KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
HAS1
Full Name:
Hyaluronan synthase 1
Alias:
EC 2.4.1.212; HA synthase 1; HAS; HuHAS1
Type:
Membrane, Integral plasma membrane protein
Mass (Da):
64832
Number AA:
578
UniProt ID:
Q92839
International Prot ID:
IPI00023768
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
Uniprot
OncoNet
Molecular Function:
GO:0050501
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007155
GO:0006024
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T10
Q
Q
D
A
P
K
P
T
P
A
A
C
R
C
S
Site 2
T100
T
A
R
S
V
A
L
T
I
S
A
Y
Q
E
D
Site 3
Y110
A
Y
Q
E
D
P
A
Y
L
R
Q
C
L
A
S
Site 4
Y123
A
S
A
R
A
L
L
Y
P
R
A
R
L
R
V
Site 5
Y143
G
N
R
A
E
D
L
Y
M
V
D
M
F
R
E
Site 6
Y160
A
D
E
D
P
A
T
Y
V
W
D
G
N
Y
H
Site 7
Y220
G
G
K
R
E
V
M
Y
T
A
F
K
A
L
G
Site 8
T221
G
K
R
E
V
M
Y
T
A
F
K
A
L
G
D
Site 9
Y232
A
L
G
D
S
V
D
Y
V
Q
V
C
D
S
D
Site 10
S238
D
Y
V
Q
V
C
D
S
D
T
R
L
D
P
M
Site 11
T240
V
Q
V
C
D
S
D
T
R
L
D
P
M
A
L
Site 12
S278
N
P
L
D
S
W
V
S
F
L
S
S
L
R
Y
Site 13
S281
D
S
W
V
S
F
L
S
S
L
R
Y
W
V
A
Site 14
S282
S
W
V
S
F
L
S
S
L
R
Y
W
V
A
F
Site 15
Y312
I
S
G
P
L
G
L
Y
R
N
N
L
L
Q
Q
Site 16
Y325
Q
Q
F
L
E
A
W
Y
N
Q
K
F
L
G
T
Site 17
T343
F
G
D
D
R
H
L
T
N
R
M
L
S
M
G
Site 18
Y351
N
R
M
L
S
M
G
Y
A
T
K
Y
T
S
R
Site 19
Y355
S
M
G
Y
A
T
K
Y
T
S
R
S
R
C
Y
Site 20
T356
M
G
Y
A
T
K
Y
T
S
R
S
R
C
Y
S
Site 21
S357
G
Y
A
T
K
Y
T
S
R
S
R
C
Y
S
E
Site 22
S359
A
T
K
Y
T
S
R
S
R
C
Y
S
E
T
P
Site 23
Y362
Y
T
S
R
S
R
C
Y
S
E
T
P
S
S
F
Site 24
S363
T
S
R
S
R
C
Y
S
E
T
P
S
S
F
L
Site 25
T365
R
S
R
C
Y
S
E
T
P
S
S
F
L
R
W
Site 26
S367
R
C
Y
S
E
T
P
S
S
F
L
R
W
L
S
Site 27
S368
C
Y
S
E
T
P
S
S
F
L
R
W
L
S
Q
Site 28
S374
S
S
F
L
R
W
L
S
Q
Q
T
R
W
S
K
Site 29
Y383
Q
T
R
W
S
K
S
Y
F
R
E
W
L
Y
N
Site 30
Y403
R
H
H
A
W
M
T
Y
E
A
V
V
S
G
L
Site 31
S486
A
L
V
T
M
N
Q
S
G
W
G
T
S
G
R
Site 32
T490
M
N
Q
S
G
W
G
T
S
G
R
R
K
L
A
Site 33
S491
N
Q
S
G
W
G
T
S
G
R
R
K
L
A
A
Site 34
Y539
P
S
R
A
A
E
A
Y
H
L
A
A
G
A
G
Site 35
Y548
L
A
A
G
A
G
A
Y
V
G
Y
W
V
A
M
Site 36
Y551
G
A
G
A
Y
V
G
Y
W
V
A
M
L
T
L
Site 37
T571
R
R
L
C
R
R
R
T
G
G
Y
R
V
Q
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation