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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RPGR
Full Name:
X-linked retinitis pigmentosa GTPase regulator
Alias:
Type:
Mass (Da):
113387
Number AA:
1020
UniProt ID:
Q92834
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
P
E
E
L
M
P
D
S
G
A
V
F
T
F
G
Site 2
T16
P
D
S
G
A
V
F
T
F
G
K
S
K
F
A
Site 3
S20
A
V
F
T
F
G
K
S
K
F
A
E
N
N
P
Site 4
S41
N
D
V
P
V
H
L
S
C
G
D
E
H
S
A
Site 5
S47
L
S
C
G
D
E
H
S
A
V
V
T
G
N
N
Site 6
T51
D
E
H
S
A
V
V
T
G
N
N
K
L
Y
M
Site 7
Y57
V
T
G
N
N
K
L
Y
M
F
G
S
N
N
W
Site 8
S73
Q
L
G
L
G
S
K
S
A
I
S
K
P
T
C
Site 9
T99
A
A
C
G
R
N
H
T
L
V
S
T
E
G
G
Site 10
S102
G
R
N
H
T
L
V
S
T
E
G
G
N
V
Y
Site 11
Y109
S
T
E
G
G
N
V
Y
A
T
G
G
N
N
E
Site 12
T124
G
Q
L
G
L
G
D
T
E
E
R
N
T
F
H
Site 13
T129
G
D
T
E
E
R
N
T
F
H
V
I
S
F
F
Site 14
S134
R
N
T
F
H
V
I
S
F
F
T
S
E
H
K
Site 15
S146
E
H
K
I
K
Q
L
S
A
G
S
N
T
S
A
Site 16
T156
S
N
T
S
A
A
L
T
E
D
G
R
L
F
M
Site 17
T206
Y
Y
H
S
A
F
V
T
T
D
G
E
L
Y
V
Site 18
Y212
V
T
T
D
G
E
L
Y
V
F
G
E
P
E
N
Site 19
T234
Q
L
L
G
N
H
R
T
P
Q
L
V
S
E
I
Site 20
T296
I
E
N
I
R
D
Q
T
I
S
Y
I
S
C
G
Site 21
Y299
I
R
D
Q
T
I
S
Y
I
S
C
G
E
N
H
Site 22
Y317
I
T
D
I
G
L
M
Y
T
F
G
D
G
R
H
Site 23
T318
T
D
I
G
L
M
Y
T
F
G
D
G
R
H
G
Site 24
Y393
S
V
A
T
F
L
P
Y
S
S
L
T
S
G
N
Site 25
S395
A
T
F
L
P
Y
S
S
L
T
S
G
N
V
L
Site 26
S398
L
P
Y
S
S
L
T
S
G
N
V
L
Q
R
T
Site 27
T405
S
G
N
V
L
Q
R
T
L
S
A
R
M
R
R
Site 28
S407
N
V
L
Q
R
T
L
S
A
R
M
R
R
R
E
Site 29
S418
R
R
R
E
R
E
R
S
P
D
S
F
S
M
R
Site 30
S421
E
R
E
R
S
P
D
S
F
S
M
R
R
T
L
Site 31
S423
E
R
S
P
D
S
F
S
M
R
R
T
L
P
P
Site 32
T427
D
S
F
S
M
R
R
T
L
P
P
I
E
G
T
Site 33
S451
N
S
V
F
P
R
C
S
E
R
N
L
Q
E
S
Site 34
S458
S
E
R
N
L
Q
E
S
V
L
S
E
Q
D
L
Site 35
Y473
M
Q
P
E
E
P
D
Y
L
L
D
E
M
T
K
Site 36
T479
D
Y
L
L
D
E
M
T
K
E
A
E
I
D
N
Site 37
S487
K
E
A
E
I
D
N
S
S
T
V
E
S
L
G
Site 38
S488
E
A
E
I
D
N
S
S
T
V
E
S
L
G
E
Site 39
T489
A
E
I
D
N
S
S
T
V
E
S
L
G
E
T
Site 40
S492
D
N
S
S
T
V
E
S
L
G
E
T
T
D
I
Site 41
S507
L
N
M
T
H
I
M
S
L
N
S
N
E
K
S
Site 42
S510
T
H
I
M
S
L
N
S
N
E
K
S
L
K
L
Site 43
S514
S
L
N
S
N
E
K
S
L
K
L
S
P
V
Q
Site 44
S518
N
E
K
S
L
K
L
S
P
V
Q
K
Q
K
K
Site 45
S544
A
L
T
E
N
D
D
S
D
E
Y
E
E
M
S
Site 46
Y547
E
N
D
D
S
D
E
Y
E
E
M
S
E
M
K
Site 47
S580
A
T
T
I
E
A
F
S
D
E
E
V
G
N
D
Site 48
T588
D
E
E
V
G
N
D
T
G
Q
V
G
P
Q
A
Site 49
T597
Q
V
G
P
Q
A
D
T
D
G
E
G
L
Q
K
Site 50
Y607
E
G
L
Q
K
E
V
Y
R
H
E
N
N
N
G
Site 51
S627
A
K
E
I
E
K
E
S
D
G
G
H
S
Q
K
Site 52
S632
K
E
S
D
G
G
H
S
Q
K
E
S
E
A
E
Site 53
S636
G
G
H
S
Q
K
E
S
E
A
E
E
I
D
S
Site 54
S643
S
E
A
E
E
I
D
S
E
K
E
T
K
L
A
Site 55
S664
D
L
R
E
R
E
K
S
T
K
K
M
S
P
F
Site 56
T665
L
R
E
R
E
K
S
T
K
K
M
S
P
F
F
Site 57
S669
E
K
S
T
K
K
M
S
P
F
F
G
N
L
P
Site 58
S696
D
F
V
K
K
R
E
S
C
K
Q
D
V
I
F
Site 59
S705
K
Q
D
V
I
F
D
S
E
R
E
S
V
E
K
Site 60
S709
I
F
D
S
E
R
E
S
V
E
K
P
D
S
Y
Site 61
S715
E
S
V
E
K
P
D
S
Y
M
E
G
A
S
E
Site 62
Y716
S
V
E
K
P
D
S
Y
M
E
G
A
S
E
S
Site 63
Y757
E
T
D
Q
N
I
R
Y
G
R
K
L
I
E
Q
Site 64
S777
T
K
P
I
I
S
K
S
M
A
K
Y
D
F
K
Site 65
Y781
I
S
K
S
M
A
K
Y
D
F
K
C
D
R
L
Site 66
S789
D
F
K
C
D
R
L
S
E
I
P
E
E
K
E
Site 67
S801
E
K
E
G
A
E
D
S
K
G
N
G
I
E
E
Site 68
T828
H
G
G
R
K
E
K
T
E
I
L
S
D
D
L
Site 69
T836
E
I
L
S
D
D
L
T
D
K
A
E
D
H
E
Site 70
T847
E
D
H
E
F
S
K
T
E
E
L
K
L
E
D
Site 71
S866
I
N
A
E
N
V
E
S
K
K
K
T
V
G
D
Site 72
T870
N
V
E
S
K
K
K
T
V
G
D
D
E
S
V
Site 73
S876
K
T
V
G
D
D
E
S
V
P
T
G
Y
H
S
Site 74
T879
G
D
D
E
S
V
P
T
G
Y
H
S
K
T
E
Site 75
Y881
D
E
S
V
P
T
G
Y
H
S
K
T
E
G
A
Site 76
T885
P
T
G
Y
H
S
K
T
E
G
A
E
R
T
N
Site 77
T891
K
T
E
G
A
E
R
T
N
D
D
S
S
A
E
Site 78
S895
A
E
R
T
N
D
D
S
S
A
E
T
I
E
K
Site 79
S896
E
R
T
N
D
D
S
S
A
E
T
I
E
K
K
Site 80
Y916
E
E
R
A
I
C
E
Y
N
E
N
P
K
G
Y
Site 81
S930
Y
M
L
D
D
A
D
S
S
S
L
E
I
L
E
Site 82
S931
M
L
D
D
A
D
S
S
S
L
E
I
L
E
N
Site 83
S932
L
D
D
A
D
S
S
S
L
E
I
L
E
N
S
Site 84
S939
S
L
E
I
L
E
N
S
E
T
T
P
S
K
D
Site 85
T941
E
I
L
E
N
S
E
T
T
P
S
K
D
M
K
Site 86
T942
I
L
E
N
S
E
T
T
P
S
K
D
M
K
K
Site 87
S944
E
N
S
E
T
T
P
S
K
D
M
K
K
T
K
Site 88
T950
P
S
K
D
M
K
K
T
K
K
I
F
L
F
K
Site 89
S961
F
L
F
K
R
V
P
S
I
N
Q
K
I
V
K
Site 90
S988
G
D
Q
I
I
L
K
S
D
N
K
D
A
D
Q
Site 91
T1010
Q
N
I
P
P
T
N
T
E
R
R
S
K
S
C
Site 92
S1014
P
T
N
T
E
R
R
S
K
S
C
T
I
L
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation