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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PROX1
Full Name:
Prospero homeobox protein 1
Alias:
Homeobox prospero-like protein PROX1; Prospero homeobox 1
Type:
Nuclear receptor co-regulator; Transcription factor
Mass (Da):
83185
Number AA:
737
UniProt ID:
Q92786
International Prot ID:
IPI00152167
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0050692
GO:0050693
GO:0003705
PhosphoSite+
KinaseNET
Biological Process:
GO:0060414
GO:0055009
GO:0007420
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
P
D
H
D
S
T
A
L
L
S
R
Q
Site 2
T7
_
M
P
D
H
D
S
T
A
L
L
S
R
Q
T
Site 3
S11
H
D
S
T
A
L
L
S
R
Q
T
K
R
R
R
Site 4
T14
T
A
L
L
S
R
Q
T
K
R
R
R
V
D
I
Site 5
S31
K
R
T
V
G
T
A
S
A
F
F
A
K
A
R
Site 6
S43
K
A
R
A
T
F
F
S
A
M
N
P
Q
G
S
Site 7
Y56
G
S
E
Q
D
V
E
Y
S
V
V
Q
H
A
D
Site 8
S57
S
E
Q
D
V
E
Y
S
V
V
Q
H
A
D
G
Site 9
S67
Q
H
A
D
G
E
K
S
N
V
L
R
K
L
L
Site 10
S79
K
L
L
K
R
A
N
S
Y
E
D
A
M
M
P
Site 11
Y80
L
L
K
R
A
N
S
Y
E
D
A
M
M
P
F
Site 12
T91
M
M
P
F
P
G
A
T
I
I
S
Q
L
L
K
Site 13
S94
F
P
G
A
T
I
I
S
Q
L
L
K
N
N
M
Site 14
S110
K
N
G
G
T
E
P
S
F
Q
A
S
G
L
S
Site 15
S114
T
E
P
S
F
Q
A
S
G
L
S
S
T
G
S
Site 16
S117
S
F
Q
A
S
G
L
S
S
T
G
S
E
V
H
Site 17
S118
F
Q
A
S
G
L
S
S
T
G
S
E
V
H
Q
Site 18
S121
S
G
L
S
S
T
G
S
E
V
H
Q
E
D
I
Site 19
S130
V
H
Q
E
D
I
C
S
N
S
S
R
D
S
P
Site 20
S132
Q
E
D
I
C
S
N
S
S
R
D
S
P
P
E
Site 21
S133
E
D
I
C
S
N
S
S
R
D
S
P
P
E
C
Site 22
S136
C
S
N
S
S
R
D
S
P
P
E
C
L
S
P
Site 23
S142
D
S
P
P
E
C
L
S
P
F
G
R
P
T
M
Site 24
T148
L
S
P
F
G
R
P
T
M
S
Q
F
D
M
D
Site 25
S150
P
F
G
R
P
T
M
S
Q
F
D
M
D
R
L
Site 26
S177
E
N
I
I
R
G
M
S
H
S
P
S
V
A
L
Site 27
S179
I
I
R
G
M
S
H
S
P
S
V
A
L
R
G
Site 28
S181
R
G
M
S
H
S
P
S
V
A
L
R
G
N
E
Site 29
S197
E
R
E
M
A
P
Q
S
V
S
P
R
E
S
Y
Site 30
S199
E
M
A
P
Q
S
V
S
P
R
E
S
Y
R
E
Site 31
S203
Q
S
V
S
P
R
E
S
Y
R
E
N
K
R
K
Site 32
Y204
S
V
S
P
R
E
S
Y
R
E
N
K
R
K
Q
Site 33
S220
L
P
Q
Q
Q
Q
Q
S
F
Q
Q
L
V
S
A
Site 34
S226
Q
S
F
Q
Q
L
V
S
A
R
K
E
Q
K
R
Site 35
Y258
R
Q
L
Q
E
K
F
Y
Q
I
Y
D
S
T
D
Site 36
Y261
Q
E
K
F
Y
Q
I
Y
D
S
T
D
S
E
N
Site 37
S263
K
F
Y
Q
I
Y
D
S
T
D
S
E
N
D
E
Site 38
T264
F
Y
Q
I
Y
D
S
T
D
S
E
N
D
E
D
Site 39
S275
N
D
E
D
G
N
L
S
E
D
S
M
R
S
E
Site 40
S278
D
G
N
L
S
E
D
S
M
R
S
E
I
L
D
Site 41
S291
L
D
A
R
A
Q
D
S
V
G
R
S
D
N
E
Site 42
S295
A
Q
D
S
V
G
R
S
D
N
E
M
C
E
L
Site 43
S340
E
R
D
H
G
P
N
S
L
Q
P
E
G
K
H
Site 44
T351
E
G
K
H
L
A
E
T
L
K
Q
E
L
N
T
Site 45
S372
D
T
V
V
K
V
F
S
A
K
P
S
R
Q
V
Site 46
S376
K
V
F
S
A
K
P
S
R
Q
V
P
Q
V
F
Site 47
S447
P
L
V
V
R
K
N
S
S
D
Q
S
A
S
G
Site 48
S451
R
K
N
S
S
D
Q
S
A
S
G
P
A
A
G
Site 49
S453
N
S
S
D
Q
S
A
S
G
P
A
A
G
G
H
Site 50
S467
H
H
Q
P
L
H
Q
S
P
L
S
A
T
T
G
Site 51
S470
P
L
H
Q
S
P
L
S
A
T
T
G
F
T
T
Site 52
S478
A
T
T
G
F
T
T
S
T
F
R
H
P
F
P
Site 53
T479
T
T
G
F
T
T
S
T
F
R
H
P
F
P
L
Site 54
S495
L
M
A
Y
P
F
Q
S
P
L
G
A
P
S
G
Site 55
S501
Q
S
P
L
G
A
P
S
G
S
F
S
G
K
D
Site 56
S503
P
L
G
A
P
S
G
S
F
S
G
K
D
R
A
Site 57
S505
G
A
P
S
G
S
F
S
G
K
D
R
A
S
P
Site 58
S511
F
S
G
K
D
R
A
S
P
E
S
L
D
L
T
Site 59
S514
K
D
R
A
S
P
E
S
L
D
L
T
R
D
T
Site 60
T518
S
P
E
S
L
D
L
T
R
D
T
T
S
L
R
Site 61
T521
S
L
D
L
T
R
D
T
T
S
L
R
T
K
M
Site 62
T522
L
D
L
T
R
D
T
T
S
L
R
T
K
M
S
Site 63
S523
D
L
T
R
D
T
T
S
L
R
T
K
M
S
S
Site 64
T526
R
D
T
T
S
L
R
T
K
M
S
S
H
H
L
Site 65
S529
T
S
L
R
T
K
M
S
S
H
H
L
S
H
H
Site 66
S530
S
L
R
T
K
M
S
S
H
H
L
S
H
H
P
Site 67
S534
K
M
S
S
H
H
L
S
H
H
P
C
S
P
A
Site 68
S539
H
L
S
H
H
P
C
S
P
A
H
P
P
S
T
Site 69
S545
C
S
P
A
H
P
P
S
T
A
E
G
L
S
L
Site 70
T546
S
P
A
H
P
P
S
T
A
E
G
L
S
L
S
Site 71
S551
P
S
T
A
E
G
L
S
L
S
L
I
K
S
E
Site 72
S557
L
S
L
S
L
I
K
S
E
C
G
D
L
Q
D
Site 73
S566
C
G
D
L
Q
D
M
S
E
I
S
P
Y
S
G
Site 74
S569
L
Q
D
M
S
E
I
S
P
Y
S
G
S
A
M
Site 75
Y571
D
M
S
E
I
S
P
Y
S
G
S
A
M
Q
E
Site 76
S572
M
S
E
I
S
P
Y
S
G
S
A
M
Q
E
G
Site 77
S574
E
I
S
P
Y
S
G
S
A
M
Q
E
G
L
S
Site 78
S581
S
A
M
Q
E
G
L
S
P
N
H
L
K
K
A
Site 79
Y594
K
A
K
L
M
F
F
Y
T
R
Y
P
S
S
N
Site 80
Y597
L
M
F
F
Y
T
R
Y
P
S
S
N
M
L
K
Site 81
Y606
S
S
N
M
L
K
T
Y
F
S
D
V
K
F
N
Site 82
Y631
F
S
N
F
R
E
F
Y
Y
I
Q
M
E
K
Y
Site 83
Y632
S
N
F
R
E
F
Y
Y
I
Q
M
E
K
Y
A
Site 84
Y638
Y
Y
I
Q
M
E
K
Y
A
R
Q
A
I
N
D
Site 85
T648
Q
A
I
N
D
G
V
T
S
T
E
E
L
S
I
Site 86
S649
A
I
N
D
G
V
T
S
T
E
E
L
S
I
T
Site 87
T650
I
N
D
G
V
T
S
T
E
E
L
S
I
T
R
Site 88
S654
V
T
S
T
E
E
L
S
I
T
R
D
C
E
L
Site 89
T656
S
T
E
E
L
S
I
T
R
D
C
E
L
Y
R
Site 90
Y662
I
T
R
D
C
E
L
Y
R
A
L
N
M
H
Y
Site 91
S705
A
G
K
D
V
D
P
S
W
K
K
A
I
Y
K
Site 92
Y711
P
S
W
K
K
A
I
Y
K
V
I
C
K
L
D
Site 93
S727
E
V
P
E
I
F
K
S
P
N
C
L
Q
E
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation