PhosphoNET

           
Protein Info 
   
Short Name:  SHIP
Full Name:  Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1
Alias:  EC 3.1.3.n1; Inositol polyphosphate-5-phosphatase of 145 kDa; Inositol polyphosphate-5-phosphatase, 145kDa; INPP5D; P150Ship; Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1; SH2-containing inositol 5'-phosphatase 1; SHIP1; SHIP-1; SIP-145
Type:  Phosphatase, lipid; EC 3.1.3.n1
Mass (Da):  133292
Number AA:  1189
UniProt ID:  Q92835
International Prot ID:  IPI00102524
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005829  GO:0019898   Uniprot OncoNet
Molecular Function:  GO:0017124  GO:0004445   PhosphoSite+ KinaseNET
Biological Process:  GO:0006915  GO:0006796   Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S13NHGNITRSKAEELLS
Site 2S20SKAEELLSRTGKDGS
Site 3S27SRTGKDGSFLVRASE
Site 4S33GSFLVRASESISRAY
Site 5S35FLVRASESISRAYAL
Site 6Y40SESISRAYALCVLYR
Site 7Y46AYALCVLYRNCVYTY
Site 8T64PNEDDKFTVQASEGV
Site 9S68DKFTVQASEGVSMRF
Site 10Y99GLVTHLQYPVPLEEE
Site 11T108VPLEEEDTGDDPEED
Site 12T116GDDPEEDTVESVVSP
Site 13S119PEEDTVESVVSPPEL
Site 14S122DTVESVVSPPELPPR
Site 15T134PPRNIPLTASSCEAK
Site 16S136RNIPLTASSCEAKEV
Site 17S146EAKEVPFSNENPRAT
Site 18T153SNENPRATETSRPSL
Site 19T155ENPRATETSRPSLSE
Site 20S156NPRATETSRPSLSET
Site 21S159ATETSRPSLSETLFQ
Site 22S161ETSRPSLSETLFQRL
Site 23T163SRPSLSETLFQRLQS
Site 24S170TLFQRLQSMDTSGLP
Site 25S174RLQSMDTSGLPEEHL
Site 26Y187HLKAIQDYLSTQLAQ
Site 27S189KAIQDYLSTQLAQDS
Site 28S196STQLAQDSEFVKTGS
Site 29T201QDSEFVKTGSSSLPH
Site 30S204EFVKTGSSSLPHLKK
Site 31S205FVKTGSSSLPHLKKL
Site 32T213LPHLKKLTTLLCKEL
Site 33T214PHLKKLTTLLCKELY
Site 34Y221TLLCKELYGEVIRTL
Site 35S230EVIRTLPSLESLQRL
Site 36S233RTLPSLESLQRLFDQ
Site 37S243RLFDQQLSPGLRPRP
Site 38S263ANPINMVSKLSQLTS
Site 39S266INMVSKLSQLTSLLS
Site 40S270SKLSQLTSLLSSIED
Site 41S273SQLTSLLSSIEDKVK
Site 42S274QLTSLLSSIEDKVKA
Site 43S289LLHEGPESPHRPSLI
Site 44S294PESPHRPSLIPPVTF
Site 45S330GKLIIKKSKDGSEDK
Site 46S334IKKSKDGSEDKFYSH
Site 47Y339DGSEDKFYSHKKILQ
Site 48S340GSEDKFYSHKKILQL
Site 49S350KILQLIKSQKFLNKL
Site 50Y373EKILRKEYVFADSKK
Site 51S378KEYVFADSKKREGFC
Site 52S424PPPKKITSWFLSKGQ
Site 53S428KITSWFLSKGQGKTR
Site 54T434LSKGQGKTRDDSADY
Site 55S438QGKTRDDSADYIPHD
Site 56Y441TRDDSADYIPHDIYV
Site 57Y447DYIPHDIYVIGTQED
Site 58S457GTQEDPLSEKEWLEI
Site 59T507NRISHICTDNVKTGI
Site 60S540TSLGFVNSHLTSGSE
Site 61S544FVNSHLTSGSEKKLR
Site 62S546NSHLTSGSEKKLRRN
Site 63Y556KLRRNQNYMNILRFL
Site 64S571ALGDKKLSPFNITHR
Site 65Y590FWFGDLNYRVDLPTW
Site 66T596NYRVDLPTWEAETII
Site 67Y611QKIKQQQYADLLSHD
Site 68S616QQYADLLSHDQLLTE
Site 69T622LSHDQLLTERREQKV
Site 70T639HFEEEEITFAPTYRF
Site 71Y644EITFAPTYRFERLTR
Site 72T650TYRFERLTRDKYAYT
Site 73Y654ERLTRDKYAYTKQKA
Site 74Y656LTRDKYAYTKQKATG
Site 75Y666QKATGMKYNLPSWCD
Site 76T693VCQSYGSTSDIMTSD
Site 77T698GSTSDIMTSDHSPVF
Site 78S699STSDIMTSDHSPVFA
Site 79S702DIMTSDHSPVFATFE
Site 80T713ATFEAGVTSQFVSKN
Site 81S714TFEAGVTSQFVSKNG
Site 82S718GVTSQFVSKNGPGTV
Site 83T724VSKNGPGTVDSQGQI
Site 84S727NGPGTVDSQGQIEFL
Site 85Y737QIEFLRCYATLKTKS
Site 86T739EFLRCYATLKTKSQT
Site 87T742RCYATLKTKSQTKFY
Site 88S744YATLKTKSQTKFYLE
Site 89Y749TKSQTKFYLEFHSSC
Site 90S754KFYLEFHSSCLESFV
Site 91S755FYLEFHSSCLESFVK
Site 92S759FHSSCLESFVKSQEG
Site 93S763CLESFVKSQEGENEE
Site 94S772EGENEEGSEGELVVK
Site 95S792PKLKPIISDPEYLLD
Site 96Y796PIISDPEYLLDQHIL
Site 97S805LDQHILISIKSSDSD
Site 98S808HILISIKSSDSDESY
Site 99S809ILISIKSSDSDESYG
Site 100S811ISIKSSDSDESYGEG
Site 101S814KSSDSDESYGEGCIA
Site 102Y815SSDSDESYGEGCIAL
Site 103T829LRLEATETQLPIYTP
Site 104Y834TETQLPIYTPLTHHG
Site 105T835ETQLPIYTPLTHHGE
Site 106T838LPIYTPLTHHGELTG
Site 107S856GEIKLQTSQGKTREK
Site 108Y865GKTREKLYDFVKTER
Site 109T870KLYDFVKTERDESSG
Site 110S875VKTERDESSGPKTLK
Site 111S876KTERDESSGPKTLKS
Site 112T880DESSGPKTLKSLTSH
Site 113S883SGPKTLKSLTSHDPM
Site 114S886KTLKSLTSHDPMKQW
Site 115T896PMKQWEVTSRAPPCS
Site 116S897MKQWEVTSRAPPCSG
Site 117S903TSRAPPCSGSSITEI
Site 118Y915TEIINPNYMGVGPFG
Site 119T932MPLHVKQTLSPDQQP
Site 120S934LHVKQTLSPDQQPTA
Site 121T940LSPDQQPTAWSYDQP
Site 122Y944QQPTAWSYDQPPKDS
Site 123S951YDQPPKDSPLGPCRG
Site 124S960LGPCRGESPPTPPGQ
Site 125T963CRGESPPTPPGQPPI
Site 126S971PPGQPPISPKKFLPS
Site 127S978SPKKFLPSTANRGLP
Site 128T979PKKFLPSTANRGLPP
Site 129T988NRGLPPRTQESRPSD
Site 130S991LPPRTQESRPSDLGK
Site 131S994RTQESRPSDLGKNAG
Site 132T1003LGKNAGDTLPQEDLP
Site 133T1012PQEDLPLTKPEMFEN
Site 134Y1022EMFENPLYGSLSSFP
Site 135S1024FENPLYGSLSSFPKP
Site 136S1026NPLYGSLSSFPKPAP
Site 137S1027PLYGSLSSFPKPAPR
Site 138S1039APRKDQESPKMPRKE
Site 139T1063LSPSIVLTKAQEADR
Site 140S1085VPAPRLRSFTCSSSA
Site 141T1087APRLRSFTCSSSAEG
Site 142S1089RLRSFTCSSSAEGRA
Site 143S1090LRSFTCSSSAEGRAA
Site 144S1091RSFTCSSSAEGRAAG
Site 145S1102RAAGGDKSQGKPKTP
Site 146T1108KSQGKPKTPVSSQAP
Site 147S1111GKPKTPVSSQAPVPA
Site 148S1112KPKTPVSSQAPVPAK
Site 149S1125AKRPIKPSRSEINQQ
Site 150S1127RPIKPSRSEINQQTP
Site 151T1133RSEINQQTPPTPTPR
Site 152T1136INQQTPPTPTPRPPL
Site 153T1138QQTPPTPTPRPPLPV
Site 154S1147RPPLPVKSPAVLHLQ
Site 155S1156AVLHLQHSKGRDYRD
Site 156Y1161QHSKGRDYRDNTELP
Site 157T1165GRDYRDNTELPHHGK
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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