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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SYMPK
Full Name:
Symplekin
Alias:
SPK; SYM; Symplekin
Type:
Unknown function
Mass (Da):
141148
Number AA:
1274
UniProt ID:
Q92797
International Prot ID:
IPI00023344
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0005654
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005488
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007155
GO:0009987
GO:0022610
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
A
S
G
S
G
D
S
V
T
R
R
Site 2
S8
M
A
S
G
S
G
D
S
V
T
R
R
S
V
A
Site 3
T10
S
G
S
G
D
S
V
T
R
R
S
V
A
S
Q
Site 4
S13
G
D
S
V
T
R
R
S
V
A
S
Q
F
F
T
Site 5
S16
V
T
R
R
S
V
A
S
Q
F
F
T
Q
E
E
Site 6
T20
S
V
A
S
Q
F
F
T
Q
E
E
G
P
G
I
Site 7
T31
G
P
G
I
D
G
M
T
T
S
E
R
V
V
D
Site 8
T132
V
V
K
K
A
I
L
T
M
T
Q
L
Y
K
V
Site 9
Y137
I
L
T
M
T
Q
L
Y
K
V
A
L
Q
W
M
Site 10
S147
A
L
Q
W
M
V
K
S
R
V
I
S
E
L
Q
Site 11
S151
M
V
K
S
R
V
I
S
E
L
Q
E
A
C
W
Site 12
S174
D
I
I
L
L
L
D
S
D
N
D
G
I
R
T
Site 13
T193
F
V
E
G
L
I
V
T
L
S
P
R
M
A
D
Site 14
S195
E
G
L
I
V
T
L
S
P
R
M
A
D
S
E
Site 15
S201
L
S
P
R
M
A
D
S
E
I
P
R
R
Q
E
Site 16
S212
R
R
Q
E
H
D
I
S
L
D
R
I
P
R
D
Site 17
Y222
R
I
P
R
D
H
P
Y
I
Q
Y
N
V
L
W
Site 18
Y225
R
D
H
P
Y
I
Q
Y
N
V
L
W
E
E
G
Site 19
T288
L
H
A
N
L
P
P
T
L
A
K
S
Q
V
S
Site 20
S292
L
P
P
T
L
A
K
S
Q
V
S
S
V
R
K
Site 21
S296
L
A
K
S
Q
V
S
S
V
R
K
N
L
K
L
Site 22
S314
S
V
L
K
H
P
A
S
L
E
F
Q
A
Q
I
Site 23
S341
E
I
A
R
N
M
P
S
S
K
D
T
R
K
R
Site 24
S342
I
A
R
N
M
P
S
S
K
D
T
R
K
R
P
Site 25
T345
N
M
P
S
S
K
D
T
R
K
R
P
R
D
D
Site 26
S353
R
K
R
P
R
D
D
S
D
S
T
L
K
K
M
Site 27
S355
R
P
R
D
D
S
D
S
T
L
K
K
M
K
L
Site 28
T356
P
R
D
D
S
D
S
T
L
K
K
M
K
L
E
Site 29
S380
K
D
L
E
P
G
P
S
G
T
S
K
A
S
A
Site 30
S386
P
S
G
T
S
K
A
S
A
Q
I
S
G
Q
S
Site 31
S390
S
K
A
S
A
Q
I
S
G
Q
S
D
T
D
I
Site 32
T398
G
Q
S
D
T
D
I
T
A
E
F
L
Q
P
L
Site 33
T455
H
L
A
R
L
M
A
T
Q
M
T
A
A
G
L
Site 34
T458
R
L
M
A
T
Q
M
T
A
A
G
L
G
P
G
Site 35
T469
L
G
P
G
V
E
Q
T
K
Q
C
K
E
E
P
Site 36
T484
K
E
E
K
V
V
K
T
E
S
V
L
I
K
R
Site 37
S486
E
K
V
V
K
T
E
S
V
L
I
K
R
R
L
Site 38
S494
V
L
I
K
R
R
L
S
A
Q
G
Q
A
I
S
Site 39
S501
S
A
Q
G
Q
A
I
S
V
V
G
S
L
S
S
Site 40
S505
Q
A
I
S
V
V
G
S
L
S
S
M
S
P
L
Site 41
S507
I
S
V
V
G
S
L
S
S
M
S
P
L
E
E
Site 42
S508
S
V
V
G
S
L
S
S
M
S
P
L
E
E
E
Site 43
S510
V
G
S
L
S
S
M
S
P
L
E
E
E
A
P
Site 44
S547
R
K
K
I
F
R
L
S
D
V
L
K
P
L
T
Site 45
T554
S
D
V
L
K
P
L
T
D
A
Q
V
E
A
M
Site 46
Y624
D
L
A
F
A
W
L
Y
Q
E
Y
N
A
Y
L
Site 47
Y627
F
A
W
L
Y
Q
E
Y
N
A
Y
L
A
A
G
Site 48
Y630
L
Y
Q
E
Y
N
A
Y
L
A
A
G
A
S
G
Site 49
S638
L
A
A
G
A
S
G
S
L
D
K
Y
E
D
C
Site 50
Y642
A
S
G
S
L
D
K
Y
E
D
C
L
I
R
L
Site 51
S651
D
C
L
I
R
L
L
S
G
L
Q
E
K
P
D
Site 52
Y685
A
L
E
V
V
R
K
Y
C
E
D
E
S
R
T
Site 53
S690
R
K
Y
C
E
D
E
S
R
T
Y
L
G
M
S
Site 54
Y693
C
E
D
E
S
R
T
Y
L
G
M
S
T
L
R
Site 55
T698
R
T
Y
L
G
M
S
T
L
R
D
L
I
F
K
Site 56
S708
D
L
I
F
K
R
P
S
R
Q
F
Q
Y
L
H
Site 57
Y713
R
P
S
R
Q
F
Q
Y
L
H
V
L
L
D
L
Site 58
S722
H
V
L
L
D
L
S
S
H
E
K
D
K
V
R
Site 59
Y740
L
L
F
I
K
R
M
Y
E
K
E
Q
L
R
E
Site 60
Y748
E
K
E
Q
L
R
E
Y
V
E
K
F
A
L
N
Site 61
S767
L
V
H
P
N
P
P
S
V
L
F
G
A
D
K
Site 62
T776
L
F
G
A
D
K
D
T
E
V
A
A
P
W
T
Site 63
T786
A
A
P
W
T
E
E
T
V
K
Q
C
L
Y
L
Site 64
T864
T
R
C
L
H
S
L
T
D
K
V
P
P
S
P
Site 65
S870
L
T
D
K
V
P
P
S
P
E
L
V
K
R
V
Site 66
Y881
V
K
R
V
R
D
L
Y
H
K
R
L
P
D
V
Site 67
S938
G
E
G
N
S
A
L
S
P
L
N
P
G
E
L
Site 68
T1007
R
T
V
I
Q
S
L
T
M
Y
P
R
L
G
G
Site 69
S1021
G
F
V
M
N
I
L
S
R
L
I
M
K
Q
V
Site 70
Y1031
I
M
K
Q
V
W
K
Y
P
K
V
W
E
G
F
Site 71
S1049
C
Q
R
T
K
P
Q
S
F
Q
V
I
L
Q
L
Site 72
S1081
P
L
L
A
H
V
R
S
F
T
P
H
Q
Q
A
Site 73
T1083
L
A
H
V
R
S
F
T
P
H
Q
Q
A
H
I
Site 74
T1125
E
D
D
L
E
P
L
T
L
A
P
A
P
A
P
Site 75
S1168
P
G
G
V
G
A
P
S
S
S
S
P
S
P
S
Site 76
S1169
G
G
V
G
A
P
S
S
S
S
P
S
P
S
P
Site 77
S1170
G
V
G
A
P
S
S
S
S
P
S
P
S
P
S
Site 78
S1171
V
G
A
P
S
S
S
S
P
S
P
S
P
S
A
Site 79
S1173
A
P
S
S
S
S
P
S
P
S
P
S
A
R
P
Site 80
S1175
S
S
S
S
P
S
P
S
P
S
A
R
P
G
P
Site 81
S1177
S
S
P
S
P
S
P
S
A
R
P
G
P
P
P
Site 82
S1185
A
R
P
G
P
P
P
S
E
E
A
M
D
F
R
Site 83
T1200
E
E
G
P
E
C
E
T
P
G
I
F
I
S
M
Site 84
S1206
E
T
P
G
I
F
I
S
M
D
D
D
S
G
L
Site 85
S1221
T
E
A
A
L
L
D
S
S
L
E
G
P
L
P
Site 86
S1222
E
A
A
L
L
D
S
S
L
E
G
P
L
P
K
Site 87
T1231
E
G
P
L
P
K
E
T
A
A
G
G
L
T
L
Site 88
S1243
L
T
L
K
E
E
R
S
P
Q
T
L
A
P
V
Site 89
T1246
K
E
E
R
S
P
Q
T
L
A
P
V
G
E
D
Site 90
T1257
V
G
E
D
A
M
K
T
P
S
P
A
A
E
D
Site 91
S1259
E
D
A
M
K
T
P
S
P
A
A
E
D
A
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation