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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
JARID2
Full Name:
Protein Jumonji
Alias:
JARD2; JMJ; jumonji (mouse) homolog; jumonji, AT rich interactive domain 2
Type:
Transcription, coactivator/corepressor
Mass (Da):
138734
Number AA:
1246
UniProt ID:
Q92833
International Prot ID:
IPI00023756
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0007417
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y15
R
N
I
I
Q
K
K
Y
D
D
S
D
G
I
P
Site 2
S18
I
Q
K
K
Y
D
D
S
D
G
I
P
W
S
E
Site 3
S24
D
S
D
G
I
P
W
S
E
E
R
V
V
R
K
Site 4
Y34
R
V
V
R
K
V
L
Y
L
S
L
K
E
F
K
Site 5
S36
V
R
K
V
L
Y
L
S
L
K
E
F
K
N
S
Site 6
S43
S
L
K
E
F
K
N
S
Q
K
R
Q
H
A
E
Site 7
S68
G
L
L
G
N
D
Q
S
K
G
L
G
P
A
S
Site 8
S75
S
K
G
L
G
P
A
S
E
Q
S
E
N
E
K
Site 9
S78
L
G
P
A
S
E
Q
S
E
N
E
K
D
D
A
Site 10
S86
E
N
E
K
D
D
A
S
Q
V
S
S
T
S
N
Site 11
S89
K
D
D
A
S
Q
V
S
S
T
S
N
D
V
S
Site 12
S90
D
D
A
S
Q
V
S
S
T
S
N
D
V
S
S
Site 13
S92
A
S
Q
V
S
S
T
S
N
D
V
S
S
S
D
Site 14
S96
S
S
T
S
N
D
V
S
S
S
D
F
E
E
G
Site 15
S97
S
T
S
N
D
V
S
S
S
D
F
E
E
G
P
Site 16
S98
T
S
N
D
V
S
S
S
D
F
E
E
G
P
S
Site 17
S105
S
D
F
E
E
G
P
S
R
K
R
P
R
L
Q
Site 18
S120
A
Q
R
K
F
A
Q
S
Q
P
N
S
P
S
T
Site 19
S124
F
A
Q
S
Q
P
N
S
P
S
T
T
P
V
K
Site 20
S126
Q
S
Q
P
N
S
P
S
T
T
P
V
K
I
V
Site 21
T127
S
Q
P
N
S
P
S
T
T
P
V
K
I
V
E
Site 22
T128
Q
P
N
S
P
S
T
T
P
V
K
I
V
E
P
Site 23
T142
P
L
L
P
P
P
A
T
Q
I
S
D
L
S
K
Site 24
S145
P
P
P
A
T
Q
I
S
D
L
S
K
R
K
P
Site 25
S148
A
T
Q
I
S
D
L
S
K
R
K
P
K
T
E
Site 26
T154
L
S
K
R
K
P
K
T
E
D
F
L
T
F
L
Site 27
T159
P
K
T
E
D
F
L
T
F
L
C
L
R
G
S
Site 28
S172
G
S
P
A
L
P
N
S
M
V
Y
F
G
S
S
Site 29
Y175
A
L
P
N
S
M
V
Y
F
G
S
S
Q
D
E
Site 30
S179
S
M
V
Y
F
G
S
S
Q
D
E
E
E
V
E
Site 31
T192
V
E
E
E
D
D
E
T
E
D
V
K
T
A
T
Site 32
T197
D
E
T
E
D
V
K
T
A
T
N
N
A
S
S
Site 33
T199
T
E
D
V
K
T
A
T
N
N
A
S
S
S
C
Site 34
S203
K
T
A
T
N
N
A
S
S
S
C
Q
S
T
P
Site 35
S204
T
A
T
N
N
A
S
S
S
C
Q
S
T
P
R
Site 36
S205
A
T
N
N
A
S
S
S
C
Q
S
T
P
R
K
Site 37
S208
N
A
S
S
S
C
Q
S
T
P
R
K
G
K
T
Site 38
T209
A
S
S
S
C
Q
S
T
P
R
K
G
K
T
H
Site 39
T215
S
T
P
R
K
G
K
T
H
K
H
V
H
N
G
Site 40
S228
N
G
H
V
F
N
G
S
S
R
S
T
R
E
K
Site 41
S231
V
F
N
G
S
S
R
S
T
R
E
K
E
P
V
Site 42
T232
F
N
G
S
S
R
S
T
R
E
K
E
P
V
Q
Site 43
S243
E
P
V
Q
K
H
K
S
K
E
A
T
P
A
K
Site 44
T247
K
H
K
S
K
E
A
T
P
A
K
E
K
H
S
Site 45
S254
T
P
A
K
E
K
H
S
D
H
R
A
D
S
R
Site 46
S260
H
S
D
H
R
A
D
S
R
R
E
Q
A
S
A
Site 47
S266
D
S
R
R
E
Q
A
S
A
N
H
P
A
A
A
Site 48
S275
N
H
P
A
A
A
P
S
T
G
S
S
A
K
G
Site 49
S279
A
A
P
S
T
G
S
S
A
K
G
L
A
A
T
Site 50
S295
H
H
P
P
L
H
R
S
A
Q
D
L
R
K
Q
Site 51
S304
Q
D
L
R
K
Q
V
S
K
V
N
G
V
T
R
Site 52
S314
N
G
V
T
R
M
S
S
L
G
A
G
V
T
S
Site 53
S331
K
M
R
E
V
R
P
S
P
S
K
T
V
K
Y
Site 54
T335
V
R
P
S
P
S
K
T
V
K
Y
T
A
T
V
Site 55
Y338
S
P
S
K
T
V
K
Y
T
A
T
V
T
K
G
Site 56
T341
K
T
V
K
Y
T
A
T
V
T
K
G
A
V
T
Site 57
Y349
V
T
K
G
A
V
T
Y
T
K
A
K
R
E
L
Site 58
S369
P
N
H
H
K
P
S
S
A
V
N
H
T
I
S
Site 59
T374
P
S
S
A
V
N
H
T
I
S
G
K
T
E
S
Site 60
S376
S
A
V
N
H
T
I
S
G
K
T
E
S
S
N
Site 61
S381
T
I
S
G
K
T
E
S
S
N
A
K
T
R
K
Site 62
S382
I
S
G
K
T
E
S
S
N
A
K
T
R
K
Q
Site 63
T386
T
E
S
S
N
A
K
T
R
K
Q
V
L
S
L
Site 64
S392
K
T
R
K
Q
V
L
S
L
G
G
A
S
K
S
Site 65
S399
S
L
G
G
A
S
K
S
T
G
P
A
V
N
G
Site 66
S410
A
V
N
G
L
K
V
S
G
R
L
N
P
K
S
Site 67
S417
S
G
R
L
N
P
K
S
C
T
K
E
V
G
G
Site 68
S440
L
R
E
G
L
R
N
S
K
R
R
L
E
E
A
Site 69
S455
H
Q
A
E
K
P
Q
S
P
P
K
K
M
K
G
Site 70
S493
K
K
E
V
P
E
R
S
L
E
R
N
R
P
K
Site 71
T503
R
N
R
P
K
R
A
T
A
G
K
S
T
P
G
Site 72
S507
K
R
A
T
A
G
K
S
T
P
G
R
Q
A
H
Site 73
T508
R
A
T
A
G
K
S
T
P
G
R
Q
A
H
G
Site 74
S519
Q
A
H
G
K
A
D
S
A
S
C
E
N
R
S
Site 75
S521
H
G
K
A
D
S
A
S
C
E
N
R
S
T
S
Site 76
S526
S
A
S
C
E
N
R
S
T
S
Q
P
E
S
V
Site 77
T527
A
S
C
E
N
R
S
T
S
Q
P
E
S
V
H
Site 78
S528
S
C
E
N
R
S
T
S
Q
P
E
S
V
H
K
Site 79
S532
R
S
T
S
Q
P
E
S
V
H
K
P
Q
D
S
Site 80
S539
S
V
H
K
P
Q
D
S
G
K
A
E
K
G
G
Site 81
S563
E
I
P
V
L
R
P
S
A
K
E
F
H
D
P
Site 82
Y573
E
F
H
D
P
L
I
Y
I
E
S
V
R
A
Q
Site 83
S576
D
P
L
I
Y
I
E
S
V
R
A
Q
V
E
K
Site 84
S637
C
I
K
K
H
L
K
S
Q
G
I
T
M
D
E
Site 85
T641
H
L
K
S
Q
G
I
T
M
D
E
L
P
L
I
Site 86
T689
D
M
L
R
I
P
R
T
A
Q
D
R
L
A
K
Site 87
Y704
L
Q
E
A
Y
C
Q
Y
L
L
S
Y
D
S
L
Site 88
S707
A
Y
C
Q
Y
L
L
S
Y
D
S
L
S
P
E
Site 89
Y708
Y
C
Q
Y
L
L
S
Y
D
S
L
S
P
E
E
Site 90
S710
Q
Y
L
L
S
Y
D
S
L
S
P
E
E
H
R
Site 91
S712
L
L
S
Y
D
S
L
S
P
E
E
H
R
R
L
Site 92
S772
A
P
R
N
G
F
R
S
K
L
K
E
V
G
Q
Site 93
T784
V
G
Q
A
Q
L
K
T
G
R
R
R
L
F
A
Site 94
Y815
N
D
F
H
K
C
I
Y
K
G
R
S
V
S
L
Site 95
S819
K
C
I
Y
K
G
R
S
V
S
L
T
T
F
Y
Site 96
S821
I
Y
K
G
R
S
V
S
L
T
T
F
Y
R
T
Site 97
T823
K
G
R
S
V
S
L
T
T
F
Y
R
T
A
R
Site 98
T824
G
R
S
V
S
L
T
T
F
Y
R
T
A
R
N
Site 99
S834
R
T
A
R
N
I
M
S
M
C
F
S
K
E
P
Site 100
S838
N
I
M
S
M
C
F
S
K
E
P
A
P
A
E
Site 101
Y850
P
A
E
I
E
Q
E
Y
W
R
L
V
E
E
K
Site 102
T872
C
G
K
V
D
T
N
T
H
G
S
G
F
P
V
Site 103
S875
V
D
T
N
T
H
G
S
G
F
P
V
G
K
S
Site 104
S882
S
G
F
P
V
G
K
S
E
P
F
S
R
H
G
Site 105
S886
V
G
K
S
E
P
F
S
R
H
G
W
N
L
T
Site 106
T893
S
R
H
G
W
N
L
T
V
L
P
N
N
T
G
Site 107
Y937
R
D
Q
N
H
L
P
Y
I
D
Y
L
H
T
G
Site 108
Y940
N
H
L
P
Y
I
D
Y
L
H
T
G
A
D
C
Site 109
Y950
T
G
A
D
C
I
W
Y
C
I
P
A
E
E
E
Site 110
S981
P
G
L
Q
M
L
E
S
N
V
M
I
S
P
E
Site 111
T1000
E
G
I
K
V
H
R
T
V
Q
Q
S
G
Q
F
Site 112
T1028
C
G
Y
S
V
S
E
T
V
H
F
A
T
T
Q
Site 113
S1057
R
H
I
A
K
P
F
S
M
E
K
L
L
Y
Q
Site 114
T1077
A
K
K
E
N
G
P
T
L
S
T
I
S
A
L
Site 115
S1079
K
E
N
G
P
T
L
S
T
I
S
A
L
L
D
Site 116
T1091
L
L
D
E
L
R
D
T
E
L
R
Q
R
R
Q
Site 117
S1106
L
F
E
A
G
L
H
S
S
A
R
Y
G
S
H
Site 118
S1107
F
E
A
G
L
H
S
S
A
R
Y
G
S
H
D
Site 119
Y1110
G
L
H
S
S
A
R
Y
G
S
H
D
G
S
S
Site 120
S1112
H
S
S
A
R
Y
G
S
H
D
G
S
S
T
V
Site 121
S1116
R
Y
G
S
H
D
G
S
S
T
V
A
D
G
K
Site 122
S1117
Y
G
S
H
D
G
S
S
T
V
A
D
G
K
K
Site 123
T1118
G
S
H
D
G
S
S
T
V
A
D
G
K
K
K
Site 124
S1174
R
H
V
E
K
Q
K
S
C
R
G
L
K
L
M
Site 125
S1206
K
V
S
G
K
N
G
S
I
E
N
C
L
S
K
Site 126
S1212
G
S
I
E
N
C
L
S
K
P
T
P
K
R
G
Site 127
T1215
E
N
C
L
S
K
P
T
P
K
R
G
P
R
K
Site 128
T1225
R
G
P
R
K
R
A
T
V
D
V
P
P
S
R
Site 129
S1231
A
T
V
D
V
P
P
S
R
L
S
A
S
S
S
Site 130
S1234
D
V
P
P
S
R
L
S
A
S
S
S
S
K
S
Site 131
S1236
P
P
S
R
L
S
A
S
S
S
S
K
S
A
S
Site 132
S1237
P
S
R
L
S
A
S
S
S
S
K
S
A
S
S
Site 133
S1238
S
R
L
S
A
S
S
S
S
K
S
A
S
S
S
Site 134
S1239
R
L
S
A
S
S
S
S
K
S
A
S
S
S
S
Site 135
S1241
S
A
S
S
S
S
K
S
A
S
S
S
S
_
_
Site 136
S1243
S
S
S
S
K
S
A
S
S
S
S
_
_
_
_
Site 137
S1244
S
S
S
K
S
A
S
S
S
S
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation