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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
APPBP2
Full Name:
Amyloid protein-binding protein 2
Alias:
Amyloid beta precursor protein-binding protein 2;Protein interacting with APP tail 1
Type:
Mass (Da):
66853
Number AA:
585
UniProt ID:
Q92624
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T12
E
L
E
W
I
P
E
T
L
Y
N
T
A
I
S
Site 2
Y25
I
S
A
V
V
D
N
Y
I
R
S
R
R
D
I
Site 3
S28
V
V
D
N
Y
I
R
S
R
R
D
I
R
S
L
Site 4
S34
R
S
R
R
D
I
R
S
L
P
E
N
I
Q
F
Site 5
Y44
E
N
I
Q
F
D
V
Y
Y
K
L
Y
Q
Q
G
Site 6
Y45
N
I
Q
F
D
V
Y
Y
K
L
Y
Q
Q
G
R
Site 7
Y48
F
D
V
Y
Y
K
L
Y
Q
Q
G
R
L
C
Q
Site 8
S106
Y
S
F
S
R
R
C
S
Y
I
A
E
S
D
A
Site 9
Y107
S
F
S
R
R
C
S
Y
I
A
E
S
D
A
A
Site 10
S111
R
C
S
Y
I
A
E
S
D
A
A
V
K
E
K
Site 11
S137
L
S
D
A
G
W
Y
S
D
A
E
K
V
F
L
Site 12
Y179
V
R
N
G
N
C
K
Y
H
L
G
E
E
T
F
Site 13
T185
K
Y
H
L
G
E
E
T
F
K
L
A
Q
T
Y
Site 14
T191
E
T
F
K
L
A
Q
T
Y
M
D
K
L
S
K
Site 15
T237
I
E
A
M
K
E
I
T
A
G
L
P
V
K
V
Site 16
Y274
Q
L
I
K
H
A
V
Y
L
A
R
D
H
F
G
Site 17
S282
L
A
R
D
H
F
G
S
K
H
P
K
Y
S
D
Site 18
Y287
F
G
S
K
H
P
K
Y
S
D
T
L
L
D
Y
Site 19
S288
G
S
K
H
P
K
Y
S
D
T
L
L
D
Y
G
Site 20
T290
K
H
P
K
Y
S
D
T
L
L
D
Y
G
F
Y
Site 21
Y338
T
A
H
E
D
L
A
Y
S
S
Y
V
H
Q
Y
Site 22
S340
H
E
D
L
A
Y
S
S
Y
V
H
Q
Y
S
S
Site 23
Y341
E
D
L
A
Y
S
S
Y
V
H
Q
Y
S
S
G
Site 24
S346
S
S
Y
V
H
Q
Y
S
S
G
K
F
D
N
A
Site 25
S412
E
A
H
D
L
H
L
S
S
L
Q
L
A
K
K
Site 26
S413
A
H
D
L
H
L
S
S
L
Q
L
A
K
K
A
Site 27
Y432
N
V
Q
T
A
K
H
Y
G
N
L
G
R
L
Y
Site 28
Y439
Y
G
N
L
G
R
L
Y
Q
S
M
R
K
F
K
Site 29
S441
N
L
G
R
L
Y
Q
S
M
R
K
F
K
E
A
Site 30
Y468
Q
L
L
G
Q
E
D
Y
E
V
A
L
S
V
G
Site 31
S479
L
S
V
G
H
L
A
S
L
Y
N
Y
D
M
N
Site 32
Y481
V
G
H
L
A
S
L
Y
N
Y
D
M
N
Q
Y
Site 33
Y483
H
L
A
S
L
Y
N
Y
D
M
N
Q
Y
E
N
Site 34
Y495
Y
E
N
A
E
K
L
Y
L
R
S
I
A
I
G
Site 35
Y515
E
G
Y
S
G
L
E
Y
D
Y
R
G
L
I
K
Site 36
Y517
Y
S
G
L
E
Y
D
Y
R
G
L
I
K
L
Y
Site 37
Y524
Y
R
G
L
I
K
L
Y
N
S
I
G
N
Y
E
Site 38
Y530
L
Y
N
S
I
G
N
Y
E
K
V
F
E
Y
H
Site 39
Y536
N
Y
E
K
V
F
E
Y
H
N
V
L
S
N
W
Site 40
Y551
N
R
L
R
D
R
Q
Y
S
V
T
D
A
L
E
Site 41
S552
R
L
R
D
R
Q
Y
S
V
T
D
A
L
E
D
Site 42
T554
R
D
R
Q
Y
S
V
T
D
A
L
E
D
V
S
Site 43
S561
T
D
A
L
E
D
V
S
T
S
P
Q
S
T
E
Site 44
T562
D
A
L
E
D
V
S
T
S
P
Q
S
T
E
E
Site 45
S563
A
L
E
D
V
S
T
S
P
Q
S
T
E
E
V
Site 46
S566
D
V
S
T
S
P
Q
S
T
E
E
V
V
Q
S
Site 47
T567
V
S
T
S
P
Q
S
T
E
E
V
V
Q
S
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation