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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CASP10
Full Name:
Caspase-10
Alias:
ALPS2; Apoptotic protease Mch-4; CASP-10; CASPA; EC 3.4.22.-; EC 3.4.22.63; FADD-like ICE2; FAS-associated death domain protein interleukin-1B-convert; ICE-like apoptotic protease 4
Type:
Protease
Mass (Da):
58951
Number AA:
521
UniProt ID:
Q92851
International Prot ID:
IPI00216197
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0004197
GO:0042802
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
GO:0008624
GO:0006508
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y9
K
S
Q
G
Q
H
W
Y
S
S
S
D
K
N
C
Site 2
S19
S
D
K
N
C
K
V
S
F
R
E
K
L
L
I
Site 3
S55
P
N
K
K
L
E
K
S
S
S
A
S
D
V
F
Site 4
S57
K
K
L
E
K
S
S
S
A
S
D
V
F
E
H
Site 5
S59
L
E
K
S
S
S
A
S
D
V
F
E
H
L
L
Site 6
S113
L
P
T
R
Q
R
V
S
L
F
R
N
L
L
Y
Site 7
Y120
S
L
F
R
N
L
L
Y
E
L
S
E
G
I
D
Site 8
S123
R
N
L
L
Y
E
L
S
E
G
I
D
S
E
N
Site 9
S128
E
L
S
E
G
I
D
S
E
N
L
K
D
M
I
Site 10
T145
L
K
D
S
L
P
K
T
E
M
T
S
L
S
F
Site 11
T168
K
I
D
E
D
N
L
T
C
L
E
D
L
C
K
Site 12
Y188
L
L
R
N
I
E
K
Y
K
R
E
K
A
I
Q
Site 13
T198
E
K
A
I
Q
I
V
T
P
P
V
D
K
E
A
Site 14
S207
P
V
D
K
E
A
E
S
Y
Q
G
E
E
E
L
Site 15
Y208
V
D
K
E
A
E
S
Y
Q
G
E
E
E
L
V
Site 16
S216
Q
G
E
E
E
L
V
S
Q
T
D
V
K
T
F
Site 17
T222
V
S
Q
T
D
V
K
T
F
L
E
A
L
P
Q
Site 18
T245
G
S
N
G
N
R
A
T
N
G
A
P
S
L
V
Site 19
S250
R
A
T
N
G
A
P
S
L
V
S
R
G
M
Q
Site 20
S253
N
G
A
P
S
L
V
S
R
G
M
Q
G
A
S
Site 21
S260
S
R
G
M
Q
G
A
S
A
N
T
L
N
S
E
Site 22
S266
A
S
A
N
T
L
N
S
E
T
S
T
K
R
A
Site 23
S269
N
T
L
N
S
E
T
S
T
K
R
A
A
V
Y
Site 24
T270
T
L
N
S
E
T
S
T
K
R
A
A
V
Y
R
Site 25
Y276
S
T
K
R
A
A
V
Y
R
M
N
R
N
H
R
Site 26
S293
C
V
I
V
N
N
H
S
F
T
S
L
K
D
R
Site 27
S296
V
N
N
H
S
F
T
S
L
K
D
R
Q
G
T
Site 28
T303
S
L
K
D
R
Q
G
T
H
K
D
A
E
I
L
Site 29
Y365
H
G
R
F
G
A
V
Y
S
S
D
E
A
L
I
Site 30
S366
G
R
F
G
A
V
Y
S
S
D
E
A
L
I
P
Site 31
S409
Q
G
E
E
I
Q
P
S
V
S
I
E
A
D
A
Site 32
T424
L
N
P
E
Q
A
P
T
S
L
Q
D
S
I
P
Site 33
S425
N
P
E
Q
A
P
T
S
L
Q
D
S
I
P
A
Site 34
S429
A
P
T
S
L
Q
D
S
I
P
A
E
A
D
F
Site 35
S448
A
T
V
P
G
Y
V
S
F
R
H
V
E
E
G
Site 36
Y458
H
V
E
E
G
S
W
Y
I
Q
S
L
C
N
H
Site 37
T480
M
L
K
F
L
E
K
T
M
E
I
R
G
R
K
Site 38
T489
E
I
R
G
R
K
R
T
V
W
G
A
K
Q
I
Site 39
S506
T
S
L
P
T
A
I
S
A
Q
T
P
R
P
P
Site 40
T509
P
T
A
I
S
A
Q
T
P
R
P
P
M
R
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation