46
S470
N
F
G
R
K
L
I
S
P
A
M
A
P
G
S
Site 47
S477
S
P
A
M
A
P
G
S
A
G
G
P
V
P
G
Site 48
S487
G
P
V
P
G
G
N
S
S
S
S
S
S
V
V
Site 49
S488
P
V
P
G
G
N
S
S
S
S
S
S
V
V
I
Site 50
S489
V
P
G
G
N
S
S
S
S
S
S
V
V
I
P
Site 51
S490
P
G
G
N
S
S
S
S
S
S
V
V
I
P
T
Site 52
S491
G
G
N
S
S
S
S
S
S
V
V
I
P
T
R
Site 53
S492
G
N
S
S
S
S
S
S
V
V
I
P
T
R
T
Site 54
S500
V
V
I
P
T
R
T
S
A
E
A
P
S
H
H
Site 55
S520
Q
Q
Q
R
L
M
K
S
E
S
M
P
V
Q
L
Site 56
S522
Q
R
L
M
K
S
E
S
M
P
V
Q
L
N
K
Site 57
S532
V
Q
L
N
K
G
L
S
S
K
N
I
S
S
S
Site 58
S533
Q
L
N
K
G
L
S
S
K
N
I
S
S
S
P
Site 59
S537
G
L
S
S
K
N
I
S
S
S
P
S
V
E
S
Site 60
S538
L
S
S
K
N
I
S
S
S
P
S
V
E
S
L
Site 61
S539
S
S
K
N
I
S
S
S
P
S
V
E
S
L
P
Site 62
S541
K
N
I
S
S
S
P
S
V
E
S
L
P
G
G
Site 63
S544
S
S
S
P
S
V
E
S
L
P
G
G
R
E
F
Site 64
T552
L
P
G
G
R
E
F
T
G
S
P
P
S
S
A
Site 65
S554
G
G
R
E
F
T
G
S
P
P
S
S
A
T
K
Site 66
S557
E
F
T
G
S
P
P
S
S
A
T
K
K
D
S
Site 67
S558
F
T
G
S
P
P
S
S
A
T
K
K
D
S
F
Site 68
T560
G
S
P
P
S
S
A
T
K
K
D
S
F
F
S
Site 69
S564
S
S
A
T
K
K
D
S
F
F
S
N
I
S
R
Site 70
S567
T
K
K
D
S
F
F
S
N
I
S
R
S
R
S
Site 71
S570
D
S
F
F
S
N
I
S
R
S
R
S
H
S
K
Site 72
S572
F
F
S
N
I
S
R
S
R
S
H
S
K
T
M
Site 73
S574
S
N
I
S
R
S
R
S
H
S
K
T
M
G
R
Site 74
S576
I
S
R
S
R
S
H
S
K
T
M
G
R
K
E
Site 75
T578
R
S
R
S
H
S
K
T
M
G
R
K
E
S
E
Site 76
S584
K
T
M
G
R
K
E
S
E
E
E
L
E
A
Q
Site 77
S593
E
E
L
E
A
Q
I
S
F
L
Q
G
Q
L
N
Site 78
Y608
D
L
D
A
M
C
K
Y
C
A
K
V
M
D
T
Site 79
T615
Y
C
A
K
V
M
D
T
H
L
V
N
I
Q
D
Site 80
S652
I
K
D
I
L
K
G
S
L
R
F
N
Q
S
Q
Site 81
S658
G
S
L
R
F
N
Q
S
Q
L
E
A
E
E
N
Site 82
Y675
I
T
I
A
D
N
H
Y
C
S
S
G
Q
G
Q
Site 83
S677
I
A
D
N
H
Y
C
S
S
G
Q
G
Q
G
R
Site 84
S678
A
D
N
H
Y
C
S
S
G
Q
G
Q
G
R
G
Site 85
S689
Q
G
R
G
Q
G
Q
S
V
Q
M
S
G
A
I
Site 86
S693
Q
G
Q
S
V
Q
M
S
G
A
I
K
Q
A
S
Site 87
S700
S
G
A
I
K
Q
A
S
S
E
T
P
G
C
T
Site 88
S701
G
A
I
K
Q
A
S
S
E
T
P
G
C
T
D
Site 89
T703
I
K
Q
A
S
S
E
T
P
G
C
T
D
R
G
Site 90
S712
G
C
T
D
R
G
N
S
D
D
F
I
L
I
S
Site 91
S719
S
D
D
F
I
L
I
S
K
D
D
D
G
S
S
Site 92
S725
I
S
K
D
D
D
G
S
S
A
R
G
S
F
S
Site 93
S726
S
K
D
D
D
G
S
S
A
R
G
S
F
S
G
Site 94
S730
D
G
S
S
A
R
G
S
F
S
G
Q
A
Q
P
Site 95
S732
S
S
A
R
G
S
F
S
G
Q
A
Q
P
L
R
Site 96
T740
G
Q
A
Q
P
L
R
T
L
R
S
T
S
G
K
Site 97
S743
Q
P
L
R
T
L
R
S
T
S
G
K
S
Q
A
Site 98
T744
P
L
R
T
L
R
S
T
S
G
K
S
Q
A
P
Site 99
S745
L
R
T
L
R
S
T
S
G
K
S
Q
A
P
V
Site 100
S748
L
R
S
T
S
G
K
S
Q
A
P
V
C
S
P
Site 101
S754
K
S
Q
A
P
V
C
S
P
L
V
F
S
D
P
Site 102
S767
D
P
L
M
G
P
A
S
A
S
S
S
N
P
S
Site 103
S769
L
M
G
P
A
S
A
S
S
S
N
P
S
S
S
Site 104
S770
M
G
P
A
S
A
S
S
S
N
P
S
S
S
P
Site 105
S771
G
P
A
S
A
S
S
S
N
P
S
S
S
P
D
Site 106
S774
S
A
S
S
S
N
P
S
S
S
P
D
D
D
S
Site 107
S775
A
S
S
S
N
P
S
S
S
P
D
D
D
S
S
Site 108
S776
S
S
S
N
P
S
S
S
P
D
D
D
S
S
K
Site 109
S781
S
S
S
P
D
D
D
S
S
K
D
S
G
F
T
Site 110
S782
S
S
P
D
D
D
S
S
K
D
S
G
F
T
I
Site 111
S785
D
D
D
S
S
K
D
S
G
F
T
I
V
S
P
Site 112
S791
D
S
G
F
T
I
V
S
P
L
D
I
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation