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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
USP6NL
Full Name:
USP6 N-terminal-like protein
Alias:
KIAA0019; Related to the N terminus of tre; Related to the N-terminus of tre; RNTRE; RN-tre; TRE2NL; US6NL; USP6 N-terminal like; USP6 N-terminal-like
Type:
GTPase activating protein, misc.
Mass (Da):
94104
Number AA:
828
UniProt ID:
Q92738
International Prot ID:
IPI00736661
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
Uniprot
OncoNet
Molecular Function:
GO:0005097
PhosphoSite+
KinaseNET
Biological Process:
GO:0032313
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y22
R
A
E
I
V
A
K
Y
D
R
G
R
E
G
A
Site 2
Y39
E
P
W
E
D
A
D
Y
L
V
Y
K
V
T
D
Site 3
T74
K
H
L
E
I
E
R
T
T
K
W
L
K
M
L
Site 4
T75
H
L
E
I
E
R
T
T
K
W
L
K
M
L
K
Site 5
Y98
E
K
F
H
R
R
I
Y
K
G
I
P
L
Q
L
Site 6
Y127
K
E
E
T
R
D
L
Y
S
K
L
K
H
R
A
Site 7
S138
K
H
R
A
R
G
C
S
P
D
I
R
Q
I
D
Site 8
Y162
H
I
M
F
R
D
R
Y
G
V
K
Q
Q
S
L
Site 9
S168
R
Y
G
V
K
Q
Q
S
L
F
H
V
L
A
A
Site 10
S247
K
I
L
N
K
F
L
S
K
L
K
Q
H
L
D
Site 11
S255
K
L
K
Q
H
L
D
S
Q
E
I
Y
T
S
F
Site 12
Y259
H
L
D
S
Q
E
I
Y
T
S
F
Y
T
M
K
Site 13
S261
D
S
Q
E
I
Y
T
S
F
Y
T
M
K
W
F
Site 14
T276
F
Q
C
F
L
D
R
T
P
F
T
L
N
L
R
Site 15
T279
F
L
D
R
T
P
F
T
L
N
L
R
I
W
D
Site 16
Y288
N
L
R
I
W
D
I
Y
I
F
E
G
E
R
V
Site 17
S315
K
K
H
L
M
K
L
S
M
E
E
L
V
E
F
Site 18
Y365
E
P
G
K
E
D
E
Y
P
K
K
P
L
G
Q
Site 19
S379
Q
L
P
P
E
L
Q
S
W
G
V
H
H
L
S
Site 20
S386
S
W
G
V
H
H
L
S
N
G
Q
R
S
V
G
Site 21
S391
H
L
S
N
G
Q
R
S
V
G
R
P
S
P
L
Site 22
S396
Q
R
S
V
G
R
P
S
P
L
A
S
G
R
R
Site 23
S400
G
R
P
S
P
L
A
S
G
R
R
E
S
G
A
Site 24
S405
L
A
S
G
R
R
E
S
G
A
P
H
R
R
H
Site 25
S415
P
H
R
R
H
E
H
S
P
H
P
Q
S
R
T
Site 26
S420
E
H
S
P
H
P
Q
S
R
T
G
T
P
E
R
Site 27
T424
H
P
Q
S
R
T
G
T
P
E
R
A
Q
P
P
Site 28
S435
A
Q
P
P
R
R
K
S
V
E
E
E
S
K
K
Site 29
S455
D
F
Q
R
K
L
P
S
G
P
Q
D
S
S
R
Site 30
S460
L
P
S
G
P
Q
D
S
S
R
Q
Y
N
H
A
Site 31
S461
P
S
G
P
Q
D
S
S
R
Q
Y
N
H
A
A
Site 32
Y464
P
Q
D
S
S
R
Q
Y
N
H
A
A
A
N
Q
Site 33
S473
H
A
A
A
N
Q
N
S
N
A
T
S
N
I
R
Site 34
S477
N
Q
N
S
N
A
T
S
N
I
R
K
E
F
V
Site 35
S491
V
P
K
W
N
K
P
S
D
V
S
A
T
E
R
Site 36
S494
W
N
K
P
S
D
V
S
A
T
E
R
T
A
K
Site 37
Y502
A
T
E
R
T
A
K
Y
T
M
E
G
K
G
R
Site 38
T503
T
E
R
T
A
K
Y
T
M
E
G
K
G
R
A
Site 39
S528
G
P
A
E
V
R
V
S
N
V
R
P
K
M
K
Site 40
S546
A
E
D
G
K
R
G
S
T
A
S
Q
Y
D
N
Site 41
T547
E
D
G
K
R
G
S
T
A
S
Q
Y
D
N
V
Site 42
S549
G
K
R
G
S
T
A
S
Q
Y
D
N
V
P
G
Site 43
Y551
R
G
S
T
A
S
Q
Y
D
N
V
P
G
P
E
Site 44
S561
V
P
G
P
E
L
D
S
G
A
S
V
E
E
A
Site 45
S564
P
E
L
D
S
G
A
S
V
E
E
A
L
E
R
Site 46
Y573
E
E
A
L
E
R
A
Y
S
Q
S
P
R
H
A
Site 47
S574
E
A
L
E
R
A
Y
S
Q
S
P
R
H
A
L
Site 48
S576
L
E
R
A
Y
S
Q
S
P
R
H
A
L
Y
P
Site 49
Y582
Q
S
P
R
H
A
L
Y
P
P
S
P
R
K
H
Site 50
S585
R
H
A
L
Y
P
P
S
P
R
K
H
A
E
P
Site 51
S593
P
R
K
H
A
E
P
S
S
S
P
S
K
V
S
Site 52
S594
R
K
H
A
E
P
S
S
S
P
S
K
V
S
N
Site 53
S595
K
H
A
E
P
S
S
S
P
S
K
V
S
N
K
Site 54
S597
A
E
P
S
S
S
P
S
K
V
S
N
K
F
T
Site 55
S600
S
S
S
P
S
K
V
S
N
K
F
T
F
K
V
Site 56
T604
S
K
V
S
N
K
F
T
F
K
V
Q
P
P
S
Site 57
S611
T
F
K
V
Q
P
P
S
H
A
R
Y
P
S
Q
Site 58
Y615
Q
P
P
S
H
A
R
Y
P
S
Q
L
D
G
E
Site 59
S617
P
S
H
A
R
Y
P
S
Q
L
D
G
E
A
R
Site 60
S631
R
G
L
A
H
P
P
S
Y
S
N
P
P
V
Y
Site 61
Y632
G
L
A
H
P
P
S
Y
S
N
P
P
V
Y
H
Site 62
S633
L
A
H
P
P
S
Y
S
N
P
P
V
Y
H
G
Site 63
Y638
S
Y
S
N
P
P
V
Y
H
G
N
S
P
K
H
Site 64
S642
P
P
V
Y
H
G
N
S
P
K
H
F
P
T
A
Site 65
T648
N
S
P
K
H
F
P
T
A
N
S
S
F
A
S
Site 66
S651
K
H
F
P
T
A
N
S
S
F
A
S
P
Q
F
Site 67
S652
H
F
P
T
A
N
S
S
F
A
S
P
Q
F
S
Site 68
S655
T
A
N
S
S
F
A
S
P
Q
F
S
P
G
T
Site 69
S659
S
F
A
S
P
Q
F
S
P
G
T
Q
L
N
P
Site 70
T662
S
P
Q
F
S
P
G
T
Q
L
N
P
S
R
R
Site 71
S667
P
G
T
Q
L
N
P
S
R
R
P
H
G
S
T
Site 72
S673
P
S
R
R
P
H
G
S
T
L
S
V
S
A
S
Site 73
T674
S
R
R
P
H
G
S
T
L
S
V
S
A
S
P
Site 74
S676
R
P
H
G
S
T
L
S
V
S
A
S
P
E
K
Site 75
S678
H
G
S
T
L
S
V
S
A
S
P
E
K
S
Y
Site 76
S680
S
T
L
S
V
S
A
S
P
E
K
S
Y
S
R
Site 77
S684
V
S
A
S
P
E
K
S
Y
S
R
P
S
P
L
Site 78
Y685
S
A
S
P
E
K
S
Y
S
R
P
S
P
L
V
Site 79
S686
A
S
P
E
K
S
Y
S
R
P
S
P
L
V
L
Site 80
S689
E
K
S
Y
S
R
P
S
P
L
V
L
P
S
S
Site 81
Y710
V
D
T
G
A
G
G
Y
S
G
N
S
G
S
P
Site 82
S711
D
T
G
A
G
G
Y
S
G
N
S
G
S
P
K
Site 83
S714
A
G
G
Y
S
G
N
S
G
S
P
K
N
G
K
Site 84
S716
G
Y
S
G
N
S
G
S
P
K
N
G
K
L
I
Site 85
Y729
L
I
I
P
P
V
D
Y
L
P
D
N
R
T
W
Site 86
T735
D
Y
L
P
D
N
R
T
W
S
E
V
S
Y
T
Site 87
S737
L
P
D
N
R
T
W
S
E
V
S
Y
T
Y
R
Site 88
Y741
R
T
W
S
E
V
S
Y
T
Y
R
P
E
T
Q
Site 89
T742
T
W
S
E
V
S
Y
T
Y
R
P
E
T
Q
G
Site 90
Y743
W
S
E
V
S
Y
T
Y
R
P
E
T
Q
G
Q
Site 91
T747
S
Y
T
Y
R
P
E
T
Q
G
Q
S
W
T
R
Site 92
S757
Q
S
W
T
R
D
A
S
R
G
N
L
P
K
Y
Site 93
Y764
S
R
G
N
L
P
K
Y
S
A
F
Q
L
A
P
Site 94
S765
R
G
N
L
P
K
Y
S
A
F
Q
L
A
P
F
Site 95
S781
D
H
G
L
P
A
V
S
V
D
S
P
V
R
Y
Site 96
S784
L
P
A
V
S
V
D
S
P
V
R
Y
K
A
S
Site 97
Y788
S
V
D
S
P
V
R
Y
K
A
S
P
A
A
E
Site 98
S791
S
P
V
R
Y
K
A
S
P
A
A
E
D
A
S
Site 99
S798
S
P
A
A
E
D
A
S
P
S
G
Y
P
Y
S
Site 100
S800
A
A
E
D
A
S
P
S
G
Y
P
Y
S
G
P
Site 101
Y802
E
D
A
S
P
S
G
Y
P
Y
S
G
P
P
P
Site 102
Y804
A
S
P
S
G
Y
P
Y
S
G
P
P
P
P
A
Site 103
S805
S
P
S
G
Y
P
Y
S
G
P
P
P
P
A
Y
Site 104
Y812
S
G
P
P
P
P
A
Y
H
Y
R
N
R
D
G
Site 105
Y814
P
P
P
P
A
Y
H
Y
R
N
R
D
G
L
S
Site 106
S821
Y
R
N
R
D
G
L
S
I
Q
E
S
V
L
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation