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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ABCC2
Full Name:
Canalicular multispecific organic anion transporter 1
Alias:
ATP-binding cassette sub-family C member 2; ATP-binding cassette, sub-family C (CFTR/MRP) member 2; Canalicular multidrug resistance; CMOAT; CMOAT1; CMRP; DJS; MRP2; Multidrug resistance-associated 2
Type:
Transporter
Mass (Da):
174191
Number AA:
1545
UniProt ID:
Q92887
International Prot ID:
IPI00023868
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
GO:0016020
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0042626
GO:0008514
PhosphoSite+
KinaseNET
Biological Process:
GO:0055085
GO:0051234
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
N
S
T
F
W
N
S
S
F
L
D
S
P
E
A
Site 2
S18
W
N
S
S
F
L
D
S
P
E
A
D
L
P
L
Site 3
Y52
P
W
Q
L
L
H
V
Y
K
S
R
T
K
R
S
Site 4
S54
Q
L
L
H
V
Y
K
S
R
T
K
R
S
S
T
Site 5
T56
L
H
V
Y
K
S
R
T
K
R
S
S
T
T
K
Site 6
S60
K
S
R
T
K
R
S
S
T
T
K
L
Y
L
A
Site 7
T61
S
R
T
K
R
S
S
T
T
K
L
Y
L
A
K
Site 8
Y65
R
S
S
T
T
K
L
Y
L
A
K
Q
V
F
V
Site 9
T95
T
E
D
S
G
Q
A
T
V
P
A
V
R
Y
T
Site 10
S160
T
L
L
Q
G
D
N
S
N
L
A
Y
S
C
L
Site 11
S185
I
L
I
F
S
A
F
S
E
N
N
E
S
S
N
Site 12
S190
A
F
S
E
N
N
E
S
S
N
N
P
S
S
I
Site 13
S191
F
S
E
N
N
E
S
S
N
N
P
S
S
I
A
Site 14
S195
N
E
S
S
N
N
P
S
S
I
A
S
F
L
S
Site 15
S196
E
S
S
N
N
P
S
S
I
A
S
F
L
S
S
Site 16
S199
N
N
P
S
S
I
A
S
F
L
S
S
I
T
Y
Site 17
Y209
S
S
I
T
Y
S
W
Y
D
S
I
I
L
K
G
Site 18
Y217
D
S
I
I
L
K
G
Y
K
R
P
L
T
L
E
Site 19
T222
K
G
Y
K
R
P
L
T
L
E
D
V
W
E
V
Site 20
T235
E
V
D
E
E
M
K
T
K
T
L
V
S
K
F
Site 21
T237
D
E
E
M
K
T
K
T
L
V
S
K
F
E
T
Site 22
T244
T
L
V
S
K
F
E
T
H
M
K
R
E
L
Q
Site 23
S264
L
Q
R
R
Q
E
K
S
S
Q
Q
N
S
G
A
Site 24
S265
Q
R
R
Q
E
K
S
S
Q
Q
N
S
G
A
R
Site 25
S269
E
K
S
S
Q
Q
N
S
G
A
R
L
P
G
L
Site 26
S281
P
G
L
N
K
N
Q
S
Q
S
Q
D
A
L
V
Site 27
S283
L
N
K
N
Q
S
Q
S
Q
D
A
L
V
L
E
Site 28
S299
V
E
K
K
K
K
K
S
G
T
K
K
D
V
P
Site 29
S308
T
K
K
D
V
P
K
S
W
L
M
K
A
L
F
Site 30
S351
K
L
L
I
S
F
A
S
D
R
D
T
Y
L
W
Site 31
T355
S
F
A
S
D
R
D
T
Y
L
W
I
G
Y
L
Site 32
T406
S
V
Y
K
K
A
L
T
L
S
N
L
A
R
K
Site 33
S408
Y
K
K
A
L
T
L
S
N
L
A
R
K
E
Y
Site 34
Y415
S
N
L
A
R
K
E
Y
T
V
G
E
T
V
N
Site 35
T420
K
E
Y
T
V
G
E
T
V
N
L
M
S
V
D
Site 36
S484
N
A
I
L
S
T
K
S
K
T
I
Q
V
K
N
Site 37
S607
I
S
S
M
L
Q
A
S
V
S
T
E
R
L
E
Site 38
S609
S
M
L
Q
A
S
V
S
T
E
R
L
E
K
Y
Site 39
Y616
S
T
E
R
L
E
K
Y
L
G
G
D
D
L
D
Site 40
T624
L
G
G
D
D
L
D
T
S
A
I
R
H
D
C
Site 41
S625
G
G
D
D
L
D
T
S
A
I
R
H
D
C
N
Site 42
S643
A
M
Q
F
S
E
A
S
F
T
W
E
H
D
S
Site 43
T645
Q
F
S
E
A
S
F
T
W
E
H
D
S
E
A
Site 44
S650
S
F
T
W
E
H
D
S
E
A
T
V
R
D
V
Site 45
T653
W
E
H
D
S
E
A
T
V
R
D
V
N
L
D
Site 46
S682
S
G
K
S
S
L
I
S
A
M
L
G
E
M
E
Site 47
Y703
T
I
K
G
T
T
A
Y
V
P
Q
Q
S
W
I
Site 48
T723
K
D
N
I
L
F
G
T
E
F
N
E
K
R
Y
Site 49
Y730
T
E
F
N
E
K
R
Y
Q
Q
V
L
E
A
C
Site 50
S762
G
E
K
G
I
N
L
S
G
G
Q
K
Q
R
I
Site 51
S770
G
G
Q
K
Q
R
I
S
L
A
R
A
T
Y
Q
Site 52
T775
R
I
S
L
A
R
A
T
Y
Q
N
L
D
I
Y
Site 53
Y782
T
Y
Q
N
L
D
I
Y
L
L
D
D
P
L
S
Site 54
T814
N
G
L
L
K
G
K
T
R
L
L
V
T
H
S
Site 55
Y845
T
I
V
E
K
G
S
Y
S
A
L
L
A
K
K
Site 56
T861
E
F
A
K
N
L
K
T
F
L
R
H
T
G
P
Site 57
T866
L
K
T
F
L
R
H
T
G
P
E
E
E
A
T
Site 58
T873
T
G
P
E
E
E
A
T
V
H
D
G
S
E
E
Site 59
S878
E
A
T
V
H
D
G
S
E
E
E
D
D
D
Y
Site 60
Y885
S
E
E
E
D
D
D
Y
G
L
I
S
S
V
E
Site 61
S889
D
D
D
Y
G
L
I
S
S
V
E
E
I
P
E
Site 62
S890
D
D
Y
G
L
I
S
S
V
E
E
I
P
E
D
Site 63
S900
E
I
P
E
D
A
A
S
I
T
M
R
R
E
N
Site 64
T902
P
E
D
A
A
S
I
T
M
R
R
E
N
S
F
Site 65
S908
I
T
M
R
R
E
N
S
F
R
R
T
L
S
R
Site 66
T912
R
E
N
S
F
R
R
T
L
S
R
S
S
R
S
Site 67
S914
N
S
F
R
R
T
L
S
R
S
S
R
S
N
G
Site 68
S916
F
R
R
T
L
S
R
S
S
R
S
N
G
R
H
Site 69
S917
R
R
T
L
S
R
S
S
R
S
N
G
R
H
L
Site 70
S926
S
N
G
R
H
L
K
S
L
R
N
S
L
K
T
Site 71
S930
H
L
K
S
L
R
N
S
L
K
T
R
N
V
N
Site 72
T933
S
L
R
N
S
L
K
T
R
N
V
N
S
L
K
Site 73
S938
L
K
T
R
N
V
N
S
L
K
E
D
E
E
L
Site 74
T959
I
K
K
E
F
I
E
T
G
K
V
K
F
S
I
Site 75
S1001
I
G
S
N
L
W
L
S
A
W
T
S
D
S
K
Site 76
S1005
L
W
L
S
A
W
T
S
D
S
K
I
F
N
S
Site 77
S1007
L
S
A
W
T
S
D
S
K
I
F
N
S
T
D
Site 78
S1012
S
D
S
K
I
F
N
S
T
D
Y
P
A
S
Q
Site 79
Y1015
K
I
F
N
S
T
D
Y
P
A
S
Q
R
D
M
Site 80
S1018
N
S
T
D
Y
P
A
S
Q
R
D
M
R
V
G
Site 81
T1074
A
P
M
R
F
F
D
T
T
P
T
G
R
I
V
Site 82
T1075
P
M
R
F
F
D
T
T
P
T
G
R
I
V
N
Site 83
T1090
R
F
A
G
D
I
S
T
V
D
D
T
L
P
Q
Site 84
T1094
D
I
S
T
V
D
D
T
L
P
Q
S
L
R
S
Site 85
S1098
V
D
D
T
L
P
Q
S
L
R
S
W
I
T
C
Site 86
S1143
S
V
Q
M
F
Y
V
S
T
S
R
Q
L
R
R
Site 87
S1153
R
Q
L
R
R
L
D
S
V
T
R
S
P
I
Y
Site 88
T1155
L
R
R
L
D
S
V
T
R
S
P
I
Y
S
H
Site 89
S1157
R
L
D
S
V
T
R
S
P
I
Y
S
H
F
S
Site 90
Y1160
S
V
T
R
S
P
I
Y
S
H
F
S
E
T
V
Site 91
S1161
V
T
R
S
P
I
Y
S
H
F
S
E
T
V
S
Site 92
S1164
S
P
I
Y
S
H
F
S
E
T
V
S
G
L
P
Site 93
T1192
H
N
E
V
R
I
D
T
N
Q
K
C
V
F
S
Site 94
T1237
R
D
T
L
S
G
D
T
V
G
F
V
L
S
N
Site 95
T1259
L
N
W
L
V
R
M
T
S
E
I
E
T
N
I
Site 96
T1264
R
M
T
S
E
I
E
T
N
I
V
A
V
E
R
Site 97
T1273
I
V
A
V
E
R
I
T
E
Y
T
K
V
E
N
Site 98
S1296
R
P
P
P
D
W
P
S
K
G
K
I
Q
F
N
Site 99
Y1305
G
K
I
Q
F
N
N
Y
Q
V
R
Y
R
P
E
Site 100
S1341
G
R
T
G
A
G
K
S
S
L
T
N
C
L
F
Site 101
S1342
R
T
G
A
G
K
S
S
L
T
N
C
L
F
R
Site 102
T1378
H
D
L
R
E
K
L
T
I
I
P
Q
D
P
I
Site 103
S1388
P
Q
D
P
I
L
F
S
G
S
L
R
M
N
L
Site 104
S1390
D
P
I
L
F
S
G
S
L
R
M
N
L
D
P
Site 105
S1402
L
D
P
F
N
N
Y
S
D
E
E
I
W
K
A
Site 106
T1431
L
G
L
S
H
E
V
T
E
A
G
G
N
L
S
Site 107
S1438
T
E
A
G
G
N
L
S
I
G
Q
R
Q
L
L
Site 108
S1455
G
R
A
L
L
R
K
S
K
I
L
V
L
D
E
Site 109
T1497
T
I
A
H
R
L
H
T
I
M
D
S
D
K
V
Site 110
S1501
R
L
H
T
I
M
D
S
D
K
V
M
V
L
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation