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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KRTHA5
Full Name:
Keratin, type I cuticular Ha5
Alias:
HA5; HA-5; HHA5; HHa5 hair keratin type I intermediate filament; HKA5; Keratin-35; KRT35
Type:
Intermediate filament protein
Mass (Da):
50356
Number AA:
455
UniProt ID:
Q92764
International Prot ID:
IPI00294649
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005882
Uniprot
OncoNet
Molecular Function:
GO:0005198
PhosphoSite+
KinaseNET
Biological Process:
GO:0009653
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
K
C
L
K
A
G
F
S
S
G
S
L
K
S
P
Site 2
S14
K
A
G
F
S
S
G
S
L
K
S
P
G
G
A
Site 3
S17
F
S
S
G
S
L
K
S
P
G
G
A
S
G
G
Site 4
S25
P
G
G
A
S
G
G
S
T
R
V
S
A
M
Y
Site 5
T26
G
G
A
S
G
G
S
T
R
V
S
A
M
Y
S
Site 6
S29
S
G
G
S
T
R
V
S
A
M
Y
S
S
S
S
Site 7
Y32
S
T
R
V
S
A
M
Y
S
S
S
S
C
K
L
Site 8
S33
T
R
V
S
A
M
Y
S
S
S
S
C
K
L
P
Site 9
S34
R
V
S
A
M
Y
S
S
S
S
C
K
L
P
S
Site 10
S36
S
A
M
Y
S
S
S
S
C
K
L
P
S
L
S
Site 11
S41
S
S
S
C
K
L
P
S
L
S
P
V
A
R
S
Site 12
S43
S
C
K
L
P
S
L
S
P
V
A
R
S
F
S
Site 13
S53
A
R
S
F
S
A
C
S
V
G
L
G
R
S
S
Site 14
S59
C
S
V
G
L
G
R
S
S
Y
R
A
T
S
C
Site 15
S60
S
V
G
L
G
R
S
S
Y
R
A
T
S
C
L
Site 16
Y61
V
G
L
G
R
S
S
Y
R
A
T
S
C
L
P
Site 17
T64
G
R
S
S
Y
R
A
T
S
C
L
P
A
L
C
Site 18
S80
P
A
G
G
F
A
T
S
Y
S
G
G
G
G
W
Site 19
S82
G
G
F
A
T
S
Y
S
G
G
G
G
W
F
G
Site 20
T94
W
F
G
E
G
I
L
T
G
N
E
K
E
T
M
Site 21
S103
N
E
K
E
T
M
Q
S
L
N
D
R
L
A
G
Site 22
Y111
L
N
D
R
L
A
G
Y
L
E
K
V
R
H
V
Site 23
Y139
W
C
E
Q
Q
V
P
Y
M
C
P
D
Y
Q
S
Site 24
Y144
V
P
Y
M
C
P
D
Y
Q
S
Y
F
R
T
I
Site 25
Y147
M
C
P
D
Y
Q
S
Y
F
R
T
I
E
E
L
Site 26
T150
D
Y
Q
S
Y
F
R
T
I
E
E
L
Q
K
K
Site 27
T158
I
E
E
L
Q
K
K
T
L
C
S
K
A
E
N
Site 28
Y186
A
D
D
F
R
T
K
Y
E
T
E
V
S
L
R
Site 29
T188
D
F
R
T
K
Y
E
T
E
V
S
L
R
Q
L
Site 30
S191
T
K
Y
E
T
E
V
S
L
R
Q
L
V
E
S
Site 31
S198
S
L
R
Q
L
V
E
S
D
I
N
G
L
R
R
Site 32
T211
R
R
I
L
D
D
L
T
L
C
K
S
D
L
E
Site 33
S215
D
D
L
T
L
C
K
S
D
L
E
A
Q
V
E
Site 34
S241
N
H
E
E
E
V
N
S
L
R
C
Q
L
G
D
Site 35
Y273
L
E
E
M
R
C
Q
Y
E
T
L
V
E
N
N
Site 36
T275
E
M
R
C
Q
Y
E
T
L
V
E
N
N
R
R
Site 37
T290
D
A
E
D
W
L
D
T
Q
S
E
E
L
N
Q
Site 38
S292
E
D
W
L
D
T
Q
S
E
E
L
N
Q
Q
V
Site 39
S302
L
N
Q
Q
V
V
S
S
S
E
Q
L
Q
S
C
Site 40
S303
N
Q
Q
V
V
S
S
S
E
Q
L
Q
S
C
Q
Site 41
S308
S
S
S
E
Q
L
Q
S
C
Q
A
E
I
I
E
Site 42
T319
E
I
I
E
L
R
R
T
V
N
A
L
E
I
E
Site 43
S332
I
E
L
Q
A
Q
H
S
M
R
D
A
L
E
S
Site 44
S339
S
M
R
D
A
L
E
S
T
L
A
E
T
E
A
Site 45
T340
M
R
D
A
L
E
S
T
L
A
E
T
E
A
R
Site 46
T344
L
E
S
T
L
A
E
T
E
A
R
Y
S
S
Q
Site 47
S349
A
E
T
E
A
R
Y
S
S
Q
L
A
Q
M
Q
Site 48
S350
E
T
E
A
R
Y
S
S
Q
L
A
Q
M
Q
C
Site 49
Y380
L
E
R
Q
N
Q
E
Y
Q
V
L
L
D
V
R
Site 50
T396
R
L
E
C
E
I
N
T
Y
R
G
L
L
E
S
Site 51
Y397
L
E
C
E
I
N
T
Y
R
G
L
L
E
S
E
Site 52
S403
T
Y
R
G
L
L
E
S
E
D
S
K
L
P
C
Site 53
S406
G
L
L
E
S
E
D
S
K
L
P
C
N
P
C
Site 54
Y417
C
N
P
C
A
P
D
Y
S
P
S
K
S
C
L
Site 55
S418
N
P
C
A
P
D
Y
S
P
S
K
S
C
L
P
Site 56
S420
C
A
P
D
Y
S
P
S
K
S
C
L
P
C
L
Site 57
S422
P
D
Y
S
P
S
K
S
C
L
P
C
L
P
A
Site 58
S435
P
A
A
S
C
G
P
S
A
A
R
T
N
C
S
Site 59
T439
C
G
P
S
A
A
R
T
N
C
S
P
R
P
I
Site 60
S442
S
A
A
R
T
N
C
S
P
R
P
I
C
V
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation