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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GTF2H4
Full Name:
General transcription factor IIH subunit 4
Alias:
Basic transcription factor 2 52 kDa subunit;General transcription factor IIH polypeptide 4;TFIIH basal transcription factor complex p52 subunit
Type:
Mass (Da):
52168
Number AA:
462
UniProt ID:
Q92759
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005675
Uniprot
OncoNet
Molecular Function:
GO:0003702
GO:0005515
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0006368
GO:0000718
GO:0006355
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S91
E
E
S
T
G
L
L
S
G
L
R
I
W
H
T
Site 2
S130
L
G
G
G
K
A
W
S
D
D
T
S
Q
L
G
Site 3
T133
G
K
A
W
S
D
D
T
S
Q
L
G
P
D
K
Site 4
S134
K
A
W
S
D
D
T
S
Q
L
G
P
D
K
H
Site 5
Y151
D
V
P
S
L
D
K
Y
A
E
E
R
W
E
V
Site 6
S180
Q
D
L
A
Q
L
L
S
Q
A
G
L
M
K
S
Site 7
S187
S
Q
A
G
L
M
K
S
T
E
P
G
E
P
P
Site 8
Y214
D
T
P
A
Q
L
W
Y
F
M
L
Q
Y
L
Q
Site 9
Y219
L
W
Y
F
M
L
Q
Y
L
Q
T
A
Q
S
R
Site 10
T244
L
F
Q
L
S
F
S
T
L
G
K
D
Y
S
V
Site 11
Y249
F
S
T
L
G
K
D
Y
S
V
E
G
M
S
D
Site 12
S250
S
T
L
G
K
D
Y
S
V
E
G
M
S
D
S
Site 13
S257
S
V
E
G
M
S
D
S
L
L
N
F
L
Q
H
Site 14
S278
V
F
Q
R
K
R
K
S
R
R
Y
Y
P
T
R
Site 15
Y281
R
K
R
K
S
R
R
Y
Y
P
T
R
L
A
I
Site 16
Y282
K
R
K
S
R
R
Y
Y
P
T
R
L
A
I
N
Site 17
T284
K
S
R
R
Y
Y
P
T
R
L
A
I
N
L
S
Site 18
Y316
V
E
T
N
Y
R
L
Y
A
Y
T
E
S
E
L
Site 19
Y318
T
N
Y
R
L
Y
A
Y
T
E
S
E
L
Q
I
Site 20
T319
N
Y
R
L
Y
A
Y
T
E
S
E
L
Q
I
A
Site 21
S350
V
A
Q
V
T
R
E
S
V
Q
Q
A
I
A
S
Site 22
T386
Q
T
P
V
L
P
P
T
I
T
D
Q
I
R
L
Site 23
T388
P
V
L
P
P
T
I
T
D
Q
I
R
L
W
E
Site 24
T404
E
R
D
R
L
R
F
T
E
G
V
L
Y
N
Q
Site 25
Y409
R
F
T
E
G
V
L
Y
N
Q
F
L
S
Q
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation