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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DVL3
Full Name:
Segment polarity protein dishevelled homolog DVL-3
Alias:
Dishevelled 3; Dishevelled-3; DSH 3; DSH-3; Segment polarity protein dishevelled DVL-3
Type:
Intracellular, Cytoplasm protein
Mass (Da):
78055
Number AA:
716
UniProt ID:
Q92997
International Prot ID:
IPI00643141
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0008013
GO:0004871
PhosphoSite+
KinaseNET
Biological Process:
GO:0016055
GO:0007507
GO:0007242
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y8
M
G
E
T
K
I
I
Y
H
L
D
G
Q
E
T
Site 2
T15
Y
H
L
D
G
Q
E
T
P
Y
L
V
K
L
P
Site 3
Y17
L
D
G
Q
E
T
P
Y
L
V
K
L
P
L
P
Site 4
S41
K
G
V
L
Q
R
P
S
Y
K
F
F
F
K
S
Site 5
Y42
G
V
L
Q
R
P
S
Y
K
F
F
F
K
S
M
Site 6
S48
S
Y
K
F
F
F
K
S
M
D
D
D
F
G
V
Site 7
S80
R
V
V
S
W
L
V
S
A
E
G
S
H
P
D
Site 8
S84
W
L
V
S
A
E
G
S
H
P
D
P
A
P
F
Site 9
S97
P
F
C
A
D
N
P
S
E
L
P
P
P
M
E
Site 10
S112
R
T
G
G
I
G
D
S
R
P
P
S
F
H
P
Site 11
S116
I
G
D
S
R
P
P
S
F
H
P
H
A
G
G
Site 12
S125
H
P
H
A
G
G
G
S
Q
E
N
L
D
N
D
Site 13
T133
Q
E
N
L
D
N
D
T
E
T
D
S
L
V
S
Site 14
T135
N
L
D
N
D
T
E
T
D
S
L
V
S
A
Q
Site 15
S137
D
N
D
T
E
T
D
S
L
V
S
A
Q
R
E
Site 16
S140
T
E
T
D
S
L
V
S
A
Q
R
E
R
P
R
Site 17
Y173
R
R
R
E
P
G
G
Y
D
S
S
S
T
L
M
Site 18
S175
R
E
P
G
G
Y
D
S
S
S
T
L
M
S
S
Site 19
S176
E
P
G
G
Y
D
S
S
S
T
L
M
S
S
E
Site 20
S177
P
G
G
Y
D
S
S
S
T
L
M
S
S
E
L
Site 21
T178
G
G
Y
D
S
S
S
T
L
M
S
S
E
L
E
Site 22
S181
D
S
S
S
T
L
M
S
S
E
L
E
T
T
S
Site 23
S182
S
S
S
T
L
M
S
S
E
L
E
T
T
S
F
Site 24
T186
L
M
S
S
E
L
E
T
T
S
F
F
D
S
D
Site 25
S188
S
S
E
L
E
T
T
S
F
F
D
S
D
E
D
Site 26
S192
E
T
T
S
F
F
D
S
D
E
D
D
S
T
S
Site 27
S197
F
D
S
D
E
D
D
S
T
S
R
F
S
S
S
Site 28
T198
D
S
D
E
D
D
S
T
S
R
F
S
S
S
T
Site 29
S199
S
D
E
D
D
S
T
S
R
F
S
S
S
T
E
Site 30
S202
D
D
S
T
S
R
F
S
S
S
T
E
Q
S
S
Site 31
S203
D
S
T
S
R
F
S
S
S
T
E
Q
S
S
A
Site 32
S204
S
T
S
R
F
S
S
S
T
E
Q
S
S
A
S
Site 33
T205
T
S
R
F
S
S
S
T
E
Q
S
S
A
S
R
Site 34
S208
F
S
S
S
T
E
Q
S
S
A
S
R
L
M
R
Site 35
S209
S
S
S
T
E
Q
S
S
A
S
R
L
M
R
R
Site 36
S227
R
R
R
K
Q
K
V
S
R
I
E
R
S
S
S
Site 37
S232
K
V
S
R
I
E
R
S
S
S
F
S
S
I
T
Site 38
S233
V
S
R
I
E
R
S
S
S
F
S
S
I
T
D
Site 39
S234
S
R
I
E
R
S
S
S
F
S
S
I
T
D
S
Site 40
S236
I
E
R
S
S
S
F
S
S
I
T
D
S
T
M
Site 41
S237
E
R
S
S
S
F
S
S
I
T
D
S
T
M
S
Site 42
T239
S
S
S
F
S
S
I
T
D
S
T
M
S
L
N
Site 43
Y257
V
T
L
N
M
E
K
Y
N
F
L
G
I
S
I
Site 44
S268
G
I
S
I
V
G
Q
S
N
E
R
G
D
G
G
Site 45
Y277
E
R
G
D
G
G
I
Y
I
G
S
I
M
K
G
Site 46
T332
K
P
G
P
I
T
L
T
V
A
K
C
W
D
P
Site 47
T346
P
S
P
R
G
C
F
T
L
P
R
S
E
P
I
Site 48
S350
G
C
F
T
L
P
R
S
E
P
I
R
P
I
D
Site 49
S380
P
A
Y
G
M
S
P
S
L
S
T
I
T
S
T
Site 50
S382
Y
G
M
S
P
S
L
S
T
I
T
S
T
S
S
Site 51
T383
G
M
S
P
S
L
S
T
I
T
S
T
S
S
S
Site 52
T385
S
P
S
L
S
T
I
T
S
T
S
S
S
I
T
Site 53
S386
P
S
L
S
T
I
T
S
T
S
S
S
I
T
S
Site 54
T387
S
L
S
T
I
T
S
T
S
S
S
I
T
S
S
Site 55
S389
S
T
I
T
S
T
S
S
S
I
T
S
S
I
P
Site 56
S390
T
I
T
S
T
S
S
S
I
T
S
S
I
P
D
Site 57
T392
T
S
T
S
S
S
I
T
S
S
I
P
D
T
E
Site 58
S393
S
T
S
S
S
I
T
S
S
I
P
D
T
E
R
Site 59
S394
T
S
S
S
I
T
S
S
I
P
D
T
E
R
L
Site 60
T398
I
T
S
S
I
P
D
T
E
R
L
D
D
F
H
Site 61
S407
R
L
D
D
F
H
L
S
I
H
S
D
M
A
A
Site 62
Y452
S
D
V
V
D
W
L
Y
H
N
V
E
G
F
T
Site 63
Y467
D
R
R
E
A
R
K
Y
A
S
N
L
L
K
A
Site 64
T480
K
A
G
F
I
R
H
T
V
N
K
I
T
F
S
Site 65
S505
C
G
N
M
A
N
L
S
L
H
D
H
D
G
S
Site 66
S512
S
L
H
D
H
D
G
S
S
G
A
S
D
Q
D
Site 67
S513
L
H
D
H
D
G
S
S
G
A
S
D
Q
D
T
Site 68
S516
H
D
G
S
S
G
A
S
D
Q
D
T
L
A
P
Site 69
T520
S
G
A
S
D
Q
D
T
L
A
P
L
P
H
P
Site 70
Y540
P
M
A
F
P
Y
Q
Y
P
P
P
P
H
P
Y
Site 71
Y547
Y
P
P
P
P
H
P
Y
N
P
H
P
G
F
P
Site 72
Y558
P
G
F
P
E
L
G
Y
S
Y
G
G
G
S
A
Site 73
S559
G
F
P
E
L
G
Y
S
Y
G
G
G
S
A
S
Site 74
Y560
F
P
E
L
G
Y
S
Y
G
G
G
S
A
S
S
Site 75
S564
G
Y
S
Y
G
G
G
S
A
S
S
Q
H
S
E
Site 76
S566
S
Y
G
G
G
S
A
S
S
Q
H
S
E
G
S
Site 77
S567
Y
G
G
G
S
A
S
S
Q
H
S
E
G
S
R
Site 78
S570
G
S
A
S
S
Q
H
S
E
G
S
R
S
S
G
Site 79
S573
S
S
Q
H
S
E
G
S
R
S
S
G
S
N
R
Site 80
S575
Q
H
S
E
G
S
R
S
S
G
S
N
R
S
G
Site 81
S576
H
S
E
G
S
R
S
S
G
S
N
R
S
G
S
Site 82
S578
E
G
S
R
S
S
G
S
N
R
S
G
S
D
R
Site 83
S581
R
S
S
G
S
N
R
S
G
S
D
R
R
K
E
Site 84
S583
S
G
S
N
R
S
G
S
D
R
R
K
E
K
D
Site 85
S596
K
D
P
K
A
G
D
S
K
S
G
G
S
G
S
Site 86
S598
P
K
A
G
D
S
K
S
G
G
S
G
S
E
S
Site 87
S601
G
D
S
K
S
G
G
S
G
S
E
S
D
H
T
Site 88
S603
S
K
S
G
G
S
G
S
E
S
D
H
T
T
R
Site 89
S605
S
G
G
S
G
S
E
S
D
H
T
T
R
S
S
Site 90
T608
S
G
S
E
S
D
H
T
T
R
S
S
L
R
G
Site 91
T609
G
S
E
S
D
H
T
T
R
S
S
L
R
G
P
Site 92
S611
E
S
D
H
T
T
R
S
S
L
R
G
P
R
E
Site 93
S612
S
D
H
T
T
R
S
S
L
R
G
P
R
E
R
Site 94
S622
G
P
R
E
R
A
P
S
E
R
S
G
P
A
A
Site 95
S630
E
R
S
G
P
A
A
S
E
H
S
H
R
S
H
Site 96
S633
G
P
A
A
S
E
H
S
H
R
S
H
H
S
L
Site 97
S636
A
S
E
H
S
H
R
S
H
H
S
L
A
S
S
Site 98
S639
H
S
H
R
S
H
H
S
L
A
S
S
L
R
S
Site 99
S642
R
S
H
H
S
L
A
S
S
L
R
S
H
H
T
Site 100
S643
S
H
H
S
L
A
S
S
L
R
S
H
H
T
H
Site 101
S646
S
L
A
S
S
L
R
S
H
H
T
H
P
S
Y
Site 102
T649
S
S
L
R
S
H
H
T
H
P
S
Y
G
P
P
Site 103
S652
R
S
H
H
T
H
P
S
Y
G
P
P
G
V
P
Site 104
Y653
S
H
H
T
H
P
S
Y
G
P
P
G
V
P
P
Site 105
S689
P
P
G
R
D
L
A
S
V
P
P
E
L
T
A
Site 106
T695
A
S
V
P
P
E
L
T
A
S
R
Q
S
F
R
Site 107
S697
V
P
P
E
L
T
A
S
R
Q
S
F
R
M
A
Site 108
S700
E
L
T
A
S
R
Q
S
F
R
M
A
M
G
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation