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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ZNF516
Full Name:
Zinc finger protein 516
Alias:
NUCLEAR PORE COMPLEX-ASSOCIATED PROTEIN TPR.
Type:
Uncharacterized protein
Mass (Da):
124289
Number AA:
1163
UniProt ID:
Q92618
International Prot ID:
IPI00741361
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0045449
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S16
M
E
L
R
R
G
P
S
P
T
R
A
G
R
G
Site 2
T18
L
R
R
G
P
S
P
T
R
A
G
R
G
H
E
Site 3
S48
K
S
F
P
F
Q
S
S
L
S
Q
H
M
R
K
Site 4
S50
F
P
F
Q
S
S
L
S
Q
H
M
R
K
H
T
Site 5
T57
S
Q
H
M
R
K
H
T
G
E
K
P
Y
K
C
Site 6
Y62
K
H
T
G
E
K
P
Y
K
C
P
Y
C
D
H
Site 7
Y66
E
K
P
Y
K
C
P
Y
C
D
H
R
A
S
Q
Site 8
S72
P
Y
C
D
H
R
A
S
Q
K
G
N
L
K
I
Site 9
S83
N
L
K
I
H
I
R
S
H
R
T
G
T
L
I
Site 10
T86
I
H
I
R
S
H
R
T
G
T
L
I
Q
G
H
Site 11
T88
I
R
S
H
R
T
G
T
L
I
Q
G
H
E
P
Site 12
S108
P
L
G
E
M
R
A
S
E
G
L
D
A
C
A
Site 13
S116
E
G
L
D
A
C
A
S
P
T
K
S
A
S
A
Site 14
T118
L
D
A
C
A
S
P
T
K
S
A
S
A
C
N
Site 15
S120
A
C
A
S
P
T
K
S
A
S
A
C
N
R
L
Site 16
S122
A
S
P
T
K
S
A
S
A
C
N
R
L
L
N
Site 17
S132
N
R
L
L
N
G
A
S
Q
A
D
G
A
R
V
Site 18
S144
A
R
V
L
N
G
A
S
Q
A
D
S
G
R
V
Site 19
S148
N
G
A
S
Q
A
D
S
G
R
V
L
L
R
S
Site 20
S155
S
G
R
V
L
L
R
S
S
K
K
G
A
E
G
Site 21
S156
G
R
V
L
L
R
S
S
K
K
G
A
E
G
S
Site 22
S163
S
K
K
G
A
E
G
S
A
C
A
P
G
E
A
Site 23
S177
A
K
A
A
V
Q
C
S
F
C
K
S
Q
F
E
Site 24
S181
V
Q
C
S
F
C
K
S
Q
F
E
R
K
K
D
Site 25
S206
P
F
K
C
R
L
C
S
Y
A
T
L
R
E
E
Site 26
S214
Y
A
T
L
R
E
E
S
L
L
S
H
I
E
R
Site 27
S217
L
R
E
E
S
L
L
S
H
I
E
R
D
H
I
Site 28
T225
H
I
E
R
D
H
I
T
A
Q
G
P
G
S
G
Site 29
S231
I
T
A
Q
G
P
G
S
G
E
A
C
V
E
N
Site 30
S244
E
N
G
K
P
E
L
S
P
G
E
F
P
C
E
Site 31
T302
M
K
A
H
G
P
K
T
G
S
K
N
R
P
K
Site 32
S304
A
H
G
P
K
T
G
S
K
N
R
P
K
S
E
Site 33
S310
G
S
K
N
R
P
K
S
E
L
D
P
I
A
T
Site 34
T345
A
K
C
G
N
L
F
T
N
L
D
S
L
N
A
Site 35
S349
N
L
F
T
N
L
D
S
L
N
A
H
N
A
I
Site 36
S363
I
H
R
R
V
E
A
S
R
T
R
A
P
A
E
Site 37
T365
R
R
V
E
A
S
R
T
R
A
P
A
E
E
G
Site 38
S392
Q
C
L
N
L
R
P
S
A
A
G
D
S
C
P
Site 39
S397
R
P
S
A
A
G
D
S
C
P
G
T
Q
A
G
Site 40
T401
A
G
D
S
C
P
G
T
Q
A
G
R
R
V
A
Site 41
Y416
E
L
D
P
V
N
S
Y
Q
A
W
Q
L
A
T
Site 42
Y433
K
V
A
E
P
A
E
Y
L
K
Y
G
A
W
D
Site 43
Y436
E
P
A
E
Y
L
K
Y
G
A
W
D
E
A
L
Site 44
Y456
F
D
K
D
R
R
E
Y
V
L
V
S
Q
E
K
Site 45
S460
R
R
E
Y
V
L
V
S
Q
E
K
R
K
R
E
Site 46
S482
G
P
P
R
K
R
A
S
G
P
G
D
P
A
P
Site 47
S497
A
G
H
L
D
P
R
S
A
A
R
P
N
R
R
Site 48
T508
P
N
R
R
A
A
A
T
T
G
Q
G
K
S
S
Site 49
T509
N
R
R
A
A
A
T
T
G
Q
G
K
S
S
E
Site 50
S514
A
T
T
G
Q
G
K
S
S
E
C
F
E
C
G
Site 51
S515
T
T
G
Q
G
K
S
S
E
C
F
E
C
G
K
Site 52
Y527
C
G
K
I
F
R
T
Y
H
Q
M
V
L
H
S
Site 53
S546
R
A
R
R
E
R
D
S
D
G
D
R
A
A
R
Site 54
S558
A
A
R
A
R
C
G
S
L
S
E
G
D
S
A
Site 55
S560
R
A
R
C
G
S
L
S
E
G
D
S
A
S
Q
Site 56
S564
G
S
L
S
E
G
D
S
A
S
Q
P
S
S
P
Site 57
S566
L
S
E
G
D
S
A
S
Q
P
S
S
P
G
S
Site 58
S569
G
D
S
A
S
Q
P
S
S
P
G
S
A
C
A
Site 59
S570
D
S
A
S
Q
P
S
S
P
G
S
A
C
A
A
Site 60
S573
S
Q
P
S
S
P
G
S
A
C
A
A
A
D
S
Site 61
S593
A
D
E
A
A
E
D
S
G
E
E
G
A
P
E
Site 62
S613
Q
P
R
R
C
C
F
S
E
E
V
T
S
T
E
Site 63
T617
C
C
F
S
E
E
V
T
S
T
E
L
S
S
G
Site 64
S618
C
F
S
E
E
V
T
S
T
E
L
S
S
G
D
Site 65
T619
F
S
E
E
V
T
S
T
E
L
S
S
G
D
Q
Site 66
S622
E
V
T
S
T
E
L
S
S
G
D
Q
S
H
K
Site 67
S623
V
T
S
T
E
L
S
S
G
D
Q
S
H
K
M
Site 68
S627
E
L
S
S
G
D
Q
S
H
K
M
G
D
N
A
Site 69
S635
H
K
M
G
D
N
A
S
E
R
D
T
G
E
S
Site 70
T639
D
N
A
S
E
R
D
T
G
E
S
K
A
G
I
Site 71
S642
S
E
R
D
T
G
E
S
K
A
G
I
A
A
S
Site 72
S656
S
V
S
I
L
E
N
S
S
R
E
T
S
R
R
Site 73
S657
V
S
I
L
E
N
S
S
R
E
T
S
R
R
Q
Site 74
T660
L
E
N
S
S
R
E
T
S
R
R
Q
E
Q
H
Site 75
S661
E
N
S
S
R
E
T
S
R
R
Q
E
Q
H
R
Site 76
S670
R
Q
E
Q
H
R
F
S
M
D
L
K
M
P
A
Site 77
S696
D
G
V
E
F
P
S
S
T
G
A
E
G
Q
T
Site 78
S711
G
H
P
A
E
K
L
S
D
L
H
N
K
E
H
Site 79
S736
D
L
M
P
L
D
L
S
A
R
S
T
R
D
D
Site 80
S739
P
L
D
L
S
A
R
S
T
R
D
D
P
S
N
Site 81
T740
L
D
L
S
A
R
S
T
R
D
D
P
S
N
K
Site 82
S745
R
S
T
R
D
D
P
S
N
K
E
T
A
S
S
Site 83
T749
D
D
P
S
N
K
E
T
A
S
S
L
Q
A
A
Site 84
S786
K
R
I
W
H
R
V
S
C
N
S
V
A
P
P
Site 85
Y800
P
W
I
Q
P
N
G
Y
K
S
I
R
S
N
L
Site 86
S802
I
Q
P
N
G
Y
K
S
I
R
S
N
L
V
F
Site 87
S805
N
G
Y
K
S
I
R
S
N
L
V
F
L
S
R
Site 88
S811
R
S
N
L
V
F
L
S
R
S
G
R
T
G
P
Site 89
S813
N
L
V
F
L
S
R
S
G
R
T
G
P
P
P
Site 90
T838
L
L
A
R
F
T
R
T
Q
V
P
G
G
M
P
Site 91
S847
V
P
G
G
M
P
G
S
K
S
G
S
S
P
L
Site 92
S849
G
G
M
P
G
S
K
S
G
S
S
P
L
G
V
Site 93
S851
M
P
G
S
K
S
G
S
S
P
L
G
V
V
T
Site 94
S852
P
G
S
K
S
G
S
S
P
L
G
V
V
T
K
Site 95
S869
S
M
P
K
N
K
E
S
H
S
G
G
P
C
A
Site 96
S871
P
K
N
K
E
S
H
S
G
G
P
C
A
L
W
Site 97
Y885
W
A
P
G
P
D
G
Y
R
Q
T
K
P
C
H
Site 98
T888
G
P
D
G
Y
R
Q
T
K
P
C
H
G
Q
E
Site 99
T901
Q
E
P
H
G
A
A
T
Q
G
P
L
A
K
P
Site 100
S913
A
K
P
R
Q
E
A
S
S
K
P
V
P
A
P
Site 101
S914
K
P
R
Q
E
A
S
S
K
P
V
P
A
P
G
Site 102
S926
A
P
G
G
G
G
F
S
R
S
A
T
P
T
P
Site 103
S928
G
G
G
G
F
S
R
S
A
T
P
T
P
T
V
Site 104
T930
G
G
F
S
R
S
A
T
P
T
P
T
V
I
A
Site 105
T932
F
S
R
S
A
T
P
T
P
T
V
I
A
R
A
Site 106
T934
R
S
A
T
P
T
P
T
V
I
A
R
A
G
A
Site 107
S944
A
R
A
G
A
Q
P
S
A
N
S
K
P
V
E
Site 108
T965
A
G
A
G
F
A
P
T
N
K
H
S
A
P
D
Site 109
S969
F
A
P
T
N
K
H
S
A
P
D
S
L
K
A
Site 110
S973
N
K
H
S
A
P
D
S
L
K
A
K
F
S
A
Site 111
S979
D
S
L
K
A
K
F
S
A
Q
P
Q
G
P
P
Site 112
S1004
L
P
P
R
E
P
P
S
K
A
A
Q
E
L
R
Site 113
T1015
Q
E
L
R
T
L
A
T
C
A
A
G
S
R
G
Site 114
Y1073
P
K
D
F
A
T
L
Y
Q
G
W
G
V
S
G
Site 115
S1079
L
Y
Q
G
W
G
V
S
G
P
G
L
E
H
R
Site 116
T1088
P
G
L
E
H
R
G
T
L
R
T
Q
A
R
P
Site 117
T1091
E
H
R
G
T
L
R
T
Q
A
R
P
G
E
F
Site 118
S1121
R
A
H
M
R
A
H
S
V
V
F
E
S
D
G
Site 119
S1126
A
H
S
V
V
F
E
S
D
G
P
R
G
S
E
Site 120
S1132
E
S
D
G
P
R
G
S
E
V
H
T
T
S
A
Site 121
T1136
P
R
G
S
E
V
H
T
T
S
A
D
A
P
K
Site 122
T1137
R
G
S
E
V
H
T
T
S
A
D
A
P
K
Q
Site 123
S1149
P
K
Q
G
R
D
H
S
N
T
G
T
V
Q
T
Site 124
T1151
Q
G
R
D
H
S
N
T
G
T
V
Q
T
V
P
Site 125
T1153
R
D
H
S
N
T
G
T
V
Q
T
V
P
L
R
Site 126
T1156
S
N
T
G
T
V
Q
T
V
P
L
R
K
G
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation