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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TNPO1
Full Name:
Transportin-1
Alias:
Importin beta 2; Importin beta-2; IPO2; Karyopherin (importin) beta 2; Karyopherin beta-2; M9 region interaction; MIP; MIP1; TRN
Type:
Karyopherin
Mass (Da):
102355
Number AA:
898
UniProt ID:
Q92973
International Prot ID:
IPI00843876
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0008139
GO:0005515
GO:0008565
PhosphoSite+
KinaseNET
Biological Process:
GO:0044419
GO:0000060
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S30
I
L
Q
L
L
K
E
S
Q
S
P
D
T
T
I
Site 2
S32
Q
L
L
K
E
S
Q
S
P
D
T
T
I
Q
R
Site 3
T35
K
E
S
Q
S
P
D
T
T
I
Q
R
T
V
Q
Site 4
T36
E
S
Q
S
P
D
T
T
I
Q
R
T
V
Q
Q
Site 5
T40
P
D
T
T
I
Q
R
T
V
Q
Q
K
L
E
Q
Site 6
Y51
K
L
E
Q
L
N
Q
Y
P
D
F
N
N
Y
L
Site 7
Y57
Q
Y
P
D
F
N
N
Y
L
I
F
V
L
T
K
Site 8
T63
N
Y
L
I
F
V
L
T
K
L
K
S
E
D
E
Site 9
S67
F
V
L
T
K
L
K
S
E
D
E
P
T
R
S
Site 10
T72
L
K
S
E
D
E
P
T
R
S
L
S
G
L
I
Site 11
S74
S
E
D
E
P
T
R
S
L
S
G
L
I
L
K
Site 12
S76
D
E
P
T
R
S
L
S
G
L
I
L
K
N
N
Site 13
S143
D
L
L
P
K
L
C
S
L
L
D
S
E
D
Y
Site 14
S147
K
L
C
S
L
L
D
S
E
D
Y
N
T
C
E
Site 15
Y150
S
L
L
D
S
E
D
Y
N
T
C
E
G
A
F
Site 16
T152
L
D
S
E
D
Y
N
T
C
E
G
A
F
G
A
Site 17
S167
L
Q
K
I
C
E
D
S
A
E
I
L
D
S
D
Site 18
S173
D
S
A
E
I
L
D
S
D
V
L
D
R
P
L
Site 19
S194
F
L
Q
F
F
K
H
S
S
P
K
I
R
S
H
Site 20
S195
L
Q
F
F
K
H
S
S
P
K
I
R
S
H
A
Site 21
S200
H
S
S
P
K
I
R
S
H
A
V
A
C
V
N
Site 22
T335
G
D
V
E
E
D
E
T
I
P
D
S
E
Q
D
Site 23
S339
E
D
E
T
I
P
D
S
E
Q
D
I
R
P
R
Site 24
T352
P
R
F
H
R
S
R
T
V
A
Q
Q
H
D
E
Site 25
T377
D
E
I
D
D
D
D
T
I
S
D
W
N
L
R
Site 26
S456
P
H
L
I
Q
C
L
S
D
K
K
A
L
V
R
Site 27
S464
D
K
K
A
L
V
R
S
I
T
C
W
T
L
S
Site 28
Y473
T
C
W
T
L
S
R
Y
A
H
W
V
V
S
Q
Site 29
T484
V
V
S
Q
P
P
D
T
Y
L
K
P
L
M
T
Site 30
Y485
V
S
Q
P
P
D
T
Y
L
K
P
L
M
T
E
Site 31
S500
L
L
K
R
I
L
D
S
N
K
R
V
Q
E
A
Site 32
S510
R
V
Q
E
A
A
C
S
A
F
A
T
L
E
E
Site 33
S559
A
I
G
T
L
A
D
S
V
G
H
H
L
N
K
Site 34
Y569
H
H
L
N
K
P
E
Y
I
Q
M
L
M
P
P
Site 35
Y612
L
Q
S
G
F
L
P
Y
C
E
P
V
Y
Q
R
Site 36
Y641
N
N
A
Q
P
D
Q
Y
E
A
P
D
K
D
F
Site 37
Y681
S
N
I
L
T
L
M
Y
Q
C
M
Q
D
K
M
Site 38
S694
K
M
P
E
V
R
Q
S
S
F
A
L
L
G
D
Site 39
T771
E
I
I
N
R
P
N
T
P
K
T
L
L
E
N
Site 40
T774
N
R
P
N
T
P
K
T
L
L
E
N
T
A
I
Site 41
T782
L
L
E
N
T
A
I
T
I
G
R
L
G
Y
V
Site 42
S820
R
D
N
E
E
K
D
S
A
F
R
G
I
C
T
Site 43
S881
D
E
N
W
R
R
F
S
D
Q
F
P
L
P
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation