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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DLG3
Full Name:
Disks large homolog 3
Alias:
Discs, large 3; Discs, large homolog 3; KIAA1232; MRX90; NEDLG; NE-DLG; Neuroendocrine-DLG; Presynaptic protein SAP102; SAP102; SAP-102; Synapse-associated protein 102; XLMR
Type:
Adaptor/scaffold
Mass (Da):
90314
Number AA:
817
UniProt ID:
Q92796
International Prot ID:
IPI00023343
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0004385
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0008285
Phosida
TranscriptoNet
STRING
Kinexus Products
Disks large homologue 3 pan-specific antibody AB-NN238-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN238-1
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y30
R
R
L
E
P
P
G
Y
G
D
W
Q
V
P
D
Site 2
Y39
D
W
Q
V
P
D
P
Y
G
P
G
G
G
N
G
Site 3
S48
P
G
G
G
N
G
A
S
A
G
Y
G
G
Y
S
Site 4
S55
S
A
G
Y
G
G
Y
S
S
Q
T
L
P
S
Q
Site 5
S56
A
G
Y
G
G
Y
S
S
Q
T
L
P
S
Q
A
Site 6
T58
Y
G
G
Y
S
S
Q
T
L
P
S
Q
A
G
A
Site 7
S61
Y
S
S
Q
T
L
P
S
Q
A
G
A
T
P
T
Site 8
T66
L
P
S
Q
A
G
A
T
P
T
P
R
T
K
A
Site 9
T68
S
Q
A
G
A
T
P
T
P
R
T
K
A
K
L
Site 10
T78
T
K
A
K
L
I
P
T
G
R
D
V
G
P
V
Site 11
S94
P
K
P
V
P
G
K
S
T
P
K
L
N
G
S
Site 12
T95
K
P
V
P
G
K
S
T
P
K
L
N
G
S
G
Site 13
S101
S
T
P
K
L
N
G
S
G
P
S
W
W
P
E
Site 14
T110
P
S
W
W
P
E
C
T
C
T
N
R
D
W
Y
Site 15
T112
W
W
P
E
C
T
C
T
N
R
D
W
Y
E
Q
Site 16
Y117
T
C
T
N
R
D
W
Y
E
Q
V
N
G
S
D
Site 17
S123
W
Y
E
Q
V
N
G
S
D
G
M
F
K
Y
E
Site 18
Y129
G
S
D
G
M
F
K
Y
E
E
I
V
L
E
R
Site 19
S139
I
V
L
E
R
G
N
S
G
L
G
F
S
I
A
Site 20
S192
R
V
N
E
V
D
V
S
E
V
V
H
S
R
A
Site 21
S197
D
V
S
E
V
V
H
S
R
A
V
E
A
L
K
Site 22
S297
R
H
E
E
A
V
A
S
L
K
N
T
S
D
M
Site 23
Y306
K
N
T
S
D
M
V
Y
L
K
V
A
K
P
G
Site 24
S314
L
K
V
A
K
P
G
S
L
H
L
N
D
M
Y
Site 25
Y321
S
L
H
L
N
D
M
Y
A
P
P
D
Y
A
S
Site 26
Y326
D
M
Y
A
P
P
D
Y
A
S
T
F
T
A
L
Site 27
S339
A
L
A
D
N
H
I
S
H
N
S
S
L
G
Y
Site 28
S343
N
H
I
S
H
N
S
S
L
G
Y
L
G
A
V
Site 29
Y346
S
H
N
S
S
L
G
Y
L
G
A
V
E
S
K
Site 30
S352
G
Y
L
G
A
V
E
S
K
V
S
Y
P
A
P
Site 31
S355
G
A
V
E
S
K
V
S
Y
P
A
P
P
Q
V
Site 32
Y356
A
V
E
S
K
V
S
Y
P
A
P
P
Q
V
P
Site 33
T365
A
P
P
Q
V
P
P
T
R
Y
S
P
I
P
R
Site 34
S368
Q
V
P
P
T
R
Y
S
P
I
P
R
H
M
L
Site 35
T381
M
L
A
E
E
D
F
T
R
E
P
R
K
I
I
Site 36
S423
A
G
G
P
A
D
L
S
G
E
L
R
R
G
D
Site 37
S434
R
R
G
D
R
I
L
S
V
N
G
V
N
L
R
Site 38
T444
G
V
N
L
R
N
A
T
H
E
Q
A
A
A
A
Site 39
S458
A
L
K
R
A
G
Q
S
V
T
I
V
A
Q
Y
Site 40
Y470
A
Q
Y
R
P
E
E
Y
S
R
F
E
S
K
I
Site 41
S471
Q
Y
R
P
E
E
Y
S
R
F
E
S
K
I
H
Site 42
S475
E
E
Y
S
R
F
E
S
K
I
H
D
L
R
E
Site 43
S487
L
R
E
Q
M
M
N
S
S
M
S
S
G
S
G
Site 44
S488
R
E
Q
M
M
N
S
S
M
S
S
G
S
G
S
Site 45
S490
Q
M
M
N
S
S
M
S
S
G
S
G
S
L
R
Site 46
S491
M
M
N
S
S
M
S
S
G
S
G
S
L
R
T
Site 47
S493
N
S
S
M
S
S
G
S
G
S
L
R
T
S
E
Site 48
S495
S
M
S
S
G
S
G
S
L
R
T
S
E
K
R
Site 49
T498
S
G
S
G
S
L
R
T
S
E
K
R
S
L
Y
Site 50
S499
G
S
G
S
L
R
T
S
E
K
R
S
L
Y
V
Site 51
S503
L
R
T
S
E
K
R
S
L
Y
V
R
A
L
F
Site 52
Y505
T
S
E
K
R
S
L
Y
V
R
A
L
F
D
Y
Site 53
Y512
Y
V
R
A
L
F
D
Y
D
R
T
R
D
S
C
Site 54
T515
A
L
F
D
Y
D
R
T
R
D
S
C
L
P
S
Site 55
S518
D
Y
D
R
T
R
D
S
C
L
P
S
Q
G
L
Site 56
S522
T
R
D
S
C
L
P
S
Q
G
L
S
F
S
Y
Site 57
S528
P
S
Q
G
L
S
F
S
Y
G
D
I
L
H
V
Site 58
S539
I
L
H
V
I
N
A
S
D
D
E
W
W
Q
A
Site 59
T550
W
W
Q
A
R
L
V
T
P
H
G
E
S
E
Q
Site 60
S563
E
Q
I
G
V
I
P
S
K
K
R
V
E
K
K
Site 61
T577
K
E
R
A
R
L
K
T
V
K
F
H
A
R
T
Site 62
S589
A
R
T
G
M
I
E
S
N
R
D
F
P
G
L
Site 63
S597
N
R
D
F
P
G
L
S
D
D
Y
Y
G
A
K
Site 64
Y600
F
P
G
L
S
D
D
Y
Y
G
A
K
N
L
K
Site 65
Y601
P
G
L
S
D
D
Y
Y
G
A
K
N
L
K
G
Site 66
S615
G
Q
E
D
A
I
L
S
Y
E
P
V
T
R
Q
Site 67
S646
R
V
N
D
D
L
I
S
E
F
P
H
K
F
G
Site 68
S654
E
F
P
H
K
F
G
S
C
V
P
H
T
T
R
Site 69
T659
F
G
S
C
V
P
H
T
T
R
P
R
R
D
N
Site 70
T660
G
S
C
V
P
H
T
T
R
P
R
R
D
N
E
Site 71
Y673
N
E
V
D
G
Q
D
Y
H
F
V
V
S
R
E
Site 72
S678
Q
D
Y
H
F
V
V
S
R
E
Q
M
E
K
D
Site 73
Y702
G
Q
F
N
D
N
L
Y
G
T
S
I
Q
S
V
Site 74
S708
L
Y
G
T
S
I
Q
S
V
R
A
V
A
E
R
Site 75
T759
M
E
M
N
R
R
Q
T
Y
E
Q
A
N
K
I
Site 76
Y760
E
M
N
R
R
Q
T
Y
E
Q
A
N
K
I
Y
Site 77
Y780
L
E
Q
E
F
G
E
Y
F
T
A
I
V
Q
G
Site 78
S789
T
A
I
V
Q
G
D
S
L
E
E
I
Y
N
K
Site 79
Y808
I
E
D
Q
S
G
H
Y
I
W
V
P
S
P
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation