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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HDAC2
Full Name:
Histone deacetylase 2
Alias:
HD2; Histone deacetylase 2 variant; RPD3; YAF1; YY1 transcription factor binding protein; YY1BP
Type:
Nuclear receptor co-regulator; Transcription, coactivator/corepressor; EC 3.5.1.98; Deacetylase
Mass (Da):
55364
Number AA:
488
UniProt ID:
Q92769
International Prot ID:
IPI00289601
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000118
GO:0005634
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0003824
GO:0004407
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0006139
GO:0006325
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y3
_
_
_
_
_
M
A
Y
S
Q
G
G
G
K
K
Site 2
S4
_
_
_
_
M
A
Y
S
Q
G
G
G
K
K
K
Site 3
Y14
G
G
K
K
K
V
C
Y
Y
Y
D
G
D
I
G
Site 4
Y15
G
K
K
K
V
C
Y
Y
Y
D
G
D
I
G
N
Site 5
Y16
K
K
K
V
C
Y
Y
Y
D
G
D
I
G
N
Y
Site 6
Y23
Y
D
G
D
I
G
N
Y
Y
Y
G
Q
G
H
P
Site 7
Y24
D
G
D
I
G
N
Y
Y
Y
G
Q
G
H
P
M
Site 8
Y25
G
D
I
G
N
Y
Y
Y
G
Q
G
H
P
M
K
Site 9
T39
K
P
H
R
I
R
M
T
H
N
L
L
L
N
Y
Site 10
Y46
T
H
N
L
L
L
N
Y
G
L
Y
R
K
M
E
Site 11
Y49
L
L
L
N
Y
G
L
Y
R
K
M
E
I
Y
R
Site 12
Y55
L
Y
R
K
M
E
I
Y
R
P
H
K
A
T
A
Site 13
T61
I
Y
R
P
H
K
A
T
A
E
E
M
T
K
Y
Site 14
Y68
T
A
E
E
M
T
K
Y
H
S
D
E
Y
I
K
Site 15
S70
E
E
M
T
K
Y
H
S
D
E
Y
I
K
F
L
Site 16
Y73
T
K
Y
H
S
D
E
Y
I
K
F
L
R
S
I
Site 17
S79
E
Y
I
K
F
L
R
S
I
R
P
D
N
M
S
Site 18
S86
S
I
R
P
D
N
M
S
E
Y
S
K
Q
M
Q
Site 19
Y88
R
P
D
N
M
S
E
Y
S
K
Q
M
Q
R
F
Site 20
T130
V
K
L
N
R
Q
Q
T
D
M
A
V
N
W
A
Site 21
S146
G
L
H
H
A
K
K
S
E
A
S
G
F
C
Y
Site 22
Y173
K
Y
H
Q
R
V
L
Y
I
D
I
D
I
H
H
Site 23
Y189
D
G
V
E
E
A
F
Y
T
T
D
R
V
M
T
Site 24
T190
G
V
E
E
A
F
Y
T
T
D
R
V
M
T
V
Site 25
T196
Y
T
T
D
R
V
M
T
V
S
F
H
K
Y
G
Site 26
Y202
M
T
V
S
F
H
K
Y
G
E
Y
F
P
G
T
Site 27
Y205
S
F
H
K
Y
G
E
Y
F
P
G
T
G
D
L
Site 28
T209
Y
G
E
Y
F
P
G
T
G
D
L
R
D
I
G
Site 29
Y222
I
G
A
G
K
G
K
Y
Y
A
V
N
F
P
M
Site 30
Y223
G
A
G
K
G
K
Y
Y
A
V
N
F
P
M
R
Site 31
S237
R
D
G
I
D
D
E
S
Y
G
Q
I
F
K
P
Site 32
Y238
D
G
I
D
D
E
S
Y
G
Q
I
F
K
P
I
Site 33
S266
V
L
Q
C
G
A
D
S
L
S
G
D
R
L
G
Site 34
S268
Q
C
G
A
D
S
L
S
G
D
R
L
G
C
F
Site 35
T291
K
C
V
E
V
V
K
T
F
N
L
P
L
L
M
Site 36
T305
M
L
G
G
G
G
Y
T
I
R
N
V
A
R
C
Site 37
T314
R
N
V
A
R
C
W
T
Y
E
T
A
V
A
L
Site 38
Y331
E
I
P
N
E
L
P
Y
N
D
Y
F
E
Y
F
Site 39
Y334
N
E
L
P
Y
N
D
Y
F
E
Y
F
G
P
D
Site 40
Y337
P
Y
N
D
Y
F
E
Y
F
G
P
D
F
K
L
Site 41
S347
P
D
F
K
L
H
I
S
P
S
N
M
T
N
Q
Site 42
S349
F
K
L
H
I
S
P
S
N
M
T
N
Q
N
T
Site 43
T352
H
I
S
P
S
N
M
T
N
Q
N
T
P
E
Y
Site 44
T356
S
N
M
T
N
Q
N
T
P
E
Y
M
E
K
I
Site 45
Y359
T
N
Q
N
T
P
E
Y
M
E
K
I
K
Q
R
Site 46
S394
E
D
A
V
H
E
D
S
G
D
E
D
G
E
D
Site 47
S407
E
D
P
D
K
R
I
S
I
R
A
S
D
K
R
Site 48
S411
K
R
I
S
I
R
A
S
D
K
R
I
A
C
D
Site 49
S422
I
A
C
D
E
E
F
S
D
S
E
D
E
G
E
Site 50
S424
C
D
E
E
F
S
D
S
E
D
E
G
E
G
G
Site 51
T459
K
E
T
E
D
K
K
T
D
V
K
E
E
D
K
Site 52
S467
D
V
K
E
E
D
K
S
K
D
N
S
G
E
K
Site 53
S471
E
D
K
S
K
D
N
S
G
E
K
T
D
T
K
Site 54
T475
K
D
N
S
G
E
K
T
D
T
K
G
T
K
S
Site 55
T477
N
S
G
E
K
T
D
T
K
G
T
K
S
E
Q
Site 56
S482
T
D
T
K
G
T
K
S
E
Q
L
S
N
P
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation