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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
USP9X
Full Name:
Probable ubiquitin carboxyl-terminal hydrolase FAF-X
Alias:
Ubiquitin thioesterase FAF-X
Type:
EC 3.1.2.15; Ubiquitin conjugating system; Protease
Mass (Da):
289541
Number AA:
2547
UniProt ID:
Q93008
International Prot ID:
IPI00003964
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0070410
GO:0004197
GO:0004221
PhosphoSite+
KinaseNET
Biological Process:
GO:0030509
GO:0051301
GO:0007059
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
T
A
T
T
R
G
S
P
V
G
G
N
D
N
Site 2
S24
G
Q
A
P
D
G
Q
S
Q
P
P
L
Q
Q
N
Site 3
T33
P
P
L
Q
Q
N
Q
T
S
S
P
D
S
S
N
Site 4
S34
P
L
Q
Q
N
Q
T
S
S
P
D
S
S
N
E
Site 5
S35
L
Q
Q
N
Q
T
S
S
P
D
S
S
N
E
N
Site 6
S38
N
Q
T
S
S
P
D
S
S
N
E
N
S
P
A
Site 7
S39
Q
T
S
S
P
D
S
S
N
E
N
S
P
A
T
Site 8
S43
P
D
S
S
N
E
N
S
P
A
T
P
P
D
E
Site 9
T46
S
N
E
N
S
P
A
T
P
P
D
E
Q
G
Q
Site 10
T70
E
E
P
A
F
P
H
T
D
L
A
K
L
D
D
Site 11
S113
K
K
G
L
D
V
K
S
E
A
C
Q
R
F
F
Site 12
S188
N
G
T
R
P
C
E
S
V
S
S
S
V
Q
L
Site 13
S190
T
R
P
C
E
S
V
S
S
S
V
Q
L
P
E
Site 14
S191
R
P
C
E
S
V
S
S
S
V
Q
L
P
E
D
Site 15
S192
P
C
E
S
V
S
S
S
V
Q
L
P
E
D
E
Site 16
S204
E
D
E
L
F
A
R
S
P
D
P
R
S
P
K
Site 17
S209
A
R
S
P
D
P
R
S
P
K
G
W
L
V
D
Site 18
T260
G
Q
C
Y
E
F
L
T
L
H
T
V
K
K
Y
Site 19
S301
E
A
K
N
D
A
L
S
M
I
I
K
S
L
K
Site 20
S306
A
L
S
M
I
I
K
S
L
K
N
L
A
S
R
Site 21
S312
K
S
L
K
N
L
A
S
R
V
P
G
Q
E
E
Site 22
T320
R
V
P
G
Q
E
E
T
V
K
N
L
E
I
F
Site 23
S340
L
R
L
L
Q
I
S
S
F
N
G
K
M
N
A
Site 24
S357
E
V
N
K
V
I
S
S
V
S
Y
Y
T
H
R
Site 25
S359
N
K
V
I
S
S
V
S
Y
Y
T
H
R
H
G
Site 26
Y360
K
V
I
S
S
V
S
Y
Y
T
H
R
H
G
N
Site 27
Y361
V
I
S
S
V
S
Y
Y
T
H
R
H
G
N
P
Site 28
T375
P
E
E
E
E
W
L
T
A
E
R
M
A
E
W
Site 29
S396
L
S
I
V
L
R
D
S
L
H
Q
P
Q
Y
V
Site 30
Y402
D
S
L
H
Q
P
Q
Y
V
E
K
L
E
K
I
Site 31
T420
V
I
K
E
K
A
L
T
L
Q
D
L
D
N
I
Site 32
S454
A
K
L
A
W
D
F
S
P
E
Q
L
D
H
L
Site 33
Y531
A
H
I
K
I
L
D
Y
S
C
S
Q
D
R
D
Site 34
S534
K
I
L
D
Y
S
C
S
Q
D
R
D
T
Q
K
Site 35
T554
R
F
I
E
E
L
R
T
N
D
K
W
V
I
P
Site 36
S581
G
E
A
P
Q
N
L
S
Q
T
Q
R
S
P
H
Site 37
T583
A
P
Q
N
L
S
Q
T
Q
R
S
P
H
V
F
Site 38
S586
N
L
S
Q
T
Q
R
S
P
H
V
F
Y
R
H
Site 39
Y616
V
A
E
N
L
A
T
Y
M
E
S
M
R
L
Y
Site 40
Y623
Y
M
E
S
M
R
L
Y
A
R
D
H
E
D
Y
Site 41
Y630
Y
A
R
D
H
E
D
Y
D
P
Q
T
V
R
L
Site 42
T634
H
E
D
Y
D
P
Q
T
V
R
L
G
S
R
Y
Site 43
S639
P
Q
T
V
R
L
G
S
R
Y
S
H
V
Q
E
Site 44
Y641
T
V
R
L
G
S
R
Y
S
H
V
Q
E
V
Q
Site 45
S642
V
R
L
G
S
R
Y
S
H
V
Q
E
V
Q
E
Site 46
Y694
R
E
A
C
F
K
W
Y
S
K
L
M
G
D
E
Site 47
S695
E
A
C
F
K
W
Y
S
K
L
M
G
D
E
P
Site 48
S723
N
V
L
Q
L
D
P
S
L
L
T
E
N
G
M
Site 49
Y754
L
V
A
K
R
R
A
Y
M
M
D
D
L
E
L
Site 50
S774
L
W
R
V
V
I
Q
S
N
D
D
I
A
S
R
Site 51
Y820
F
D
R
L
K
A
S
Y
D
T
L
C
V
L
D
Site 52
T822
R
L
K
A
S
Y
D
T
L
C
V
L
D
G
D
Site 53
S832
V
L
D
G
D
K
D
S
V
N
C
A
R
Q
E
Site 54
Y853
V
L
T
V
L
R
E
Y
I
N
E
C
D
S
D
Site 55
Y861
I
N
E
C
D
S
D
Y
H
E
E
R
T
I
L
Site 56
T866
S
D
Y
H
E
E
R
T
I
L
P
M
S
R
A
Site 57
S871
E
R
T
I
L
P
M
S
R
A
F
R
G
K
H
Site 58
S880
A
F
R
G
K
H
L
S
F
V
V
R
F
P
N
Site 59
S952
Q
L
N
L
K
D
K
S
L
I
T
A
K
L
T
Site 60
S963
A
K
L
T
Q
I
S
S
N
M
P
S
S
P
D
Site 61
S967
Q
I
S
S
N
M
P
S
S
P
D
S
S
S
D
Site 62
S968
I
S
S
N
M
P
S
S
P
D
S
S
S
D
S
Site 63
S971
N
M
P
S
S
P
D
S
S
S
D
S
S
T
G
Site 64
S972
M
P
S
S
P
D
S
S
S
D
S
S
T
G
S
Site 65
S973
P
S
S
P
D
S
S
S
D
S
S
T
G
S
P
Site 66
S975
S
P
D
S
S
S
D
S
S
T
G
S
P
G
N
Site 67
S976
P
D
S
S
S
D
S
S
T
G
S
P
G
N
H
Site 68
T977
D
S
S
S
D
S
S
T
G
S
P
G
N
H
G
Site 69
S979
S
S
D
S
S
T
G
S
P
G
N
H
G
N
H
Site 70
Y987
P
G
N
H
G
N
H
Y
S
D
G
P
N
P
E
Site 71
S988
G
N
H
G
N
H
Y
S
D
G
P
N
P
E
V
Site 72
S1012
S
L
H
P
R
Y
I
S
F
L
W
Q
V
A
D
Site 73
S1044
M
K
L
M
P
P
D
S
T
T
I
E
K
L
R
Site 74
T1046
L
M
P
P
D
S
T
T
I
E
K
L
R
A
I
Site 75
S1064
H
A
K
L
G
E
S
S
L
S
P
S
L
D
S
Site 76
S1066
K
L
G
E
S
S
L
S
P
S
L
D
S
L
F
Site 77
S1068
G
E
S
S
L
S
P
S
L
D
S
L
F
F
G
Site 78
S1103
G
A
P
L
A
D
D
S
S
D
F
Q
F
H
F
Site 79
S1104
A
P
L
A
D
D
S
S
D
F
Q
F
H
F
L
Site 80
T1136
L
P
N
A
D
M
E
T
R
R
G
A
Y
L
N
Site 81
Y1141
M
E
T
R
R
G
A
Y
L
N
A
L
K
I
A
Site 82
S1197
V
L
Q
S
A
L
Q
S
I
P
N
P
S
S
E
Site 83
S1203
Q
S
I
P
N
P
S
S
E
C
M
L
R
N
V
Site 84
S1219
V
R
L
A
Q
Q
I
S
D
E
A
S
R
Y
M
Site 85
S1252
G
S
L
Q
L
V
F
S
P
N
E
E
I
T
K
Site 86
S1300
P
T
A
L
D
A
L
S
K
E
K
A
W
Q
T
Site 87
S1318
D
L
L
L
H
C
H
S
K
T
V
R
Q
V
A
Site 88
T1320
L
L
H
C
H
S
K
T
V
R
Q
V
A
Q
E
Site 89
Y1368
R
A
K
H
S
G
D
Y
F
T
L
L
R
H
L
Site 90
T1370
K
H
S
G
D
Y
F
T
L
L
R
H
L
L
N
Site 91
Y1378
L
L
R
H
L
L
N
Y
A
Y
N
S
N
I
N
Site 92
Y1380
R
H
L
L
N
Y
A
Y
N
S
N
I
N
V
P
Site 93
S1436
E
L
L
A
F
Q
T
S
E
K
K
F
H
I
G
Site 94
Y1470
A
S
N
V
Y
L
Q
Y
M
R
N
G
E
L
P
Site 95
T1517
K
Q
I
V
D
S
L
T
E
M
Y
Y
I
G
T
Site 96
Y1537
E
A
L
T
E
W
E
Y
L
P
P
V
G
P
R
Site 97
Y1560
K
N
A
G
A
T
C
Y
M
N
S
V
I
Q
Q
Site 98
Y1569
N
S
V
I
Q
Q
L
Y
M
I
P
S
I
R
N
Site 99
S1586
L
A
I
E
G
T
G
S
D
V
D
D
D
M
S
Site 100
S1593
S
D
V
D
D
D
M
S
G
D
E
K
Q
D
N
Site 101
S1602
D
E
K
Q
D
N
E
S
N
V
D
P
R
D
D
Site 102
Y1613
P
R
D
D
V
F
G
Y
P
Q
Q
F
E
D
K
Site 103
T1626
D
K
P
A
L
S
K
T
E
D
R
K
E
Y
N
Site 104
Y1632
K
T
E
D
R
K
E
Y
N
I
G
V
L
R
H
Site 105
Y1654
L
A
A
S
R
L
Q
Y
Y
V
P
R
G
F
W
Site 106
Y1655
A
A
S
R
L
Q
Y
Y
V
P
R
G
F
W
K
Site 107
S1685
D
A
L
E
F
F
N
S
L
V
D
S
L
D
E
Site 108
T1731
Y
E
C
E
E
S
F
T
T
L
N
V
D
I
R
Site 109
T1732
E
C
E
E
S
F
T
T
L
N
V
D
I
R
N
Site 110
S1746
N
H
Q
N
L
L
D
S
L
E
Q
Y
V
K
G
Site 111
Y1750
L
L
D
S
L
E
Q
Y
V
K
G
D
L
L
E
Site 112
Y1762
L
L
E
G
A
N
A
Y
H
C
E
K
C
N
K
Site 113
T1773
K
C
N
K
K
V
D
T
V
K
R
L
L
I
K
Site 114
Y1795
I
Q
L
K
R
F
D
Y
D
W
E
R
E
C
A
Site 115
Y1808
C
A
I
K
F
N
D
Y
F
E
F
P
R
E
L
Site 116
Y1820
R
E
L
D
M
E
P
Y
T
V
A
G
V
A
K
Site 117
S1837
G
D
N
V
N
P
E
S
Q
L
I
Q
Q
S
E
Site 118
S1843
E
S
Q
L
I
Q
Q
S
E
Q
S
E
S
E
T
Site 119
S1848
Q
Q
S
E
Q
S
E
S
E
T
A
G
S
T
K
Site 120
T1850
S
E
Q
S
E
S
E
T
A
G
S
T
K
Y
R
Site 121
S1853
S
E
S
E
T
A
G
S
T
K
Y
R
L
V
G
Site 122
S1869
L
V
H
S
G
Q
A
S
G
G
H
Y
Y
S
Y
Site 123
Y1873
G
Q
A
S
G
G
H
Y
Y
S
Y
I
I
Q
R
Site 124
Y1876
S
G
G
H
Y
Y
S
Y
I
I
Q
R
N
G
G
Site 125
Y1891
D
G
E
R
N
R
W
Y
K
F
D
D
G
D
V
Site 126
T1899
K
F
D
D
G
D
V
T
E
C
K
M
D
D
D
Site 127
Y1946
W
N
A
Y
I
L
F
Y
E
R
M
D
T
I
D
Site 128
T1951
L
F
Y
E
R
M
D
T
I
D
Q
D
D
E
L
Site 129
Y1961
Q
D
D
E
L
I
R
Y
I
S
E
L
A
I
T
Site 130
S1963
D
E
L
I
R
Y
I
S
E
L
A
I
T
T
R
Site 131
S1983
M
P
S
A
I
E
R
S
V
R
K
Q
N
V
Q
Site 132
Y2002
R
M
Q
Y
S
M
E
Y
F
Q
F
M
K
K
L
Site 133
Y2016
L
L
T
C
N
G
V
Y
L
N
P
P
P
G
Q
Site 134
S2059
T
K
K
V
V
R
G
S
A
S
D
W
Y
D
A
Site 135
S2094
F
N
V
S
N
R
F
S
E
Y
L
L
E
C
P
Site 136
Y2096
V
S
N
R
F
S
E
Y
L
L
E
C
P
S
A
Site 137
S2128
L
Q
D
G
P
C
P
S
P
F
A
S
P
G
P
Site 138
S2132
P
C
P
S
P
F
A
S
P
G
P
S
S
Q
A
Site 139
S2136
P
F
A
S
P
G
P
S
S
Q
A
Y
D
N
L
Site 140
S2137
F
A
S
P
G
P
S
S
Q
A
Y
D
N
L
S
Site 141
Y2140
P
G
P
S
S
Q
A
Y
D
N
L
S
L
S
D
Site 142
S2144
S
Q
A
Y
D
N
L
S
L
S
D
H
L
L
R
Site 143
S2146
A
Y
D
N
L
S
L
S
D
H
L
L
R
A
V
Site 144
S2162
N
L
L
R
R
E
V
S
E
H
G
R
H
L
Q
Site 145
Y2171
H
G
R
H
L
Q
Q
Y
F
N
L
F
V
M
Y
Site 146
Y2213
G
P
G
P
P
I
K
Y
Q
Y
A
E
L
G
K
Site 147
Y2215
G
P
P
I
K
Y
Q
Y
A
E
L
G
K
L
Y
Site 148
S2240
N
V
S
S
R
M
Q
S
S
I
N
G
N
P
P
Site 149
S2241
V
S
S
R
M
Q
S
S
I
N
G
N
P
P
L
Site 150
S2258
P
F
G
D
P
N
L
S
Q
P
I
M
P
I
Q
Site 151
S2287
K
K
I
I
E
D
C
S
N
S
E
E
T
V
K
Site 152
S2289
I
I
E
D
C
S
N
S
E
E
T
V
K
L
L
Site 153
S2307
C
W
E
N
P
Q
F
S
S
T
V
L
S
E
L
Site 154
S2308
W
E
N
P
Q
F
S
S
T
V
L
S
E
L
L
Site 155
T2309
E
N
P
Q
F
S
S
T
V
L
S
E
L
L
W
Site 156
T2365
D
R
D
G
L
F
D
T
I
Q
R
S
K
N
H
Site 157
Y2373
I
Q
R
S
K
N
H
Y
Q
K
R
A
Y
Q
C
Site 158
Y2424
D
E
L
E
R
R
P
Y
T
G
N
P
Q
Y
T
Site 159
T2425
E
L
E
R
R
P
Y
T
G
N
P
Q
Y
T
Y
Site 160
Y2430
P
Y
T
G
N
P
Q
Y
T
Y
N
N
W
S
P
Site 161
T2431
Y
T
G
N
P
Q
Y
T
Y
N
N
W
S
P
P
Site 162
Y2432
T
G
N
P
Q
Y
T
Y
N
N
W
S
P
P
V
Site 163
S2436
Q
Y
T
Y
N
N
W
S
P
P
V
Q
S
N
E
Site 164
S2441
N
W
S
P
P
V
Q
S
N
E
T
S
N
G
Y
Site 165
S2445
P
V
Q
S
N
E
T
S
N
G
Y
F
L
E
R
Site 166
Y2448
S
N
E
T
S
N
G
Y
F
L
E
R
S
H
S
Site 167
S2453
N
G
Y
F
L
E
R
S
H
S
A
R
M
T
L
Site 168
S2455
Y
F
L
E
R
S
H
S
A
R
M
T
L
A
K
Site 169
T2459
R
S
H
S
A
R
M
T
L
A
K
A
C
E
L
Site 170
S2483
D
A
P
D
E
H
E
S
P
P
P
E
D
A
P
Site 171
Y2492
P
P
E
D
A
P
L
Y
P
H
S
P
G
S
Q
Site 172
S2495
D
A
P
L
Y
P
H
S
P
G
S
Q
Y
Q
Q
Site 173
S2498
L
Y
P
H
S
P
G
S
Q
Y
Q
Q
N
N
H
Site 174
Y2500
P
H
S
P
G
S
Q
Y
Q
Q
N
N
H
V
H
Site 175
Y2511
N
H
V
H
G
Q
P
Y
T
G
P
A
A
H
H
Site 176
T2512
H
V
H
G
Q
P
Y
T
G
P
A
A
H
H
M
Site 177
Y2533
G
Q
R
A
Q
E
N
Y
E
G
S
E
E
V
S
Site 178
S2536
A
Q
E
N
Y
E
G
S
E
E
V
S
P
P
Q
Site 179
S2540
Y
E
G
S
E
E
V
S
P
P
Q
T
K
D
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation