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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GGH
Full Name:
Gamma-glutamyl hydrolase
Alias:
Conjugase; Conjugase, folylpolygammaglutamyl hydrolase; EC 3.4.19.9; Folylpolygammaglutamyl hydrolase; Gamma-Glu-X carboxypeptidase; GH
Type:
Cofactor and Vitamin Metabolism - folate biosynthesis; Protease; EC 3.4.19.9
Mass (Da):
35964
Number AA:
318
UniProt ID:
Q92820
International Prot ID:
IPI00023728
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005615
GO:0005764
GO:0042470
Uniprot
OncoNet
Molecular Function:
GO:0034722
PhosphoSite+
KinaseNET
Biological Process:
GO:0006541
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S24
G
A
A
S
L
E
L
S
R
P
H
G
D
T
A
Site 2
T30
L
S
R
P
H
G
D
T
A
K
K
P
I
I
G
Site 3
Y51
R
N
K
V
M
K
N
Y
G
R
Y
Y
I
A
A
Site 4
Y55
M
K
N
Y
G
R
Y
Y
I
A
A
S
Y
V
K
Site 5
Y60
R
Y
Y
I
A
A
S
Y
V
K
Y
L
E
S
A
Site 6
Y63
I
A
A
S
Y
V
K
Y
L
E
S
A
G
A
R
Site 7
T79
V
P
V
R
L
D
L
T
E
K
D
Y
E
I
L
Site 8
Y83
L
D
L
T
E
K
D
Y
E
I
L
F
K
S
I
Site 9
S99
G
I
L
F
P
G
G
S
V
D
L
R
R
S
D
Site 10
S105
G
S
V
D
L
R
R
S
D
Y
A
K
V
A
K
Site 11
Y107
V
D
L
R
R
S
D
Y
A
K
V
A
K
I
F
Site 12
S118
A
K
I
F
Y
N
L
S
I
Q
S
F
D
D
G
Site 13
Y127
Q
S
F
D
D
G
D
Y
F
P
V
W
G
T
C
Site 14
T179
R
M
F
Q
N
F
P
T
E
L
L
L
S
L
A
Site 15
S184
F
P
T
E
L
L
L
S
L
A
V
E
P
L
T
Site 16
T191
S
L
A
V
E
P
L
T
A
N
F
H
K
W
S
Site 17
S198
T
A
N
F
H
K
W
S
L
S
V
K
N
F
T
Site 18
S200
N
F
H
K
W
S
L
S
V
K
N
F
T
M
N
Site 19
T230
G
K
I
E
F
I
S
T
M
E
G
Y
K
Y
P
Site 20
Y236
S
T
M
E
G
Y
K
Y
P
V
Y
G
V
Q
W
Site 21
Y239
E
G
Y
K
Y
P
V
Y
G
V
Q
W
H
P
E
Site 22
Y250
W
H
P
E
K
A
P
Y
E
W
K
N
L
D
G
Site 23
S288
K
N
N
H
H
F
K
S
E
S
E
E
E
K
A
Site 24
S290
N
H
H
F
K
S
E
S
E
E
E
K
A
L
I
Site 25
Y298
E
E
E
K
A
L
I
Y
Q
F
S
P
I
Y
T
Site 26
T305
Y
Q
F
S
P
I
Y
T
G
N
I
S
S
F
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation