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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RREB1
Full Name:
Ras-responsive element-binding protein 1
Alias:
Hindsight; HNT; Raf-responsive zinc finger protein LZ321; Ras responsive element binding protein 1; Zep-1; Zinc-finger motif-enhancer binding-protein-1
Type:
Transcription, coactivator/corepressor
Mass (Da):
181420
Number AA:
1687
UniProt ID:
Q92766
International Prot ID:
IPI00455375
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0016607
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0016563
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0007265
GO:0007275
GO:0006355
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T2
_
_
_
_
_
_
M
T
S
S
S
P
A
G
L
Site 2
S5
_
_
_
M
T
S
S
S
P
A
G
L
E
G
S
Site 3
S12
S
P
A
G
L
E
G
S
D
L
S
S
I
N
T
Site 4
S15
G
L
E
G
S
D
L
S
S
I
N
T
M
M
S
Site 5
S16
L
E
G
S
D
L
S
S
I
N
T
M
M
S
A
Site 6
T31
V
M
S
V
G
K
V
T
E
N
G
G
S
P
Q
Site 7
S36
K
V
T
E
N
G
G
S
P
Q
G
I
K
S
P
Site 8
S42
G
S
P
Q
G
I
K
S
P
S
K
P
P
G
P
Site 9
S44
P
Q
G
I
K
S
P
S
K
P
P
G
P
N
R
Site 10
T59
I
G
R
R
N
Q
E
T
K
E
E
K
S
S
Y
Site 11
S64
Q
E
T
K
E
E
K
S
S
Y
N
C
P
L
C
Site 12
S65
E
T
K
E
E
K
S
S
Y
N
C
P
L
C
E
Site 13
Y66
T
K
E
E
K
S
S
Y
N
C
P
L
C
E
K
Site 14
S98
D
T
G
G
A
D
H
S
C
S
I
C
G
K
S
Site 15
S100
G
G
A
D
H
S
C
S
I
C
G
K
S
L
S
Site 16
S107
S
I
C
G
K
S
L
S
S
A
S
S
L
D
R
Site 17
S108
I
C
G
K
S
L
S
S
A
S
S
L
D
R
H
Site 18
S111
K
S
L
S
S
A
S
S
L
D
R
H
M
L
V
Site 19
S120
D
R
H
M
L
V
H
S
G
E
R
P
Y
K
C
Site 20
Y125
V
H
S
G
E
R
P
Y
K
C
T
V
C
G
Q
Site 21
T128
G
E
R
P
Y
K
C
T
V
C
G
Q
S
F
T
Site 22
S153
I
H
E
K
D
P
N
S
A
T
A
T
A
P
P
Site 23
T157
D
P
N
S
A
T
A
T
A
P
P
S
P
L
K
Site 24
S161
A
T
A
T
A
P
P
S
P
L
K
R
R
R
L
Site 25
S169
P
L
K
R
R
R
L
S
S
K
R
K
L
S
H
Site 26
S170
L
K
R
R
R
L
S
S
K
R
K
L
S
H
D
Site 27
S175
L
S
S
K
R
K
L
S
H
D
A
E
S
E
R
Site 28
S180
K
L
S
H
D
A
E
S
E
R
E
D
P
A
P
Site 29
S197
K
M
V
E
D
G
Q
S
G
D
L
E
K
K
A
Site 30
Y221
F
K
E
F
V
C
K
Y
G
L
E
T
H
M
E
Site 31
S231
E
T
H
M
E
T
H
S
D
N
P
L
R
C
D
Site 32
S276
P
F
I
Q
N
N
P
S
I
P
A
G
F
H
D
Site 33
S290
D
L
G
F
T
D
F
S
C
R
K
F
P
R
I
Site 34
T351
G
Q
E
K
P
Q
A
T
P
L
P
G
D
A
L
Site 35
T372
A
L
L
G
L
Q
H
T
K
D
V
R
P
A
P
Site 36
S438
K
D
S
I
K
H
L
S
L
Q
P
F
Q
K
G
Site 37
S485
A
S
A
P
P
Q
I
S
L
P
P
F
S
K
A
Site 38
T517
K
P
L
V
T
P
R
T
V
V
A
T
S
T
P
Site 39
S522
P
R
T
V
V
A
T
S
T
P
P
P
L
I
N
Site 40
T523
R
T
V
V
A
T
S
T
P
P
P
L
I
N
A
Site 41
S534
L
I
N
A
Q
Q
A
S
P
G
C
I
S
P
S
Site 42
S539
Q
A
S
P
G
C
I
S
P
S
L
P
P
P
P
Site 43
S541
S
P
G
C
I
S
P
S
L
P
P
P
P
L
K
Site 44
S558
K
G
S
V
E
A
A
S
N
A
H
L
L
Q
S
Site 45
S565
S
N
A
H
L
L
Q
S
K
S
G
T
Q
P
H
Site 46
S567
A
H
L
L
Q
S
K
S
G
T
Q
P
H
A
A
Site 47
T569
L
L
Q
S
K
S
G
T
Q
P
H
A
A
T
R
Site 48
S578
P
H
A
A
T
R
L
S
L
Q
Q
P
R
A
E
Site 49
T594
P
G
Q
P
E
M
K
T
Q
L
E
Q
D
S
I
Site 50
T628
G
E
L
K
A
F
M
T
A
P
G
G
K
K
T
Site 51
T635
T
A
P
G
G
K
K
T
P
A
M
R
K
V
L
Site 52
Y643
P
A
M
R
K
V
L
Y
P
C
R
F
C
N
Q
Site 53
S664
V
L
R
A
H
V
R
S
H
L
G
I
S
P
Y
Site 54
Y671
S
H
L
G
I
S
P
Y
Q
C
N
I
C
D
Y
Site 55
S694
I
R
H
L
R
T
H
S
G
E
R
P
Y
I
C
Site 56
Y699
T
H
S
G
E
R
P
Y
I
C
K
I
C
H
Y
Site 57
Y736
D
I
E
K
N
I
E
Y
V
S
S
S
A
A
E
Site 58
S739
K
N
I
E
Y
V
S
S
S
A
A
E
L
V
D
Site 59
Y765
C
G
E
D
L
K
H
Y
R
A
L
R
I
H
M
Site 60
T774
A
L
R
I
H
M
R
T
H
C
G
R
G
L
G
Site 61
S796
P
F
E
C
K
E
C
S
A
A
F
A
A
K
R
Site 62
Y824
P
E
Q
D
I
E
S
Y
V
L
A
A
D
G
L
Site 63
S842
E
A
P
A
A
E
A
S
G
R
G
E
D
S
G
Site 64
S848
A
S
G
R
G
E
D
S
G
C
A
A
L
G
D
Site 65
T860
L
G
D
C
K
P
L
T
A
F
L
E
P
Q
N
Site 66
T875
G
F
L
H
R
G
P
T
Q
P
P
P
P
H
V
Site 67
S883
Q
P
P
P
P
H
V
S
I
K
L
E
P
A
S
Site 68
S891
I
K
L
E
P
A
S
S
F
A
V
D
F
N
E
Site 69
S918
Q
V
K
Q
E
N
I
S
F
L
S
P
S
S
L
Site 70
S921
Q
E
N
I
S
F
L
S
P
S
S
L
V
P
Y
Site 71
Y928
S
P
S
S
L
V
P
Y
D
C
S
M
E
P
I
Site 72
S938
S
M
E
P
I
D
L
S
I
P
K
N
F
R
K
Site 73
T952
K
G
D
K
D
L
A
T
P
S
E
A
K
K
P
Site 74
S954
D
K
D
L
A
T
P
S
E
A
K
K
P
E
E
Site 75
S965
K
P
E
E
E
A
G
S
S
E
Q
P
S
P
C
Site 76
S966
P
E
E
E
A
G
S
S
E
Q
P
S
P
C
P
Site 77
S970
A
G
S
S
E
Q
P
S
P
C
P
A
P
G
P
Site 78
T1000
M
A
P
A
P
A
A
T
P
E
P
P
A
Q
P
Site 79
T1084
S
A
P
T
L
L
K
T
K
V
A
D
P
G
P
Site 80
S1093
V
A
D
P
G
P
A
S
T
G
S
N
T
T
A
Site 81
S1096
P
G
P
A
S
T
G
S
N
T
T
A
S
D
S
Site 82
T1098
P
A
S
T
G
S
N
T
T
A
S
D
S
L
G
Site 83
T1099
A
S
T
G
S
N
T
T
A
S
D
S
L
G
G
Site 84
S1101
T
G
S
N
T
T
A
S
D
S
L
G
G
S
V
Site 85
S1103
S
N
T
T
A
S
D
S
L
G
G
S
V
P
K
Site 86
S1107
A
S
D
S
L
G
G
S
V
P
K
A
A
T
T
Site 87
T1116
P
K
A
A
T
T
A
T
P
A
A
T
T
S
P
Site 88
T1120
T
T
A
T
P
A
A
T
T
S
P
K
E
S
S
Site 89
T1121
T
A
T
P
A
A
T
T
S
P
K
E
S
S
E
Site 90
S1122
A
T
P
A
A
T
T
S
P
K
E
S
S
E
P
Site 91
S1126
A
T
T
S
P
K
E
S
S
E
P
P
A
P
A
Site 92
S1127
T
T
S
P
K
E
S
S
E
P
P
A
P
A
S
Site 93
S1134
S
E
P
P
A
P
A
S
S
P
E
A
A
S
P
Site 94
S1135
E
P
P
A
P
A
S
S
P
E
A
A
S
P
T
Site 95
S1140
A
S
S
P
E
A
A
S
P
T
E
Q
G
P
A
Site 96
S1161
G
R
K
R
G
M
R
S
R
P
R
A
N
S
G
Site 97
S1167
R
S
R
P
R
A
N
S
G
G
V
D
L
D
S
Site 98
S1174
S
G
G
V
D
L
D
S
S
G
E
F
A
S
I
Site 99
S1175
G
G
V
D
L
D
S
S
G
E
F
A
S
I
E
Site 100
S1180
D
S
S
G
E
F
A
S
I
E
K
M
L
A
T
Site 101
T1190
K
M
L
A
T
T
D
T
N
K
F
S
P
F
L
Site 102
S1194
T
T
D
T
N
K
F
S
P
F
L
Q
T
A
E
Site 103
S1219
P
A
D
H
H
G
P
S
D
E
E
Q
G
S
P
Site 104
S1225
P
S
D
E
E
Q
G
S
P
P
E
D
K
L
L
Site 105
S1238
L
L
R
A
K
R
N
S
Y
T
N
C
L
Q
K
Site 106
Y1239
L
R
A
K
R
N
S
Y
T
N
C
L
Q
K
I
Site 107
S1260
R
V
F
P
W
A
S
S
L
Q
R
H
M
L
T
Site 108
T1267
S
L
Q
R
H
M
L
T
H
T
D
S
Q
S
D
Site 109
T1269
Q
R
H
M
L
T
H
T
D
S
Q
S
D
A
E
Site 110
S1271
H
M
L
T
H
T
D
S
Q
S
D
A
E
T
A
Site 111
S1273
L
T
H
T
D
S
Q
S
D
A
E
T
A
A
A
Site 112
T1277
D
S
Q
S
D
A
E
T
A
A
A
A
G
E
V
Site 113
T1288
A
G
E
V
L
D
L
T
S
R
D
R
E
Q
P
Site 114
S1289
G
E
V
L
D
L
T
S
R
D
R
E
Q
P
S
Site 115
T1300
E
Q
P
S
E
G
A
T
E
L
R
Q
V
A
G
Site 116
T1315
D
A
P
V
E
Q
A
T
A
E
T
A
S
P
V
Site 117
T1318
V
E
Q
A
T
A
E
T
A
S
P
V
H
R
E
Site 118
S1320
Q
A
T
A
E
T
A
S
P
V
H
R
E
E
H
Site 119
S1332
E
E
H
G
R
G
E
S
H
E
P
E
E
E
H
Site 120
T1341
E
P
E
E
E
H
G
T
E
E
S
T
G
D
A
Site 121
S1356
D
G
A
E
E
D
A
S
S
N
Q
S
L
D
L
Site 122
S1357
G
A
E
E
D
A
S
S
N
Q
S
L
D
L
D
Site 123
S1360
E
D
A
S
S
N
Q
S
L
D
L
D
F
A
T
Site 124
S1388
A
G
A
G
G
A
A
S
Q
E
Q
K
L
A
C
Site 125
T1397
E
Q
K
L
A
C
D
T
C
G
K
S
F
K
F
Site 126
S1401
A
C
D
T
C
G
K
S
F
K
F
L
G
T
L
Site 127
T1407
K
S
F
K
F
L
G
T
L
S
R
H
R
K
A
Site 128
S1409
F
K
F
L
G
T
L
S
R
H
R
K
A
H
G
Site 129
S1429
D
E
K
G
D
G
A
S
T
A
E
E
G
P
Q
Site 130
T1448
Q
E
E
K
P
P
E
T
P
A
E
V
V
E
S
Site 131
S1455
T
P
A
E
V
V
E
S
A
P
G
A
G
E
A
Site 132
S1475
A
E
E
T
E
G
P
S
D
G
E
S
A
A
E
Site 133
S1479
E
G
P
S
D
G
E
S
A
A
E
K
R
S
S
Site 134
S1486
S
A
A
E
K
R
S
S
E
K
S
D
D
D
K
Site 135
S1489
E
K
R
S
S
E
K
S
D
D
D
K
K
P
K
Site 136
T1497
D
D
D
K
K
P
K
T
D
S
P
K
S
V
A
Site 137
S1499
D
K
K
P
K
T
D
S
P
K
S
V
A
S
K
Site 138
S1502
P
K
T
D
S
P
K
S
V
A
S
K
A
D
K
Site 139
T1535
T
R
H
M
R
S
H
T
G
E
R
P
Y
K
C
Site 140
Y1540
S
H
T
G
E
R
P
Y
K
C
Q
T
C
E
R
Site 141
T1544
E
R
P
Y
K
C
Q
T
C
E
R
T
F
T
L
Site 142
T1548
K
C
Q
T
C
E
R
T
F
T
L
K
H
S
L
Site 143
T1550
Q
T
C
E
R
T
F
T
L
K
H
S
L
V
R
Site 144
S1554
D
K
K
P
K
T
D
S
P
K
S
V
A
S
K
Site 145
S1575
A
K
H
H
G
K
D
S
D
K
E
E
R
G
E
Site 146
S1585
E
E
R
G
E
E
D
S
E
N
E
S
T
H
S
Site 147
S1589
E
E
D
S
E
N
E
S
T
H
S
G
N
N
A
Site 148
T1590
E
D
S
E
N
E
S
T
H
S
G
N
N
A
V
Site 149
S1592
S
E
N
E
S
T
H
S
G
N
N
A
V
S
E
Site 150
S1598
H
S
G
N
N
A
V
S
E
N
E
A
E
L
A
Site 151
S1609
A
E
L
A
P
N
A
S
N
H
M
A
V
T
R
Site 152
T1615
A
S
N
H
M
A
V
T
R
S
R
K
E
G
L
Site 153
S1624
S
R
K
E
G
L
A
S
A
T
K
D
C
S
H
Site 154
S1630
A
S
A
T
K
D
C
S
H
R
E
E
K
V
T
Site 155
T1637
S
H
R
E
E
K
V
T
A
G
W
P
S
E
P
Site 156
S1642
K
V
T
A
G
W
P
S
E
P
G
Q
G
D
L
Site 157
S1653
Q
G
D
L
N
P
E
S
P
A
A
L
G
Q
D
Site 158
S1666
Q
D
L
L
E
P
R
S
K
R
P
A
H
P
I
Site 159
S1681
L
A
T
A
D
G
A
S
Q
L
V
G
M
E
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation