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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
APBB2
Full Name:
Amyloid beta A4 precursor protein-binding family B member 2
Alias:
Amyloid beta A4 precursor protein-binding family B member 2: Fe65-like protein: Amyloid beta A4 precursor protein-binding family B member 2: Fe65-like protein; Fe65-like protein
Type:
Membrane protein
Mass (Da):
83346
Number AA:
758
UniProt ID:
Q92870
International Prot ID:
IPI00470455
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030426
GO:0030027
GO:0016020
Uniprot
OncoNet
Molecular Function:
GO:0001540
GO:0008134
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007050
GO:0007242
GO:0045749
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T27
S
S
G
T
T
D
V
T
N
R
N
S
P
A
T
Site 2
S31
T
D
V
T
N
R
N
S
P
A
T
P
P
N
T
Site 3
T34
T
N
R
N
S
P
A
T
P
P
N
T
L
N
L
Site 4
T38
S
P
A
T
P
P
N
T
L
N
L
R
S
S
H
Site 5
S43
P
N
T
L
N
L
R
S
S
H
N
E
L
L
N
Site 6
S44
N
T
L
N
L
R
S
S
H
N
E
L
L
N
A
Site 7
T56
L
N
A
E
I
K
H
T
E
T
K
N
S
T
P
Site 8
S61
K
H
T
E
T
K
N
S
T
P
P
K
C
R
K
Site 9
T62
H
T
E
T
K
N
S
T
P
P
K
C
R
K
K
Site 10
Y70
P
P
K
C
R
K
K
Y
A
L
T
N
I
Q
A
Site 11
S94
Q
P
L
L
G
N
G
S
A
N
I
K
L
V
K
Site 12
S123
Q
D
P
N
K
N
L
S
P
T
A
V
I
N
I
Site 13
S145
K
E
P
H
P
Q
D
S
S
S
C
E
I
L
P
Site 14
S146
E
P
H
P
Q
D
S
S
S
C
E
I
L
P
S
Site 15
S147
P
H
P
Q
D
S
S
S
C
E
I
L
P
S
Q
Site 16
S153
S
S
C
E
I
L
P
S
Q
P
R
R
T
K
S
Site 17
T158
L
P
S
Q
P
R
R
T
K
S
F
L
N
Y
Y
Site 18
S160
S
Q
P
R
R
T
K
S
F
L
N
Y
Y
A
D
Site 19
Y164
R
T
K
S
F
L
N
Y
Y
A
D
L
E
T
S
Site 20
Y165
T
K
S
F
L
N
Y
Y
A
D
L
E
T
S
A
Site 21
S171
Y
Y
A
D
L
E
T
S
A
R
E
L
E
Q
N
Site 22
S190
H
G
T
A
E
E
K
S
Q
P
V
Q
G
Q
A
Site 23
S198
Q
P
V
Q
G
Q
A
S
T
I
I
G
N
G
D
Site 24
S216
Q
K
P
N
R
P
Q
S
S
P
E
D
G
Q
V
Site 25
S217
K
P
N
R
P
Q
S
S
P
E
D
G
Q
V
A
Site 26
T225
P
E
D
G
Q
V
A
T
V
S
S
S
P
E
T
Site 27
S227
D
G
Q
V
A
T
V
S
S
S
P
E
T
K
K
Site 28
S229
Q
V
A
T
V
S
S
S
P
E
T
K
K
D
H
Site 29
T232
T
V
S
S
S
P
E
T
K
K
D
H
P
K
T
Site 30
T239
T
K
K
D
H
P
K
T
G
A
K
T
D
C
A
Site 31
T243
H
P
K
T
G
A
K
T
D
C
A
L
H
R
I
Site 32
S256
R
I
Q
N
L
A
P
S
D
E
E
S
S
W
T
Site 33
S260
L
A
P
S
D
E
E
S
S
W
T
T
L
S
Q
Site 34
S261
A
P
S
D
E
E
S
S
W
T
T
L
S
Q
D
Site 35
T263
S
D
E
E
S
S
W
T
T
L
S
Q
D
S
A
Site 36
T264
D
E
E
S
S
W
T
T
L
S
Q
D
S
A
S
Site 37
S266
E
S
S
W
T
T
L
S
Q
D
S
A
S
P
S
Site 38
S269
W
T
T
L
S
Q
D
S
A
S
P
S
S
P
D
Site 39
S271
T
L
S
Q
D
S
A
S
P
S
S
P
D
E
T
Site 40
S273
S
Q
D
S
A
S
P
S
S
P
D
E
T
D
I
Site 41
S274
Q
D
S
A
S
P
S
S
P
D
E
T
D
I
W
Site 42
T278
S
P
S
S
P
D
E
T
D
I
W
S
D
H
S
Site 43
S285
T
D
I
W
S
D
H
S
F
Q
T
D
P
D
L
Site 44
S300
P
P
G
W
K
R
V
S
D
I
A
G
T
Y
Y
Site 45
Y306
V
S
D
I
A
G
T
Y
Y
W
H
I
P
T
G
Site 46
Y307
S
D
I
A
G
T
Y
Y
W
H
I
P
T
G
T
Site 47
S322
T
Q
W
E
R
P
V
S
I
P
A
D
L
Q
G
Site 48
S330
I
P
A
D
L
Q
G
S
R
K
G
S
L
S
S
Site 49
S334
L
Q
G
S
R
K
G
S
L
S
S
V
T
P
S
Site 50
S336
G
S
R
K
G
S
L
S
S
V
T
P
S
P
T
Site 51
S337
S
R
K
G
S
L
S
S
V
T
P
S
P
T
P
Site 52
T339
K
G
S
L
S
S
V
T
P
S
P
T
P
E
N
Site 53
S341
S
L
S
S
V
T
P
S
P
T
P
E
N
E
K
Site 54
T343
S
S
V
T
P
S
P
T
P
E
N
E
K
Q
P
Site 55
S352
E
N
E
K
Q
P
W
S
D
F
A
V
L
N
G
Site 56
T374
W
K
D
L
H
A
A
T
V
N
P
D
P
S
L
Site 57
S380
A
T
V
N
P
D
P
S
L
K
E
F
E
G
A
Site 58
T388
L
K
E
F
E
G
A
T
L
R
Y
A
S
L
K
Site 59
S393
G
A
T
L
R
Y
A
S
L
K
L
R
N
A
P
Site 60
S407
P
H
P
D
D
D
D
S
C
S
I
N
S
D
P
Site 61
S409
P
D
D
D
D
S
C
S
I
N
S
D
P
E
A
Site 62
S412
D
D
S
C
S
I
N
S
D
P
E
A
K
C
F
Site 63
S439
E
D
L
A
P
G
K
S
S
V
A
V
N
N
C
Site 64
Y471
W
G
E
G
K
D
M
Y
L
I
L
E
N
D
M
Site 65
S480
I
L
E
N
D
M
L
S
L
V
D
P
M
D
R
Site 66
S488
L
V
D
P
M
D
R
S
V
L
H
S
Q
P
I
Site 67
S492
M
D
R
S
V
L
H
S
Q
P
I
V
S
I
R
Site 68
Y513
D
N
G
R
D
F
A
Y
V
A
R
D
K
D
T
Site 69
T581
P
L
Q
V
D
F
P
T
P
K
T
E
L
V
Q
Site 70
T584
V
D
F
P
T
P
K
T
E
L
V
Q
K
F
H
Site 71
Y594
V
Q
K
F
H
V
Q
Y
L
G
M
L
P
V
D
Site 72
T618
S
A
I
E
N
L
M
T
S
S
N
K
E
D
W
Site 73
S658
E
C
R
V
R
F
L
S
F
M
G
V
G
K
D
Site 74
T675
T
F
A
F
I
M
D
T
G
N
Q
R
F
E
C
Site 75
S716
C
L
V
A
R
P
P
S
Q
K
V
R
P
P
P
Site 76
S728
P
P
P
P
P
A
D
S
V
T
R
R
V
T
T
Site 77
T730
P
P
P
A
D
S
V
T
R
R
V
T
T
N
V
Site 78
T734
D
S
V
T
R
R
V
T
T
N
V
K
R
G
V
Site 79
T735
S
V
T
R
R
V
T
T
N
V
K
R
G
V
L
Site 80
S743
N
V
K
R
G
V
L
S
L
I
D
T
L
K
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation