KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
USP13
Full Name:
Ubiquitin carboxyl-terminal hydrolase 13
Alias:
Deubiquitinating enzyme 13; EC 3.1.2.15; Isopeptidase T-3; ISOT3; ISOT-3; Ubiquitin thioesterase 13; Ubiquitin-specific-processing protease 13; UBP13
Type:
Ubiquitin conjugating system
Mass (Da):
97327
Number AA:
863
UniProt ID:
Q92995
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0004197
GO:0004221
GO:0004843
PhosphoSite+
KinaseNET
Biological Process:
GO:0006511
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
L
F
G
M
P
G
G
S
G
G
R
K
M
A
A
Site 2
T34
L
L
V
P
H
M
P
T
I
R
V
P
R
S
G
Site 3
S40
P
T
I
R
V
P
R
S
G
D
R
V
Y
K
N
Site 4
Y45
P
R
S
G
D
R
V
Y
K
N
E
C
A
F
S
Site 5
S52
Y
K
N
E
C
A
F
S
Y
D
S
P
N
S
E
Site 6
Y53
K
N
E
C
A
F
S
Y
D
S
P
N
S
E
G
Site 7
S55
E
C
A
F
S
Y
D
S
P
N
S
E
G
G
L
Site 8
S58
F
S
Y
D
S
P
N
S
E
G
G
L
Y
V
C
Site 9
Y63
P
N
S
E
G
G
L
Y
V
C
M
N
T
F
L
Site 10
T84
V
E
R
H
F
R
K
T
G
Q
S
V
Y
M
H
Site 11
Y89
R
K
T
G
Q
S
V
Y
M
H
L
K
R
H
V
Site 12
S104
R
E
K
V
R
G
A
S
G
G
A
L
P
K
R
Site 13
S114
A
L
P
K
R
R
N
S
K
I
F
L
D
L
D
Site 14
T122
K
I
F
L
D
L
D
T
D
D
D
L
N
S
D
Site 15
S128
D
T
D
D
D
L
N
S
D
D
Y
E
Y
E
D
Site 16
Y131
D
D
L
N
S
D
D
Y
E
Y
E
D
E
A
K
Site 17
Y133
L
N
S
D
D
Y
E
Y
E
D
E
A
K
L
V
Site 18
S169
I
A
C
D
A
V
L
S
S
K
S
P
Y
R
K
Site 19
S170
A
C
D
A
V
L
S
S
K
S
P
Y
R
K
Q
Site 20
S172
D
A
V
L
S
S
K
S
P
Y
R
K
Q
D
P
Site 21
T181
Y
R
K
Q
D
P
D
T
W
E
N
E
L
P
V
Site 22
Y191
N
E
L
P
V
S
K
Y
A
N
N
L
T
Q
L
Site 23
T196
S
K
Y
A
N
N
L
T
Q
L
D
N
G
V
R
Site 24
S228
W
L
N
L
T
D
G
S
V
L
C
G
K
W
F
Site 25
S239
G
K
W
F
F
D
S
S
G
G
N
G
H
A
L
Site 26
Y249
N
G
H
A
L
E
H
Y
R
D
M
G
Y
P
L
Site 27
Y254
E
H
Y
R
D
M
G
Y
P
L
A
V
K
L
G
Site 28
Y271
T
P
D
G
A
D
V
Y
S
F
Q
E
E
E
P
Site 29
S272
P
D
G
A
D
V
Y
S
F
Q
E
E
E
P
V
Site 30
S315
N
D
I
K
L
R
V
S
E
W
E
V
I
Q
E
Site 31
Y331
G
T
K
L
K
P
M
Y
G
P
G
Y
T
G
L
Site 32
Y335
K
P
M
Y
G
P
G
Y
T
G
L
K
N
L
G
Site 33
Y346
K
N
L
G
N
S
C
Y
L
S
S
V
M
Q
A
Site 34
Y364
I
P
E
F
Q
R
A
Y
V
G
N
L
P
R
I
Site 35
Y374
N
L
P
R
I
F
D
Y
S
P
L
D
P
T
Q
Site 36
S375
L
P
R
I
F
D
Y
S
P
L
D
P
T
Q
D
Site 37
T380
D
Y
S
P
L
D
P
T
Q
D
F
N
T
Q
M
Site 38
T385
D
P
T
Q
D
F
N
T
Q
M
T
K
L
G
H
Site 39
T388
Q
D
F
N
T
Q
M
T
K
L
G
H
G
L
L
Site 40
S396
K
L
G
H
G
L
L
S
G
Q
Y
S
K
P
P
Site 41
Y399
H
G
L
L
S
G
Q
Y
S
K
P
P
V
K
S
Site 42
S400
G
L
L
S
G
Q
Y
S
K
P
P
V
K
S
E
Site 43
S406
Y
S
K
P
P
V
K
S
E
L
I
E
Q
V
M
Site 44
S425
K
P
Q
Q
N
G
I
S
P
R
M
F
K
A
F
Site 45
S434
R
M
F
K
A
F
V
S
K
S
H
P
E
F
S
Site 46
S436
F
K
A
F
V
S
K
S
H
P
E
F
S
S
N
Site 47
S441
S
K
S
H
P
E
F
S
S
N
R
Q
Q
D
A
Site 48
S442
K
S
H
P
E
F
S
S
N
R
Q
Q
D
A
Q
Site 49
S466
V
E
R
N
R
I
G
S
E
N
P
S
D
V
F
Site 50
S470
R
I
G
S
E
N
P
S
D
V
F
R
F
L
V
Site 51
T492
Q
T
R
K
V
R
Y
T
E
R
V
D
Y
L
M
Site 52
Y497
R
Y
T
E
R
V
D
Y
L
M
Q
L
P
V
A
Site 53
Y517
N
K
D
E
L
I
A
Y
E
L
T
R
R
E
A
Site 54
S566
S
S
A
L
Q
A
K
S
A
G
V
K
T
S
R
Site 55
T571
A
K
S
A
G
V
K
T
S
R
F
A
S
F
P
Site 56
S572
K
S
A
G
V
K
T
S
R
F
A
S
F
P
E
Site 57
Y580
R
F
A
S
F
P
E
Y
L
V
V
Q
I
K
K
Site 58
S630
E
E
E
L
P
D
I
S
P
P
I
V
I
P
D
Site 59
S639
P
I
V
I
P
D
D
S
K
D
R
L
M
N
Q
Site 60
S651
M
N
Q
L
I
D
P
S
D
I
D
E
S
S
V
Site 61
S656
D
P
S
D
I
D
E
S
S
V
M
Q
L
A
E
Site 62
S657
P
S
D
I
D
E
S
S
V
M
Q
L
A
E
M
Site 63
Y676
E
A
C
R
K
A
V
Y
F
T
G
N
M
G
A
Site 64
T704
P
D
F
A
E
P
L
T
M
P
G
Y
G
G
A
Site 65
Y708
E
P
L
T
M
P
G
Y
G
G
A
A
S
A
G
Site 66
T753
A
I
Q
A
L
R
A
T
N
N
N
L
E
R
A
Site 67
S766
R
A
L
D
W
I
F
S
H
P
E
F
E
E
D
Site 68
S774
H
P
E
F
E
E
D
S
D
F
V
I
E
M
E
Site 69
S803
G
P
R
V
K
D
G
S
G
T
Y
E
L
F
A
Site 70
T817
A
F
I
S
H
M
G
T
S
T
M
S
G
H
Y
Site 71
Y837
K
E
G
R
W
V
I
Y
N
D
H
K
V
C
A
Site 72
S845
N
D
H
K
V
C
A
S
E
R
P
P
K
D
L
Site 73
Y854
R
P
P
K
D
L
G
Y
M
Y
F
Y
R
R
I
Site 74
Y856
P
K
D
L
G
Y
M
Y
F
Y
R
R
I
P
S
Site 75
Y858
D
L
G
Y
M
Y
F
Y
R
R
I
P
S
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation