KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
CUL5
Full Name:
Cullin-5
Alias:
CUL-5; Cullin 5; VAC1; VACM1; VACM-1; Vasopressin-activated calcium-mobilizing receptor
Type:
Ubiquitin conjugating protein
Mass (Da):
90955
Number AA:
780
UniProt ID:
Q93034
International Prot ID:
IPI00216003
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0031461
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0005262
GO:0004872
GO:0031625
PhosphoSite+
KinaseNET
Biological Process:
GO:0000082
GO:0007050
GO:0008283
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
N
L
L
K
N
K
G
S
L
Q
F
E
D
K
W
Site 2
S34
L
K
L
L
R
Q
E
S
V
T
K
Q
Q
W
F
Site 3
T36
L
L
R
Q
E
S
V
T
K
Q
Q
W
F
D
L
Site 4
S82
Q
A
Q
A
R
V
L
S
H
Q
D
D
T
A
L
Site 5
T117
P
F
C
Q
L
E
I
T
L
M
G
K
Q
G
S
Site 6
S124
T
L
M
G
K
Q
G
S
N
K
K
S
N
V
E
Site 7
S128
K
Q
G
S
N
K
K
S
N
V
E
D
S
I
V
Site 8
S133
K
K
S
N
V
E
D
S
I
V
R
K
L
M
L
Site 9
T142
V
R
K
L
M
L
D
T
W
N
E
S
I
F
S
Site 10
S158
I
K
N
R
L
Q
D
S
A
M
K
L
V
H
A
Site 11
Y198
P
E
D
K
L
Q
I
Y
R
D
N
F
E
K
A
Site 12
Y206
R
D
N
F
E
K
A
Y
L
D
S
T
E
R
F
Site 13
S209
F
E
K
A
Y
L
D
S
T
E
R
F
Y
R
T
Site 14
T210
E
K
A
Y
L
D
S
T
E
R
F
Y
R
T
Q
Site 15
Y214
L
D
S
T
E
R
F
Y
R
T
Q
A
P
S
Y
Site 16
T216
S
T
E
R
F
Y
R
T
Q
A
P
S
Y
L
Q
Site 17
S220
F
Y
R
T
Q
A
P
S
Y
L
Q
Q
N
G
V
Site 18
Y221
Y
R
T
Q
A
P
S
Y
L
Q
Q
N
G
V
Q
Site 19
Y230
Q
Q
N
G
V
Q
N
Y
M
K
Y
A
D
A
K
Site 20
Y233
G
V
Q
N
Y
M
K
Y
A
D
A
K
L
K
E
Site 21
T251
R
A
L
R
Y
L
E
T
R
R
E
C
N
S
V
Site 22
S257
E
T
R
R
E
C
N
S
V
E
A
L
M
E
C
Site 23
T290
G
M
I
K
R
N
E
T
E
K
L
H
L
M
F
Site 24
S298
E
K
L
H
L
M
F
S
L
M
D
K
V
P
N
Site 25
T335
A
A
A
E
T
I
T
T
D
S
E
K
Y
V
E
Site 26
Y340
I
T
T
D
S
E
K
Y
V
E
Q
L
L
T
L
Site 27
T346
K
Y
V
E
Q
L
L
T
L
F
N
R
F
S
K
Site 28
T367
Q
D
D
P
R
F
L
T
A
R
D
K
A
Y
K
Site 29
Y373
L
T
A
R
D
K
A
Y
K
A
V
V
N
D
A
Site 30
T398
Q
K
G
V
G
L
K
T
Q
P
E
S
K
C
P
Site 31
S402
G
L
K
T
Q
P
E
S
K
C
P
E
L
L
A
Site 32
T419
C
D
M
L
L
R
K
T
P
L
S
K
K
L
T
Site 33
S422
L
L
R
K
T
P
L
S
K
K
L
T
S
E
E
Site 34
T426
T
P
L
S
K
K
L
T
S
E
E
I
E
A
K
Site 35
Y453
N
K
D
V
F
M
R
Y
H
K
A
H
L
T
R
Site 36
T459
R
Y
H
K
A
H
L
T
R
R
L
I
L
D
I
Site 37
S467
R
R
L
I
L
D
I
S
A
D
S
E
I
E
E
Site 38
Y489
E
V
G
M
P
A
D
Y
V
N
K
L
A
R
M
Site 39
S539
N
A
G
A
W
S
R
S
S
E
K
V
F
V
S
Site 40
S540
A
G
A
W
S
R
S
S
E
K
V
F
V
S
L
Site 41
S546
S
S
E
K
V
F
V
S
L
P
T
E
L
E
D
Site 42
Y591
F
K
N
E
V
G
Q
Y
D
L
E
V
T
T
F
Site 43
S615
Q
R
P
R
E
K
I
S
F
E
N
L
K
L
A
Site 44
Y650
L
K
R
Q
V
L
L
Y
E
P
Q
V
N
S
P
Site 45
S656
L
Y
E
P
Q
V
N
S
P
K
D
F
T
E
G
Site 46
S673
F
S
V
N
Q
E
F
S
L
I
K
N
A
K
V
Site 47
T695
L
I
G
R
L
Q
L
T
T
E
R
M
R
E
E
Site 48
T696
I
G
R
L
Q
L
T
T
E
R
M
R
E
E
E
Site 49
S730
M
K
M
R
K
K
I
S
N
A
Q
L
Q
T
E
Site 50
Y765
E
W
L
I
E
H
K
Y
I
R
R
D
E
S
D
Site 51
S771
K
Y
I
R
R
D
E
S
D
I
N
T
F
I
Y
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation