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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NSMAF
Full Name:
Protein FAN
Alias:
factor associated with N-SMase activation; FAN; neutral sphingomyelinase (N-SMase) activation associated factor
Type:
Adaptor/scaffold
Mass (Da):
104320
Number AA:
UniProt ID:
Q92636
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005625
Uniprot
OncoNet
Molecular Function:
GO:0005057
PhosphoSite+
KinaseNET
Biological Process:
GO:0006672
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y16
Q
E
Q
Q
L
Q
L
Y
S
K
E
R
F
S
L
Site 2
S17
E
Q
Q
L
Q
L
Y
S
K
E
R
F
S
L
L
Site 3
Y31
L
L
L
N
L
E
E
Y
Y
F
E
Q
H
R
A
Site 4
Y32
L
L
N
L
E
E
Y
Y
F
E
Q
H
R
A
N
Site 5
S55
H
E
R
K
I
R
G
S
L
K
I
C
S
K
S
Site 6
S60
R
G
S
L
K
I
C
S
K
S
V
I
F
E
P
Site 7
S62
S
L
K
I
C
S
K
S
V
I
F
E
P
D
S
Site 8
T98
N
G
A
N
R
H
F
T
K
A
K
S
G
G
I
Site 9
S102
R
H
F
T
K
A
K
S
G
G
I
S
L
I
F
Site 10
Y113
S
L
I
F
S
Q
V
Y
F
I
K
E
H
N
V
Site 11
Y133
I
E
R
G
K
M
E
Y
V
F
E
L
D
V
P
Site 12
S157
L
L
Q
L
H
R
A
S
C
L
D
K
L
G
D
Site 13
S181
Q
S
R
L
A
R
T
S
F
D
K
N
R
F
Q
Site 14
T204
E
C
K
A
E
M
V
T
P
L
V
T
N
P
G
Site 15
Y221
C
I
T
D
T
N
L
Y
F
Q
P
L
N
G
Y
Site 16
Y228
Y
F
Q
P
L
N
G
Y
P
K
P
V
V
Q
I
Site 17
Y244
L
Q
D
V
R
R
I
Y
K
R
R
H
G
L
M
Site 18
Y269
D
D
L
C
S
D
I
Y
L
K
F
Y
E
P
Q
Site 19
Y273
S
D
I
Y
L
K
F
Y
E
P
Q
D
R
D
D
Site 20
Y282
P
Q
D
R
D
D
L
Y
F
Y
I
A
T
Y
L
Site 21
Y284
D
R
D
D
L
Y
F
Y
I
A
T
Y
L
E
H
Site 22
Y313
Q
R
G
H
L
S
N
Y
Q
Y
L
L
H
L
N
Site 23
Y315
G
H
L
S
N
Y
Q
Y
L
L
H
L
N
N
L
Site 24
S326
L
N
N
L
A
D
R
S
C
N
D
L
S
Q
Y
Site 25
Y343
F
P
W
I
I
H
D
Y
S
S
S
E
L
D
L
Site 26
S344
P
W
I
I
H
D
Y
S
S
S
E
L
D
L
S
Site 27
S345
W
I
I
H
D
Y
S
S
S
E
L
D
L
S
N
Site 28
S346
I
I
H
D
Y
S
S
S
E
L
D
L
S
N
P
Site 29
S351
S
S
S
E
L
D
L
S
N
P
G
T
F
R
D
Site 30
T355
L
D
L
S
N
P
G
T
F
R
D
L
S
K
P
Site 31
S360
P
G
T
F
R
D
L
S
K
P
V
G
A
L
N
Site 32
T376
E
R
L
E
R
L
L
T
R
Y
Q
E
M
P
E
Site 33
Y378
L
E
R
L
L
T
R
Y
Q
E
M
P
E
P
K
Site 34
Y388
M
P
E
P
K
F
M
Y
G
S
H
Y
S
S
P
Site 35
S390
E
P
K
F
M
Y
G
S
H
Y
S
S
P
G
Y
Site 36
Y392
K
F
M
Y
G
S
H
Y
S
S
P
G
Y
V
L
Site 37
S394
M
Y
G
S
H
Y
S
S
P
G
Y
V
L
F
Y
Site 38
Y397
S
H
Y
S
S
P
G
Y
V
L
F
Y
L
V
R
Site 39
T440
K
N
C
L
D
G
A
T
D
F
K
E
L
I
P
Site 40
Y450
K
E
L
I
P
E
F
Y
G
D
D
V
S
F
L
Site 41
S455
E
F
Y
G
D
D
V
S
F
L
V
N
S
L
K
Site 42
S484
V
E
L
P
P
W
A
S
S
P
E
D
F
L
Q
Site 43
S485
E
L
P
P
W
A
S
S
P
E
D
F
L
Q
K
Site 44
S493
P
E
D
F
L
Q
K
S
K
D
A
L
E
S
N
Site 45
S499
K
S
K
D
A
L
E
S
N
Y
V
S
E
H
L
Site 46
Y501
K
D
A
L
E
S
N
Y
V
S
E
H
L
H
E
Site 47
Y516
W
I
D
L
I
F
G
Y
K
Q
K
G
S
D
A
Site 48
S521
F
G
Y
K
Q
K
G
S
D
A
V
G
A
H
N
Site 49
T534
H
N
V
F
H
P
L
T
Y
E
G
G
V
D
L
Site 50
S543
E
G
G
V
D
L
N
S
I
Q
D
P
D
E
K
Site 51
T570
T
P
K
Q
L
F
V
T
P
H
P
R
R
I
T
Site 52
T577
T
P
H
P
R
R
I
T
P
K
F
K
S
L
S
Site 53
S582
R
I
T
P
K
F
K
S
L
S
Q
T
S
S
Y
Site 54
S584
T
P
K
F
K
S
L
S
Q
T
S
S
Y
N
A
Site 55
T586
K
F
K
S
L
S
Q
T
S
S
Y
N
A
S
M
Site 56
S588
K
S
L
S
Q
T
S
S
Y
N
A
S
M
A
D
Site 57
S592
Q
T
S
S
Y
N
A
S
M
A
D
S
P
G
E
Site 58
S596
Y
N
A
S
M
A
D
S
P
G
E
E
S
F
E
Site 59
S601
A
D
S
P
G
E
E
S
F
E
D
L
T
E
E
Site 60
T606
E
E
S
F
E
D
L
T
E
E
S
K
T
L
A
Site 61
T611
D
L
T
E
E
S
K
T
L
A
W
N
N
I
T
Site 62
T618
T
L
A
W
N
N
I
T
K
L
Q
L
H
E
H
Site 63
Y626
K
L
Q
L
H
E
H
Y
K
I
H
K
E
A
V
Site 64
T634
K
I
H
K
E
A
V
T
G
I
T
V
S
R
N
Site 65
T637
K
E
A
V
T
G
I
T
V
S
R
N
G
S
S
Site 66
S643
I
T
V
S
R
N
G
S
S
V
F
T
T
S
Q
Site 67
T647
R
N
G
S
S
V
F
T
T
S
Q
D
S
T
L
Site 68
T648
N
G
S
S
V
F
T
T
S
Q
D
S
T
L
K
Site 69
S649
G
S
S
V
F
T
T
S
Q
D
S
T
L
K
M
Site 70
T653
F
T
T
S
Q
D
S
T
L
K
M
F
S
K
E
Site 71
S658
D
S
T
L
K
M
F
S
K
E
S
K
M
L
Q
Site 72
S667
E
S
K
M
L
Q
R
S
I
S
F
S
N
M
A
Site 73
S669
K
M
L
Q
R
S
I
S
F
S
N
M
A
L
S
Site 74
Y697
S
S
W
D
N
N
V
Y
F
Y
S
I
A
F
G
Site 75
Y699
W
D
N
N
V
Y
F
Y
S
I
A
F
G
R
R
Site 76
T709
A
F
G
R
R
Q
D
T
L
M
G
H
D
D
A
Site 77
S731
D
N
R
L
Y
S
A
S
W
D
S
T
V
K
V
Site 78
S734
L
Y
S
A
S
W
D
S
T
V
K
V
W
S
G
Site 79
T735
Y
S
A
S
W
D
S
T
V
K
V
W
S
G
V
Site 80
S740
D
S
T
V
K
V
W
S
G
V
P
A
E
M
P
Site 81
T749
V
P
A
E
M
P
G
T
K
R
H
H
F
D
L
Site 82
S765
A
E
L
E
H
D
V
S
V
D
T
I
S
L
N
Site 83
T786
V
S
G
T
K
E
G
T
V
N
I
W
D
L
T
Site 84
T811
H
S
G
I
V
C
D
T
A
F
S
P
D
S
R
Site 85
S817
D
T
A
F
S
P
D
S
R
H
V
L
S
T
G
Site 86
S822
P
D
S
R
H
V
L
S
T
G
T
D
G
C
L
Site 87
T823
D
S
R
H
V
L
S
T
G
T
D
G
C
L
N
Site 88
S841
V
Q
T
G
M
L
I
S
S
M
T
S
D
E
P
Site 89
S845
M
L
I
S
S
M
T
S
D
E
P
Q
R
C
F
Site 90
S858
C
F
V
W
D
G
N
S
V
L
S
G
S
Q
S
Site 91
S861
W
D
G
N
S
V
L
S
G
S
Q
S
G
E
L
Site 92
S879
D
L
L
G
A
K
I
S
E
R
I
Q
G
H
T
Site 93
T886
S
E
R
I
Q
G
H
T
G
A
V
T
C
I
W
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation