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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
UPF1
Full Name:
Regulator of nonsense transcripts 1
Alias:
ATP-dependent helicase RENT1; HUPF1; KIAA0221; Nonsense mRNA reducing factor 1; NORF1; PNORF1; RENT1; RNT1; UP Frameshift 1; UPF1 regulator of nonsense transcripts; Up-frameshift suppressor 1 homolog
Type:
EC 3.6.1.-; Hydrolase
Mass (Da):
124345
Number AA:
1129
UniProt ID:
Q92900
International Prot ID:
IPI00034049
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000785
GO:0000932
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004004
GO:0003677
PhosphoSite+
KinaseNET
Biological Process:
GO:0006281
GO:0006260
GO:0007049
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y6
_
_
M
S
V
E
A
Y
G
P
S
S
Q
T
L
Site 2
S10
V
E
A
Y
G
P
S
S
Q
T
L
T
F
L
D
Site 3
T14
G
P
S
S
Q
T
L
T
F
L
D
T
E
E
A
Site 4
T18
Q
T
L
T
F
L
D
T
E
E
A
E
L
L
G
Site 5
T28
A
E
L
L
G
A
D
T
Q
G
S
E
F
E
F
Site 6
S31
L
G
A
D
T
Q
G
S
E
F
E
F
T
D
F
Site 7
T36
Q
G
S
E
F
E
F
T
D
F
T
L
P
S
Q
Site 8
T39
E
F
E
F
T
D
F
T
L
P
S
Q
T
Q
T
Site 9
S42
F
T
D
F
T
L
P
S
Q
T
Q
T
P
P
G
Site 10
T44
D
F
T
L
P
S
Q
T
Q
T
P
P
G
G
P
Site 11
T46
T
L
P
S
Q
T
Q
T
P
P
G
G
P
G
G
Site 12
S92
Q
N
G
A
V
D
D
S
V
A
K
T
S
Q
L
Site 13
Y113
E
E
D
E
E
D
T
Y
Y
T
K
D
L
P
I
Site 14
Y114
E
D
E
E
D
T
Y
Y
T
K
D
L
P
I
H
Site 15
Y136
H
D
P
A
C
V
V
Y
C
N
T
S
K
K
W
Site 16
T151
F
C
N
G
R
G
N
T
S
G
S
H
I
V
N
Site 17
S154
G
R
G
N
T
S
G
S
H
I
V
N
H
L
V
Site 18
T179
K
D
G
P
L
G
E
T
V
L
E
C
Y
N
C
Site 19
Y184
G
E
T
V
L
E
C
Y
N
C
G
C
R
N
V
Site 20
S215
L
C
R
Q
P
C
A
S
Q
S
S
L
K
D
I
Site 21
S218
Q
P
C
A
S
Q
S
S
L
K
D
I
N
W
D
Site 22
S247
S
W
L
V
K
I
P
S
E
Q
E
Q
L
R
A
Site 23
T258
Q
L
R
A
R
Q
I
T
A
Q
Q
I
N
K
L
Site 24
Y296
P
Q
H
V
L
L
R
Y
E
D
A
Y
Q
Y
Q
Site 25
Y300
L
L
R
Y
E
D
A
Y
Q
Y
Q
N
I
F
G
Site 26
Y302
R
Y
E
D
A
Y
Q
Y
Q
N
I
F
G
P
L
Site 27
Y316
L
V
K
L
E
A
D
Y
D
K
K
L
K
E
S
Site 28
T325
K
K
L
K
E
S
Q
T
Q
D
N
I
T
V
R
Site 29
T330
S
Q
T
Q
D
N
I
T
V
R
W
D
L
G
L
Site 30
Y344
L
N
K
K
R
I
A
Y
F
T
L
P
K
T
D
Site 31
T346
K
K
R
I
A
Y
F
T
L
P
K
T
D
S
G
Site 32
T350
A
Y
F
T
L
P
K
T
D
S
G
N
E
D
L
Site 33
S352
F
T
L
P
K
T
D
S
G
N
E
D
L
V
I
Site 34
Y398
V
I
K
V
P
D
N
Y
G
D
E
I
A
I
E
Site 35
S430
D
F
V
W
K
S
T
S
F
D
R
M
Q
S
A
Site 36
S436
T
S
F
D
R
M
Q
S
A
L
K
T
F
A
V
Site 37
T440
R
M
Q
S
A
L
K
T
F
A
V
D
E
T
S
Site 38
T446
K
T
F
A
V
D
E
T
S
V
S
G
Y
I
Y
Site 39
S447
T
F
A
V
D
E
T
S
V
S
G
Y
I
Y
H
Site 40
Y451
D
E
T
S
V
S
G
Y
I
Y
H
K
L
L
G
Site 41
Y453
T
S
V
S
G
Y
I
Y
H
K
L
L
G
H
E
Site 42
T475
C
Q
L
P
K
R
F
T
A
Q
G
L
P
D
L
Site 43
S485
G
L
P
D
L
N
H
S
Q
V
Y
A
V
K
T
Site 44
Y488
D
L
N
H
S
Q
V
Y
A
V
K
T
V
L
Q
Site 45
T492
S
Q
V
Y
A
V
K
T
V
L
Q
R
P
L
S
Site 46
S499
T
V
L
Q
R
P
L
S
L
I
Q
G
P
P
G
Site 47
T542
N
I
A
V
D
Q
L
T
E
K
I
H
Q
T
G
Site 48
S559
V
V
R
L
C
A
K
S
R
E
A
I
D
S
P
Site 49
S568
E
A
I
D
S
P
V
S
F
L
A
L
H
N
Q
Site 50
S581
N
Q
I
R
N
M
D
S
M
P
E
L
Q
K
L
Site 51
T595
L
Q
Q
L
K
D
E
T
G
E
L
S
S
A
D
Site 52
S599
K
D
E
T
G
E
L
S
S
A
D
E
K
R
Y
Site 53
T612
R
Y
R
A
L
K
R
T
A
E
R
E
L
L
M
Site 54
T650
S
I
L
I
D
E
S
T
Q
A
T
E
P
E
C
Site 55
T653
I
D
E
S
T
Q
A
T
E
P
E
C
M
V
P
Site 56
S692
K
A
A
K
A
G
L
S
Q
S
L
F
E
R
L
Site 57
Y713
P
I
R
L
Q
V
Q
Y
R
M
H
P
A
L
S
Site 58
S720
Y
R
M
H
P
A
L
S
A
F
P
S
N
I
F
Site 59
Y728
A
F
P
S
N
I
F
Y
E
G
S
L
Q
N
G
Site 60
S731
S
N
I
F
Y
E
G
S
L
Q
N
G
V
T
A
Site 61
Y760
P
D
K
P
M
F
F
Y
V
T
Q
G
Q
E
E
Site 62
S770
Q
G
Q
E
E
I
A
S
S
G
T
S
Y
L
N
Site 63
S771
G
Q
E
E
I
A
S
S
G
T
S
Y
L
N
R
Site 64
S774
E
I
A
S
S
G
T
S
Y
L
N
R
T
E
A
Site 65
Y775
I
A
S
S
G
T
S
Y
L
N
R
T
E
A
A
Site 66
T805
P
D
Q
I
G
I
I
T
P
Y
E
G
Q
R
S
Site 67
Y807
Q
I
G
I
I
T
P
Y
E
G
Q
R
S
Y
L
Site 68
Y813
P
Y
E
G
Q
R
S
Y
L
V
Q
Y
M
Q
F
Site 69
Y817
Q
R
S
Y
L
V
Q
Y
M
Q
F
S
G
S
L
Site 70
S823
Q
Y
M
Q
F
S
G
S
L
H
T
K
L
Y
Q
Site 71
Y829
G
S
L
H
T
K
L
Y
Q
E
V
E
I
A
S
Site 72
T875
R
R
L
N
V
A
L
T
R
A
R
Y
G
V
I
Site 73
Y879
V
A
L
T
R
A
R
Y
G
V
I
I
V
G
N
Site 74
S891
V
G
N
P
K
A
L
S
K
Q
P
L
W
N
H
Site 75
S920
P
L
N
N
L
R
E
S
L
M
Q
F
S
K
P
Site 76
S925
R
E
S
L
M
Q
F
S
K
P
R
K
L
V
N
Site 77
T933
K
P
R
K
L
V
N
T
I
N
P
G
A
R
F
Site 78
T942
N
P
G
A
R
F
M
T
T
A
M
Y
D
A
R
Site 79
Y946
R
F
M
T
T
A
M
Y
D
A
R
E
A
I
I
Site 80
S956
R
E
A
I
I
P
G
S
V
Y
D
R
S
S
Q
Site 81
Y958
A
I
I
P
G
S
V
Y
D
R
S
S
Q
G
R
Site 82
S961
P
G
S
V
Y
D
R
S
S
Q
G
R
P
S
S
Site 83
S962
G
S
V
Y
D
R
S
S
Q
G
R
P
S
S
M
Site 84
S967
R
S
S
Q
G
R
P
S
S
M
Y
F
Q
T
H
Site 85
S968
S
S
Q
G
R
P
S
S
M
Y
F
Q
T
H
D
Site 86
Y970
Q
G
R
P
S
S
M
Y
F
Q
T
H
D
Q
I
Site 87
S981
H
D
Q
I
G
M
I
S
A
G
P
S
H
V
A
Site 88
Y1008
P
P
M
P
P
P
G
Y
F
G
Q
A
N
G
P
Site 89
T1021
G
P
A
A
G
R
G
T
P
K
G
K
T
G
R
Site 90
T1026
R
G
T
P
K
G
K
T
G
R
G
G
R
Q
K
Site 91
S1042
R
F
G
L
P
G
P
S
Q
T
N
L
P
N
S
Site 92
T1044
G
L
P
G
P
S
Q
T
N
L
P
N
S
Q
A
Site 93
S1049
S
Q
T
N
L
P
N
S
Q
A
S
Q
D
V
A
Site 94
S1052
N
L
P
N
S
Q
A
S
Q
D
V
A
S
Q
P
Site 95
S1057
Q
A
S
Q
D
V
A
S
Q
P
F
S
Q
G
A
Site 96
S1061
D
V
A
S
Q
P
F
S
Q
G
A
L
T
Q
G
Site 97
T1066
P
F
S
Q
G
A
L
T
Q
G
Y
I
S
M
S
Site 98
Y1069
Q
G
A
L
T
Q
G
Y
I
S
M
S
Q
P
S
Site 99
S1073
T
Q
G
Y
I
S
M
S
Q
P
S
Q
M
S
Q
Site 100
S1076
Y
I
S
M
S
Q
P
S
Q
M
S
Q
P
G
L
Site 101
S1079
M
S
Q
P
S
Q
M
S
Q
P
G
L
S
Q
P
Site 102
S1084
Q
M
S
Q
P
G
L
S
Q
P
E
L
S
Q
D
Site 103
S1089
Y
L
G
D
E
F
K
S
Q
I
D
V
A
L
S
Site 104
Y1093
P
E
L
S
Q
D
S
Y
L
G
D
E
F
K
S
Site 105
S1100
Y
L
G
D
E
F
K
S
Q
I
D
V
A
L
S
Site 106
S1107
S
Q
I
D
V
A
L
S
Q
D
S
T
Y
Q
G
Site 107
S1110
D
V
A
L
S
Q
D
S
T
Y
Q
G
E
R
A
Site 108
T1111
V
A
L
S
Q
D
S
T
Y
Q
G
E
R
A
Y
Site 109
Y1112
A
L
S
Q
D
S
T
Y
Q
G
E
R
A
Y
Q
Site 110
Y1118
T
Y
Q
G
E
R
A
Y
Q
H
G
G
V
T
G
Site 111
T1124
A
Y
Q
H
G
G
V
T
G
L
S
Q
Y
_
_
Site 112
S1127
H
G
G
V
T
G
L
S
Q
Y
_
_
_
_
_
Site 113
Y1129
G
V
T
G
L
S
Q
Y
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation