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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CREBBP
Full Name:
CREB-binding protein
Alias:
CBP; CREB binding protein; CREB binding protein (CBP); KAT3A; RSTS; RTS
Type:
Transcription, coactivator/corepressor; EC 2.3.1.48; Nuclear receptor co-regulator; Acetyltransferase
Mass (Da):
265351
Number AA:
2442
UniProt ID:
Q92793
International Prot ID:
IPI00023339
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0051577
GO:0004402
GO:0002039
PhosphoSite+
KinaseNET
Biological Process:
GO:0018076
GO:0016573
GO:0042592
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S18
N
P
K
R
A
K
L
S
S
P
G
F
S
A
N
Site 2
S19
P
K
R
A
K
L
S
S
P
G
F
S
A
N
D
Site 3
S23
K
L
S
S
P
G
F
S
A
N
D
S
T
D
F
Site 4
S27
P
G
F
S
A
N
D
S
T
D
F
G
S
L
F
Site 5
T28
G
F
S
A
N
D
S
T
D
F
G
S
L
F
D
Site 6
S32
N
D
S
T
D
F
G
S
L
F
D
L
E
N
D
Site 7
S71
A
S
K
H
K
Q
L
S
E
L
L
R
G
G
S
Site 8
S78
S
E
L
L
R
G
G
S
G
S
S
I
N
P
G
Site 9
S80
L
L
R
G
G
S
G
S
S
I
N
P
G
I
G
Site 10
S81
L
R
G
G
S
G
S
S
I
N
P
G
I
G
N
Site 11
S90
N
P
G
I
G
N
V
S
A
S
S
P
V
Q
Q
Site 12
S92
G
I
G
N
V
S
A
S
S
P
V
Q
Q
G
L
Site 13
S93
I
G
N
V
S
A
S
S
P
V
Q
Q
G
L
G
Site 14
S109
Q
A
Q
G
Q
P
N
S
A
N
M
A
S
L
S
Site 15
S114
P
N
S
A
N
M
A
S
L
S
A
M
G
K
S
Site 16
S121
S
L
S
A
M
G
K
S
P
L
S
Q
G
D
S
Site 17
S124
A
M
G
K
S
P
L
S
Q
G
D
S
S
A
P
Site 18
S128
S
P
L
S
Q
G
D
S
S
A
P
S
L
P
K
Site 19
S129
P
L
S
Q
G
D
S
S
A
P
S
L
P
K
Q
Site 20
S132
Q
G
D
S
S
A
P
S
L
P
K
Q
A
A
S
Site 21
S139
S
L
P
K
Q
A
A
S
T
S
G
P
T
P
A
Site 22
S141
P
K
Q
A
A
S
T
S
G
P
T
P
A
A
S
Site 23
T144
A
A
S
T
S
G
P
T
P
A
A
S
Q
A
L
Site 24
S148
S
G
P
T
P
A
A
S
Q
A
L
N
P
Q
A
Site 25
T163
Q
K
Q
V
G
L
A
T
S
S
P
A
T
S
Q
Site 26
S164
K
Q
V
G
L
A
T
S
S
P
A
T
S
Q
T
Site 27
S165
Q
V
G
L
A
T
S
S
P
A
T
S
Q
T
G
Site 28
T168
L
A
T
S
S
P
A
T
S
Q
T
G
P
G
I
Site 29
S169
A
T
S
S
P
A
T
S
Q
T
G
P
G
I
C
Site 30
T171
S
S
P
A
T
S
Q
T
G
P
G
I
C
M
N
Site 31
S191
T
H
P
G
L
L
N
S
N
S
G
H
S
L
I
Site 32
S193
P
G
L
L
N
S
N
S
G
H
S
L
I
N
Q
Site 33
S196
L
N
S
N
S
G
H
S
L
I
N
Q
A
S
Q
Site 34
S202
H
S
L
I
N
Q
A
S
Q
G
Q
A
Q
V
M
Site 35
S212
Q
A
Q
V
M
N
G
S
L
G
A
A
G
R
G
Site 36
Y226
G
R
G
A
G
M
P
Y
P
T
P
A
M
Q
G
Site 37
T228
G
A
G
M
P
Y
P
T
P
A
M
Q
G
A
S
Site 38
T242
S
S
S
V
L
A
E
T
L
T
Q
V
S
P
Q
Site 39
S247
A
E
T
L
T
Q
V
S
P
Q
M
T
G
H
A
Site 40
T251
T
Q
V
S
P
Q
M
T
G
H
A
G
L
N
T
Site 41
T258
T
G
H
A
G
L
N
T
A
Q
A
G
G
M
A
Site 42
T270
G
M
A
K
M
G
I
T
G
N
T
S
P
F
G
Site 43
S274
M
G
I
T
G
N
T
S
P
F
G
Q
P
F
S
Site 44
S281
S
P
F
G
Q
P
F
S
Q
A
G
G
Q
P
M
Site 45
S299
G
V
N
P
Q
L
A
S
K
Q
S
M
V
N
S
Site 46
S302
P
Q
L
A
S
K
Q
S
M
V
N
S
L
P
T
Site 47
S306
S
K
Q
S
M
V
N
S
L
P
T
F
P
T
D
Site 48
T309
S
M
V
N
S
L
P
T
F
P
T
D
I
K
N
Site 49
T312
N
S
L
P
T
F
P
T
D
I
K
N
T
S
V
Site 50
S318
P
T
D
I
K
N
T
S
V
T
N
V
P
N
M
Site 51
T320
D
I
K
N
T
S
V
T
N
V
P
N
M
S
Q
Site 52
S326
V
T
N
V
P
N
M
S
Q
M
Q
T
S
V
G
Site 53
T330
P
N
M
S
Q
M
Q
T
S
V
G
I
V
P
T
Site 54
S331
N
M
S
Q
M
Q
T
S
V
G
I
V
P
T
Q
Site 55
S381
N
G
E
V
R
A
C
S
L
P
H
C
R
T
M
Site 56
S437
C
L
P
L
K
N
A
S
D
K
R
N
Q
Q
T
Site 57
T444
S
D
K
R
N
Q
Q
T
I
L
G
S
P
A
S
Site 58
S448
N
Q
Q
T
I
L
G
S
P
A
S
G
I
Q
N
Site 59
S459
G
I
Q
N
T
I
G
S
V
G
T
G
Q
Q
N
Site 60
S469
T
G
Q
Q
N
A
T
S
L
S
N
P
N
P
I
Site 61
S471
Q
Q
N
A
T
S
L
S
N
P
N
P
I
D
P
Site 62
S480
P
N
P
I
D
P
S
S
M
Q
R
A
Y
A
A
Site 63
Y485
P
S
S
M
Q
R
A
Y
A
A
L
G
L
P
Y
Site 64
T520
Q
T
H
Q
Q
M
R
T
L
N
P
L
G
N
N
Site 65
S547
Q
Q
P
P
N
L
I
S
E
S
A
L
P
T
S
Site 66
S549
P
P
N
L
I
S
E
S
A
L
P
T
S
L
G
Site 67
T553
I
S
E
S
A
L
P
T
S
L
G
A
T
N
P
Site 68
S554
S
E
S
A
L
P
T
S
L
G
A
T
N
P
L
Site 69
S566
N
P
L
M
N
D
G
S
N
S
G
N
I
G
T
Site 70
S568
L
M
N
D
G
S
N
S
G
N
I
G
T
L
S
Site 71
T579
G
T
L
S
T
I
P
T
A
A
P
P
S
S
T
Site 72
S584
I
P
T
A
A
P
P
S
S
T
G
V
R
K
G
Site 73
S585
P
T
A
A
P
P
S
S
T
G
V
R
K
G
W
Site 74
Y632
R
M
E
N
L
V
A
Y
A
K
K
V
E
G
D
Site 75
Y641
K
K
V
E
G
D
M
Y
E
S
A
N
S
R
D
Site 76
S643
V
E
G
D
M
Y
E
S
A
N
S
R
D
E
Y
Site 77
S646
D
M
Y
E
S
A
N
S
R
D
E
Y
Y
H
L
Site 78
Y650
S
A
N
S
R
D
E
Y
Y
H
L
L
A
E
K
Site 79
Y651
A
N
S
R
D
E
Y
Y
H
L
L
A
E
K
I
Site 80
Y659
H
L
L
A
E
K
I
Y
K
I
Q
K
E
L
E
Site 81
S671
E
L
E
E
K
R
R
S
R
L
H
K
Q
G
I
Site 82
S709
R
P
P
N
G
P
L
S
L
P
V
N
R
M
Q
Site 83
S723
Q
V
S
Q
G
M
N
S
F
N
P
M
S
L
G
Site 84
S728
M
N
S
F
N
P
M
S
L
G
N
V
Q
L
P
Site 85
S745
P
M
G
P
R
A
A
S
P
M
N
H
S
V
Q
Site 86
S750
A
A
S
P
M
N
H
S
V
Q
M
N
S
M
G
Site 87
S755
N
H
S
V
Q
M
N
S
M
G
S
V
P
G
M
Site 88
S765
S
V
P
G
M
A
I
S
P
S
R
M
P
Q
P
Site 89
S767
P
G
M
A
I
S
P
S
R
M
P
Q
P
P
N
Site 90
S801
L
P
Q
N
Q
F
P
S
S
S
G
A
M
S
V
Site 91
S802
P
Q
N
Q
F
P
S
S
S
G
A
M
S
V
G
Site 92
S803
Q
N
Q
F
P
S
S
S
G
A
M
S
V
G
M
Site 93
S807
P
S
S
S
G
A
M
S
V
G
M
G
Q
P
P
Site 94
S820
P
P
A
Q
T
G
V
S
Q
G
Q
V
P
G
A
Site 95
S841
N
M
L
G
P
Q
A
S
Q
L
P
C
P
P
V
Site 96
T849
Q
L
P
C
P
P
V
T
Q
S
P
L
H
P
T
Site 97
S851
P
C
P
P
V
T
Q
S
P
L
H
P
T
P
P
Site 98
T856
T
Q
S
P
L
H
P
T
P
P
P
A
S
T
A
Site 99
S861
H
P
T
P
P
P
A
S
T
A
A
G
M
P
S
Site 100
T862
P
T
P
P
P
A
S
T
A
A
G
M
P
S
L
Site 101
S868
S
T
A
A
G
M
P
S
L
Q
H
T
T
P
P
Site 102
T872
G
M
P
S
L
Q
H
T
T
P
P
G
M
T
P
Site 103
T873
M
P
S
L
Q
H
T
T
P
P
G
M
T
P
P
Site 104
T878
H
T
T
P
P
G
M
T
P
P
Q
P
A
A
P
Site 105
T886
P
P
Q
P
A
A
P
T
Q
P
S
T
P
V
S
Site 106
S889
P
A
A
P
T
Q
P
S
T
P
V
S
S
S
G
Site 107
T890
A
A
P
T
Q
P
S
T
P
V
S
S
S
G
Q
Site 108
S893
T
Q
P
S
T
P
V
S
S
S
G
Q
T
P
T
Site 109
S895
P
S
T
P
V
S
S
S
G
Q
T
P
T
P
T
Site 110
T898
P
V
S
S
S
G
Q
T
P
T
P
T
P
G
S
Site 111
T900
S
S
S
G
Q
T
P
T
P
T
P
G
S
V
P
Site 112
T902
S
G
Q
T
P
T
P
T
P
G
S
V
P
S
A
Site 113
S905
T
P
T
P
T
P
G
S
V
P
S
A
T
Q
T
Site 114
S908
P
T
P
G
S
V
P
S
A
T
Q
T
Q
S
T
Site 115
T910
P
G
S
V
P
S
A
T
Q
T
Q
S
T
P
T
Site 116
T912
S
V
P
S
A
T
Q
T
Q
S
T
P
T
V
Q
Site 117
S914
P
S
A
T
Q
T
Q
S
T
P
T
V
Q
A
A
Site 118
T915
S
A
T
Q
T
Q
S
T
P
T
V
Q
A
A
A
Site 119
T927
A
A
A
Q
A
Q
V
T
P
Q
P
Q
T
P
V
Site 120
T932
Q
V
T
P
Q
P
Q
T
P
V
Q
P
P
S
V
Site 121
S938
Q
T
P
V
Q
P
P
S
V
A
T
P
Q
S
S
Site 122
T941
V
Q
P
P
S
V
A
T
P
Q
S
S
Q
Q
Q
Site 123
S944
P
S
V
A
T
P
Q
S
S
Q
Q
Q
P
T
P
Site 124
S945
S
V
A
T
P
Q
S
S
Q
Q
Q
P
T
P
V
Site 125
T950
Q
S
S
Q
Q
Q
P
T
P
V
H
A
Q
P
P
Site 126
T959
V
H
A
Q
P
P
G
T
P
L
S
Q
A
A
A
Site 127
S962
Q
P
P
G
T
P
L
S
Q
A
A
A
S
I
D
Site 128
T974
S
I
D
N
R
V
P
T
P
S
S
V
A
S
A
Site 129
S976
D
N
R
V
P
T
P
S
S
V
A
S
A
E
T
Site 130
S977
N
R
V
P
T
P
S
S
V
A
S
A
E
T
N
Site 131
S980
P
T
P
S
S
V
A
S
A
E
T
N
S
Q
Q
Site 132
S985
V
A
S
A
E
T
N
S
Q
Q
P
G
P
D
V
Site 133
T1001
V
L
E
M
K
T
E
T
Q
A
E
D
T
E
P
Site 134
S1019
E
S
K
G
E
P
R
S
E
M
M
E
E
D
L
Site 135
S1030
E
E
D
L
Q
G
A
S
Q
V
K
E
E
T
D
Site 136
S1043
T
D
I
A
E
Q
K
S
E
P
M
E
V
D
E
Site 137
S1065
E
V
K
E
E
E
E
S
S
S
N
G
T
A
S
Site 138
S1066
V
K
E
E
E
E
S
S
S
N
G
T
A
S
Q
Site 139
S1067
K
E
E
E
E
S
S
S
N
G
T
A
S
Q
S
Site 140
T1070
E
E
S
S
S
N
G
T
A
S
Q
S
T
S
P
Site 141
S1072
S
S
S
N
G
T
A
S
Q
S
T
S
P
S
Q
Site 142
S1074
S
N
G
T
A
S
Q
S
T
S
P
S
Q
P
R
Site 143
S1076
G
T
A
S
Q
S
T
S
P
S
Q
P
R
K
K
Site 144
S1078
A
S
Q
S
T
S
P
S
Q
P
R
K
K
I
F
Site 145
S1108
L
Y
R
Q
D
P
E
S
L
P
F
R
Q
P
V
Site 146
S1136
V
K
N
P
M
D
L
S
T
I
K
R
K
L
D
Site 147
T1137
K
N
P
M
D
L
S
T
I
K
R
K
L
D
T
Site 148
Y1147
R
K
L
D
T
G
Q
Y
Q
E
P
W
Q
Y
V
Site 149
Y1167
M
F
N
N
A
W
L
Y
N
R
K
T
S
R
V
Site 150
T1171
A
W
L
Y
N
R
K
T
S
R
V
Y
K
F
C
Site 151
Y1175
N
R
K
T
S
R
V
Y
K
F
C
S
K
L
A
Site 152
Y1198
P
V
M
Q
S
L
G
Y
C
C
G
R
K
Y
E
Site 153
Y1204
G
Y
C
C
G
R
K
Y
E
F
S
P
Q
T
L
Site 154
Y1227
T
I
P
R
D
A
A
Y
Y
S
Y
Q
N
R
Y
Site 155
Y1228
I
P
R
D
A
A
Y
Y
S
Y
Q
N
R
Y
H
Site 156
Y1230
R
D
A
A
Y
Y
S
Y
Q
N
R
Y
H
F
C
Site 157
S1256
V
T
L
G
D
D
P
S
Q
P
Q
T
T
I
S
Site 158
T1260
D
D
P
S
Q
P
Q
T
T
I
S
K
D
Q
F
Site 159
S1263
S
Q
P
Q
T
T
I
S
K
D
Q
F
E
K
K
Site 160
T1274
F
E
K
K
K
N
D
T
L
D
P
E
P
F
V
Site 161
T1315
C
D
N
C
L
K
K
T
G
R
P
R
K
E
N
Site 162
S1325
P
R
K
E
N
K
F
S
A
K
R
L
Q
T
T
Site 163
T1331
F
S
A
K
R
L
Q
T
T
R
L
G
N
H
L
Site 164
T1368
V
V
A
S
S
D
K
T
V
E
V
K
P
G
M
Site 165
S1377
E
V
K
P
G
M
K
S
R
F
V
D
S
G
E
Site 166
S1382
M
K
S
R
F
V
D
S
G
E
M
S
E
S
F
Site 167
S1386
F
V
D
S
G
E
M
S
E
S
F
P
Y
R
T
Site 168
S1388
D
S
G
E
M
S
E
S
F
P
Y
R
T
K
A
Site 169
Y1391
E
M
S
E
S
F
P
Y
R
T
K
A
L
F
A
Site 170
Y1417
F
G
M
H
V
Q
E
Y
G
S
D
C
P
P
P
Site 171
T1426
S
D
C
P
P
P
N
T
R
R
V
Y
I
S
Y
Site 172
Y1430
P
P
N
T
R
R
V
Y
I
S
Y
L
D
S
I
Site 173
S1432
N
T
R
R
V
Y
I
S
Y
L
D
S
I
H
F
Site 174
Y1433
T
R
R
V
Y
I
S
Y
L
D
S
I
H
F
F
Site 175
Y1450
R
C
L
R
T
A
V
Y
H
E
I
L
I
G
Y
Site 176
Y1457
Y
H
E
I
L
I
G
Y
L
E
Y
V
K
K
L
Site 177
Y1460
I
L
I
G
Y
L
E
Y
V
K
K
L
G
Y
V
Site 178
Y1466
E
Y
V
K
K
L
G
Y
V
T
G
H
I
W
A
Site 179
Y1482
P
P
S
E
G
D
D
Y
I
F
H
C
H
P
P
Site 180
Y1503
P
K
R
L
Q
E
W
Y
K
K
M
L
D
K
A
Site 181
Y1519
A
E
R
I
I
H
D
Y
K
D
I
F
K
Q
A
Site 182
T1527
K
D
I
F
K
Q
A
T
E
D
R
L
T
S
A
Site 183
T1532
Q
A
T
E
D
R
L
T
S
A
K
E
L
P
Y
Site 184
S1533
A
T
E
D
R
L
T
S
A
K
E
L
P
Y
F
Site 185
Y1539
T
S
A
K
E
L
P
Y
F
E
G
D
F
W
P
Site 186
S1568
E
E
R
K
K
E
E
S
T
A
A
S
E
T
T
Site 187
T1569
E
R
K
K
E
E
S
T
A
A
S
E
T
T
E
Site 188
S1572
K
E
E
S
T
A
A
S
E
T
T
E
G
S
Q
Site 189
T1574
E
S
T
A
A
S
E
T
T
E
G
S
Q
G
D
Site 190
S1578
A
S
E
T
T
E
G
S
Q
G
D
S
K
N
A
Site 191
S1582
T
E
G
S
Q
G
D
S
K
N
A
K
K
K
N
Site 192
T1593
K
K
K
N
N
K
K
T
N
K
N
K
S
S
I
Site 193
S1598
K
K
T
N
K
N
K
S
S
I
S
R
A
N
K
Site 194
S1599
K
T
N
K
N
K
S
S
I
S
R
A
N
K
K
Site 195
S1609
R
A
N
K
K
K
P
S
M
P
N
V
S
N
D
Site 196
S1614
K
P
S
M
P
N
V
S
N
D
L
S
Q
K
L
Site 197
S1618
P
N
V
S
N
D
L
S
Q
K
L
Y
A
T
M
Site 198
Y1622
N
D
L
S
Q
K
L
Y
A
T
M
E
K
H
K
Site 199
S1657
V
D
P
D
P
L
L
S
C
D
L
M
D
G
R
Site 200
T1669
D
G
R
D
A
F
L
T
L
A
R
D
K
H
W
Site 201
S1679
R
D
K
H
W
E
F
S
S
L
R
R
S
K
W
Site 202
S1680
D
K
H
W
E
F
S
S
L
R
R
S
K
W
S
Site 203
S1684
E
F
S
S
L
R
R
S
K
W
S
T
L
C
M
Site 204
S1687
S
L
R
R
S
K
W
S
T
L
C
M
L
V
E
Site 205
Y1705
Q
G
Q
D
R
F
V
Y
T
C
N
E
C
K
H
Site 206
S1754
L
G
L
D
D
E
G
S
S
Q
G
E
P
Q
S
Site 207
S1755
G
L
D
D
E
G
S
S
Q
G
E
P
Q
S
K
Site 208
S1761
S
S
Q
G
E
P
Q
S
K
S
P
Q
E
S
R
Site 209
S1763
Q
G
E
P
Q
S
K
S
P
Q
E
S
R
R
L
Site 210
S1767
Q
S
K
S
P
Q
E
S
R
R
L
S
I
Q
R
Site 211
S1771
P
Q
E
S
R
R
L
S
I
Q
R
C
I
Q
S
Site 212
T1812
T
K
G
C
K
R
K
T
N
G
G
C
P
V
C
Site 213
T1871
L
M
R
R
R
M
A
T
M
N
T
R
N
V
P
Site 214
T1874
R
R
M
A
T
M
N
T
R
N
V
P
Q
Q
S
Site 215
S1881
T
R
N
V
P
Q
Q
S
L
P
S
P
T
S
A
Site 216
S1884
V
P
Q
Q
S
L
P
S
P
T
S
A
P
P
G
Site 217
S1887
Q
S
L
P
S
P
T
S
A
P
P
G
T
P
T
Site 218
T1892
P
T
S
A
P
P
G
T
P
T
Q
Q
P
S
T
Site 219
T1894
S
A
P
P
G
T
P
T
Q
Q
P
S
T
P
Q
Site 220
S1898
G
T
P
T
Q
Q
P
S
T
P
Q
T
P
Q
P
Site 221
T1899
T
P
T
Q
Q
P
S
T
P
Q
T
P
Q
P
P
Site 222
T1902
Q
Q
P
S
T
P
Q
T
P
Q
P
P
A
Q
P
Site 223
S1912
P
P
A
Q
P
Q
P
S
P
V
S
M
S
P
A
Site 224
S1915
Q
P
Q
P
S
P
V
S
M
S
P
A
G
F
P
Site 225
S1917
Q
P
S
P
V
S
M
S
P
A
G
F
P
S
V
Site 226
S1923
M
S
P
A
G
F
P
S
V
A
R
T
Q
P
P
Site 227
T1927
G
F
P
S
V
A
R
T
Q
P
P
T
T
V
S
Site 228
T1931
V
A
R
T
Q
P
P
T
T
V
S
T
G
K
P
Site 229
T1932
A
R
T
Q
P
P
T
T
V
S
T
G
K
P
T
Site 230
S1934
T
Q
P
P
T
T
V
S
T
G
K
P
T
S
Q
Site 231
S1940
V
S
T
G
K
P
T
S
Q
V
P
A
P
P
P
Site 232
Y1973
A
Q
Q
Q
Q
H
L
Y
R
V
N
I
N
N
S
Site 233
S1980
Y
R
V
N
I
N
N
S
M
P
P
G
R
T
G
Site 234
T1990
P
G
R
T
G
M
G
T
P
G
S
Q
M
A
P
Site 235
S1999
G
S
Q
M
A
P
V
S
L
N
V
P
R
P
N
Site 236
S2009
V
P
R
P
N
Q
V
S
G
P
V
M
P
S
M
Site 237
S2015
V
S
G
P
V
M
P
S
M
P
P
G
Q
W
Q
Site 238
S2055
V
A
G
P
R
M
P
S
V
Q
P
P
R
S
I
Site 239
S2061
P
S
V
Q
P
P
R
S
I
S
P
S
A
L
Q
Site 240
S2063
V
Q
P
P
R
S
I
S
P
S
A
L
Q
D
L
Site 241
S2065
P
P
R
S
I
S
P
S
A
L
Q
D
L
L
R
Site 242
T2073
A
L
Q
D
L
L
R
T
L
K
S
P
S
S
P
Site 243
S2076
D
L
L
R
T
L
K
S
P
S
S
P
Q
Q
Q
Site 244
S2078
L
R
T
L
K
S
P
S
S
P
Q
Q
Q
Q
Q
Site 245
S2079
R
T
L
K
S
P
S
S
P
Q
Q
Q
Q
Q
V
Site 246
Y2108
I
K
Q
R
T
A
K
Y
V
A
N
Q
P
G
M
Site 247
S2123
Q
P
Q
P
G
L
Q
S
Q
P
G
M
Q
P
Q
Site 248
S2138
P
G
M
H
Q
Q
P
S
L
Q
N
L
N
A
M
Site 249
Y2189
M
A
S
M
N
P
Q
Y
R
E
M
L
R
R
Q
Site 250
Y2240
Q
P
Q
G
P
G
G
Y
P
P
A
M
Q
Q
Q
Site 251
S2259
Q
H
L
P
L
Q
G
S
S
M
G
Q
M
A
A
Site 252
S2283
Q
P
G
L
G
A
D
S
T
P
N
I
Q
Q
A
Site 253
T2284
P
G
L
G
A
D
S
T
P
N
I
Q
Q
A
L
Site 254
S2307
Q
M
K
Q
Q
I
G
S
P
G
Q
P
N
P
M
Site 255
S2315
P
G
Q
P
N
P
M
S
P
Q
Q
H
M
L
S
Site 256
S2322
S
P
Q
Q
H
M
L
S
G
Q
P
Q
A
S
H
Site 257
S2328
L
S
G
Q
P
Q
A
S
H
L
P
G
Q
Q
I
Site 258
S2338
P
G
Q
Q
I
A
T
S
L
S
N
Q
V
R
S
Site 259
S2340
Q
Q
I
A
T
S
L
S
N
Q
V
R
S
P
A
Site 260
S2345
S
L
S
N
Q
V
R
S
P
A
P
V
Q
S
P
Site 261
S2351
R
S
P
A
P
V
Q
S
P
R
P
Q
S
Q
P
Site 262
S2356
V
Q
S
P
R
P
Q
S
Q
P
P
H
S
S
P
Site 263
S2361
P
Q
S
Q
P
P
H
S
S
P
S
P
R
I
Q
Site 264
S2362
Q
S
Q
P
P
H
S
S
P
S
P
R
I
Q
P
Site 265
S2364
Q
P
P
H
S
S
P
S
P
R
I
Q
P
Q
P
Site 266
S2372
P
R
I
Q
P
Q
P
S
P
H
H
V
S
P
Q
Site 267
S2377
Q
P
S
P
H
H
V
S
P
Q
T
G
S
P
H
Site 268
T2380
P
H
H
V
S
P
Q
T
G
S
P
H
P
G
L
Site 269
S2382
H
V
S
P
Q
T
G
S
P
H
P
G
L
A
V
Site 270
T2390
P
H
P
G
L
A
V
T
M
A
S
S
I
D
Q
Site 271
S2394
L
A
V
T
M
A
S
S
I
D
Q
G
H
L
G
Site 272
S2406
H
L
G
N
P
E
Q
S
A
M
L
P
Q
L
N
Site 273
T2414
A
M
L
P
Q
L
N
T
P
S
R
S
A
L
S
Site 274
S2416
L
P
Q
L
N
T
P
S
R
S
A
L
S
S
E
Site 275
S2418
Q
L
N
T
P
S
R
S
A
L
S
S
E
L
S
Site 276
S2421
T
P
S
R
S
A
L
S
S
E
L
S
L
V
G
Site 277
S2422
P
S
R
S
A
L
S
S
E
L
S
L
V
G
D
Site 278
T2431
L
S
L
V
G
D
T
T
G
D
T
L
E
K
F
Site 279
T2434
V
G
D
T
T
G
D
T
L
E
K
F
V
E
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation