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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PCAF
Full Name:
Histone acetyltransferase KAT2B
Alias:
CAF; CREBBP-associated factor; GCN5; GCN5L; Histone acetylase PCAF; Histone acetyltransferase PCAF; K (lysine) acetyltransferase 2B; P/CAF; P300/CBP-associated factor
Type:
EC 2.3.1.48; Acetyltransferase; Nuclear receptor co-regulator
Mass (Da):
93013
Number AA:
832
UniProt ID:
Q92831
International Prot ID:
IPI00022055
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000125
GO:0016585
Uniprot
OncoNet
Molecular Function:
GO:0004402
GO:0042826
GO:0003713
PhosphoSite+
KinaseNET
Biological Process:
GO:0018076
GO:0007050
GO:0032869
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S40
P
P
A
P
P
Q
G
S
P
C
A
A
A
A
G
Site 2
S72
E
G
P
G
G
G
G
S
A
R
I
A
V
K
K
Site 3
S84
V
K
K
A
Q
L
R
S
A
P
R
A
K
K
L
Site 4
S117
G
W
K
N
P
N
P
S
P
T
P
P
R
A
D
Site 5
T119
K
N
P
N
P
S
P
T
P
P
R
A
D
L
Q
Site 6
S131
D
L
Q
Q
I
I
V
S
L
T
E
S
C
R
S
Site 7
T133
Q
Q
I
I
V
S
L
T
E
S
C
R
S
C
S
Site 8
S138
S
L
T
E
S
C
R
S
C
S
H
A
L
A
A
Site 9
S140
T
E
S
C
R
S
C
S
H
A
L
A
A
H
V
Site 10
T173
L
D
V
E
Y
L
F
T
C
V
H
K
E
E
D
Site 11
T183
H
K
E
E
D
A
D
T
K
Q
V
Y
F
Y
L
Site 12
Y189
D
T
K
Q
V
Y
F
Y
L
F
K
L
L
R
K
Site 13
S197
L
F
K
L
L
R
K
S
I
L
Q
R
G
K
P
Site 14
S209
G
K
P
V
V
E
G
S
L
E
K
K
P
P
F
Site 15
S234
N
F
V
Q
Y
K
F
S
H
L
P
A
K
E
R
Site 16
T243
L
P
A
K
E
R
Q
T
I
V
E
L
A
K
M
Site 17
Y257
M
F
L
N
R
I
N
Y
W
H
L
E
A
P
S
Site 18
S264
Y
W
H
L
E
A
P
S
Q
R
R
L
R
S
P
Site 19
S270
P
S
Q
R
R
L
R
S
P
N
D
D
I
S
G
Site 20
S276
R
S
P
N
D
D
I
S
G
Y
K
E
N
Y
T
Site 21
Y278
P
N
D
D
I
S
G
Y
K
E
N
Y
T
R
W
Site 22
S297
N
V
P
Q
F
C
D
S
L
P
R
Y
E
T
T
Site 23
Y301
F
C
D
S
L
P
R
Y
E
T
T
Q
V
F
G
Site 24
T303
D
S
L
P
R
Y
E
T
T
Q
V
F
G
R
T
Site 25
T344
E
K
R
T
L
I
L
T
H
F
P
K
F
L
S
Site 26
S351
T
H
F
P
K
F
L
S
M
L
E
E
E
V
Y
Site 27
Y358
S
M
L
E
E
E
V
Y
S
Q
N
S
P
I
W
Site 28
S359
M
L
E
E
E
V
Y
S
Q
N
S
P
I
W
D
Site 29
S362
E
E
V
Y
S
Q
N
S
P
I
W
D
Q
D
F
Site 30
S371
I
W
D
Q
D
F
L
S
A
S
S
R
T
S
Q
Site 31
S373
D
Q
D
F
L
S
A
S
S
R
T
S
Q
L
G
Site 32
S377
L
S
A
S
S
R
T
S
Q
L
G
I
Q
T
V
Site 33
S395
P
P
V
A
G
T
I
S
Y
N
S
T
S
S
S
Site 34
Y396
P
V
A
G
T
I
S
Y
N
S
T
S
S
S
L
Site 35
S398
A
G
T
I
S
Y
N
S
T
S
S
S
L
E
Q
Site 36
T399
G
T
I
S
Y
N
S
T
S
S
S
L
E
Q
P
Site 37
S400
T
I
S
Y
N
S
T
S
S
S
L
E
Q
P
N
Site 38
S402
S
Y
N
S
T
S
S
S
L
E
Q
P
N
A
G
Site 39
S412
Q
P
N
A
G
S
S
S
P
A
C
K
A
S
S
Site 40
T432
P
G
E
K
R
K
M
T
D
S
H
V
L
E
E
Site 41
S434
E
K
R
K
M
T
D
S
H
V
L
E
E
A
K
Site 42
S476
G
P
E
T
N
F
L
S
A
H
S
A
R
D
E
Site 43
S502
E
F
H
V
V
G
N
S
L
N
Q
K
P
N
K
Site 44
S523
V
G
L
Q
N
V
F
S
H
Q
L
P
R
M
P
Site 45
Y533
L
P
R
M
P
K
E
Y
I
T
R
L
V
F
D
Site 46
T545
V
F
D
P
K
H
K
T
L
A
L
I
K
D
G
Site 47
Y612
F
L
T
Y
A
D
E
Y
A
I
G
Y
F
K
K
Site 48
Y616
A
D
E
Y
A
I
G
Y
F
K
K
Q
G
F
S
Site 49
T631
K
E
I
K
I
P
K
T
K
Y
V
G
Y
I
K
Site 50
Y633
I
K
I
P
K
T
K
Y
V
G
Y
I
K
D
Y
Site 51
Y640
Y
V
G
Y
I
K
D
Y
E
G
A
T
L
M
G
Site 52
Y685
Q
A
Q
I
R
K
V
Y
P
G
L
S
C
F
K
Site 53
S689
R
K
V
Y
P
G
L
S
C
F
K
D
G
V
R
Site 54
T709
S
I
P
G
I
R
E
T
G
W
K
P
S
G
K
Site 55
S714
R
E
T
G
W
K
P
S
G
K
E
K
S
K
E
Site 56
S719
K
P
S
G
K
E
K
S
K
E
P
R
D
P
D
Site 57
Y729
P
R
D
P
D
Q
L
Y
S
T
L
K
S
I
L
Site 58
S730
R
D
P
D
Q
L
Y
S
T
L
K
S
I
L
Q
Site 59
T731
D
P
D
Q
L
Y
S
T
L
K
S
I
L
Q
Q
Site 60
S734
Q
L
Y
S
T
L
K
S
I
L
Q
Q
V
K
S
Site 61
S741
S
I
L
Q
Q
V
K
S
H
Q
S
A
W
P
F
Site 62
T755
F
M
E
P
V
K
R
T
E
A
P
G
Y
Y
E
Site 63
Y760
K
R
T
E
A
P
G
Y
Y
E
V
I
R
F
P
Site 64
Y761
R
T
E
A
P
G
Y
Y
E
V
I
R
F
P
M
Site 65
T772
R
F
P
M
D
L
K
T
M
S
E
R
L
K
N
Site 66
S774
P
M
D
L
K
T
M
S
E
R
L
K
N
R
Y
Site 67
Y781
S
E
R
L
K
N
R
Y
Y
V
S
K
K
L
F
Site 68
Y782
E
R
L
K
N
R
Y
Y
V
S
K
K
L
F
M
Site 69
T797
A
D
L
Q
R
V
F
T
N
C
K
E
Y
N
P
Site 70
Y802
V
F
T
N
C
K
E
Y
N
P
P
E
S
E
Y
Site 71
S807
K
E
Y
N
P
P
E
S
E
Y
Y
K
C
A
N
Site 72
Y809
Y
N
P
P
E
S
E
Y
Y
K
C
A
N
I
L
Site 73
Y810
N
P
P
E
S
E
Y
Y
K
C
A
N
I
L
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation