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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EZH1
Full Name:
Histone-lysine N-methyltransferase EZH1
Alias:
EC 2.1.1.43; Enhancer of zeste 1; ENX-2
Type:
Nucleus protein
Mass (Da):
85271
Number AA:
747
UniProt ID:
Q92800
International Prot ID:
IPI00783198
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0003682
GO:0018024
PhosphoSite+
KinaseNET
Biological Process:
GO:0009653
GO:0016568
GO:0045449
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T13
P
P
T
S
K
C
I
T
Y
W
K
R
K
V
K
Site 2
Y14
P
T
S
K
C
I
T
Y
W
K
R
K
V
K
S
Site 3
S21
Y
W
K
R
K
V
K
S
E
Y
M
R
L
R
Q
Site 4
Y23
K
R
K
V
K
S
E
Y
M
R
L
R
Q
L
K
Site 5
S70
L
R
V
Q
P
V
Q
S
M
K
P
V
S
G
H
Site 6
S75
V
Q
S
M
K
P
V
S
G
H
P
F
L
K
K
Site 7
Y134
T
V
L
C
N
I
P
Y
M
G
D
E
V
K
E
Site 8
T145
E
V
K
E
E
D
E
T
F
I
E
E
L
I
N
Site 9
S187
V
D
A
L
N
Q
Y
S
D
E
E
E
E
G
H
Site 10
S198
E
E
G
H
N
D
T
S
D
G
K
Q
D
D
S
Site 11
S205
S
D
G
K
Q
D
D
S
K
E
D
L
P
V
T
Site 12
T212
S
K
E
D
L
P
V
T
R
K
R
K
R
H
A
Site 13
S226
A
I
E
G
N
K
K
S
S
K
K
Q
F
P
N
Site 14
T261
K
E
R
Y
R
E
L
T
E
M
S
D
P
N
A
Site 15
S264
Y
R
E
L
T
E
M
S
D
P
N
A
L
P
P
Site 16
T274
N
A
L
P
P
Q
C
T
P
N
I
D
G
P
N
Site 17
S284
I
D
G
P
N
A
K
S
V
Q
R
E
Q
S
L
Site 18
S290
K
S
V
Q
R
E
Q
S
L
H
S
F
H
T
L
Site 19
S293
Q
R
E
Q
S
L
H
S
F
H
T
L
F
C
R
Site 20
Y305
F
C
R
R
C
F
K
Y
D
C
F
L
H
P
F
Site 21
T315
F
L
H
P
F
H
A
T
P
N
V
Y
K
R
K
Site 22
Y319
F
H
A
T
P
N
V
Y
K
R
K
N
K
E
I
Site 23
S355
A
M
L
H
N
P
R
S
K
C
S
G
R
R
R
Site 24
S358
H
N
P
R
S
K
C
S
G
R
R
R
R
R
H
Site 25
S369
R
R
R
H
H
I
V
S
A
S
C
S
N
A
S
Site 26
S371
R
H
H
I
V
S
A
S
C
S
N
A
S
A
S
Site 27
S378
S
C
S
N
A
S
A
S
A
V
A
E
T
K
E
Site 28
S388
A
E
T
K
E
G
D
S
D
R
D
T
G
N
D
Site 29
T392
E
G
D
S
D
R
D
T
G
N
D
W
A
S
S
Site 30
S398
D
T
G
N
D
W
A
S
S
S
S
E
A
N
S
Site 31
S400
G
N
D
W
A
S
S
S
S
E
A
N
S
R
C
Site 32
S401
N
D
W
A
S
S
S
S
E
A
N
S
R
C
Q
Site 33
S405
S
S
S
S
E
A
N
S
R
C
Q
T
P
T
K
Site 34
T409
E
A
N
S
R
C
Q
T
P
T
K
Q
K
A
S
Site 35
T411
N
S
R
C
Q
T
P
T
K
Q
K
A
S
P
A
Site 36
S416
T
P
T
K
Q
K
A
S
P
A
P
P
Q
L
C
Site 37
S440
E
W
T
G
A
E
E
S
L
F
R
V
F
H
G
Site 38
S490
T
D
E
L
M
N
P
S
Q
K
K
K
R
K
H
Site 39
S514
I
Q
L
K
K
D
N
S
S
T
Q
V
Y
N
Y
Site 40
Y519
D
N
S
S
T
Q
V
Y
N
Y
Q
P
C
D
H
Site 41
Y521
S
S
T
Q
V
Y
N
Y
Q
P
C
D
H
P
D
Site 42
Y575
N
T
K
Q
C
P
C
Y
L
A
V
R
E
C
D
Site 43
S606
V
V
S
C
K
N
C
S
I
Q
R
G
L
K
K
Site 44
T627
S
D
V
A
G
W
G
T
F
I
K
E
S
V
Q
Site 45
Y642
K
N
E
F
I
S
E
Y
C
G
E
L
I
S
Q
Site 46
S648
E
Y
C
G
E
L
I
S
Q
D
E
A
D
R
R
Site 47
Y659
A
D
R
R
G
K
V
Y
D
K
Y
M
S
S
F
Site 48
Y662
R
G
K
V
Y
D
K
Y
M
S
S
F
L
F
N
Site 49
Y697
H
S
V
N
P
N
C
Y
A
K
V
V
M
V
N
Site 50
Y727
G
E
E
L
F
F
D
Y
R
Y
S
Q
A
D
A
Site 51
Y729
E
L
F
F
D
Y
R
Y
S
Q
A
D
A
L
K
Site 52
S730
L
F
F
D
Y
R
Y
S
Q
A
D
A
L
K
Y
Site 53
Y737
S
Q
A
D
A
L
K
Y
V
G
I
E
R
E
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation