KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
ERCC4
Full Name:
DNA repair endonuclease XPF
Alias:
DNA excision repair protein ERCC-4; DNA repair protein complementing XP-F cells; Excision repair cross-complementing rodent repair deficiency, complementation group 4; RAD1; Xeroderma pigmentosum group F-complementing protein; Xeroderma pigmentosum, complementation group F; XPF
Type:
Deoxyribonuclease; EC 3.1.-.-; DNA repair
Mass (Da):
104486
Number AA:
916
UniProt ID:
Q92889
International Prot ID:
IPI00784335
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000784
GO:0005654
GO:0000109
Uniprot
OncoNet
Molecular Function:
GO:0003684
GO:0004520
GO:0000287
PhosphoSite+
KinaseNET
Biological Process:
GO:0000724
GO:0032205
GO:0000718
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y71
T
Q
P
A
E
E
E
Y
F
I
N
Q
L
K
I
Site 2
T89
E
H
L
P
R
R
V
T
N
E
I
T
S
N
S
Site 3
Y98
E
I
T
S
N
S
R
Y
E
V
Y
T
Q
G
G
Site 4
Y101
S
N
S
R
Y
E
V
Y
T
Q
G
G
V
I
F
Site 5
T102
N
S
R
Y
E
V
Y
T
Q
G
G
V
I
F
A
Site 6
Y191
N
L
F
V
R
K
L
Y
L
W
P
R
F
H
V
Site 7
S202
R
F
H
V
A
V
N
S
F
L
E
Q
H
K
P
Site 8
S253
S
L
E
V
E
D
L
S
L
E
N
A
I
G
K
Site 9
T265
I
G
K
P
F
D
K
T
I
R
H
Y
L
D
P
Site 10
Y269
F
D
K
T
I
R
H
Y
L
D
P
L
W
H
Q
Site 11
S283
Q
L
G
A
K
T
K
S
L
V
Q
D
L
K
I
Site 12
T293
Q
D
L
K
I
L
R
T
L
L
Q
Y
L
S
Q
Site 13
S299
R
T
L
L
Q
Y
L
S
Q
Y
D
C
V
T
F
Site 14
S312
T
F
L
N
L
L
E
S
L
R
A
T
E
K
A
Site 15
T316
L
L
E
S
L
R
A
T
E
K
A
F
G
Q
N
Site 16
S324
E
K
A
F
G
Q
N
S
G
W
L
F
L
D
S
Site 17
Y344
I
N
A
R
A
R
V
Y
H
L
P
D
A
K
M
Site 18
S398
I
E
A
E
N
K
E
S
E
A
L
G
G
P
G
Site 19
S412
G
Q
V
L
I
C
A
S
D
D
R
T
C
S
Q
Site 20
T416
I
C
A
S
D
D
R
T
C
S
Q
L
R
D
Y
Site 21
S418
A
S
D
D
R
T
C
S
Q
L
R
D
Y
I
T
Site 22
Y423
T
C
S
Q
L
R
D
Y
I
T
L
G
A
E
A
Site 23
Y436
E
A
F
L
L
R
L
Y
R
K
T
F
E
K
D
Site 24
T439
L
L
R
L
Y
R
K
T
F
E
K
D
S
K
A
Site 25
S444
R
K
T
F
E
K
D
S
K
A
E
E
V
W
M
Site 26
S458
M
K
F
R
K
E
D
S
S
K
R
I
R
K
S
Site 27
S459
K
F
R
K
E
D
S
S
K
R
I
R
K
S
H
Site 28
S465
S
S
K
R
I
R
K
S
H
K
R
P
K
D
P
Site 29
S479
P
Q
N
K
E
R
A
S
T
K
E
R
T
L
K
Site 30
T480
Q
N
K
E
R
A
S
T
K
E
R
T
L
K
K
Site 31
T493
K
K
K
K
R
K
L
T
L
T
Q
M
V
G
K
Site 32
T495
K
K
R
K
L
T
L
T
Q
M
V
G
K
P
E
Site 33
Y514
E
G
D
V
E
E
G
Y
R
R
E
I
S
S
S
Site 34
S519
E
G
Y
R
R
E
I
S
S
S
P
E
S
C
P
Site 35
S520
G
Y
R
R
E
I
S
S
S
P
E
S
C
P
E
Site 36
S521
Y
R
R
E
I
S
S
S
P
E
S
C
P
E
E
Site 37
S524
E
I
S
S
S
P
E
S
C
P
E
E
I
K
H
Site 38
Y577
L
H
E
V
E
P
R
Y
V
V
L
Y
D
A
E
Site 39
Y594
F
V
R
Q
L
E
I
Y
R
A
S
R
P
G
K
Site 40
S597
Q
L
E
I
Y
R
A
S
R
P
G
K
P
L
R
Site 41
S613
Y
F
L
I
Y
G
G
S
T
E
E
Q
R
Y
L
Site 42
Y619
G
S
T
E
E
Q
R
Y
L
T
A
L
R
K
E
Site 43
T621
T
E
E
Q
R
Y
L
T
A
L
R
K
E
K
E
Site 44
T652
E
R
E
G
R
D
E
T
N
L
D
L
V
R
G
Site 45
T660
N
L
D
L
V
R
G
T
A
S
A
D
V
S
T
Site 46
S662
D
L
V
R
G
T
A
S
A
D
V
S
T
D
T
Site 47
S666
G
T
A
S
A
D
V
S
T
D
T
R
K
A
G
Site 48
T667
T
A
S
A
D
V
S
T
D
T
R
K
A
G
G
Site 49
T669
S
A
D
V
S
T
D
T
R
K
A
G
G
Q
E
Site 50
T680
G
G
Q
E
Q
N
G
T
Q
Q
S
I
V
V
D
Site 51
S683
E
Q
N
G
T
Q
Q
S
I
V
V
D
M
R
E
Site 52
S693
V
D
M
R
E
F
R
S
E
L
P
S
L
I
H
Site 53
S697
E
F
R
S
E
L
P
S
L
I
H
R
R
G
I
Site 54
T719
E
V
G
D
Y
I
L
T
P
E
M
C
V
E
R
Site 55
S728
E
M
C
V
E
R
K
S
I
S
D
L
I
G
S
Site 56
S730
C
V
E
R
K
S
I
S
D
L
I
G
S
L
N
Site 57
S735
S
I
S
D
L
I
G
S
L
N
N
G
R
L
Y
Site 58
Y742
S
L
N
N
G
R
L
Y
S
Q
C
I
S
M
S
Site 59
S743
L
N
N
G
R
L
Y
S
Q
C
I
S
M
S
R
Site 60
Y751
Q
C
I
S
M
S
R
Y
Y
K
R
P
V
L
L
Site 61
Y752
C
I
S
M
S
R
Y
Y
K
R
P
V
L
L
I
Site 62
S768
F
D
P
S
K
P
F
S
L
T
S
R
G
A
L
Site 63
T770
P
S
K
P
F
S
L
T
S
R
G
A
L
F
Q
Site 64
S780
G
A
L
F
Q
E
I
S
S
N
D
I
S
S
K
Site 65
S781
A
L
F
Q
E
I
S
S
N
D
I
S
S
K
L
Site 66
S785
E
I
S
S
N
D
I
S
S
K
L
T
L
L
T
Site 67
T792
S
S
K
L
T
L
L
T
L
H
F
P
R
L
R
Site 68
T809
W
C
P
S
P
H
A
T
A
E
L
F
E
E
L
Site 69
S835
A
L
A
I
T
A
D
S
E
T
L
P
E
S
E
Site 70
T837
A
I
T
A
D
S
E
T
L
P
E
S
E
K
Y
Site 71
S841
D
S
E
T
L
P
E
S
E
K
Y
N
P
G
P
Site 72
Y844
T
L
P
E
S
E
K
Y
N
P
G
P
Q
D
F
Site 73
Y898
A
A
N
A
K
Q
L
Y
D
F
I
H
T
S
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation