KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
KIAA0226
Full Name:
Run domain Beclin-1 interacting and cystein-rich containing protein
Alias:
K0226
Type:
Unknown function
Mass (Da):
108562
Number AA:
972
UniProt ID:
Q92622
International Prot ID:
IPI00022496
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S21
E
E
R
L
P
E
E
S
R
R
E
H
W
Q
L
Site 2
S41
T
T
V
E
G
L
V
S
T
N
S
P
N
V
W
Site 3
T42
T
V
E
G
L
V
S
T
N
S
P
N
V
W
S
Site 4
S44
E
G
L
V
S
T
N
S
P
N
V
W
S
K
Y
Site 5
Y51
S
P
N
V
W
S
K
Y
G
G
L
E
R
L
C
Site 6
Y66
R
D
M
Q
S
I
L
Y
H
G
L
I
R
D
Q
Site 7
Y81
A
C
R
R
Q
T
D
Y
W
Q
F
V
K
D
I
Site 8
S92
V
K
D
I
R
W
L
S
P
H
S
A
L
H
V
Site 9
S95
I
R
W
L
S
P
H
S
A
L
H
V
E
K
F
Site 10
S104
L
H
V
E
K
F
I
S
V
H
E
N
D
Q
S
Site 11
S111
S
V
H
E
N
D
Q
S
S
A
D
G
A
S
E
Site 12
S112
V
H
E
N
D
Q
S
S
A
D
G
A
S
E
R
Site 13
S117
Q
S
S
A
D
G
A
S
E
R
A
V
A
E
L
Site 14
Y148
P
L
L
G
D
R
Q
Y
I
R
K
F
Y
T
D
Site 15
Y153
R
Q
Y
I
R
K
F
Y
T
D
A
A
F
L
L
Site 16
S189
L
L
A
Q
I
D
A
S
M
F
A
R
K
H
E
Site 17
S197
M
F
A
R
K
H
E
S
P
L
L
V
T
K
S
Site 18
T202
H
E
S
P
L
L
V
T
K
S
Q
S
L
T
A
Site 19
T208
V
T
K
S
Q
S
L
T
A
L
P
S
S
T
Y
Site 20
S212
Q
S
L
T
A
L
P
S
S
T
Y
T
P
P
N
Site 21
S213
S
L
T
A
L
P
S
S
T
Y
T
P
P
N
S
Site 22
T214
L
T
A
L
P
S
S
T
Y
T
P
P
N
S
Y
Site 23
Y215
T
A
L
P
S
S
T
Y
T
P
P
N
S
Y
A
Site 24
T216
A
L
P
S
S
T
Y
T
P
P
N
S
Y
A
Q
Site 25
S220
S
T
Y
T
P
P
N
S
Y
A
Q
H
S
Y
F
Site 26
S225
P
N
S
Y
A
Q
H
S
Y
F
G
S
F
S
S
Site 27
Y226
N
S
Y
A
Q
H
S
Y
F
G
S
F
S
S
L
Site 28
S229
A
Q
H
S
Y
F
G
S
F
S
S
L
H
Q
S
Site 29
S231
H
S
Y
F
G
S
F
S
S
L
H
Q
S
V
P
Site 30
S232
S
Y
F
G
S
F
S
S
L
H
Q
S
V
P
N
Site 31
S236
S
F
S
S
L
H
Q
S
V
P
N
N
G
S
E
Site 32
S242
Q
S
V
P
N
N
G
S
E
R
R
S
T
S
F
Site 33
S246
N
N
G
S
E
R
R
S
T
S
F
P
L
S
G
Site 34
T247
N
G
S
E
R
R
S
T
S
F
P
L
S
G
P
Site 35
S248
G
S
E
R
R
S
T
S
F
P
L
S
G
P
P
Site 36
S252
R
S
T
S
F
P
L
S
G
P
P
R
K
P
Q
Site 37
S261
P
P
R
K
P
Q
E
S
R
G
H
V
S
P
A
Site 38
S266
Q
E
S
R
G
H
V
S
P
A
E
D
Q
T
I
Site 39
T272
V
S
P
A
E
D
Q
T
I
Q
A
P
P
V
S
Site 40
S287
V
S
A
L
A
R
D
S
P
L
T
P
N
E
M
Site 41
T290
L
A
R
D
S
P
L
T
P
N
E
M
S
S
S
Site 42
S295
P
L
T
P
N
E
M
S
S
S
T
L
T
S
P
Site 43
S297
T
P
N
E
M
S
S
S
T
L
T
S
P
I
E
Site 44
T300
E
M
S
S
S
T
L
T
S
P
I
E
A
S
W
Site 45
S306
L
T
S
P
I
E
A
S
W
V
S
S
Q
N
D
Site 46
S310
I
E
A
S
W
V
S
S
Q
N
D
S
P
G
D
Site 47
S314
W
V
S
S
Q
N
D
S
P
G
D
A
S
E
G
Site 48
S319
N
D
S
P
G
D
A
S
E
G
P
E
Y
L
A
Site 49
Y324
D
A
S
E
G
P
E
Y
L
A
I
G
N
L
D
Site 50
T336
N
L
D
P
R
G
R
T
A
S
C
Q
S
H
S
Site 51
S338
D
P
R
G
R
T
A
S
C
Q
S
H
S
S
N
Site 52
S341
G
R
T
A
S
C
Q
S
H
S
S
N
A
E
S
Site 53
S343
T
A
S
C
Q
S
H
S
S
N
A
E
S
S
S
Site 54
S344
A
S
C
Q
S
H
S
S
N
A
E
S
S
S
S
Site 55
S348
S
H
S
S
N
A
E
S
S
S
S
N
L
F
S
Site 56
S349
H
S
S
N
A
E
S
S
S
S
N
L
F
S
S
Site 57
S350
S
S
N
A
E
S
S
S
S
N
L
F
S
S
S
Site 58
S351
S
N
A
E
S
S
S
S
N
L
F
S
S
S
S
Site 59
S355
S
S
S
S
N
L
F
S
S
S
S
S
Q
K
P
Site 60
S356
S
S
S
N
L
F
S
S
S
S
S
Q
K
P
D
Site 61
S357
S
S
N
L
F
S
S
S
S
S
Q
K
P
D
S
Site 62
S358
S
N
L
F
S
S
S
S
S
Q
K
P
D
S
A
Site 63
S359
N
L
F
S
S
S
S
S
Q
K
P
D
S
A
A
Site 64
S364
S
S
S
Q
K
P
D
S
A
A
S
S
L
G
D
Site 65
S368
K
P
D
S
A
A
S
S
L
G
D
Q
E
G
G
Site 66
S378
D
Q
E
G
G
G
E
S
Q
L
S
S
V
L
R
Site 67
S381
G
G
G
E
S
Q
L
S
S
V
L
R
R
S
S
Site 68
S382
G
G
E
S
Q
L
S
S
V
L
R
R
S
S
F
Site 69
S387
L
S
S
V
L
R
R
S
S
F
S
E
G
Q
T
Site 70
S388
S
S
V
L
R
R
S
S
F
S
E
G
Q
T
L
Site 71
S390
V
L
R
R
S
S
F
S
E
G
Q
T
L
T
V
Site 72
T394
S
S
F
S
E
G
Q
T
L
T
V
T
S
G
A
Site 73
T396
F
S
E
G
Q
T
L
T
V
T
S
G
A
K
K
Site 74
S399
G
Q
T
L
T
V
T
S
G
A
K
K
S
H
I
Site 75
S404
V
T
S
G
A
K
K
S
H
I
R
S
H
S
D
Site 76
S408
A
K
K
S
H
I
R
S
H
S
D
T
S
I
A
Site 77
S410
K
S
H
I
R
S
H
S
D
T
S
I
A
S
R
Site 78
T412
H
I
R
S
H
S
D
T
S
I
A
S
R
G
A
Site 79
S413
I
R
S
H
S
D
T
S
I
A
S
R
G
A
P
Site 80
S422
A
S
R
G
A
P
E
S
C
N
D
K
A
K
L
Site 81
Y435
K
L
R
G
P
L
P
Y
S
G
Q
S
S
E
V
Site 82
S436
L
R
G
P
L
P
Y
S
G
Q
S
S
E
V
S
Site 83
S439
P
L
P
Y
S
G
Q
S
S
E
V
S
T
P
S
Site 84
S440
L
P
Y
S
G
Q
S
S
E
V
S
T
P
S
S
Site 85
S443
S
G
Q
S
S
E
V
S
T
P
S
S
L
Y
M
Site 86
T444
G
Q
S
S
E
V
S
T
P
S
S
L
Y
M
E
Site 87
S447
S
E
V
S
T
P
S
S
L
Y
M
E
Y
E
G
Site 88
Y449
V
S
T
P
S
S
L
Y
M
E
Y
E
G
G
R
Site 89
Y452
P
S
S
L
Y
M
E
Y
E
G
G
R
Y
L
C
Site 90
Y457
M
E
Y
E
G
G
R
Y
L
C
S
G
E
G
M
Site 91
S460
E
G
G
R
Y
L
C
S
G
E
G
M
F
R
R
Site 92
S469
E
G
M
F
R
R
P
S
E
G
Q
S
L
I
S
Site 93
S473
R
R
P
S
E
G
Q
S
L
I
S
Y
L
S
E
Site 94
S476
S
E
G
Q
S
L
I
S
Y
L
S
E
Q
D
F
Site 95
Y477
E
G
Q
S
L
I
S
Y
L
S
E
Q
D
F
G
Site 96
S479
Q
S
L
I
S
Y
L
S
E
Q
D
F
G
S
C
Site 97
S485
L
S
E
Q
D
F
G
S
C
A
D
L
E
K
E
Site 98
S497
E
K
E
N
A
H
F
S
I
S
E
S
L
I
A
Site 99
S528
E
E
V
E
E
E
D
S
D
R
E
I
Q
E
L
Site 100
T548
L
R
R
Q
Q
I
R
T
K
N
L
L
P
M
Y
Site 101
Y555
T
K
N
L
L
P
M
Y
Q
E
A
E
H
G
S
Site 102
S562
Y
Q
E
A
E
H
G
S
F
R
V
T
S
S
S
Site 103
T566
E
H
G
S
F
R
V
T
S
S
S
S
Q
F
S
Site 104
S567
H
G
S
F
R
V
T
S
S
S
S
Q
F
S
S
Site 105
S568
G
S
F
R
V
T
S
S
S
S
Q
F
S
S
R
Site 106
S569
S
F
R
V
T
S
S
S
S
Q
F
S
S
R
D
Site 107
S570
F
R
V
T
S
S
S
S
Q
F
S
S
R
D
S
Site 108
S573
T
S
S
S
S
Q
F
S
S
R
D
S
A
Q
L
Site 109
S574
S
S
S
S
Q
F
S
S
R
D
S
A
Q
L
S
Site 110
S577
S
Q
F
S
S
R
D
S
A
Q
L
S
D
S
G
Site 111
S581
S
R
D
S
A
Q
L
S
D
S
G
S
A
D
E
Site 112
S583
D
S
A
Q
L
S
D
S
G
S
A
D
E
V
D
Site 113
S585
A
Q
L
S
D
S
G
S
A
D
E
V
D
E
F
Site 114
T603
D
A
D
I
R
R
N
T
A
S
S
S
K
S
F
Site 115
S605
D
I
R
R
N
T
A
S
S
S
K
S
F
V
S
Site 116
S606
I
R
R
N
T
A
S
S
S
K
S
F
V
S
S
Site 117
S607
R
R
N
T
A
S
S
S
K
S
F
V
S
S
Q
Site 118
S609
N
T
A
S
S
S
K
S
F
V
S
S
Q
S
S
Site 119
S612
S
S
S
K
S
F
V
S
S
Q
S
S
S
H
C
Site 120
S613
S
S
K
S
F
V
S
S
Q
S
S
S
H
C
F
Site 121
S615
K
S
F
V
S
S
Q
S
S
S
H
C
F
L
H
Site 122
S616
S
F
V
S
S
Q
S
S
S
H
C
F
L
H
S
Site 123
S617
F
V
S
S
Q
S
S
S
H
C
F
L
H
S
T
Site 124
S667
K
L
L
P
I
P
D
S
L
P
I
S
P
D
D
Site 125
S671
I
P
D
S
L
P
I
S
P
D
D
G
Q
H
A
Site 126
Y681
D
G
Q
H
A
D
I
Y
K
L
R
I
R
V
R
Site 127
Y732
G
I
R
T
D
P
D
Y
I
K
R
L
R
Y
C
Site 128
Y738
D
Y
I
K
R
L
R
Y
C
E
Y
L
G
K
Y
Site 129
Y741
K
R
L
R
Y
C
E
Y
L
G
K
Y
F
C
Q
Site 130
Y771
R
K
W
D
F
S
K
Y
Y
V
S
N
F
S
K
Site 131
Y772
K
W
D
F
S
K
Y
Y
V
S
N
F
S
K
D
Site 132
Y800
Q
D
I
N
S
A
L
Y
R
K
V
K
L
L
N
Site 133
S835
L
A
K
E
L
L
D
S
F
D
T
V
P
G
H
Site 134
T838
E
L
L
D
S
F
D
T
V
P
G
H
L
T
E
Site 135
T844
D
T
V
P
G
H
L
T
E
D
L
H
L
Y
S
Site 136
Y850
L
T
E
D
L
H
L
Y
S
L
N
D
L
T
A
Site 137
S851
T
E
D
L
H
L
Y
S
L
N
D
L
T
A
T
Site 138
T856
L
Y
S
L
N
D
L
T
A
T
R
K
G
E
L
Site 139
T871
G
P
R
L
A
E
L
T
R
A
G
A
T
H
V
Site 140
S928
K
A
C
F
K
S
G
S
C
P
R
C
E
R
L
Site 141
S946
R
E
A
L
A
R
Q
S
L
E
S
Y
L
S
D
Site 142
S949
L
A
R
Q
S
L
E
S
Y
L
S
D
Y
E
E
Site 143
Y950
A
R
Q
S
L
E
S
Y
L
S
D
Y
E
E
E
Site 144
S952
Q
S
L
E
S
Y
L
S
D
Y
E
E
E
P
A
Site 145
Y954
L
E
S
Y
L
S
D
Y
E
E
E
P
A
E
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation